UniProtKB - Q91ZV7 (PLDX1_MOUSE)
Protein
Plexin domain-containing protein 1
Gene
Plxdc1
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a critical role in endothelial cell capillary morphogenesis.1 Publication
GO - Biological processi
- angiogenesis Source: InterPro
- spinal cord development Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Plexin domain-containing protein 1Alternative name(s): Tumor endothelial marker 7 |
Gene namesi | Name:Plxdc1 Synonyms:Tem7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919574, Plxdc1 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Other locations
- tight junction By similarity
Note: Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- bicellular tight junction Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- dendrite Source: MGI
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: MGI
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 426 | ExtracellularSequence analysisAdd BLAST | 407 | |
Transmembranei | 427 – 447 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 448 – 500 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Tight junctionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000232752 | 20 – 500 | Plexin domain-containing protein 1Add BLAST | 481 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 81 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 190 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 198 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 318 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 322 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q91ZV7 |
PeptideAtlasi | Q91ZV7 |
PRIDEi | Q91ZV7 |
PTM databases
GlyGeni | Q91ZV7, 6 sites |
iPTMneti | Q91ZV7 |
PhosphoSitePlusi | Q91ZV7 |
Expressioni
Tissue specificityi
Detected in brain. Highly expressed in Purkinje cells of the cerebellum.1 Publication
Developmental stagei
Expression increases in endothelial cells undergoing capillary morphogenesis.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000017417, Expressed in motor neuron and 167 other tissues |
ExpressionAtlasi | Q91ZV7, baseline and differential |
Genevisiblei | Q91ZV7, MM |
Interactioni
Subunit structurei
Interacts with NID1. May interact with CTTN.
2 PublicationsBinary interactionsi
Q91ZV7
With | #Exp. | IntAct |
---|---|---|
Nid1 [P08460] from Rattus norvegicus. | 2 | EBI-8280807,EBI-8280787 |
Protein-protein interaction databases
IntActi | Q91ZV7, 1 interactor |
MINTi | Q91ZV7 |
STRINGi | 10090.ENSMUSP00000103191 |
Miscellaneous databases
RNActi | Q91ZV7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the plexin family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3848, Eukaryota |
GeneTreei | ENSGT00440000033408 |
HOGENOMi | CLU_029494_3_1_1 |
InParanoidi | Q91ZV7 |
OMAi | NCPEEAK |
OrthoDBi | 1361987at2759 |
PhylomeDBi | Q91ZV7 |
TreeFami | TF314400 |
Family and domain databases
InterProi | View protein in InterPro IPR002165, Plexin_repeat IPR031152, PLXDC IPR031153, PLXDC1 |
PANTHERi | PTHR13055, PTHR13055, 1 hit PTHR13055:SF10, PTHR13055:SF10, 1 hit |
Pfami | View protein in Pfam PF01437, PSI, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q91ZV7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRAQLWLLQL LLLRGAARAL SPATPAGHNE GQDSAWTAKR TRQGWSRRPR
60 70 80 90 100
ESPAQVLKPG KTQLSQDLGG GSLAIDTLPD NRTRVVEDNH NYYVSRVYGP
110 120 130 140 150
GEKQSQDLWV DLAVANRSHV KIHRILSSSH RQASRVVLSF DFPFYGHPLR
160 170 180 190 200
QITIATGGFI FMGDMLHRML TATQYVAPLM ANFNPGYSDN STVAYFDNGT
210 220 230 240 250
VFVVQWDHVY LQDREDRGSF TFQAALHRDG RIVFGYKEIP MAVLDISSAQ
260 270 280 290 300
HPVKAGLSDA FMILNSSPEV PASQRRTIFE YHRVELDSSK ITTTSAVEFT
310 320 330 340 350
PLPTCLQHQS CDTCVSSNLT FNCSWCHVLQ RCSSGFDRYR QEWLTYGCAQ
360 370 380 390 400
EAEGKTCEDF QDDSHYSASP DSSFSPFNGD STTSSSLFID SLTTEDDTKL
410 420 430 440 450
NPYAEGDGLP DHSSPKSKGP PVHLGTIVGI VLAVLLVAAI ILAGIYISGH
460 470 480 490 500
PNSNAALFFI ERRPHHWPAM KFHNHPNHST YTEVEPSGHE KEGFVEAEQC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2A539 | A2A539_MOUSE | Plexin domain-containing protein 1 | Plxdc1 | 111 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 104 | Q → R in AAI14353 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 248 | S → P in AAI14353 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 272 | A → E in AAL11997 (PubMed:11559528).Curated | 1 | |
Sequence conflicti | 272 | A → E in AAI14353 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017975 | 86 | V → VALSLSPQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF378760 mRNA Translation: AAL11997.1 AK010361 mRNA Translation: BAB26881.1 AK036144 mRNA Translation: BAC29318.1 AK153684 mRNA Translation: BAE32144.1 AL591209 Genomic DNA No translation available. CH466556 Genomic DNA Translation: EDL16106.1 BC114352 mRNA Translation: AAI14353.1 |
CCDSi | CCDS25333.1 [Q91ZV7-1] CCDS48897.1 [Q91ZV7-2] |
RefSeqi | NP_001157080.1, NM_001163608.1 [Q91ZV7-2] NP_082475.3, NM_028199.3 [Q91ZV7-1] |
Genome annotation databases
Ensembli | ENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417 [Q91ZV7-1] ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417 [Q91ZV7-2] |
GeneIDi | 72324 |
KEGGi | mmu:72324 |
UCSCi | uc007lfc.2, mouse [Q91ZV7-1] uc011ydx.1, mouse [Q91ZV7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF378760 mRNA Translation: AAL11997.1 AK010361 mRNA Translation: BAB26881.1 AK036144 mRNA Translation: BAC29318.1 AK153684 mRNA Translation: BAE32144.1 AL591209 Genomic DNA No translation available. CH466556 Genomic DNA Translation: EDL16106.1 BC114352 mRNA Translation: AAI14353.1 |
CCDSi | CCDS25333.1 [Q91ZV7-1] CCDS48897.1 [Q91ZV7-2] |
RefSeqi | NP_001157080.1, NM_001163608.1 [Q91ZV7-2] NP_082475.3, NM_028199.3 [Q91ZV7-1] |
3D structure databases
SMRi | Q91ZV7 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q91ZV7, 1 interactor |
MINTi | Q91ZV7 |
STRINGi | 10090.ENSMUSP00000103191 |
PTM databases
GlyGeni | Q91ZV7, 6 sites |
iPTMneti | Q91ZV7 |
PhosphoSitePlusi | Q91ZV7 |
Proteomic databases
PaxDbi | Q91ZV7 |
PeptideAtlasi | Q91ZV7 |
PRIDEi | Q91ZV7 |
Protocols and materials databases
Antibodypediai | 2551, 346 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000017561; ENSMUSP00000017561; ENSMUSG00000017417 [Q91ZV7-1] ENSMUST00000107565; ENSMUSP00000103191; ENSMUSG00000017417 [Q91ZV7-2] |
GeneIDi | 72324 |
KEGGi | mmu:72324 |
UCSCi | uc007lfc.2, mouse [Q91ZV7-1] uc011ydx.1, mouse [Q91ZV7-2] |
Organism-specific databases
CTDi | 57125 |
MGIi | MGI:1919574, Plxdc1 |
Phylogenomic databases
eggNOGi | KOG3848, Eukaryota |
GeneTreei | ENSGT00440000033408 |
HOGENOMi | CLU_029494_3_1_1 |
InParanoidi | Q91ZV7 |
OMAi | NCPEEAK |
OrthoDBi | 1361987at2759 |
PhylomeDBi | Q91ZV7 |
TreeFami | TF314400 |
Miscellaneous databases
BioGRID-ORCSi | 72324, 2 hits in 17 CRISPR screens |
ChiTaRSi | Plxdc1, mouse |
PROi | PR:Q91ZV7 |
RNActi | Q91ZV7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000017417, Expressed in motor neuron and 167 other tissues |
ExpressionAtlasi | Q91ZV7, baseline and differential |
Genevisiblei | Q91ZV7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR002165, Plexin_repeat IPR031152, PLXDC IPR031153, PLXDC1 |
PANTHERi | PTHR13055, PTHR13055, 1 hit PTHR13055:SF10, PTHR13055:SF10, 1 hit |
Pfami | View protein in Pfam PF01437, PSI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLDX1_MOUSE | |
Accessioni | Q91ZV7Primary (citable) accession number: Q91ZV7 Secondary accession number(s): A2A537 Q9CWV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families