Adarb1

Functionⁱ

Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can inhibit cell proliferation and migration and can stimulate exocytosis.1 Publication

Catalytic activityⁱ

adenosine in double-stranded RNA
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Search chemical reactions in Rhea for this molecule.
+
H⁺
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
inosine in double-stranded RNA
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Search chemical reactions in Rhea for this molecule.
+
NH₄⁺
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
EC:
3.5.4.37
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
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adenosine in double-stranded RNA
AMP residue
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+
H⁺
+
H₂O
=
inosine in double-stranded RNA
IMP residue
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NH₄⁺
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Cofactorⁱ

1D-myo-inositol hexakisphosphateBy similarityNote: Binds 1 myo-inositol hexakisphosphate (IP6) per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	394	ZincPROSITE-ProRule annotation	1
Active siteⁱ	396	Proton donorPROSITE-ProRule annotation	1
Binding siteⁱ	400	Inositol hexakisphosphateBy similarity	1
Binding siteⁱ	401	Inositol hexakisphosphateBy similarity	1
Metal bindingⁱ	451	ZincPROSITE-ProRule annotation	1
Metal bindingⁱ	526	ZincPROSITE-ProRule annotation	1
Binding siteⁱ	529	Inositol hexakisphosphateBy similarity	1
Binding siteⁱ	532	Inositol hexakisphosphateBy similarity	1
Binding siteⁱ	639	Inositol hexakisphosphateBy similarity	1
Binding siteⁱ	672	Inositol hexakisphosphateBy similarity	1
Binding siteⁱ	682	Inositol hexakisphosphateBy similarity	1
Binding siteⁱ	700	Inositol hexakisphosphateBy similarity	1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, RNA-binding
Biological process	mRNA processing
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-75102, C6 deamination of adenosine R-MMU-77042, Formation of editosomes by ADAR proteins

Reactomeⁱ

R-MMU-75102, C6 deamination of adenosine
R-MMU-77042, Formation of editosomes by ADAR proteins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Double-stranded RNA-specific editase 1 (EC:3.5.4.37) Alternative name(s): RNA-editing deaminase 1 RNA-editing enzyme 1 dsRNA adenosine deaminase
Gene namesⁱ	Name:Adarb1 Synonyms:Adar2, Red1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:891999, Adarb1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000171780	1 – 711	Double-stranded RNA-specific editase 1Add BLAST		711

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	149	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q91ZS8
PeptideAtlas More...PeptideAtlasⁱ	Q91ZS8
PRIDEⁱ	Q91ZS8

PTM databases

iPTMnetⁱ	Q91ZS8
PhosphoSitePlusⁱ	Q91ZS8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020262, Expressed in brain and 261 other tissues
Genevisibleⁱ	Q91ZS8, MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Homodimerization is essential for its catalytic activity. Can form heterodimers with isoform 5 of ADAR/ADAR1 (By similarity).

By similarity

GO - Molecular functionⁱ

identical protein binding Source: MGI

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	225680, 1 interactor
IntActⁱ	Q91ZS8, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q91ZS8
STRINGⁱ	10090.ENSMUSP00000095976

Miscellaneous databases

RNActⁱ	Q91ZS8, protein

RNActⁱ

Q91ZS8, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	236 – 243	Combined sources	8
Beta strandⁱ	248 – 256	Combined sources	9
Beta strandⁱ	262 – 269	Combined sources	8
Beta strandⁱ	272 – 280	Combined sources	9
Helixⁱ	281 – 296	Combined sources	16

Show more details

3D structure databases

BMRBⁱ	Q91ZS8
SMRⁱ	Q91ZS8
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q91ZS8

EvolutionaryTraceⁱ

Q91ZS8

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	78 – 144	DRBM 1PROSITE-ProRule annotationAdd BLAST	67
Domainⁱ	231 – 298	DRBM 2PROSITE-ProRule annotationAdd BLAST	68
Domainⁱ	370 – 707	A to I editasePROSITE-ProRule annotationAdd BLAST	338

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	83 – 88	Interaction with substrate RNABy similarity	6
Regionⁱ	104 – 105	Interaction with substrate RNABy similarity	2
Regionⁱ	237 – 242	Interaction with substrate RNABy similarity	6
Regionⁱ	259	Interaction with substrate RNABy similarity	1

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG2777, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155992
HOGENOMⁱ	CLU_005382_3_1_1
InParanoidⁱ	Q91ZS8
OMAⁱ	HESKLVA
Database of Orthologous Groups More...OrthoDBⁱ	947117at2759
PhylomeDBⁱ	Q91ZS8
TreeFamⁱ	TF315806

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00048, DSRM, 2 hits
InterProⁱ	View protein in InterPro IPR002466, A_deamin IPR014720, dsRBD_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02137, A_deamin, 1 hit PF00035, dsrm, 2 hits
SMARTⁱ	View protein in SMART SM00552, ADEAMc, 1 hit SM00358, DSRM, 2 hits
PROSITEⁱ	View protein in PROSITE PS50141, A_DEAMIN_EDITASE, 1 hit PS50137, DS_RBD, 2 hits

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q91ZS8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MDIEDEENMS SSSTDIKENR NLDNMPPKDS STPGPGEGIP LSNGGGGSTS 
        60         70         80         90        100
RKRPLEEGSN GHSKYRLKKR RKTPGPVLPK NALMQLNEIK PGLQYMLLSQ 
       110        120        130        140        150
TGPVHAPLFV MSVEVNGQVF EGSGPTKKKA KLHAAEKALR SFVQFPNASE 
       160        170        180        190        200
AHLAMGRTLS VNTDFTSDQA DFPDTLFNGF ETPDKSEPPF YVGSNGDDSF 
       210        220        230        240        250
SSSGDVSLSA SPVPASLTQP PLPIPPPFPP PSGKNPVMIL NELRPGLKYD 
       260        270        280        290        300
FLSESGESHA KSFVMSVVVD GQFFEGSGRN KKLAKARAAQ SALATVFNLH 
       310        320        330        340        350
LDQTPSRQPV LSEGLQLHLP QVLADAVSRL VLGKFSDLTD NFSSPHARRK 
       360        370        380        390        400
VLSGVVMTTG TDVKDAKVIS VSTGTKCING EYMSDRGLAL NDCHAEIISR 
       410        420        430        440        450
RSLLRFLYAQ LELYLNNKED QKKSIFQKSE RGGFRLKDTV QFHLYISTSP 
       460        470        480        490        500
CGDARIFSPH EPVLEGMTPD SHQLTEPADR HPNRKARGQL RTKIESGEGT 
       510        520        530        540        550
IPVRSNASIQ TWDGVLQGER LLTMSCSDKI ARWNVVGIQG SLLSIFVEPI 
       560        570        580        590        600
YFSSIILGSL YHGDHLSRAM YQRISNIEDL PPLYTLNKPL LSGISNAEAR 
       610        620        630        640        650
QPGKAPNFSV NWTVGDATIE VINATTGKDE LGRPSRLCKH ALYCRWMRVH 
       660        670        680        690        700
GKVPPHLLRT KITKPTTYHE SKLAAREYQA AKARLFTAFI KAGLGAWVEK 
       710 
PTEQDQFSFT P

Length:711

Mass (Da):78,001

Last modified:December 1, 2001 - v1

Checksum:ⁱA5C87E894C867DE1

GO

Isoform 2 (identifier: Q91ZS8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
466-475: Missing.

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        10         20         30         40         50
MDIEDEENMS SSSTDIKENR NLDNMPPKDS STPGPGEGIP LSNGGGGSTS 
        60         70         80         90        100
RKRPLEEGSN GHSKYRLKKR RKTPGPVLPK NALMQLNEIK PGLQYMLLSQ 
       110        120        130        140        150
TGPVHAPLFV MSVEVNGQVF EGSGPTKKKA KLHAAEKALR SFVQFPNASE 
       160        170        180        190        200
AHLAMGRTLS VNTDFTSDQA DFPDTLFNGF ETPDKSEPPF YVGSNGDDSF 
       210        220        230        240        250
SSSGDVSLSA SPVPASLTQP PLPIPPPFPP PSGKNPVMIL NELRPGLKYD 
       260        270        280        290        300
FLSESGESHA KSFVMSVVVD GQFFEGSGRN KKLAKARAAQ SALATVFNLH 
       310        320        330        340        350
LDQTPSRQPV LSEGLQLHLP QVLADAVSRL VLGKFSDLTD NFSSPHARRK 
       360        370        380        390        400
VLSGVVMTTG TDVKDAKVIS VSTGTKCING EYMSDRGLAL NDCHAEIISR 
       410        420        430        440        450
RSLLRFLYAQ LELYLNNKED QKKSIFQKSE RGGFRLKDTV QFHLYISTSP 
       460        470        480        490        500
CGDARIFSPH EPVLEEPADR HPNRKARGQL RTKIESGEGT IPVRSNASIQ 
       510        520        530        540        550
TWDGVLQGER LLTMSCSDKI ARWNVVGIQG SLLSIFVEPI YFSSIILGSL 
       560        570        580        590        600
YHGDHLSRAM YQRISNIEDL PPLYTLNKPL LSGISNAEAR QPGKAPNFSV 
       610        620        630        640        650
NWTVGDATIE VINATTGKDE LGRPSRLCKH ALYCRWMRVH GKVPPHLLRT 
       660        670        680        690        700
KITKPTTYHE SKLAAREYQA AKARLFTAFI KAGLGAWVEK PTEQDQFSFT 

P

Show »

Length:701

Mass (Da):76,932

Checksum:ⁱ9DC35AB940ECDC1B

GO

Isoform 3 (identifier: Q91ZS8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-10: MDIEDEENMS → MPLG
466-475: Missing.

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        10         20         30         40         50
MPLGSSSTDI KENRNLDNMP PKDSSTPGPG EGIPLSNGGG GSTSRKRPLE 
        60         70         80         90        100
EGSNGHSKYR LKKRRKTPGP VLPKNALMQL NEIKPGLQYM LLSQTGPVHA 
       110        120        130        140        150
PLFVMSVEVN GQVFEGSGPT KKKAKLHAAE KALRSFVQFP NASEAHLAMG 
       160        170        180        190        200
RTLSVNTDFT SDQADFPDTL FNGFETPDKS EPPFYVGSNG DDSFSSSGDV 
       210        220        230        240        250
SLSASPVPAS LTQPPLPIPP PFPPPSGKNP VMILNELRPG LKYDFLSESG 
       260        270        280        290        300
ESHAKSFVMS VVVDGQFFEG SGRNKKLAKA RAAQSALATV FNLHLDQTPS 
       310        320        330        340        350
RQPVLSEGLQ LHLPQVLADA VSRLVLGKFS DLTDNFSSPH ARRKVLSGVV 
       360        370        380        390        400
MTTGTDVKDA KVISVSTGTK CINGEYMSDR GLALNDCHAE IISRRSLLRF 
       410        420        430        440        450
LYAQLELYLN NKEDQKKSIF QKSERGGFRL KDTVQFHLYI STSPCGDARI 
       460        470        480        490        500
FSPHEPVLEE PADRHPNRKA RGQLRTKIES GEGTIPVRSN ASIQTWDGVL 
       510        520        530        540        550
QGERLLTMSC SDKIARWNVV GIQGSLLSIF VEPIYFSSII LGSLYHGDHL 
       560        570        580        590        600
SRAMYQRISN IEDLPPLYTL NKPLLSGISN AEARQPGKAP NFSVNWTVGD 
       610        620        630        640        650
ATIEVINATT GKDELGRPSR LCKHALYCRW MRVHGKVPPH LLRTKITKPT 
       660        670        680        690 
TYHESKLAAR EYQAAKARLF TAFIKAGLGA WVEKPTEQDQ FSFTP

Show »

Length:695

Mass (Da):76,137

Checksum:ⁱF88ED2F95BBC3A98

GO

Isoform 4 (identifier: Q91ZS8-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-24: Missing.

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        10         20         30         40         50
MPPKDSSTPG PGEGIPLSNG GGGSTSRKRP LEEGSNGHSK YRLKKRRKTP 
        60         70         80         90        100
GPVLPKNALM QLNEIKPGLQ YMLLSQTGPV HAPLFVMSVE VNGQVFEGSG 
       110        120        130        140        150
PTKKKAKLHA AEKALRSFVQ FPNASEAHLA MGRTLSVNTD FTSDQADFPD 
       160        170        180        190        200
TLFNGFETPD KSEPPFYVGS NGDDSFSSSG DVSLSASPVP ASLTQPPLPI 
       210        220        230        240        250
PPPFPPPSGK NPVMILNELR PGLKYDFLSE SGESHAKSFV MSVVVDGQFF 
       260        270        280        290        300
EGSGRNKKLA KARAAQSALA TVFNLHLDQT PSRQPVLSEG LQLHLPQVLA 
       310        320        330        340        350
DAVSRLVLGK FSDLTDNFSS PHARRKVLSG VVMTTGTDVK DAKVISVSTG 
       360        370        380        390        400
TKCINGEYMS DRGLALNDCH AEIISRRSLL RFLYAQLELY LNNKEDQKKS 
       410        420        430        440        450
IFQKSERGGF RLKDTVQFHL YISTSPCGDA RIFSPHEPVL EGMTPDSHQL 
       460        470        480        490        500
TEPADRHPNR KARGQLRTKI ESGEGTIPVR SNASIQTWDG VLQGERLLTM 
       510        520        530        540        550
SCSDKIARWN VVGIQGSLLS IFVEPIYFSS IILGSLYHGD HLSRAMYQRI 
       560        570        580        590        600
SNIEDLPPLY TLNKPLLSGI SNAEARQPGK APNFSVNWTV GDATIEVINA 
       610        620        630        640        650
TTGKDELGRP SRLCKHALYC RWMRVHGKVP PHLLRTKITK PTTYHESKLA 
       660        670        680 
AREYQAAKAR LFTAFIKAGL GAWVEKPTEQ DQFSFTP

Show »

Length:687

Mass (Da):75,232

Checksum:ⁱAE6B8C4AAAD81726

GO

Isoform 5 (identifier: Q91ZS8-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-24: Missing.
466-475: Missing.

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        10         20         30         40         50
MPPKDSSTPG PGEGIPLSNG GGGSTSRKRP LEEGSNGHSK YRLKKRRKTP 
        60         70         80         90        100
GPVLPKNALM QLNEIKPGLQ YMLLSQTGPV HAPLFVMSVE VNGQVFEGSG 
       110        120        130        140        150
PTKKKAKLHA AEKALRSFVQ FPNASEAHLA MGRTLSVNTD FTSDQADFPD 
       160        170        180        190        200
TLFNGFETPD KSEPPFYVGS NGDDSFSSSG DVSLSASPVP ASLTQPPLPI 
       210        220        230        240        250
PPPFPPPSGK NPVMILNELR PGLKYDFLSE SGESHAKSFV MSVVVDGQFF 
       260        270        280        290        300
EGSGRNKKLA KARAAQSALA TVFNLHLDQT PSRQPVLSEG LQLHLPQVLA 
       310        320        330        340        350
DAVSRLVLGK FSDLTDNFSS PHARRKVLSG VVMTTGTDVK DAKVISVSTG 
       360        370        380        390        400
TKCINGEYMS DRGLALNDCH AEIISRRSLL RFLYAQLELY LNNKEDQKKS 
       410        420        430        440        450
IFQKSERGGF RLKDTVQFHL YISTSPCGDA RIFSPHEPVL EEPADRHPNR 
       460        470        480        490        500
KARGQLRTKI ESGEGTIPVR SNASIQTWDG VLQGERLLTM SCSDKIARWN 
       510        520        530        540        550
VVGIQGSLLS IFVEPIYFSS IILGSLYHGD HLSRAMYQRI SNIEDLPPLY 
       560        570        580        590        600
TLNKPLLSGI SNAEARQPGK APNFSVNWTV GDATIEVINA TTGKDELGRP 
       610        620        630        640        650
SRLCKHALYC RWMRVHGKVP PHLLRTKITK PTTYHESKLA AREYQAAKAR 
       660        670 
LFTAFIKAGL GAWVEKPTEQ DQFSFTP

Show »

Length:677

Mass (Da):74,164

Checksum:ⁱCB889950207BC99B

GO

Isoform 6 (identifier: Q91ZS8-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MASLGLGTLTVGAFFSFVGRRYKRRRKKRSERKDKRGLRQSRSPQKCFTM

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        10         20         30         40         50
MASLGLGTLT VGAFFSFVGR RYKRRRKKRS ERKDKRGLRQ SRSPQKCFTM 
        60         70         80         90        100
DIEDEENMSS SSTDIKENRN LDNMPPKDSS TPGPGEGIPL SNGGGGSTSR 
       110        120        130        140        150
KRPLEEGSNG HSKYRLKKRR KTPGPVLPKN ALMQLNEIKP GLQYMLLSQT 
       160        170        180        190        200
GPVHAPLFVM SVEVNGQVFE GSGPTKKKAK LHAAEKALRS FVQFPNASEA 
       210        220        230        240        250
HLAMGRTLSV NTDFTSDQAD FPDTLFNGFE TPDKSEPPFY VGSNGDDSFS 
       260        270        280        290        300
SSGDVSLSAS PVPASLTQPP LPIPPPFPPP SGKNPVMILN ELRPGLKYDF 
       310        320        330        340        350
LSESGESHAK SFVMSVVVDG QFFEGSGRNK KLAKARAAQS ALATVFNLHL 
       360        370        380        390        400
DQTPSRQPVL SEGLQLHLPQ VLADAVSRLV LGKFSDLTDN FSSPHARRKV 
       410        420        430        440        450
LSGVVMTTGT DVKDAKVISV STGTKCINGE YMSDRGLALN DCHAEIISRR 
       460        470        480        490        500
SLLRFLYAQL ELYLNNKEDQ KKSIFQKSER GGFRLKDTVQ FHLYISTSPC 
       510        520        530        540        550
GDARIFSPHE PVLEGMTPDS HQLTEPADRH PNRKARGQLR TKIESGEGTI 
       560        570        580        590        600
PVRSNASIQT WDGVLQGERL LTMSCSDKIA RWNVVGIQGS LLSIFVEPIY 
       610        620        630        640        650
FSSIILGSLY HGDHLSRAMY QRISNIEDLP PLYTLNKPLL SGISNAEARQ 
       660        670        680        690        700
PGKAPNFSVN WTVGDATIEV INATTGKDEL GRPSRLCKHA LYCRWMRVHG 
       710        720        730        740        750
KVPPHLLRTK ITKPTTYHES KLAAREYQAA KARLFTAFIK AGLGAWVEKP 
       760
TEQDQFSFTP

Note: Likely expressed from an alternative promoter. Contains a region highly similar to the so-called ssRNA-binding R-domain of ADARB2.Curated

Show »

Length:760

Mass (Da):83,732

Checksum:ⁱ0EDD0CC438EE2393

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RDS5	D6RDS5_MOUSE	Double-stranded RNA-specific editas... Double-stranded RNA-specific editase 1	Adarb1	38	Annotation score:
D6RGS1	D6RGS1_MOUSE	Double-stranded RNA-specific editas... Double-stranded RNA-specific editase 1	Adarb1	82	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	65	Y → C in AAK17102 (PubMed:12709013).Curated		1
Sequence conflictⁱ	559	S → G in AAK17102 (PubMed:12709013).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_013709	1 – 24	Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST	24
Alternative sequenceⁱVSP_013710	1 – 10	MDIEDEENMS → MPLG in isoform 3. 1 Publication	10
Alternative sequenceⁱVSP_041423	1	M → MASLGLGTLTVGAFFSFVGR RYKRRRKKRSERKDKRGLRQ SRSPQKCFTM in isoform 6. 1 Publication	1
Alternative sequenceⁱVSP_013711	466 – 475	Missing in isoform 2, isoform 3 and isoform 5. 2 Publications	10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF403106 mRNA Translation: AAL01301.1 AF403107 mRNA Translation: AAL01302.1 AF403108 mRNA Translation: AAL01303.1 AF403109 mRNA Translation: AAL01304.1 AF525421 mRNA Translation: AAM83099.1 AY162454 mRNA Translation: AAN86546.1 AF291049 mRNA Translation: AAK17102.1 FJ169505 mRNA Translation: ACN49026.1 AK141777 mRNA Translation: BAE24831.1 AK147298 mRNA Translation: BAE27830.1 CH466553 Genomic DNA Translation: EDL31813.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35948.1 [Q91ZS8-1] CCDS35949.1 [Q91ZS8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001020008.1, NM_001024837.2 [Q91ZS8-1] NP_570965.2, NM_130895.3 [Q91ZS8-2] XP_006513128.1, XM_006513065.1

Genome annotation databases

Ensemblⁱ	ENSMUST00000020496; ENSMUSP00000020496; ENSMUSG00000020262 [Q91ZS8-2] ENSMUST00000098374; ENSMUSP00000095976; ENSMUSG00000020262 [Q91ZS8-1] ENSMUST00000105406; ENSMUSP00000101046; ENSMUSG00000020262 [Q91ZS8-1]
GeneIDⁱ	110532
KEGGⁱ	mmu:110532
UCSC genome browser More...UCSCⁱ	uc007fvl.2, mouse [Q91ZS8-3] uc007fvm.2, mouse [Q91ZS8-1] uc007fvn.2, mouse [Q91ZS8-5] uc007fvp.2, mouse [Q91ZS8-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91ZS8	double-stranded RNA-specific editase 1 isoform X1		MUSCR		775	UniRef100_Q91ZS8
Isoform 4 of Double-stranded RNA-specific editase 1		MOUSE		687
double-stranded RNA-specific editase 1 isoform X5		MUSCR		711
double-stranded RNA-specific editase 1 isoform X9		MUSCR		687
Q91ZS8-2	double-stranded RNA-specific editase 1 isoform X2		MUSCR		765	UniRef100_A0A6P5QHS2
Isoform 5 of Double-stranded RNA-specific editase 1		MOUSE		677
double-stranded RNA-specific editase 1 isoform X7		MUSCR		701
Q91ZS8-3	double-stranded RNA-specific editase 1 isoform X8		MUSCR		695	UniRef100_A0A6P7RC52

Protein	Similar proteins		Species	Score	Length	Source
Q91ZS8	double-stranded RNA-specific editase 1 isoform X1		MUSCR		775	UniRef90_Q91ZS8
Isoform 4 of Double-stranded RNA-specific editase 1		MOUSE		687
Adenosine deaminase, RNA-specific, B1, isoform CRA_d		RAT		687
double-stranded RNA-specific editase 1 isoform X5		MUSCR		711
double-stranded RNA-specific editase 1 isoform X9		MUSCR		687
+17
Q91ZS8-3	Double-stranded RNA-specific editase 1	)	HUMAN		741	UniRef90_P78563
Double-stranded RNA-specific editase 1	)	RAT		711
double-stranded RNA-specific editase 1 isoform X1		SAPAP		838
Uncharacterized protein		CEBCI		743
Adenosine deaminase RNA specific B1		CALJA		767
+96

Protein	Similar proteins		Species	Score	Length	Source
Q91ZS8	Isoform 2 of Double-stranded RNA-specific editase 1		HUMAN		701	UniRef50_P78563-2
Uncharacterized protein		RHIBE		783
Uncharacterized protein		RHIRO		701
Uncharacterized protein		COLAP		701
Uncharacterized protein		MACFA		783
+309
Q91ZS8-3	Double-stranded RNA-specific editase 1	)	HUMAN		741	UniRef50_P78563
Double-stranded RNA-specific editase 1	)	RAT		711
double-stranded RNA-specific editase 1 isoform X1		SAPAP		838
Uncharacterized protein		CEBCI		743
Adenosine deaminase RNA specific B1		CALJA		767
+271

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF403106 mRNA Translation: AAL01301.1 AF403107 mRNA Translation: AAL01302.1 AF403108 mRNA Translation: AAL01303.1 AF403109 mRNA Translation: AAL01304.1 AF525421 mRNA Translation: AAM83099.1 AY162454 mRNA Translation: AAN86546.1 AF291049 mRNA Translation: AAK17102.1 FJ169505 mRNA Translation: ACN49026.1 AK141777 mRNA Translation: BAE24831.1 AK147298 mRNA Translation: BAE27830.1 CH466553 Genomic DNA Translation: EDL31813.1
CCDSⁱ	CCDS35948.1 [Q91ZS8-1] CCDS35949.1 [Q91ZS8-2]
RefSeqⁱ	NP_001020008.1, NM_001024837.2 [Q91ZS8-1] NP_570965.2, NM_130895.3 [Q91ZS8-2] XP_006513128.1, XM_006513065.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2L2K	NMR	-	B	231-301	[»]
BMRBⁱ	Q91ZS8
SMRⁱ	Q91ZS8
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	225680, 1 interactor
IntActⁱ	Q91ZS8, 1 interactor
MINTⁱ	Q91ZS8
STRINGⁱ	10090.ENSMUSP00000095976

PTM databases

iPTMnetⁱ	Q91ZS8
PhosphoSitePlusⁱ	Q91ZS8

Proteomic databases

PaxDbⁱ	Q91ZS8
PeptideAtlasⁱ	Q91ZS8
PRIDEⁱ	Q91ZS8

Protocols and materials databases

Antibodypediaⁱ	10404, 125 antibodies
The DNASU plasmid repository More...DNASUⁱ	110532

Genome annotation databases

Ensemblⁱ	ENSMUST00000020496; ENSMUSP00000020496; ENSMUSG00000020262 [Q91ZS8-2] ENSMUST00000098374; ENSMUSP00000095976; ENSMUSG00000020262 [Q91ZS8-1] ENSMUST00000105406; ENSMUSP00000101046; ENSMUSG00000020262 [Q91ZS8-1]
GeneIDⁱ	110532
KEGGⁱ	mmu:110532
UCSCⁱ	uc007fvl.2, mouse [Q91ZS8-3] uc007fvm.2, mouse [Q91ZS8-1] uc007fvn.2, mouse [Q91ZS8-5] uc007fvp.2, mouse [Q91ZS8-2]

Organism-specific databases

CTDⁱ	104
MGIⁱ	MGI:891999, Adarb1

Phylogenomic databases

eggNOGⁱ	KOG2777, Eukaryota
GeneTreeⁱ	ENSGT00940000155992
HOGENOMⁱ	CLU_005382_3_1_1
InParanoidⁱ	Q91ZS8
OMAⁱ	HESKLVA
OrthoDBⁱ	947117at2759
PhylomeDBⁱ	Q91ZS8
TreeFamⁱ	TF315806

Enzyme and pathway databases

Reactomeⁱ	R-MMU-75102, C6 deamination of adenosine R-MMU-77042, Formation of editosomes by ADAR proteins

Reactomeⁱ

R-MMU-75102, C6 deamination of adenosine
R-MMU-77042, Formation of editosomes by ADAR proteins

Miscellaneous databases

BioGRID-ORCSⁱ	110532, 3 hits in 15 CRISPR screens
ChiTaRSⁱ	Adarb1, mouse
EvolutionaryTraceⁱ	Q91ZS8
Protein Ontology More...PROⁱ	PR:Q91ZS8
RNActⁱ	Q91ZS8, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020262, Expressed in brain and 261 other tissues
Genevisibleⁱ	Q91ZS8, MM

Family and domain databases

CDDⁱ	cd00048, DSRM, 2 hits
InterProⁱ	View protein in InterPro IPR002466, A_deamin IPR014720, dsRBD_dom
Pfamⁱ	View protein in Pfam PF02137, A_deamin, 1 hit PF00035, dsrm, 2 hits
SMARTⁱ	View protein in SMART SM00552, ADEAMc, 1 hit SM00358, DSRM, 2 hits
PROSITEⁱ	View protein in PROSITE PS50141, A_DEAMIN_EDITASE, 1 hit PS50137, DS_RBD, 2 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RED1_MOUSE
Accessionⁱ	Q91ZS8Primary (citable) accession number: Q91ZS8 Secondary accession number(s): C3TTQ1 Q99MU8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
	Last sequence update:	December 1, 2001
	Last modified:	December 2, 2020
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q91ZS8 (RED1_MOUSE)

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Double-stranded RNA-specific editase 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

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Keywords - Coding sequence diversityi

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Sequence databases

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Proteomic databases

Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ