UniProtKB - Q91ZS8 (RED1_MOUSE)
Double-stranded RNA-specific editase 1
Adarb1
Functioni
Catalytic activityi
- EC:3.5.4.37
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 394 | ZincPROSITE-ProRule annotation | 1 | |
Active sitei | 396 | Proton donorPROSITE-ProRule annotation | 1 | |
Binding sitei | 400 | Inositol hexakisphosphateBy similarity | 1 | |
Binding sitei | 401 | Inositol hexakisphosphateBy similarity | 1 | |
Metal bindingi | 451 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 526 | ZincPROSITE-ProRule annotation | 1 | |
Binding sitei | 529 | Inositol hexakisphosphateBy similarity | 1 | |
Binding sitei | 532 | Inositol hexakisphosphateBy similarity | 1 | |
Binding sitei | 639 | Inositol hexakisphosphateBy similarity | 1 | |
Binding sitei | 672 | Inositol hexakisphosphateBy similarity | 1 | |
Binding sitei | 682 | Inositol hexakisphosphateBy similarity | 1 | |
Binding sitei | 700 | Inositol hexakisphosphateBy similarity | 1 |
GO - Molecular functioni
- double-stranded RNA adenosine deaminase activity Source: HGNC-UCL
- double-stranded RNA binding Source: HGNC-UCL
- identical protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: HGNC-UCL
- tRNA-specific adenosine deaminase activity Source: GO_Central
GO - Biological processi
- adenosine to inosine editing Source: UniProtKB
- base conversion or substitution editing Source: MGI
- facial nerve morphogenesis Source: MGI
- hypoglossal nerve morphogenesis Source: MGI
- innervation Source: MGI
- motor behavior Source: MGI
- motor neuron apoptotic process Source: MGI
- mRNA modification Source: MGI
- mRNA processing Source: UniProtKB-KW
- multicellular organism growth Source: MGI
- muscle tissue morphogenesis Source: MGI
- negative regulation of cell migration Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of protein kinase activity by regulation of protein phosphorylation Source: UniProtKB
- neuromuscular process controlling posture Source: MGI
- neuromuscular synaptic transmission Source: MGI
- positive regulation of mRNA processing Source: MGI
- positive regulation of viral genome replication Source: UniProtKB
- regulation of cell cycle Source: UniProtKB
- RNA processing Source: HGNC-UCL
- spinal cord ventral commissure morphogenesis Source: MGI
Keywordsi
Molecular function | Hydrolase, RNA-binding |
Biological process | mRNA processing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-75102, C6 deamination of adenosine R-MMU-77042, Formation of editosomes by ADAR proteins |
Names & Taxonomyi
Protein namesi | Recommended name: Double-stranded RNA-specific editase 1 (EC:3.5.4.37)Alternative name(s): RNA-editing deaminase 1 RNA-editing enzyme 1 dsRNA adenosine deaminase |
Gene namesi | Name:Adarb1 Synonyms:Adar2, Red1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:891999, Adarb1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171780 | 1 – 711 | Double-stranded RNA-specific editase 1Add BLAST | 711 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 149 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q91ZS8 |
PeptideAtlasi | Q91ZS8 |
PRIDEi | Q91ZS8 |
PTM databases
iPTMneti | Q91ZS8 |
PhosphoSitePlusi | Q91ZS8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020262, Expressed in brain and 261 other tissues |
Genevisiblei | Q91ZS8, MM |
Interactioni
Subunit structurei
Homodimer. Homodimerization is essential for its catalytic activity. Can form heterodimers with isoform 5 of ADAR/ADAR1 (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 225680, 1 interactor |
IntActi | Q91ZS8, 1 interactor |
MINTi | Q91ZS8 |
STRINGi | 10090.ENSMUSP00000095976 |
Miscellaneous databases
RNActi | Q91ZS8, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q91ZS8 |
SMRi | Q91ZS8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q91ZS8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 144 | DRBM 1PROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 231 – 298 | DRBM 2PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 370 – 707 | A to I editasePROSITE-ProRule annotationAdd BLAST | 338 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 83 – 88 | Interaction with substrate RNABy similarity | 6 | |
Regioni | 104 – 105 | Interaction with substrate RNABy similarity | 2 | |
Regioni | 237 – 242 | Interaction with substrate RNABy similarity | 6 | |
Regioni | 259 | Interaction with substrate RNABy similarity | 1 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2777, Eukaryota |
GeneTreei | ENSGT00940000155992 |
HOGENOMi | CLU_005382_3_1_1 |
InParanoidi | Q91ZS8 |
OMAi | HESKLVA |
OrthoDBi | 947117at2759 |
PhylomeDBi | Q91ZS8 |
TreeFami | TF315806 |
Family and domain databases
CDDi | cd00048, DSRM, 2 hits |
InterProi | View protein in InterPro IPR002466, A_deamin IPR014720, dsRBD_dom |
Pfami | View protein in Pfam PF02137, A_deamin, 1 hit PF00035, dsrm, 2 hits |
SMARTi | View protein in SMART SM00552, ADEAMc, 1 hit SM00358, DSRM, 2 hits |
PROSITEi | View protein in PROSITE PS50141, A_DEAMIN_EDITASE, 1 hit PS50137, DS_RBD, 2 hits |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDIEDEENMS SSSTDIKENR NLDNMPPKDS STPGPGEGIP LSNGGGGSTS
60 70 80 90 100
RKRPLEEGSN GHSKYRLKKR RKTPGPVLPK NALMQLNEIK PGLQYMLLSQ
110 120 130 140 150
TGPVHAPLFV MSVEVNGQVF EGSGPTKKKA KLHAAEKALR SFVQFPNASE
160 170 180 190 200
AHLAMGRTLS VNTDFTSDQA DFPDTLFNGF ETPDKSEPPF YVGSNGDDSF
210 220 230 240 250
SSSGDVSLSA SPVPASLTQP PLPIPPPFPP PSGKNPVMIL NELRPGLKYD
260 270 280 290 300
FLSESGESHA KSFVMSVVVD GQFFEGSGRN KKLAKARAAQ SALATVFNLH
310 320 330 340 350
LDQTPSRQPV LSEGLQLHLP QVLADAVSRL VLGKFSDLTD NFSSPHARRK
360 370 380 390 400
VLSGVVMTTG TDVKDAKVIS VSTGTKCING EYMSDRGLAL NDCHAEIISR
410 420 430 440 450
RSLLRFLYAQ LELYLNNKED QKKSIFQKSE RGGFRLKDTV QFHLYISTSP
460 470 480 490 500
CGDARIFSPH EPVLEGMTPD SHQLTEPADR HPNRKARGQL RTKIESGEGT
510 520 530 540 550
IPVRSNASIQ TWDGVLQGER LLTMSCSDKI ARWNVVGIQG SLLSIFVEPI
560 570 580 590 600
YFSSIILGSL YHGDHLSRAM YQRISNIEDL PPLYTLNKPL LSGISNAEAR
610 620 630 640 650
QPGKAPNFSV NWTVGDATIE VINATTGKDE LGRPSRLCKH ALYCRWMRVH
660 670 680 690 700
GKVPPHLLRT KITKPTTYHE SKLAAREYQA AKARLFTAFI KAGLGAWVEK
710
PTEQDQFSFT P
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MASLGLGTLTVGAFFSFVGRRYKRRRKKRSERKDKRGLRQSRSPQKCFTM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RDS5 | D6RDS5_MOUSE | Double-stranded RNA-specific editas... | Adarb1 | 38 | Annotation score: | ||
D6RGS1 | D6RGS1_MOUSE | Double-stranded RNA-specific editas... | Adarb1 | 82 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | Y → C in AAK17102 (PubMed:12709013).Curated | 1 | |
Sequence conflicti | 559 | S → G in AAK17102 (PubMed:12709013).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013709 | 1 – 24 | Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_013710 | 1 – 10 | MDIEDEENMS → MPLG in isoform 3. 1 Publication | 10 | |
Alternative sequenceiVSP_041423 | 1 | M → MASLGLGTLTVGAFFSFVGR RYKRRRKKRSERKDKRGLRQ SRSPQKCFTM in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_013711 | 466 – 475 | Missing in isoform 2, isoform 3 and isoform 5. 2 Publications | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF403106 mRNA Translation: AAL01301.1 AF403107 mRNA Translation: AAL01302.1 AF403108 mRNA Translation: AAL01303.1 AF403109 mRNA Translation: AAL01304.1 AF525421 mRNA Translation: AAM83099.1 AY162454 mRNA Translation: AAN86546.1 AF291049 mRNA Translation: AAK17102.1 FJ169505 mRNA Translation: ACN49026.1 AK141777 mRNA Translation: BAE24831.1 AK147298 mRNA Translation: BAE27830.1 CH466553 Genomic DNA Translation: EDL31813.1 |
CCDSi | CCDS35948.1 [Q91ZS8-1] CCDS35949.1 [Q91ZS8-2] |
RefSeqi | NP_001020008.1, NM_001024837.2 [Q91ZS8-1] NP_570965.2, NM_130895.3 [Q91ZS8-2] XP_006513128.1, XM_006513065.1 |
Genome annotation databases
Ensembli | ENSMUST00000020496; ENSMUSP00000020496; ENSMUSG00000020262 [Q91ZS8-2] ENSMUST00000098374; ENSMUSP00000095976; ENSMUSG00000020262 [Q91ZS8-1] ENSMUST00000105406; ENSMUSP00000101046; ENSMUSG00000020262 [Q91ZS8-1] |
GeneIDi | 110532 |
KEGGi | mmu:110532 |
UCSCi | uc007fvl.2, mouse [Q91ZS8-3] uc007fvm.2, mouse [Q91ZS8-1] uc007fvn.2, mouse [Q91ZS8-5] uc007fvp.2, mouse [Q91ZS8-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF403106 mRNA Translation: AAL01301.1 AF403107 mRNA Translation: AAL01302.1 AF403108 mRNA Translation: AAL01303.1 AF403109 mRNA Translation: AAL01304.1 AF525421 mRNA Translation: AAM83099.1 AY162454 mRNA Translation: AAN86546.1 AF291049 mRNA Translation: AAK17102.1 FJ169505 mRNA Translation: ACN49026.1 AK141777 mRNA Translation: BAE24831.1 AK147298 mRNA Translation: BAE27830.1 CH466553 Genomic DNA Translation: EDL31813.1 |
CCDSi | CCDS35948.1 [Q91ZS8-1] CCDS35949.1 [Q91ZS8-2] |
RefSeqi | NP_001020008.1, NM_001024837.2 [Q91ZS8-1] NP_570965.2, NM_130895.3 [Q91ZS8-2] XP_006513128.1, XM_006513065.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2L2K | NMR | - | B | 231-301 | [»] | |
BMRBi | Q91ZS8 | |||||
SMRi | Q91ZS8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 225680, 1 interactor |
IntActi | Q91ZS8, 1 interactor |
MINTi | Q91ZS8 |
STRINGi | 10090.ENSMUSP00000095976 |
PTM databases
iPTMneti | Q91ZS8 |
PhosphoSitePlusi | Q91ZS8 |
Proteomic databases
PaxDbi | Q91ZS8 |
PeptideAtlasi | Q91ZS8 |
PRIDEi | Q91ZS8 |
Protocols and materials databases
Antibodypediai | 10404, 125 antibodies |
DNASUi | 110532 |
Genome annotation databases
Ensembli | ENSMUST00000020496; ENSMUSP00000020496; ENSMUSG00000020262 [Q91ZS8-2] ENSMUST00000098374; ENSMUSP00000095976; ENSMUSG00000020262 [Q91ZS8-1] ENSMUST00000105406; ENSMUSP00000101046; ENSMUSG00000020262 [Q91ZS8-1] |
GeneIDi | 110532 |
KEGGi | mmu:110532 |
UCSCi | uc007fvl.2, mouse [Q91ZS8-3] uc007fvm.2, mouse [Q91ZS8-1] uc007fvn.2, mouse [Q91ZS8-5] uc007fvp.2, mouse [Q91ZS8-2] |
Organism-specific databases
CTDi | 104 |
MGIi | MGI:891999, Adarb1 |
Phylogenomic databases
eggNOGi | KOG2777, Eukaryota |
GeneTreei | ENSGT00940000155992 |
HOGENOMi | CLU_005382_3_1_1 |
InParanoidi | Q91ZS8 |
OMAi | HESKLVA |
OrthoDBi | 947117at2759 |
PhylomeDBi | Q91ZS8 |
TreeFami | TF315806 |
Enzyme and pathway databases
Reactomei | R-MMU-75102, C6 deamination of adenosine R-MMU-77042, Formation of editosomes by ADAR proteins |
Miscellaneous databases
BioGRID-ORCSi | 110532, 3 hits in 15 CRISPR screens |
ChiTaRSi | Adarb1, mouse |
EvolutionaryTracei | Q91ZS8 |
PROi | PR:Q91ZS8 |
RNActi | Q91ZS8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020262, Expressed in brain and 261 other tissues |
Genevisiblei | Q91ZS8, MM |
Family and domain databases
CDDi | cd00048, DSRM, 2 hits |
InterProi | View protein in InterPro IPR002466, A_deamin IPR014720, dsRBD_dom |
Pfami | View protein in Pfam PF02137, A_deamin, 1 hit PF00035, dsrm, 2 hits |
SMARTi | View protein in SMART SM00552, ADEAMc, 1 hit SM00358, DSRM, 2 hits |
PROSITEi | View protein in PROSITE PS50141, A_DEAMIN_EDITASE, 1 hit PS50137, DS_RBD, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RED1_MOUSE | |
Accessioni | Q91ZS8Primary (citable) accession number: Q91ZS8 Secondary accession number(s): C3TTQ1 Q99MU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references