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Protein

Histamine H4 receptor

Gene

Hrh4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390650 Histamine receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H4 receptor
Short name:
H4R
Short name:
HH4R
Gene namesi
Name:Hrh4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2429635 Hrh4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 52CytoplasmicSequence analysisAdd BLAST12
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 87ExtracellularSequence analysisAdd BLAST14
Transmembranei88 – 108Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini109 – 131CytoplasmicSequence analysisAdd BLAST23
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 174ExtracellularSequence analysisAdd BLAST22
Transmembranei175 – 195Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini196 – 306CytoplasmicSequence analysisAdd BLAST111
Transmembranei307 – 327Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini328 – 343ExtracellularSequence analysisAdd BLAST16
Transmembranei344 – 364Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini365 – 391CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5657
GuidetoPHARMACOLOGYi265

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003032381 – 391Histamine H4 receptorAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi87 ↔ 166PROSITE-ProRule annotation
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91ZY2
PRIDEiQ91ZY2

PTM databases

iPTMnetiQ91ZY2
PhosphoSitePlusiQ91ZY2

Expressioni

Gene expression databases

BgeeiENSMUSG00000037346 Expressed in 7 organ(s), highest expression level in testis
CleanExiMM_HRH4
GenevisibleiQ91ZY2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041061

Chemistry databases

BindingDBiQ91ZY2

Structurei

3D structure databases

ProteinModelPortaliQ91ZY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000048707
HOVERGENiHBG102132
InParanoidiQ91ZY2
KOiK04152
OMAiLMVAVWV
OrthoDBiEOG091G097A
PhylomeDBiQ91ZY2
TreeFamiTF351747

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008102 Histamine_H4_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01726 HISTAMINEH4R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91ZY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESNSTGIL PPAAQVPLAF LMSSFAFAIM VGNAVVILAF VVDRNLRHRS
60 70 80 90 100
NYFFLNLAIS DFLVGLISIP LYIPHVLFNW NFGSGICMFW LITDYLLCTA
110 120 130 140 150
SVYNIVLISY DRYQSVSNAV SYRAQHTGIM KIVAQMVAVW ILAFLVNGPM
160 170 180 190 200
ILASDSWKNS TNTKDCEPGF VTEWYILTIT MLLEFLLPVI SVAYFNVQIY
210 220 230 240 250
WSLWKRRALS RCPSHAGFST TSSSASGHLH RAGVACRTSN PGLKESAASR
260 270 280 290 300
HSESPRRKSS ILVSLRTHMN SSITAFKVGS FWRSESAALR QREYAELLRG
310 320 330 340 350
RKLARSLAIL LSAFAICWAP YCLFTIVLST YPRTERPKSV WYSIAFWLQW
360 370 380 390
FNSFVNPFLY PLCHRRFQKA FWKILCVTKQ PALSQNQSVS S
Length:391
Mass (Da):44,249
Last modified:December 1, 2001 - v1
Checksum:i59EC73CB5214C5E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358859 mRNA Translation: AAK97380.1
CCDSiCCDS29069.1
RefSeqiNP_694727.1, NM_153087.2
UniGeneiMm.207073

Genome annotation databases

EnsembliENSMUST00000041676; ENSMUSP00000041061; ENSMUSG00000037346
GeneIDi225192
KEGGimmu:225192
UCSCiuc008edb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358859 mRNA Translation: AAK97380.1
CCDSiCCDS29069.1
RefSeqiNP_694727.1, NM_153087.2
UniGeneiMm.207073

3D structure databases

ProteinModelPortaliQ91ZY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041061

Chemistry databases

BindingDBiQ91ZY2
ChEMBLiCHEMBL5657
GuidetoPHARMACOLOGYi265

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ91ZY2
PhosphoSitePlusiQ91ZY2

Proteomic databases

PaxDbiQ91ZY2
PRIDEiQ91ZY2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041676; ENSMUSP00000041061; ENSMUSG00000037346
GeneIDi225192
KEGGimmu:225192
UCSCiuc008edb.1 mouse

Organism-specific databases

CTDi59340
MGIiMGI:2429635 Hrh4

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000048707
HOVERGENiHBG102132
InParanoidiQ91ZY2
KOiK04152
OMAiLMVAVWV
OrthoDBiEOG091G097A
PhylomeDBiQ91ZY2
TreeFamiTF351747

Enzyme and pathway databases

ReactomeiR-MMU-390650 Histamine receptors
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:Q91ZY2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037346 Expressed in 7 organ(s), highest expression level in testis
CleanExiMM_HRH4
GenevisibleiQ91ZY2 MM

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008102 Histamine_H4_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01726 HISTAMINEH4R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHRH4_MOUSE
AccessioniPrimary (citable) accession number: Q91ZY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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