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Entry version 173 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

Gene

Smarca5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi204 – 211ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC:3.6.4.-)
Alternative name(s):
Sucrose nonfermenting protein 2 homolog
Short name:
mSnf2h
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Smarca5
Synonyms:Snf2h
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1935129 Smarca5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743552 – 1051SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5Add BLAST1050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei55PhosphothreonineCombined sources1
Modified residuei65PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei112PhosphothreonineCombined sources1
Modified residuei115PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei439N6-acetyllysineCombined sources1
Cross-linki643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki646Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki693Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki721Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki734Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei754PhosphoserineBy similarity1
Cross-linki965Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q91ZW3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q91ZW3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q91ZW3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q91ZW3

PeptideAtlas

More...
PeptideAtlasi
Q91ZW3

PRoteomics IDEntifications database

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PRIDEi
Q91ZW3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q91ZW3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91ZW3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q91ZW3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in CD34-positive erythrocyte progenitor cells. Down-regulated upon differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031715 Expressed in 312 organ(s), highest expression level in cumulus cell

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q91ZW3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. Each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5. ACF/WCRF contains BAZ1A; CHRAC contains BAZ1A, CHRAC1, and POLE3; RSF contains HBXAP; WICH contains BAZ1B/WSTF. SMARCA5 is the catalytic subunit of the NoRC chromatin-remodeling complex, which also contains BAZ2A/TIP5. The BAZ2A/TIP5 subunit of NoRC also interacts with DNMT1, DNMT3B and HDAC1, which allows NoRC to actively suppress rDNA transcription by a combination of nucleosome remodeling, histone deacetylation, and DNA methylation. Catalytic subunit of SMARCA5/cohesin/NuRD complexes.

Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.

Interacts with MYO1C.

Interacts with BEND3 (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
220300, 18 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1133 B-WICH chromatin remodelling complex
CPX-424 NoRC complex
CPX-444 ACF complex
CPX-463 RSF complex
CPX-841 WICH chromatin remodelling complex
CPX-858 CHRAC chromatin remodeling complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q91ZW3

Database of interacting proteins

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DIPi
DIP-36073N

Protein interaction database and analysis system

More...
IntActi
Q91ZW3, 18 interactors

Molecular INTeraction database

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MINTi
Q91ZW3

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044361

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q91ZW3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 356Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini486 – 637Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152
Domaini839 – 891SANT 1PROSITE-ProRule annotationAdd BLAST53
Domaini942 – 1006SANT 2PROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi307 – 310DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 13Poly-Pro7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0385 Eukaryota
COG0553 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156733

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000192862

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q91ZW3

KEGG Orthology (KO)

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KOi
K11654

Identification of Orthologs from Complete Genome Data

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OMAi
FGDSEVF

Database of Orthologous Groups

More...
OrthoDBi
61251at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q91ZW3

TreeFam database of animal gene trees

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TreeFami
TF300674

Family and domain databases

Conserved Domains Database

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CDDi
cd00167 SANT, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1040.30, 1 hit
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020838 DBINO
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR009057 Homeobox-like_sf
IPR015194 ISWI_HAND-dom
IPR036306 ISWI_HAND-dom_sf
IPR029915 ISWI_metazoa
IPR027417 P-loop_NTPase
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR015195 SLIDE
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

The PANTHER Classification System

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PANTHERi
PTHR10799:SF819 PTHR10799:SF819, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF13892 DBINO, 1 hit
PF09110 HAND, 1 hit
PF00271 Helicase_C, 1 hit
PF09111 SLIDE, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00717 SANT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101224 SSF101224, 1 hit
SSF46689 SSF46689, 2 hits
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51293 SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q91ZW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAVEPPPP PPPESAPSKP SAAGAGGSSS GNKGGPEGGA APAAPCAAGS
60 70 80 90 100
GPADTEMEEV FDHGSPGKQK EIQEPDPTYE EKMQTDRANR FEYLLKQTEL
110 120 130 140 150
FAHFIQPAAQ KTPTSPLKMK PGRPRVKKDE KQNLLSVGDY RHRRTEQEED
160 170 180 190 200
EELLTESSKA TNVCTRFEDS PSYVKWGKLR DYQVRGLNWL ISLYENGING
210 220 230 240 250
ILADEMGLGK TLQTISLLGY MKHYRNIPGP HMVLVPKSTL HNWMSEFKKW
260 270 280 290 300
VPTLRSVCLI GDKEQRAAFV RDVLLPGEWD VCVTSYEMLI KEKSVFKKFN
310 320 330 340 350
WRYLVIDEAH RIKNEKSKLS EIVREFKTTN RLLLTGTPLQ NNLHELWSLL
360 370 380 390 400
NFLLPDVFNS ADDFDSWFDT NNCLGDQKLV ERLHMVLRPF LLRRIKADVE
410 420 430 440 450
KSLPPKKEVK IYVGLSKMQR EWYTRILMKD IDILNSAGKM DKMRLLNILM
460 470 480 490 500
QLRKCCNHPY LFDGAEPGPP YTTDMHLVTN SGKMVVLDKL LPKLKEQGSR
510 520 530 540 550
VLIFSQMTRV LDILEDYCMW RNYEYCRLDG QTPHDERQDS INAYNEPNST
560 570 580 590 600
KFVFMLSTRA GGLGINLATA DVVILYDSDW NPQVDLQAMD RAHRIGQTKT
610 620 630 640 650
VRVFRFITDN TVEERIVERA EMKLRLDSIV IQQGRLVDQN LNKIGKDEML
660 670 680 690 700
QMIRHGATHV FASKESEITD EDIDGILERG AKKTAEMNEK LSKMGESSLR
710 720 730 740 750
NFTMDTESSV YNFEGEDYRE KQKIAFTEWI EPPKRERKAN YAVDAYFREA
760 770 780 790 800
LRVSEPKAPK APRPPKQPNV QDFQFFPPRL FELLEKEILY YRKTIGYKVP
810 820 830 840 850
RSPDLPNAAQ AQKEEQLKID EAEPLNDEEL EEKEKLLTQG FTNWNKRDFN
860 870 880 890 900
QFIKANEKWG RDDIENIARE VEGKTPEEVI EYSAVFWERC NELQDIEKIM
910 920 930 940 950
AQIERGEARI QRRISIKKAL DTKIGRYKAP FHQLRISYGT NKGKNYTEEE
960 970 980 990 1000
DRFLICMLHK LGFDKENVYD ELRQCIRNSP QFRFDWFLKS RTAMELQRRC
1010 1020 1030 1040 1050
NTLITLIERE NMELEEKEKA EKKKRGPKPS TQKRKMDGAP DGRGRKKKLK

L
Length:1,051
Mass (Da):121,627
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6CB69E7FADE73FC
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21922 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44 – 45AP → GS in AAK52454 (PubMed:11359880).Curated2
Sequence conflicti143R → C in AAK52454 (PubMed:11359880).Curated1
Sequence conflicti157S → R in AAK52454 (PubMed:11359880).Curated1
Sequence conflicti249K → R in AAK52454 (PubMed:11359880).Curated1
Sequence conflicti318K → N in AAK52454 (PubMed:11359880).Curated1
Sequence conflicti373C → S in AAK52454 (PubMed:11359880).Curated1
Sequence conflicti498G → S in AAK52454 (PubMed:11359880).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF375046 mRNA Translation: AAL25793.1
AF325921 mRNA Translation: AAK52454.1
BC021922 mRNA Translation: AAH21922.1 Different initiation.
BC053069 mRNA Translation: AAH53069.1
AK039811 mRNA Translation: BAC30458.1
AK052320 mRNA Translation: BAC34934.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS22442.1

NCBI Reference Sequences

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RefSeqi
NP_444354.2, NM_053124.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000043359; ENSMUSP00000044361; ENSMUSG00000031715

Database of genes from NCBI RefSeq genomes

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GeneIDi
93762

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:93762

UCSC genome browser

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UCSCi
uc009mja.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF375046 mRNA Translation: AAL25793.1
AF325921 mRNA Translation: AAK52454.1
BC021922 mRNA Translation: AAH21922.1 Different initiation.
BC053069 mRNA Translation: AAH53069.1
AK039811 mRNA Translation: BAC30458.1
AK052320 mRNA Translation: BAC34934.2
CCDSiCCDS22442.1
RefSeqiNP_444354.2, NM_053124.2

3D structure databases

SMRiQ91ZW3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi220300, 18 interactors
ComplexPortaliCPX-1133 B-WICH chromatin remodelling complex
CPX-424 NoRC complex
CPX-444 ACF complex
CPX-463 RSF complex
CPX-841 WICH chromatin remodelling complex
CPX-858 CHRAC chromatin remodeling complex
CORUMiQ91ZW3
DIPiDIP-36073N
IntActiQ91ZW3, 18 interactors
MINTiQ91ZW3
STRINGi10090.ENSMUSP00000044361

PTM databases

iPTMnetiQ91ZW3
PhosphoSitePlusiQ91ZW3
SwissPalmiQ91ZW3

Proteomic databases

EPDiQ91ZW3
jPOSTiQ91ZW3
MaxQBiQ91ZW3
PaxDbiQ91ZW3
PeptideAtlasiQ91ZW3
PRIDEiQ91ZW3

Genome annotation databases

EnsembliENSMUST00000043359; ENSMUSP00000044361; ENSMUSG00000031715
GeneIDi93762
KEGGimmu:93762
UCSCiuc009mja.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8467
MGIiMGI:1935129 Smarca5

Phylogenomic databases

eggNOGiKOG0385 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00940000156733
HOGENOMiHOG000192862
InParanoidiQ91ZW3
KOiK11654
OMAiFGDSEVF
OrthoDBi61251at2759
PhylomeDBiQ91ZW3
TreeFamiTF300674

Enzyme and pathway databases

ReactomeiR-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Smarca5 mouse

Protein Ontology

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PROi
PR:Q91ZW3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031715 Expressed in 312 organ(s), highest expression level in cumulus cell
GenevisibleiQ91ZW3 MM

Family and domain databases

CDDicd00167 SANT, 2 hits
Gene3Di1.10.1040.30, 1 hit
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR020838 DBINO
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR009057 Homeobox-like_sf
IPR015194 ISWI_HAND-dom
IPR036306 ISWI_HAND-dom_sf
IPR029915 ISWI_metazoa
IPR027417 P-loop_NTPase
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR015195 SLIDE
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR10799:SF819 PTHR10799:SF819, 1 hit
PfamiView protein in Pfam
PF13892 DBINO, 1 hit
PF09110 HAND, 1 hit
PF00271 Helicase_C, 1 hit
PF09111 SLIDE, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00717 SANT, 2 hits
SUPFAMiSSF101224 SSF101224, 1 hit
SSF46689 SSF46689, 2 hits
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51293 SANT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMCA5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91ZW3
Secondary accession number(s): Q8C791
, Q8CA22, Q8VDG1, Q925M9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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