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Protein

CD209 antigen-like protein A

Gene

Cd209a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.

Caution

In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified. Mouse CD209A product was named DC-SIGN by PubMed:11581173 because of its similar expression pattern and chromosomal location in juxtaposition to CD23, but despite of the low sequence similarity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi198CalciumBy similarity1
Metal bindingi200CalciumBy similarity1
Metal bindingi202Calcium; via carbonyl oxygenBy similarity1
Metal bindingi205CalciumBy similarity1
Metal bindingi216CalciumBy similarity1
Metal bindingi217CalciumBy similarity1

GO - Molecular functioni

  • calcium-dependent protein binding Source: MGI
  • carbohydrate binding Source: MGI
  • carbohydrate derivative binding Source: MGI
  • mannose binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • virus receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandCalcium, Lectin, Mannose-binding, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5621575 CD209 (DC-SIGN) signaling
R-MMU-8851680 Butyrophilin (BTN) family interactions

Names & Taxonomyi

Protein namesi
Recommended name:
CD209 antigen-like protein A
Alternative name(s):
Dendritic cell-specific ICAM-3-grabbing non-integrin
Short name:
DC-SIGN
CD_antigen: CD209
Gene namesi
Name:Cd209a
Synonyms:Cire
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2157942 Cd209a

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini73 – 238ExtracellularSequence analysisAdd BLAST166

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466041 – 238CD209 antigen-like protein AAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi108 ↔ 119PROSITE-ProRule annotation
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 228PROSITE-ProRule annotation
Disulfide bondi207 ↔ 220PROSITE-ProRule annotation
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91ZX1
PRIDEiQ91ZX1

PTM databases

iPTMnetiQ91ZX1
PhosphoSitePlusiQ91ZX1

Expressioni

Tissue specificityi

Predominantly expressed in dendritic cells. Detected at very low levels in lung, spleen, lymph nodes and bone marrow.2 Publications

Inductioni

Down-regulated upon activation of dendritic cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000031494 Expressed in 46 organ(s), highest expression level in zone of skin
CleanExiMM_CD209A
ExpressionAtlasiQ91ZX1 baseline and differential
GenevisibleiQ91ZX1 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000012847

Structurei

3D structure databases

ProteinModelPortaliQ91ZX1
SMRiQ91ZX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 229C-type lectinPROSITE-ProRule annotationAdd BLAST115

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000013222
HOVERGENiHBG050992
InParanoidiQ91ZX1
KOiK06563
OrthoDBiEOG091G0M9Q
PhylomeDBiQ91ZX1
TreeFamiTF333341

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q91ZX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDSKEMGKR QLRPLDEELL TSSHTRHSIK GFGFQTNSGF SSFTGCLVHS
60 70 80 90 100
QVPLALQVLF LAVCSVLLVV ILVKVYKIPS SQEENNQMNV YQELTQLKAG
110 120 130 140 150
VDRLCRSCPW DWTHFQGSCY FFSVAQKSWN DSATACHNVG AQLVVIKSDE
160 170 180 190 200
EQNFLQQTSK KRGYTWMGLI DMSKESTWYW VDGSPLTLSF MKYWSKGEPN
210 220 230
NLGEEDCAEF RDDGWNDTKC TNKKFWICKK LSTSCPSK
Length:238
Mass (Da):27,149
Last modified:December 1, 2001 - v1
Checksum:i05C025FCF2E63DC2
GO
Isoform 2 (identifier: Q91ZX1-2) [UniParc]FASTAAdd to basket
Also known as: neck-less

The sequence of this isoform differs from the canonical sequence as follows:
     75-101: Missing.

Show »
Length:211
Mass (Da):24,055
Checksum:i1AF2988F95FD9634
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LI09A0A140LI09_MOUSE
CD209 antigen-like protein A
Cd209a
179Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01006775 – 101Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373408 mRNA Translation: AAL13234.1
AF374470 mRNA Translation: AAL27539.1
AY049062 mRNA Translation: AAK85825.1
AK054139 mRNA Translation: BAC35667.1
AK171639 mRNA Translation: BAE42579.1
CCDSiCCDS22073.1 [Q91ZX1-1]
RefSeqiNP_573501.1, NM_133238.5 [Q91ZX1-1]
UniGeneiMm.32510

Genome annotation databases

EnsembliENSMUST00000012847; ENSMUSP00000012847; ENSMUSG00000031494 [Q91ZX1-1]
ENSMUST00000207979; ENSMUSP00000146702; ENSMUSG00000031494 [Q91ZX1-2]
GeneIDi170786
KEGGimmu:170786
UCSCiuc009ksq.2 mouse [Q91ZX1-1]
uc012fyt.1 mouse [Q91ZX1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

SIGNR5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373408 mRNA Translation: AAL13234.1
AF374470 mRNA Translation: AAL27539.1
AY049062 mRNA Translation: AAK85825.1
AK054139 mRNA Translation: BAC35667.1
AK171639 mRNA Translation: BAE42579.1
CCDSiCCDS22073.1 [Q91ZX1-1]
RefSeqiNP_573501.1, NM_133238.5 [Q91ZX1-1]
UniGeneiMm.32510

3D structure databases

ProteinModelPortaliQ91ZX1
SMRiQ91ZX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000012847

PTM databases

iPTMnetiQ91ZX1
PhosphoSitePlusiQ91ZX1

Proteomic databases

PaxDbiQ91ZX1
PRIDEiQ91ZX1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000012847; ENSMUSP00000012847; ENSMUSG00000031494 [Q91ZX1-1]
ENSMUST00000207979; ENSMUSP00000146702; ENSMUSG00000031494 [Q91ZX1-2]
GeneIDi170786
KEGGimmu:170786
UCSCiuc009ksq.2 mouse [Q91ZX1-1]
uc012fyt.1 mouse [Q91ZX1-2]

Organism-specific databases

CTDi170786
MGIiMGI:2157942 Cd209a

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000013222
HOVERGENiHBG050992
InParanoidiQ91ZX1
KOiK06563
OrthoDBiEOG091G0M9Q
PhylomeDBiQ91ZX1
TreeFamiTF333341

Enzyme and pathway databases

ReactomeiR-MMU-5621575 CD209 (DC-SIGN) signaling
R-MMU-8851680 Butyrophilin (BTN) family interactions

Miscellaneous databases

PROiPR:Q91ZX1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031494 Expressed in 46 organ(s), highest expression level in zone of skin
CleanExiMM_CD209A
ExpressionAtlasiQ91ZX1 baseline and differential
GenevisibleiQ91ZX1 MM

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC209A_MOUSE
AccessioniPrimary (citable) accession number: Q91ZX1
Secondary accession number(s): Q3TAT9, Q91ZW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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