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Entry version 185 (29 Sep 2021)
Sequence version 1 (01 Dec 2001)
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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Gene

Smarca5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity (By similarity).

Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails (PubMed:11532953, PubMed:11980720, PubMed:12198165).

Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:11532953, PubMed:11980720, PubMed:12198165).

Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (By similarity).

The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:11532953, PubMed:11980720, PubMed:12198165).

The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (By similarity).

Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (By similarity).

Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase (By similarity).

Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter (PubMed:12198165).

The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes (PubMed:19092802).

Essential component of the NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (PubMed:11532953, PubMed:12198165, PubMed:12368916).

Required for embryonic development and differentiation, and the proliferation of early blastocyst-derived stem cells (PubMed:14617767).

By similarity6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi204 – 211ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5250924, B-WICH complex positively regulates rRNA expression
R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-606279, Deposition of new CENPA-containing nucleosomes at the centromere

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC:3.6.4.-By similarity)
Alternative name(s):
Sucrose nonfermenting protein 2 homolog
Short name:
mSnf2h
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Smarca5
Synonyms:Snf2h
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1935129, Smarca5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000031715

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743552 – 1051SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5Add BLAST1050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei55PhosphothreonineCombined sources1
Modified residuei65PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei112PhosphothreonineCombined sources1
Modified residuei115PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei439N6-acetyllysineCombined sources1
Cross-linki643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki646Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki693Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki721Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki734Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei754PhosphoserineBy similarity1
Cross-linki965Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q91ZW3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q91ZW3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q91ZW3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q91ZW3

PeptideAtlas

More...
PeptideAtlasi
Q91ZW3

PRoteomics IDEntifications database

More...
PRIDEi
Q91ZW3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
257265

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q91ZW3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91ZW3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q91ZW3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in CD34-positive erythrocyte progenitor cells. Down-regulated upon differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031715, Expressed in forelimb bud and 330 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q91ZW3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ACF-5 ISWI chromatin-remodeling complex (also called the ACF/WCRF complex) at least composed of SMARCA5/SNF2H and BAZ1A/ACF1, which regulates the spacing of histone octamers on the DNA template to facilitate access to DNA (By similarity). Within the complex interacts with BAZ1A/ACF1; the interaction is direct and is required to slide nucleosomes from end to center positions on a DNA template in an ATP-dependent manner (By similarity).

Component of the CHRAC ISWI chromatin-remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP-dependent nucleosome-remodeling activity (By similarity). Within the complex interacts with BAZ1A/ACF1; the interaction is direct and promotes the interaction with the POLE3-CHRAC1 heterodimer (By similarity). Within the complex interacts with the POLE3-CHRAC1 heterodimer; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction (By similarity). Neither POLE3 nor CHRAC1 alone enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity).

Component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex) at least composed of SMARCA5/SNF2H and BAZ1B/WSTF, which regulates the spacing of histone octamers on the DNA template to facilitate access to DNA (PubMed:11980720). Within the complex interacts with BAZ1B/WSTF (PubMed:11980720, PubMed:19092802).

Component of the NoRC-5 ISWI chromatin-remodeling complex (also called the NoRC chromatin-remodeling complex) at least composed of SMARCA5/SNF2H and BAZ2A/TIP5; the complex suppresses rDNA transcription by a combination of nucleosome remodeling, histone deacetylation, and DNA methylation (PubMed:11532953, PubMed:12198165). Within the complex interacts with BAZ2A/TIP5 (PubMed:11532953, PubMed:12198165). Within the complex interacts with HDAC1 (PubMed:12198165).

Component of the BRF-5 ISWI chromatin-remodeling complex at least composed of SMARCA5/SNF2H and BAZ2B (By similarity). Within the complex interacts with BAZ2B (By similarity).

Component of the NURF-5 ISWI chromatin-remodeling complex at least composed of SMARCA5/SNF2H and BPTF (By similarity). Within the complex interacts with BPFT (By similarity).

Component of the CERF-5 ISWI chromatin-remodeling complex at least composed of SMARCA5/SNF2H and CECR2 (By similarity). Within the complex interacts with CECR2 (By similarity).

Component of the RSF-5 ISWI chromatin-remodeling complex (also called the RSF complex) at least composed of SMARCA5/SNF2H and RSF1 (By similarity). Within the complex interacts with RSF1 (By similarity).

Interacts with the cohesin complex component RAD21; the interaction is direct (By similarity).

Interacts with the NuRD complex components HDAC2, RBBP4 and CHD4; the interactions are direct (By similarity).

Interacts with PCNA (By similarity).

Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 which positively regulates RNA polymerase III transcription (By similarity).

Interacts with

Interacts with MYO1C (PubMed:16514417).

Interacts with BEND3 (By similarity). *The BAZ2A/TIP5 subunit of NoRC also interacts with DNMT1, DNMT3B and HDAC1, which allows NoRC to actively suppress rDNA transcription by a combination of nucleosome remodeling, histone deacetylation, and DNA methylation ref7, ref8*.

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
220300, 28 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1133, B-WICH chromatin remodelling complex
CPX-424, NoRC complex
CPX-444, ACF chromatin remodeling complex
CPX-463, RSF complex
CPX-841, WICH chromatin remodelling complex
CPX-858, CHRAC chromatin remodeling complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q91ZW3

Database of interacting proteins

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DIPi
DIP-36073N

Protein interaction database and analysis system

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IntActi
Q91ZW3, 19 interactors

Molecular INTeraction database

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MINTi
Q91ZW3

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000044361

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q91ZW3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q91ZW3

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 356Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini486 – 637Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152
Domaini839 – 891SANT 1PROSITE-ProRule annotationAdd BLAST53
Domaini942 – 1006SANT 2PROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 81DisorderedSequence analysisAdd BLAST81
Regioni1014 – 1051DisorderedSequence analysisAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi307 – 310DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18Pro residuesSequence analysisAdd BLAST18
Compositional biasi56 – 81Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1014 – 1044Basic and acidic residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0385, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156733

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000315_0_3_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q91ZW3

Identification of Orthologs from Complete Genome Data

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OMAi
CAGHPYL

Database of Orthologous Groups

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OrthoDBi
61251at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q91ZW3

TreeFam database of animal gene trees

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TreeFami
TF300674

Family and domain databases

Conserved Domains Database

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CDDi
cd00167, SANT, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1040.30, 1 hit
3.40.50.10810, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR009057, Homeobox-like_sf
IPR015194, ISWI_HAND-dom
IPR036306, ISWI_HAND-dom_sf
IPR027417, P-loop_NTPase
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR015195, SLIDE
IPR038718, SNF2-like_sf
IPR000330, SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09110, HAND, 1 hit
PF00271, Helicase_C, 1 hit
PF09111, SLIDE, 1 hit
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00717, SANT, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101224, SSF101224, 1 hit
SSF46689, SSF46689, 2 hits
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51293, SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q91ZW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAVEPPPP PPPESAPSKP SAAGAGGSSS GNKGGPEGGA APAAPCAAGS
60 70 80 90 100
GPADTEMEEV FDHGSPGKQK EIQEPDPTYE EKMQTDRANR FEYLLKQTEL
110 120 130 140 150
FAHFIQPAAQ KTPTSPLKMK PGRPRVKKDE KQNLLSVGDY RHRRTEQEED
160 170 180 190 200
EELLTESSKA TNVCTRFEDS PSYVKWGKLR DYQVRGLNWL ISLYENGING
210 220 230 240 250
ILADEMGLGK TLQTISLLGY MKHYRNIPGP HMVLVPKSTL HNWMSEFKKW
260 270 280 290 300
VPTLRSVCLI GDKEQRAAFV RDVLLPGEWD VCVTSYEMLI KEKSVFKKFN
310 320 330 340 350
WRYLVIDEAH RIKNEKSKLS EIVREFKTTN RLLLTGTPLQ NNLHELWSLL
360 370 380 390 400
NFLLPDVFNS ADDFDSWFDT NNCLGDQKLV ERLHMVLRPF LLRRIKADVE
410 420 430 440 450
KSLPPKKEVK IYVGLSKMQR EWYTRILMKD IDILNSAGKM DKMRLLNILM
460 470 480 490 500
QLRKCCNHPY LFDGAEPGPP YTTDMHLVTN SGKMVVLDKL LPKLKEQGSR
510 520 530 540 550
VLIFSQMTRV LDILEDYCMW RNYEYCRLDG QTPHDERQDS INAYNEPNST
560 570 580 590 600
KFVFMLSTRA GGLGINLATA DVVILYDSDW NPQVDLQAMD RAHRIGQTKT
610 620 630 640 650
VRVFRFITDN TVEERIVERA EMKLRLDSIV IQQGRLVDQN LNKIGKDEML
660 670 680 690 700
QMIRHGATHV FASKESEITD EDIDGILERG AKKTAEMNEK LSKMGESSLR
710 720 730 740 750
NFTMDTESSV YNFEGEDYRE KQKIAFTEWI EPPKRERKAN YAVDAYFREA
760 770 780 790 800
LRVSEPKAPK APRPPKQPNV QDFQFFPPRL FELLEKEILY YRKTIGYKVP
810 820 830 840 850
RSPDLPNAAQ AQKEEQLKID EAEPLNDEEL EEKEKLLTQG FTNWNKRDFN
860 870 880 890 900
QFIKANEKWG RDDIENIARE VEGKTPEEVI EYSAVFWERC NELQDIEKIM
910 920 930 940 950
AQIERGEARI QRRISIKKAL DTKIGRYKAP FHQLRISYGT NKGKNYTEEE
960 970 980 990 1000
DRFLICMLHK LGFDKENVYD ELRQCIRNSP QFRFDWFLKS RTAMELQRRC
1010 1020 1030 1040 1050
NTLITLIERE NMELEEKEKA EKKKRGPKPS TQKRKMDGAP DGRGRKKKLK

L
Length:1,051
Mass (Da):121,627
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6CB69E7FADE73FC
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21922 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44 – 45AP → GS in AAK52454 (PubMed:11359880).Curated2
Sequence conflicti143R → C in AAK52454 (PubMed:11359880).Curated1
Sequence conflicti157S → R in AAK52454 (PubMed:11359880).Curated1
Sequence conflicti249K → R in AAK52454 (PubMed:11359880).Curated1
Sequence conflicti318K → N in AAK52454 (PubMed:11359880).Curated1
Sequence conflicti373C → S in AAK52454 (PubMed:11359880).Curated1
Sequence conflicti498G → S in AAK52454 (PubMed:11359880).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF375046 mRNA Translation: AAL25793.1
AF325921 mRNA Translation: AAK52454.1
BC021922 mRNA Translation: AAH21922.1 Different initiation.
BC053069 mRNA Translation: AAH53069.1
AK039811 mRNA Translation: BAC30458.1
AK052320 mRNA Translation: BAC34934.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS22442.1

NCBI Reference Sequences

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RefSeqi
NP_444354.2, NM_053124.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000043359; ENSMUSP00000044361; ENSMUSG00000031715

Database of genes from NCBI RefSeq genomes

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GeneIDi
93762

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:93762

UCSC genome browser

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UCSCi
uc009mja.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF375046 mRNA Translation: AAL25793.1
AF325921 mRNA Translation: AAK52454.1
BC021922 mRNA Translation: AAH21922.1 Different initiation.
BC053069 mRNA Translation: AAH53069.1
AK039811 mRNA Translation: BAC30458.1
AK052320 mRNA Translation: BAC34934.2
CCDSiCCDS22442.1
RefSeqiNP_444354.2, NM_053124.2

3D structure databases

SMRiQ91ZW3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi220300, 28 interactors
ComplexPortaliCPX-1133, B-WICH chromatin remodelling complex
CPX-424, NoRC complex
CPX-444, ACF chromatin remodeling complex
CPX-463, RSF complex
CPX-841, WICH chromatin remodelling complex
CPX-858, CHRAC chromatin remodeling complex
CORUMiQ91ZW3
DIPiDIP-36073N
IntActiQ91ZW3, 19 interactors
MINTiQ91ZW3
STRINGi10090.ENSMUSP00000044361

PTM databases

iPTMnetiQ91ZW3
PhosphoSitePlusiQ91ZW3
SwissPalmiQ91ZW3

Proteomic databases

EPDiQ91ZW3
jPOSTiQ91ZW3
MaxQBiQ91ZW3
PaxDbiQ91ZW3
PeptideAtlasiQ91ZW3
PRIDEiQ91ZW3
ProteomicsDBi257265

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1804, 388 antibodies

The DNASU plasmid repository

More...
DNASUi
93762

Genome annotation databases

EnsembliENSMUST00000043359; ENSMUSP00000044361; ENSMUSG00000031715
GeneIDi93762
KEGGimmu:93762
UCSCiuc009mja.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8467
MGIiMGI:1935129, Smarca5
VEuPathDBiHostDB:ENSMUSG00000031715

Phylogenomic databases

eggNOGiKOG0385, Eukaryota
GeneTreeiENSGT00940000156733
HOGENOMiCLU_000315_0_3_1
InParanoidiQ91ZW3
OMAiCAGHPYL
OrthoDBi61251at2759
PhylomeDBiQ91ZW3
TreeFamiTF300674

Enzyme and pathway databases

ReactomeiR-MMU-5250924, B-WICH complex positively regulates rRNA expression
R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-606279, Deposition of new CENPA-containing nucleosomes at the centromere

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
93762, 34 hits in 102 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Smarca5, mouse

Protein Ontology

More...
PROi
PR:Q91ZW3
RNActiQ91ZW3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031715, Expressed in forelimb bud and 330 other tissues
GenevisibleiQ91ZW3, MM

Family and domain databases

CDDicd00167, SANT, 2 hits
Gene3Di1.10.1040.30, 1 hit
3.40.50.10810, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR009057, Homeobox-like_sf
IPR015194, ISWI_HAND-dom
IPR036306, ISWI_HAND-dom_sf
IPR027417, P-loop_NTPase
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR015195, SLIDE
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
PfamiView protein in Pfam
PF09110, HAND, 1 hit
PF00271, Helicase_C, 1 hit
PF09111, SLIDE, 1 hit
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00717, SANT, 2 hits
SUPFAMiSSF101224, SSF101224, 1 hit
SSF46689, SSF46689, 2 hits
SSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51293, SANT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMCA5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91ZW3
Secondary accession number(s): Q8C791
, Q8CA22, Q8VDG1, Q925M9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: December 1, 2001
Last modified: September 29, 2021
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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