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Protein

Sorting nexin-18

Gene

Snx18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis (By similarity). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei302Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei304Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei328Phosphatidylinositol 4,5-bisphosphateBy similarity1
Binding sitei342Phosphatidylinositol 4,5-bisphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Endocytosis, Mitosis, Protein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-18
Alternative name(s):
Sorting nexin-associated Golgi protein 1
Gene namesi
Name:Snx18
Synonyms:Snag1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2137642 Snx18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138671 – 614Sorting nexin-18Add BLAST614

Proteomic databases

EPDiQ91ZR2
MaxQBiQ91ZR2
PeptideAtlasiQ91ZR2
PRIDEiQ91ZR2

PTM databases

iPTMnetiQ91ZR2
PhosphoSitePlusiQ91ZR2

Expressioni

Gene expression databases

CleanExiMM_SNX18

Interactioni

Subunit structurei

Heterodimer with SNX9. Interacts with ITCH. Interacts with dynamin, SYNJ1 and WASL. Interacts with the AP-1 complex (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FASLGP480234EBI-6879954,EBI-495538From Homo sapiens.

Protein-protein interaction databases

IntActiQ91ZR2, 2 interactors
MINTiQ91ZR2

Structurei

3D structure databases

ProteinModelPortaliQ91ZR2
SMRiQ91ZR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61SH3PROSITE-ProRule annotationAdd BLAST61
Domaini266 – 376PXPROSITE-ProRule annotationAdd BLAST111
Domaini411 – 614BARAdd BLAST204

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOGENOMiHOG000261633
HOVERGENiHBG009996
InParanoidiQ91ZR2
PhylomeDBiQ91ZR2

Family and domain databases

CDDicd07286 PX_SNX18, 1 hit
cd11897 SH3_SNX18, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035703 SNX18_PX
IPR035557 SNX18_SH3
IPR014536 Snx9_fam
IPR039358 Sorting_nexin-like
IPR019497 Sorting_nexin_WASP-bd-dom
PANTHERiPTHR10555 PTHR10555, 2 hits
PfamiView protein in Pfam
PF10456 BAR_3_WASP_bdg, 1 hit
PF00787 PX, 1 hit
PF14604 SH3_9, 1 hit
PIRSFiPIRSF027744 Snx9, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91ZR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRARALYD FKSENPGEIS LREHEVLSLC SEQDIEGWLE GINSRGDRGL
60 70 80 90 100
FPASYVQVIR APEPGPPADG GPGAPARYAN VPPGGFEPLP AAPPAAFPPL
110 120 130 140 150
LQPQASPGSF QPPGAGFPYG GGALQPSPQQ LYGGYQASLG SDDDWDDEWD
160 170 180 190 200
DSSTVADEPG ALGSGAYPDL DGSSSAGGGA AGRYRLSTRS DLSLGSRGVS
210 220 230 240 250
APPAPSVWSQ ELGHGEPQPQ SLLHLRQVGR GGLRAGRGVR LREGWGQAVR
260 270 280 290 300
GAGSYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL VPTHTQVPVH
310 320 330 340 350
RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM
360 370 380 390 400
NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT
410 420 430 440 450
LSTPPAAALD LQEVESKIDG FKCFTKKMDD SALQLNHTAN EFARKQVTGF
460 470 480 490 500
KKEYQKVGQS FRGLSQAFEL DQQAFSVGLN QAIAFTGDAY DAIGELFAEQ
510 520 530 540 550
PRQDLDPVMD LLALYQGHLA NFPDIIHVQK GALTKVKESR RHVEEGKMEV
560 570 580 590 600
QKADGIQDRC NTISFATLAE IHHFHQIRVR DFKSQMQHFL QQQIIFFQKV
610
TQKLEEALHK YDSV
Length:614
Mass (Da):67,904
Last modified:December 1, 2001 - v1
Checksum:iBACED9D104571098
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C788Q8C788_MOUSE
Sorting nexin
Snx18 Snag1
615Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF408408 mRNA Translation: AAL02105.1
UniGeneiMm.33721

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF408408 mRNA Translation: AAL02105.1
UniGeneiMm.33721

3D structure databases

ProteinModelPortaliQ91ZR2
SMRiQ91ZR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91ZR2, 2 interactors
MINTiQ91ZR2

PTM databases

iPTMnetiQ91ZR2
PhosphoSitePlusiQ91ZR2

Proteomic databases

EPDiQ91ZR2
MaxQBiQ91ZR2
PeptideAtlasiQ91ZR2
PRIDEiQ91ZR2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2137642 Snx18

Phylogenomic databases

HOGENOMiHOG000261633
HOVERGENiHBG009996
InParanoidiQ91ZR2
PhylomeDBiQ91ZR2

Miscellaneous databases

PROiPR:Q91ZR2
SOURCEiSearch...

Gene expression databases

CleanExiMM_SNX18

Family and domain databases

CDDicd07286 PX_SNX18, 1 hit
cd11897 SH3_SNX18, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035703 SNX18_PX
IPR035557 SNX18_SH3
IPR014536 Snx9_fam
IPR039358 Sorting_nexin-like
IPR019497 Sorting_nexin_WASP-bd-dom
PANTHERiPTHR10555 PTHR10555, 2 hits
PfamiView protein in Pfam
PF10456 BAR_3_WASP_bdg, 1 hit
PF00787 PX, 1 hit
PF14604 SH3_9, 1 hit
PIRSFiPIRSF027744 Snx9, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNX18_MOUSE
AccessioniPrimary (citable) accession number: Q91ZR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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