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Protein

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Gene

Pde6c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97cGMPBy similarity1
Binding sitei116cGMPBy similarity1
Binding sitei176cGMPBy similarity1
Active sitei562Proton donorBy similarity1
Metal bindingi566Divalent metal cation 1By similarity1
Metal bindingi602Divalent metal cation 1By similarity1
Metal bindingi603Divalent metal cation 1By similarity1
Metal bindingi603Divalent metal cation 2By similarity1
Metal bindingi723Divalent metal cation 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 172cGMPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • phototransduction, visible light Source: MGI
  • retinal cone cell development Source: MGI
  • sensory perception of light stimulus Source: MGI
  • visual perception Source: MGI

Keywordsi

Molecular functionHydrolase
Biological processSensory transduction, Vision
LigandcGMP, cGMP-binding, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC:3.1.4.35By similarity)
Alternative name(s):
cGMP phosphodiesterase 6C
Gene namesi
Name:Pde6c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:105956 Pde6c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002260681 – 858Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'Add BLAST858
PropeptideiPRO_0000370789859 – 861Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei858Cysteine methyl esterSequence analysis1
Lipidationi858S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ91ZQ1
PRIDEiQ91ZQ1

PTM databases

iPTMnetiQ91ZQ1
PhosphoSitePlusiQ91ZQ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000024992
GenevisibleiQ91ZQ1 MM

Interactioni

Subunit structurei

Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025956

Structurei

3D structure databases

ProteinModelPortaliQ91ZQ1
SMRiQ91ZQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 224GAF 1Add BLAST150
Domaini256 – 433GAF 2Add BLAST178
Domaini486 – 819PDEasePROSITE-ProRule annotationAdd BLAST334

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00760000119066
HOGENOMiHOG000007069
HOVERGENiHBG053539
InParanoidiQ91ZQ1
KOiK13757
OMAiFEINVVE
OrthoDBiEOG091G01RK
PhylomeDBiQ91ZQ1
TreeFamiTF316499

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
3.30.450.40, 2 hits
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF01590 GAF, 2 hits
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00065 GAF, 2 hits
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91ZQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEISQEAVE RYLEKNPCFA KEYFDKKLRV EALGVIFKNS HAGVQTGLSL
60 70 80 90 100
PEMTQVEESA VCLELLQCMQ DEAGSAEQMA HRALQRLAQL LQADCCSMFS
110 120 130 140 150
CRARNGIPEV ASRLLNVTPT SKFEDNLVAP DREVVFPLDI GIVGWVAHVK
160 170 180 190 200
KALNVSDVKK NSHFSDFMDK QTGYVTRNLL AVPIVAGKEV LAVVMAVNKI
210 220 230 240 250
SAPEFSKQDE EVFSKYLSFV AVALRLQHTS YLYSVESRRS QILMWSANKV
260 270 280 290 300
FEELTDVERQ FHKALYTIRT YLNCDRYSIG LLDMTKEKEF YDEWPIKLGE
310 320 330 340 350
VEPYKGPKTP DGREIIFYKI IDYILHGKEE INVIPSPPAD HWTLVSGLPT
360 370 380 390 400
YVAENGFICN MLNAPADEYF TFQKGPVDET GWVIKNVLSL PIVNKKEDIV
410 420 430 440 450
GVATFYNRKD GKPFDEHDEH ITETLTQFLG WSLLNTDTYE RVNKLESRKD
460 470 480 490 500
IAQEMVMNLT KATPDEISSI LKFKEKLNVE VIEECEERQL LAILKEDLPD
510 520 530 540 550
PRTADLYEFC FSDFPITEHE LVKCGLRLFL EINVVEKFKV PVEVLTRWMY
560 570 580 590 600
TVRKGYRPVT YHNWRHGFNV GQTMFTLLMT GRLKKYYTDL EAFAMLAAAF
610 620 630 640 650
CHDIDHRGTN NLYQMKSTSP LARLHGTSIL ERHHLEYSKT LLQDESLNIF
660 670 680 690 700
QNLNKRQFET VIHLFEVAII ATDLALYFKK RTMFQKIVDT CEQMQSEEET
710 720 730 740 750
IKYVTSDPTK KEVIMAMMMT ACDLSAITKP WEVQSQVALL VANEFWEQGD
760 770 780 790 800
LERTVLQQQP IPMMDRSKKD ELPKLQVGFI DFVCTFVYKE FSRFHGEITP
810 820 830 840 850
MLNGLQNNRV EWKSLAEEYE AKVKVTEEEA GKQEEEASDG KAATDLGGSA
860
EDKKSKTCLM L
Length:861
Mass (Da):98,785
Last modified:December 1, 2001 - v1
Checksum:iC582D78114652B5B
GO
Isoform 2 (identifier: Q91ZQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     737-761: Missing.

Note: No experimental confirmation available.
Show »
Length:836
Mass (Da):95,906
Checksum:iA8D60FAAFE6C9D9E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017422737 – 761Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411063 mRNA Translation: AAK96254.1
BC027050 mRNA Translation: AAH27050.1
CCDSiCCDS37971.1 [Q91ZQ1-1]
CCDS50431.1 [Q91ZQ1-2]
RefSeqiNP_001164430.1, NM_001170959.1 [Q91ZQ1-2]
NP_291092.1, NM_033614.2 [Q91ZQ1-1]
UniGeneiMm.450141

Genome annotation databases

EnsembliENSMUST00000025956; ENSMUSP00000025956; ENSMUSG00000024992 [Q91ZQ1-1]
ENSMUST00000112329; ENSMUSP00000107948; ENSMUSG00000024992 [Q91ZQ1-2]
GeneIDi110855
KEGGimmu:110855
UCSCiuc008hjf.2 mouse [Q91ZQ1-1]
uc012blg.1 mouse [Q91ZQ1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPDE6C_MOUSE
AccessioniPrimary (citable) accession number: Q91ZQ1
Secondary accession number(s): Q8R0D4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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