UniProtKB - Q91ZV7 (PLDX1_MOUSE)

BLAST

>sp|Q91ZV7|PLDX1_MOUSE Plexin domain-containing protein 1 OS=Mus musculus OX=10090 GN=Plxdc1 PE=1 SV=2
MRAQLWLLQLLLLRGAARALSPATPAGHNEGQDSAWTAKRTRQGWSRRPRESPAQVLKPG
KTQLSQDLGGGSLAIDTLPDNRTRVVEDNHNYYVSRVYGPGEKQSQDLWVDLAVANRSHV
KIHRILSSSHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDMLHRMLTATQYVAPLM
ANFNPGYSDNSTVAYFDNGTVFVVQWDHVYLQDREDRGSFTFQAALHRDGRIVFGYKEIP
MAVLDISSAQHPVKAGLSDAFMILNSSPEVPASQRRTIFEYHRVELDSSKITTTSAVEFT
PLPTCLQHQSCDTCVSSNLTFNCSWCHVLQRCSSGFDRYRQEWLTYGCAQEAEGKTCEDF
QDDSHYSASPDSSFSPFNGDSTTSSSLFIDSLTTEDDTKLNPYAEGDGLPDHSSPKSKGP
PVHLGTIVGIVLAVLLVAAIILAGIYISGHPNSNAALFFIERRPHHWPAMKFHNHPNHST
YTEVEPSGHEKEGFVEAEQC

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History
Entry version 104 (07 Nov 2018)
Sequence version 2 (11 Jan 2011)
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Protein

Plexin domain-containing protein 1

Gene

Plxdc1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a critical role in endothelial cell capillary morphogenesis.1 Publication

GO - Biological processⁱ

angiogenesis Source: InterPro
spinal cord development Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plexin domain-containing protein 1 Alternative name(s): Tumor endothelial marker 7
Gene namesⁱ	Name:Plxdc1 Synonyms:Tem7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1919574 Plxdc1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 426	ExtracellularSequence analysisAdd BLAST	407
Transmembraneⁱ	427 – 447	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	448 – 500	CytoplasmicSequence analysisAdd BLAST	53

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000232752	20 – 500	Plexin domain-containing protein 1Add BLAST		481

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	81	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	116	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	190	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	198	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	318	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	322	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q91ZV7
PeptideAtlas More...PeptideAtlasⁱ	Q91ZV7
PRIDEⁱ	Q91ZV7

PTM databases

iPTMnetⁱ	Q91ZV7
PhosphoSitePlusⁱ	Q91ZV7

Expressionⁱ

Tissue specificityⁱ

Detected in brain. Highly expressed in Purkinje cells of the cerebellum.1 Publication

Developmental stageⁱ

Expression increases in endothelial cells undergoing capillary morphogenesis.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000017417 Expressed in 143 organ(s), highest expression level in motor neuron
CleanExⁱ	MM_PLXDC1
ExpressionAtlasⁱ	Q91ZV7 baseline and differential
Genevisibleⁱ	Q91ZV7 MM

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Nid1	P08460	2	EBI-8280807,EBI-8280787	From Rattus norvegicus.

With

Entry

#Exp.

IntAct

Notes

Nid1

P08460

EBI-8280807,EBI-8280787

From Rattus norvegicus.

Protein-protein interaction databases

IntActⁱ	Q91ZV7, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q91ZV7
STRINGⁱ	10090.ENSMUSP00000103191

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91ZV7
SMRⁱ	Q91ZV7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the plexin family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3848 Eukaryota ENOG410Y7ZQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033408
HOGENOMⁱ	HOG000234044
HOVERGENⁱ	HBG079500
InParanoidⁱ	Q91ZV7
OMAⁱ	TVFIVQW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0827
PhylomeDBⁱ	Q91ZV7
TreeFamⁱ	TF314400

Family and domain databases

InterProⁱ	View protein in InterPro IPR002165 Plexin_repeat IPR031152 PLXDC IPR031153 PLXDC1
PANTHERⁱ	PTHR13055 PTHR13055, 1 hit PTHR13055:SF10 PTHR13055:SF10, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01437 PSI, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q91ZV7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAQLWLLQL LLLRGAARAL SPATPAGHNE GQDSAWTAKR TRQGWSRRPR 
        60         70         80         90        100
ESPAQVLKPG KTQLSQDLGG GSLAIDTLPD NRTRVVEDNH NYYVSRVYGP 
       110        120        130        140        150
GEKQSQDLWV DLAVANRSHV KIHRILSSSH RQASRVVLSF DFPFYGHPLR 
       160        170        180        190        200
QITIATGGFI FMGDMLHRML TATQYVAPLM ANFNPGYSDN STVAYFDNGT 
       210        220        230        240        250
VFVVQWDHVY LQDREDRGSF TFQAALHRDG RIVFGYKEIP MAVLDISSAQ 
       260        270        280        290        300
HPVKAGLSDA FMILNSSPEV PASQRRTIFE YHRVELDSSK ITTTSAVEFT 
       310        320        330        340        350
PLPTCLQHQS CDTCVSSNLT FNCSWCHVLQ RCSSGFDRYR QEWLTYGCAQ 
       360        370        380        390        400
EAEGKTCEDF QDDSHYSASP DSSFSPFNGD STTSSSLFID SLTTEDDTKL 
       410        420        430        440        450
NPYAEGDGLP DHSSPKSKGP PVHLGTIVGI VLAVLLVAAI ILAGIYISGH 
       460        470        480        490        500
PNSNAALFFI ERRPHHWPAM KFHNHPNHST YTEVEPSGHE KEGFVEAEQC

Length:500

Mass (Da):55,635

Last modified:January 11, 2011 - v2

Checksum:ⁱ802D6865F8CA18BD

Isoform 2 (identifier: Q91ZV7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
86-86: V → VALSLSPQ

« Hide

        10         20         30         40         50
MRAQLWLLQL LLLRGAARAL SPATPAGHNE GQDSAWTAKR TRQGWSRRPR 
        60         70         80         90        100
ESPAQVLKPG KTQLSQDLGG GSLAIDTLPD NRTRVVALSL SPQEDNHNYY 
       110        120        130        140        150
VSRVYGPGEK QSQDLWVDLA VANRSHVKIH RILSSSHRQA SRVVLSFDFP 
       160        170        180        190        200
FYGHPLRQIT IATGGFIFMG DMLHRMLTAT QYVAPLMANF NPGYSDNSTV 
       210        220        230        240        250
AYFDNGTVFV VQWDHVYLQD REDRGSFTFQ AALHRDGRIV FGYKEIPMAV 
       260        270        280        290        300
LDISSAQHPV KAGLSDAFMI LNSSPEVPAS QRRTIFEYHR VELDSSKITT 
       310        320        330        340        350
TSAVEFTPLP TCLQHQSCDT CVSSNLTFNC SWCHVLQRCS SGFDRYRQEW 
       360        370        380        390        400
LTYGCAQEAE GKTCEDFQDD SHYSASPDSS FSPFNGDSTT SSSLFIDSLT 
       410        420        430        440        450
TEDDTKLNPY AEGDGLPDHS SPKSKGPPVH LGTIVGIVLA VLLVAAIILA 
       460        470        480        490        500
GIYISGHPNS NAALFFIERR PHHWPAMKFH NHPNHSTYTE VEPSGHEKEG 

FVEAEQC

Note: No experimental confirmation available.

Show »

Length:507

Mass (Da):56,332

Checksum:ⁱC2D50B44561C3415

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A2A539	A2A539_MOUSE		Plexin domain-containing protein 1 Plexin domain-containing protein 1	Plxdc1	111	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	104	Q → R in AAI14353 (PubMed:15489334).Curated	1
Sequence conflictⁱ	248	S → P in AAI14353 (PubMed:15489334).Curated	1
Sequence conflictⁱ	272	A → E in AAL11997 (PubMed:11559528).Curated	1
Sequence conflictⁱ	272	A → E in AAI14353 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_017975	86	V → VALSLSPQ in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF378760 mRNA Translation: AAL11997.1 AK010361 mRNA Translation: BAB26881.1 AK036144 mRNA Translation: BAC29318.1 AK153684 mRNA Translation: BAE32144.1 AL591209 Genomic DNA Translation: CAM20410.1 AL591209 Genomic DNA Translation: CAM20411.1 CH466556 Genomic DNA Translation: EDL16106.1 BC114352 mRNA Translation: AAI14353.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25333.1 [Q91ZV7-1] CCDS48897.1 [Q91ZV7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001157080.1, NM_001163608.1 [Q91ZV7-2] NP_082475.3, NM_028199.3 [Q91ZV7-1]
UniGeneⁱ	Mm.39617 Mm.482750

Genome annotation databases

Ensemblⁱ	ENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417 [Q91ZV7-1] ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417 [Q91ZV7-2]
GeneIDⁱ	72324
KEGGⁱ	mmu:72324
UCSC genome browser More...UCSCⁱ	uc007lfc.2 mouse [Q91ZV7-1] uc011ydx.1 mouse [Q91ZV7-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91ZV7	Isoform 2 of Plexin domain-containing protein 1		MOUSE		507	UniRef90_Q91ZV7
ADP-ribosylation factor-like 12 (Predicted)		RAT		500
UPI000A309AB0		MUSPA		508
UPI00038BDB06		MICOH		500
UPI00042AB739		PERMB		500
+1

Protein	Similar proteins		Species	Score	Length	Source
Q91ZV7	Plexin domain-containing protein 1		HUMAN		500	UniRef50_Q8IUK5
Plexin domain-containing protein 2		MOUSE		530
Plexin domain-containing protein 2		XENLA		513
Plexin domain-containing protein 1		CALJA		500
Plexin domain containing 1		MACMU		500
+573

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF378760 mRNA Translation: AAL11997.1 AK010361 mRNA Translation: BAB26881.1 AK036144 mRNA Translation: BAC29318.1 AK153684 mRNA Translation: BAE32144.1 AL591209 Genomic DNA Translation: CAM20410.1 AL591209 Genomic DNA Translation: CAM20411.1 CH466556 Genomic DNA Translation: EDL16106.1 BC114352 mRNA Translation: AAI14353.1
CCDSⁱ	CCDS25333.1 [Q91ZV7-1] CCDS48897.1 [Q91ZV7-2]
RefSeqⁱ	NP_001157080.1, NM_001163608.1 [Q91ZV7-2] NP_082475.3, NM_028199.3 [Q91ZV7-1]
UniGeneⁱ	Mm.39617 Mm.482750

3D structure databases

ProteinModelPortalⁱ	Q91ZV7
SMRⁱ	Q91ZV7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q91ZV7, 1 interactor
MINTⁱ	Q91ZV7
STRINGⁱ	10090.ENSMUSP00000103191

PTM databases

iPTMnetⁱ	Q91ZV7
PhosphoSitePlusⁱ	Q91ZV7

Proteomic databases

PaxDbⁱ	Q91ZV7
PeptideAtlasⁱ	Q91ZV7
PRIDEⁱ	Q91ZV7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417 [Q91ZV7-1] ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417 [Q91ZV7-2]
GeneIDⁱ	72324
KEGGⁱ	mmu:72324
UCSCⁱ	uc007lfc.2 mouse [Q91ZV7-1] uc011ydx.1 mouse [Q91ZV7-2]

Organism-specific databases

CTDⁱ	57125
MGIⁱ	MGI:1919574 Plxdc1

Phylogenomic databases

eggNOGⁱ	KOG3848 Eukaryota ENOG410Y7ZQ LUCA
GeneTreeⁱ	ENSGT00440000033408
HOGENOMⁱ	HOG000234044
HOVERGENⁱ	HBG079500
InParanoidⁱ	Q91ZV7
OMAⁱ	TVFIVQW
OrthoDBⁱ	EOG091G0827
PhylomeDBⁱ	Q91ZV7
TreeFamⁱ	TF314400

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91ZV7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000017417 Expressed in 143 organ(s), highest expression level in motor neuron
CleanExⁱ	MM_PLXDC1
ExpressionAtlasⁱ	Q91ZV7 baseline and differential
Genevisibleⁱ	Q91ZV7 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR002165 Plexin_repeat IPR031152 PLXDC IPR031153 PLXDC1
PANTHERⁱ	PTHR13055 PTHR13055, 1 hit PTHR13055:SF10 PTHR13055:SF10, 1 hit
Pfamⁱ	View protein in Pfam PF01437 PSI, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLDX1_MOUSE
Accessionⁱ	Q91ZV7Primary (citable) accession number: Q91ZV7 Secondary accession number(s): A2A537 , A2A538, Q29R73, Q8BM20, Q9CWV5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91ZV7 (PLDX1_MOUSE)

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Plexin domain-containing protein 1

Plxdc1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ