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Protein

Ankyrin repeat and SOCS box protein 10

Gene

Asb10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 10
Short name:
ASB-10
Gene namesi
Name:Asb10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2152836 Asb10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669431 – 467Ankyrin repeat and SOCS box protein 10Add BLAST467

Proteomic databases

PaxDbiQ91ZT7
PRIDEiQ91ZT7

PTM databases

PhosphoSitePlusiQ91ZT7

Expressioni

Gene expression databases

BgeeiENSMUSG00000038204
CleanExiMM_ASB10
ExpressionAtlasiQ91ZT7 baseline and differential
GenevisibleiQ91ZT7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041539

Structurei

3D structure databases

ProteinModelPortaliQ91ZT7
SMRiQ91ZT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati115 – 144ANK 1Add BLAST30
Repeati147 – 176ANK 2Add BLAST30
Repeati180 – 209ANK 3Add BLAST30
Repeati214 – 243ANK 4Add BLAST30
Repeati247 – 289ANK 5Add BLAST43
Repeati293 – 322ANK 6Add BLAST30
Repeati326 – 361ANK 7Add BLAST36
Domaini412 – 467SOCS boxPROSITE-ProRule annotationAdd BLAST56

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000011960
HOGENOMiHOG000232066
HOVERGENiHBG073573
InParanoidiQ91ZT7
KOiK10332
OMAiACLPHAL
OrthoDBiEOG091G0711
PhylomeDBiQ91ZT7
TreeFamiTF323921

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 2 hits
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 7 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q91ZT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMSWSPEEC RDQGEPQGDR YSLCAKLVEK PDRGSEEHLE PGLGPIIIRS
60 70 80 90 100
ASGPTLAFWQ AVLVGDVGSV SRILSDSSTG LAPDSIFDTS DPERWRDYRF
110 120 130 140 150
NIRALRLWSL TYEEELTTPL HVAASRGHTE VLELLLRRRA KPDSAPGGRT
160 170 180 190 200
ALHEACSAGH AACVRVLLVA GADPNTLDQD GKRPLHLCRG PGILECVELL
210 220 230 240 250
LKFGAQVDGR TEDEEETPLH IAARLGHVEL ADLLLRWGAC PDVRNSEGWT
260 270 280 290 300
PLLAACDIRC QSPKDAEATT NRCFQLCRLL LSVGADADAA NQDKQRPLHL
310 320 330 340 350
ACRHGHSAVV QLLLSCGVNA NAMDYGGHTP LHCALLGPTT AVAHSPEHTV
360 370 380 390 400
RDLLNHGAVR VWPGALPKVL DRWCMSPRTI EVLMNTYRVV QLPEEAKGLV
410 420 430 440 450
PPEILQKYHG FYSSLFALVR QPRSLQHLCR CALRSHLEGC LPHALPRLPL
460
PPRMLRFLQL DFEDLLY
Length:467
Mass (Da):51,583
Last modified:December 1, 2001 - v1
Checksum:i7DF5BCFDD2EAA4AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF398971 mRNA Translation: AAK97493.1
AK028538 mRNA Translation: BAC25997.1
AK052929 mRNA Translation: BAC35206.1
BC141311 mRNA Translation: AAI41312.1
BC141313 mRNA Translation: AAI41314.1
CCDSiCCDS19124.1
RefSeqiNP_001297405.1, NM_001310476.1
NP_536692.1, NM_080444.5
UniGeneiMm.207071

Genome annotation databases

EnsembliENSMUST00000048302; ENSMUSP00000041539; ENSMUSG00000038204
GeneIDi117590
KEGGimmu:117590
UCSCiuc008wry.1 mouse

Similar proteinsi

Entry informationi

Entry nameiASB10_MOUSE
AccessioniPrimary (citable) accession number: Q91ZT7
Secondary accession number(s): B2RUP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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