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Protein

Beta-synuclein

Gene

Sncb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in neuronal plasticity.By similarity

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: MGI
  • dopamine metabolic process Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • synapse organization Source: MGI
  • synaptic vesicle endocytosis Source: SynGO

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-synuclein
Gene namesi
Name:Sncb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1889011 Sncb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002861761 – 133Beta-synucleinAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineCombined sources1
Modified residuei117Phosphoserine; by BARK1, CK2 and GRK5By similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91ZZ3
PaxDbiQ91ZZ3
PeptideAtlasiQ91ZZ3
PRIDEiQ91ZZ3

2D gel databases

UCD-2DPAGEiQ91ZZ3

PTM databases

iPTMnetiQ91ZZ3
PhosphoSitePlusiQ91ZZ3

Expressioni

Tissue specificityi

Highly expressed in the brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000034891 Expressed in 132 organ(s), highest expression level in cerebellum
CleanExiMM_SNCB
GenevisibleiQ91ZZ3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91ZZ3, 1 interactor
MINTiQ91ZZ3
STRINGi10090.ENSMUSP00000043074

Structurei

3D structure databases

ProteinModelPortaliQ91ZZ3
SMRiQ91ZZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 553; approximateAdd BLAST14
Repeati56 – 664Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 664 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST47

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZ8U Eukaryota
ENOG4111Y4R LUCA
GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiQ91ZZ3
OMAiDPEGETY
OrthoDBiEOG091G11PA
PhylomeDBiQ91ZZ3
TreeFamiTF332776

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002461 Synuclein_beta
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF4 PTHR13820:SF4, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01213 BSYNUCLEIN
PR01211 SYNUCLEIN

Sequencei

Sequence statusi: Complete.

Q91ZZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTSGVVQG
60 70 80 90 100
VASVAEKTKE QASHLGGAVF SGAGNIAAAT GLVKKEEFPT DLKPEEVAQE
110 120 130
AAEEPLIEPL MEPEGESYED SPQEEYQEYE PEA
Length:133
Mass (Da):14,052
Last modified:December 1, 2001 - v1
Checksum:i8274D8A6A0D8E4D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348164, AF348162, AF348163 Genomic DNA Translation: AAK83238.1
BC019409 mRNA Translation: AAH19409.1
CCDSiCCDS36670.1
RefSeqiNP_291088.1, NM_033610.2
XP_006517078.1, XM_006517015.3
XP_006517079.1, XM_006517016.3
UniGeneiMm.200843

Genome annotation databases

EnsembliENSMUST00000036825; ENSMUSP00000043074; ENSMUSG00000034891
ENSMUST00000134110; ENSMUSP00000116296; ENSMUSG00000034891
GeneIDi104069
KEGGimmu:104069
UCSCiuc007qpc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348164, AF348162, AF348163 Genomic DNA Translation: AAK83238.1
BC019409 mRNA Translation: AAH19409.1
CCDSiCCDS36670.1
RefSeqiNP_291088.1, NM_033610.2
XP_006517078.1, XM_006517015.3
XP_006517079.1, XM_006517016.3
UniGeneiMm.200843

3D structure databases

ProteinModelPortaliQ91ZZ3
SMRiQ91ZZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91ZZ3, 1 interactor
MINTiQ91ZZ3
STRINGi10090.ENSMUSP00000043074

PTM databases

iPTMnetiQ91ZZ3
PhosphoSitePlusiQ91ZZ3

2D gel databases

UCD-2DPAGEiQ91ZZ3

Proteomic databases

MaxQBiQ91ZZ3
PaxDbiQ91ZZ3
PeptideAtlasiQ91ZZ3
PRIDEiQ91ZZ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036825; ENSMUSP00000043074; ENSMUSG00000034891
ENSMUST00000134110; ENSMUSP00000116296; ENSMUSG00000034891
GeneIDi104069
KEGGimmu:104069
UCSCiuc007qpc.1 mouse

Organism-specific databases

CTDi6620
MGIiMGI:1889011 Sncb

Phylogenomic databases

eggNOGiENOG410IZ8U Eukaryota
ENOG4111Y4R LUCA
GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiQ91ZZ3
OMAiDPEGETY
OrthoDBiEOG091G11PA
PhylomeDBiQ91ZZ3
TreeFamiTF332776

Miscellaneous databases

ChiTaRSiSncb mouse
PROiPR:Q91ZZ3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034891 Expressed in 132 organ(s), highest expression level in cerebellum
CleanExiMM_SNCB
GenevisibleiQ91ZZ3 MM

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002461 Synuclein_beta
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF4 PTHR13820:SF4, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01213 BSYNUCLEIN
PR01211 SYNUCLEIN
ProtoNetiSearch...

Entry informationi

Entry nameiSYUB_MOUSE
AccessioniPrimary (citable) accession number: Q91ZZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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