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Protein

CD209 antigen-like protein E

Gene

Cd209e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments.

Caution

In mouse, 5 genes homologous to human CD209/DC-SIGN and CD209L/DC-SIGNR have been identified.Curated

GO - Molecular functioni

  • mannose binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-5621575 CD209 (DC-SIGN) signaling
R-MMU-8851680 Butyrophilin (BTN) family interactions

Names & Taxonomyi

Protein namesi
Recommended name:
CD209 antigen-like protein E
Alternative name(s):
DC-SIGN-related protein 4
Short name:
DC-SIGNR4
CD_antigen: CD209
Gene namesi
Name:Cd209e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2157948 Cd209e

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini38 – 208ExtracellularSequence analysisAdd BLAST171

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466081 – 208CD209 antigen-like protein EAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi77 ↔ 88PROSITE-ProRule annotation
Disulfide bondi105 ↔ 197PROSITE-ProRule annotation
Disulfide bondi176 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ91ZW7
PaxDbiQ91ZW7
PRIDEiQ91ZW7

Expressioni

Gene expression databases

BgeeiENSMUSG00000040197 Expressed in 19 organ(s), highest expression level in zone of skin
CleanExiMM_CD209E
ExpressionAtlasiQ91ZW7 baseline and differential
GenevisibleiQ91ZW7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033888

Structurei

3D structure databases

ProteinModelPortaliQ91ZW7
SMRiQ91ZW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 198C-type lectinPROSITE-ProRule annotationAdd BLAST116

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3Z Eukaryota
ENOG410YSMB LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000013222
HOVERGENiHBG050992
InParanoidiQ91ZW7
KOiK06563
OMAiWDWTLFQ
OrthoDBiEOG091G0NK5
PhylomeDBiQ91ZW7
TreeFamiTF333341

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91ZW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAPQMGSLG FLDKGHIPLV LQLLFLILFT GLLVAIIIQV SKMPSSEEIQ
60 70 80 90 100
WEHTKQEKMY KDLSQLKSEV DRLCRLCPWD WTFFNGNCYF FSKSQRDWHD
110 120 130 140 150
SMTACKEMGA QLVIIKSHEE QSFLQQTSKK NSYTWMGLSD LNKEGEWYWL
160 170 180 190 200
DGSPLSDSFE KYWKKGQPNN VGGQDCVEFR DNGWNDAKCE QRKFWICKKI

ATTCLSKW
Length:208
Mass (Da):24,389
Last modified:December 1, 2001 - v1
Checksum:i219CF71ED878DEB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373412 mRNA Translation: AAL13238.1
AK040917 mRNA Translation: BAC30744.1
CCDSiCCDS22074.1
RefSeqiNP_570975.1, NM_130905.2
UniGeneiMm.52281

Genome annotation databases

EnsembliENSMUST00000033888; ENSMUSP00000033888; ENSMUSG00000040197
GeneIDi170780
KEGGimmu:170780
UCSCiuc009kss.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

SIGNR4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF373412 mRNA Translation: AAL13238.1
AK040917 mRNA Translation: BAC30744.1
CCDSiCCDS22074.1
RefSeqiNP_570975.1, NM_130905.2
UniGeneiMm.52281

3D structure databases

ProteinModelPortaliQ91ZW7
SMRiQ91ZW7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033888

Proteomic databases

EPDiQ91ZW7
PaxDbiQ91ZW7
PRIDEiQ91ZW7

Protocols and materials databases

DNASUi170780
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033888; ENSMUSP00000033888; ENSMUSG00000040197
GeneIDi170780
KEGGimmu:170780
UCSCiuc009kss.1 mouse

Organism-specific databases

CTDi170780
MGIiMGI:2157948 Cd209e

Phylogenomic databases

eggNOGiENOG410IS3Z Eukaryota
ENOG410YSMB LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000013222
HOVERGENiHBG050992
InParanoidiQ91ZW7
KOiK06563
OMAiWDWTLFQ
OrthoDBiEOG091G0NK5
PhylomeDBiQ91ZW7
TreeFamiTF333341

Enzyme and pathway databases

ReactomeiR-MMU-5621575 CD209 (DC-SIGN) signaling
R-MMU-8851680 Butyrophilin (BTN) family interactions

Miscellaneous databases

PROiPR:Q91ZW7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040197 Expressed in 19 organ(s), highest expression level in zone of skin
CleanExiMM_CD209E
ExpressionAtlasiQ91ZW7 baseline and differential
GenevisibleiQ91ZW7 MM

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC209E_MOUSE
AccessioniPrimary (citable) accession number: Q91ZW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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