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Protein

Glutamate receptor ionotropic, NMDA 3B

Gene

Grin3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandCalcium, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3B
Short name:
GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subunit NR3B
Short name:
NMDAR3B
Short name:
NR3B
NMDA receptor 4
Short name:
Nr4
Gene namesi
Name:Grin3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2150393 Grin3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 564ExtracellularSequence analysisAdd BLAST540
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 648CytoplasmicSequence analysisAdd BLAST63
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Topological domaini670 – 826ExtracellularSequence analysisAdd BLAST157
Transmembranei827 – 847HelicalSequence analysisAdd BLAST21
Topological domaini848 – 1003CytoplasmicSequence analysisAdd BLAST156

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3832634

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001157125 – 1003Glutamate receptor ionotropic, NMDA 3BAdd BLAST979

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi786N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91ZU9
PRIDEiQ91ZU9

PTM databases

iPTMnetiQ91ZU9
PhosphoSitePlusiQ91ZU9

Expressioni

Tissue specificityi

Expressed in the facial nucleus and the ambiguus nucleus of the brainstem, pons, medulla, spinal cord and cerebellum.3 Publications

Gene expression databases

BgeeiENSMUSG00000035745 Expressed in 103 organ(s), highest expression level in spinal cord
CleanExiMM_GRIN3B
ExpressionAtlasiQ91ZU9 baseline and differential
GenevisibleiQ91ZU9 MM

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1 and GRIN2A or GRIN2B.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048576

Structurei

3D structure databases

ProteinModelPortaliQ91ZU9
SMRiQ91ZU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni952 – 985Involved in the trafficking and surface expression of NMDARsAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili947 – 986Sequence analysisAdd BLAST40

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000231528
HOVERGENiHBG052634
InParanoidiQ91ZU9
KOiK05214
OrthoDBiEOG091G00PT
PhylomeDBiQ91ZU9
TreeFamiTF314731

Family and domain databases

InterProiView protein in InterPro
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
PfamiView protein in Pfam
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91ZU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MECVQTLWLS LALALARGSW VVRGHPQPCG VPTRAGASVR LAALLPRAPA
60 70 80 90 100
ARARVLAALA TPSPRLPHNL SLELVAVASP TRDPASLARG LCQVLAPPGV
110 120 130 140 150
VASITFPEAR PELRLLQFLA AATETPVLSV LRREVRAPLG APTPFHLQLD
160 170 180 190 200
WASPLETILD VLVSLVRAHA WEDIALVLCR VRDPSGLVTL WTSRASQAPK
210 220 230 240 250
FVLDLSQLDS GNDSLRATLA LLGTLEGGGT PVSAAVLLGC STAHAHEVLE
260 270 280 290 300
AAPPGPQWLL GTPLPAEALP KTGLPPGVLV LGETGQPSLE AAVHDMVELV
310 320 330 340 350
ARALSSMALM HPERALLPAA VNCEDLKTGG SESTARTLAR FLSNTSFQGR
360 370 380 390 400
TGAVWVAGSS QVHVSRHFKV WSLRRDPLGA PAWATVGSWQ DGQLDFQPGA
410 420 430 440 450
AALRVPSPSG TQARPKLRVV TLVEHPFVFT RESDEDGQCP AGQLCLDPGT
460 470 480 490 500
NDSARLDALF TALENGSVPR TLRRCCYGYC IDLLERLAED LAFDFELYIV
510 520 530 540 550
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS
560 570 580 590 600
TSLGIMVRTR DTASPIGAFM WPLHWSMWVG VFAALHLTAL FLTLYEWRSP
610 620 630 640 650
YGLTPRGRNR GTVFSYSSAL NLCYAILFGR TVSSKTPKCP TGRFLMNLWA
660 670 680 690 700
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPSQ GFRFGTVWES
710 720 730 740 750
SAEAYIKASF PEMHAHMRRH SAPTTPHGVA MLTSDPPKLN AFIMDKSLLD
760 770 780 790 800
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI
810 820 830 840 850
DLLHDKWYKM VPCGKRVFAV TETLQMGVYH LSGLFVLLCL GLGSALLTSL
860 870 880 890 900
GEHVFYRLVL PRIRRGNKLQ YWLHTSQKIH RALNTGPPEG QQERAEQECS
910 920 930 940 950
GPKEEQPAAD GAGRWRRVRR AVVERERRVR FLLEPGEAGG DHPWLCSNGP
960 970 980 990 1000
GVQAELRELE LRIEAARERL RSALLRRGEL RAQLGDGTRL RPLRLLHAAP

AES
Length:1,003
Mass (Da):109,158
Last modified:December 1, 2001 - v1
Checksum:i911CBF784E8B7A16
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7BA29F7BA29_MOUSE
Glutamate receptor ionotropic, NMDA...
Grin3b
542Annotation score:
F7ARC5F7ARC5_MOUSE
Glutamate receptor ionotropic, NMDA...
Grin3b
399Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti674F → S in AAL40418 (PubMed:11735224).Curated1
Sequence conflicti700 – 701SS → GN in AAL40418 (PubMed:11735224).Curated2
Sequence conflicti798G → D in AAL40418 (PubMed:11735224).Curated1
Sequence conflicti900S → R in AAL40418 (PubMed:11735224).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF396649 mRNA Translation: AAL10018.1
AY062435 mRNA Translation: AAL38983.1
AF373861 mRNA Translation: AAL40418.1
CCDSiCCDS24001.1
RefSeqiNP_569722.1, NM_130455.2
UniGeneiMm.391566

Genome annotation databases

EnsembliENSMUST00000045085; ENSMUSP00000048576; ENSMUSG00000035745
GeneIDi170483
KEGGimmu:170483
UCSCiuc007gau.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF396649 mRNA Translation: AAL10018.1
AY062435 mRNA Translation: AAL38983.1
AF373861 mRNA Translation: AAL40418.1
CCDSiCCDS24001.1
RefSeqiNP_569722.1, NM_130455.2
UniGeneiMm.391566

3D structure databases

ProteinModelPortaliQ91ZU9
SMRiQ91ZU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048576

Chemistry databases

ChEMBLiCHEMBL3832634

PTM databases

iPTMnetiQ91ZU9
PhosphoSitePlusiQ91ZU9

Proteomic databases

PaxDbiQ91ZU9
PRIDEiQ91ZU9

Protocols and materials databases

DNASUi170483
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045085; ENSMUSP00000048576; ENSMUSG00000035745
GeneIDi170483
KEGGimmu:170483
UCSCiuc007gau.1 mouse

Organism-specific databases

CTDi116444
MGIiMGI:2150393 Grin3b

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000231528
HOVERGENiHBG052634
InParanoidiQ91ZU9
KOiK05214
OrthoDBiEOG091G00PT
PhylomeDBiQ91ZU9
TreeFamiTF314731

Miscellaneous databases

PROiPR:Q91ZU9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035745 Expressed in 103 organ(s), highest expression level in spinal cord
CleanExiMM_GRIN3B
ExpressionAtlasiQ91ZU9 baseline and differential
GenevisibleiQ91ZU9 MM

Family and domain databases

InterProiView protein in InterPro
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
PfamiView protein in Pfam
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNMD3B_MOUSE
AccessioniPrimary (citable) accession number: Q91ZU9
Secondary accession number(s): Q8VHV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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