Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat and SOCS box protein 6

Gene

Asb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 6
Short name:
ASB-6
Gene namesi
Name:Asb6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919573 Asb6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669341 – 418Ankyrin repeat and SOCS box protein 6Add BLAST418

Proteomic databases

EPDiQ91ZU1
MaxQBiQ91ZU1
PaxDbiQ91ZU1
PRIDEiQ91ZU1

PTM databases

iPTMnetiQ91ZU1
PhosphoSitePlusiQ91ZU1

Expressioni

Tissue specificityi

Detected in adipocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000039483 Expressed in 247 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
CleanExiMM_ASB6
ExpressionAtlasiQ91ZU1 baseline and differential
GenevisibleiQ91ZU1 MM

Interactioni

Subunit structurei

Binds APS. Identified in a complex with ELOB and ELOC. Interacts with CUL5 and RNF7 (By similarity).By similarity

Protein-protein interaction databases

BioGridi215308, 3 interactors
STRINGi10090.ENSMUSP00000043462

Structurei

3D structure databases

ProteinModelPortaliQ91ZU1
SMRiQ91ZU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati65 – 95ANK 1Add BLAST31
Repeati100 – 129ANK 2Add BLAST30
Repeati134 – 164ANK 3Add BLAST31
Repeati168 – 203ANK 4Add BLAST36
Repeati224 – 253ANK 5Add BLAST30
Repeati258 – 287ANK 6Add BLAST30
Domaini358 – 413SOCS boxPROSITE-ProRule annotationAdd BLAST56

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000006784
HOGENOMiHOG000231756
HOVERGENiHBG037329
InParanoidiQ91ZU1
KOiK10328
OMAiFCFQVTQ
OrthoDBiEOG091G07QG
PhylomeDBiQ91ZU1
TreeFamiTF330837

Family and domain databases

CDDicd00204 ANK, 2 hits
cd03725 SOCS_ASB6, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037327 ASB6_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50225 SOCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91ZU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFLHGFRRI IFEYQPLVDA ILGALGIQDL ERQEPLDDSA SSEESRILVL
60 70 80 90 100
TELLEQKAHS PFYQEGVSNA LLKMAELGLT RAAAVLLQSG ANLNFEDPVT
110 120 130 140 150
YYTALHIAVL RNQPDMVELL VRHGADINRR DRIHESSPLD LASEEPERLP
160 170 180 190 200
CLQRLLDLGA DVNAADKNGK TALLHALASS DGVQIHNTEN IRLLLEGGAD
210 220 230 240 250
VKATTKDGDT VFTCIIFLLG ETVCGDKEEA PMINRFCFQV TQLLLAHGAD
260 270 280 290 300
PSECPAHESL THICLKSFKL HFPLLCFLLE SGAAYNCSLH GASCWSGFNL
310 320 330 340 350
VFERLCSHPG CAEDDSHIEL LHKAETVLDL MVTSSQRLQL PENLNIHPVG
360 370 380 390 400
SLAGKIQALH ASLRQLESYP PPLKHLCRVS IRLCLRPWPV DTKVKALPLP
410
DRLKWYLLSA HSDTQDTC
Length:418
Mass (Da):46,276
Last modified:December 1, 2001 - v1
Checksum:i04ADE4CC0CF6E964
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YY11A0A0A6YY11_MOUSE
Ankyrin repeat and SOCS box protein...
Asb6
38Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189E → D in AAH19192 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398967 mRNA Translation: AAK97489.1
BC019192 mRNA Translation: AAH19192.1
CCDSiCCDS38096.1
RefSeqiNP_579924.1, NM_133346.2
UniGeneiMm.27656

Genome annotation databases

EnsembliENSMUST00000041726; ENSMUSP00000043462; ENSMUSG00000039483
GeneIDi72323
KEGGimmu:72323
UCSCiuc008jcx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398967 mRNA Translation: AAK97489.1
BC019192 mRNA Translation: AAH19192.1
CCDSiCCDS38096.1
RefSeqiNP_579924.1, NM_133346.2
UniGeneiMm.27656

3D structure databases

ProteinModelPortaliQ91ZU1
SMRiQ91ZU1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215308, 3 interactors
STRINGi10090.ENSMUSP00000043462

PTM databases

iPTMnetiQ91ZU1
PhosphoSitePlusiQ91ZU1

Proteomic databases

EPDiQ91ZU1
MaxQBiQ91ZU1
PaxDbiQ91ZU1
PRIDEiQ91ZU1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041726; ENSMUSP00000043462; ENSMUSG00000039483
GeneIDi72323
KEGGimmu:72323
UCSCiuc008jcx.1 mouse

Organism-specific databases

CTDi140459
MGIiMGI:1919573 Asb6

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000006784
HOGENOMiHOG000231756
HOVERGENiHBG037329
InParanoidiQ91ZU1
KOiK10328
OMAiFCFQVTQ
OrthoDBiEOG091G07QG
PhylomeDBiQ91ZU1
TreeFamiTF330837

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q91ZU1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039483 Expressed in 247 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
CleanExiMM_ASB6
ExpressionAtlasiQ91ZU1 baseline and differential
GenevisibleiQ91ZU1 MM

Family and domain databases

CDDicd00204 ANK, 2 hits
cd03725 SOCS_ASB6, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037327 ASB6_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASB6_MOUSE
AccessioniPrimary (citable) accession number: Q91ZU1
Secondary accession number(s): Q8VEC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again