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Protein

Plexin domain-containing protein 1

Gene

Plxdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a critical role in endothelial cell capillary morphogenesis.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin domain-containing protein 1
Alternative name(s):
Tumor endothelial marker 7
Gene namesi
Name:Plxdc1
Synonyms:Tem7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919574 Plxdc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 426ExtracellularSequence analysisAdd BLAST407
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 500CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000023275220 – 500Plexin domain-containing protein 1Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91ZV7
PeptideAtlasiQ91ZV7
PRIDEiQ91ZV7

PTM databases

iPTMnetiQ91ZV7
PhosphoSitePlusiQ91ZV7

Expressioni

Tissue specificityi

Detected in brain. Highly expressed in Purkinje cells of the cerebellum.1 Publication

Developmental stagei

Expression increases in endothelial cells undergoing capillary morphogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000017417 Expressed in 143 organ(s), highest expression level in motor neuron
CleanExiMM_PLXDC1
ExpressionAtlasiQ91ZV7 baseline and differential
GenevisibleiQ91ZV7 MM

Interactioni

Subunit structurei

Interacts with NID1. May interact with CTTN.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Nid1P084602EBI-8280807,EBI-8280787From Rattus norvegicus.

Protein-protein interaction databases

IntActiQ91ZV7, 1 interactor
MINTiQ91ZV7
STRINGi10090.ENSMUSP00000103191

Structurei

3D structure databases

ProteinModelPortaliQ91ZV7
SMRiQ91ZV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3848 Eukaryota
ENOG410Y7ZQ LUCA
GeneTreeiENSGT00440000033408
HOGENOMiHOG000234044
HOVERGENiHBG079500
InParanoidiQ91ZV7
OMAiTVFIVQW
OrthoDBiEOG091G0827
PhylomeDBiQ91ZV7
TreeFamiTF314400

Family and domain databases

InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR031152 PLXDC
IPR031153 PLXDC1
PANTHERiPTHR13055 PTHR13055, 1 hit
PTHR13055:SF10 PTHR13055:SF10, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q91ZV7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRAQLWLLQL LLLRGAARAL SPATPAGHNE GQDSAWTAKR TRQGWSRRPR
60 70 80 90 100
ESPAQVLKPG KTQLSQDLGG GSLAIDTLPD NRTRVVEDNH NYYVSRVYGP
110 120 130 140 150
GEKQSQDLWV DLAVANRSHV KIHRILSSSH RQASRVVLSF DFPFYGHPLR
160 170 180 190 200
QITIATGGFI FMGDMLHRML TATQYVAPLM ANFNPGYSDN STVAYFDNGT
210 220 230 240 250
VFVVQWDHVY LQDREDRGSF TFQAALHRDG RIVFGYKEIP MAVLDISSAQ
260 270 280 290 300
HPVKAGLSDA FMILNSSPEV PASQRRTIFE YHRVELDSSK ITTTSAVEFT
310 320 330 340 350
PLPTCLQHQS CDTCVSSNLT FNCSWCHVLQ RCSSGFDRYR QEWLTYGCAQ
360 370 380 390 400
EAEGKTCEDF QDDSHYSASP DSSFSPFNGD STTSSSLFID SLTTEDDTKL
410 420 430 440 450
NPYAEGDGLP DHSSPKSKGP PVHLGTIVGI VLAVLLVAAI ILAGIYISGH
460 470 480 490 500
PNSNAALFFI ERRPHHWPAM KFHNHPNHST YTEVEPSGHE KEGFVEAEQC
Length:500
Mass (Da):55,635
Last modified:January 11, 2011 - v2
Checksum:i802D6865F8CA18BD
GO
Isoform 2 (identifier: Q91ZV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-86: V → VALSLSPQ

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):56,332
Checksum:iC2D50B44561C3415
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A539A2A539_MOUSE
Plexin domain-containing protein 1
Plxdc1
111Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104Q → R in AAI14353 (PubMed:15489334).Curated1
Sequence conflicti248S → P in AAI14353 (PubMed:15489334).Curated1
Sequence conflicti272A → E in AAL11997 (PubMed:11559528).Curated1
Sequence conflicti272A → E in AAI14353 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01797586V → VALSLSPQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378760 mRNA Translation: AAL11997.1
AK010361 mRNA Translation: BAB26881.1
AK036144 mRNA Translation: BAC29318.1
AK153684 mRNA Translation: BAE32144.1
AL591209 Genomic DNA Translation: CAM20410.1
AL591209 Genomic DNA Translation: CAM20411.1
CH466556 Genomic DNA Translation: EDL16106.1
BC114352 mRNA Translation: AAI14353.1
CCDSiCCDS25333.1 [Q91ZV7-1]
CCDS48897.1 [Q91ZV7-2]
RefSeqiNP_001157080.1, NM_001163608.1 [Q91ZV7-2]
NP_082475.3, NM_028199.3 [Q91ZV7-1]
UniGeneiMm.39617
Mm.482750

Genome annotation databases

EnsembliENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417 [Q91ZV7-1]
ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417 [Q91ZV7-2]
GeneIDi72324
KEGGimmu:72324
UCSCiuc007lfc.2 mouse [Q91ZV7-1]
uc011ydx.1 mouse [Q91ZV7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378760 mRNA Translation: AAL11997.1
AK010361 mRNA Translation: BAB26881.1
AK036144 mRNA Translation: BAC29318.1
AK153684 mRNA Translation: BAE32144.1
AL591209 Genomic DNA Translation: CAM20410.1
AL591209 Genomic DNA Translation: CAM20411.1
CH466556 Genomic DNA Translation: EDL16106.1
BC114352 mRNA Translation: AAI14353.1
CCDSiCCDS25333.1 [Q91ZV7-1]
CCDS48897.1 [Q91ZV7-2]
RefSeqiNP_001157080.1, NM_001163608.1 [Q91ZV7-2]
NP_082475.3, NM_028199.3 [Q91ZV7-1]
UniGeneiMm.39617
Mm.482750

3D structure databases

ProteinModelPortaliQ91ZV7
SMRiQ91ZV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91ZV7, 1 interactor
MINTiQ91ZV7
STRINGi10090.ENSMUSP00000103191

PTM databases

iPTMnetiQ91ZV7
PhosphoSitePlusiQ91ZV7

Proteomic databases

PaxDbiQ91ZV7
PeptideAtlasiQ91ZV7
PRIDEiQ91ZV7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417 [Q91ZV7-1]
ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417 [Q91ZV7-2]
GeneIDi72324
KEGGimmu:72324
UCSCiuc007lfc.2 mouse [Q91ZV7-1]
uc011ydx.1 mouse [Q91ZV7-2]

Organism-specific databases

CTDi57125
MGIiMGI:1919574 Plxdc1

Phylogenomic databases

eggNOGiKOG3848 Eukaryota
ENOG410Y7ZQ LUCA
GeneTreeiENSGT00440000033408
HOGENOMiHOG000234044
HOVERGENiHBG079500
InParanoidiQ91ZV7
OMAiTVFIVQW
OrthoDBiEOG091G0827
PhylomeDBiQ91ZV7
TreeFamiTF314400

Miscellaneous databases

PROiPR:Q91ZV7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017417 Expressed in 143 organ(s), highest expression level in motor neuron
CleanExiMM_PLXDC1
ExpressionAtlasiQ91ZV7 baseline and differential
GenevisibleiQ91ZV7 MM

Family and domain databases

InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR031152 PLXDC
IPR031153 PLXDC1
PANTHERiPTHR13055 PTHR13055, 1 hit
PTHR13055:SF10 PTHR13055:SF10, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLDX1_MOUSE
AccessioniPrimary (citable) accession number: Q91ZV7
Secondary accession number(s): A2A537
, A2A538, Q29R73, Q8BM20, Q9CWV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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