UniProtKB - Q91ZN7 (CHK1_RAT)

BLAST

>sp|Q91ZN7|CHK1_RAT Serine/threonine-protein kinase Chk1 OS=Rattus norvegicus OX=10116 GN=Chek1 PE=2 SV=1
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAIDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLK
RKEFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLNRGAKRPRATSGGMSESSSGFSKHIHSNLDF
SPINSGSSEENVKFSSSQPEPRTGLSLWDTGPSNVDKLVQGISFSQPTCPDHMLVNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETFEKLGYQWKKSCMNQVTVSTMDRR
NNKLIFKINLVEMDEKILVDFRLSKGDGLEFKRHFLKIKGKLSDIVSSQKVWFPVT

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History
Entry version 138 (12 Sep 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Serine/threonine-protein kinase Chk1

Gene

Chek1

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. This inhibits their activity through proteasomal degradation, nucleo-cytoplasmic shuttling and inhibition by proteins of the 13-3-3 family. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1, which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA. May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes. May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (By similarity).By similarity

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

Activated through phosphorylation predominantly by ATR but also by ATM in response to DNA damage or inhibition of DNA replication. Activation is modulated by several mediators including CLSPN, BRCA1 and FEM1B (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	38	ATPPROSITE-ProRule annotation		1
Active siteⁱ	130	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	15 – 23	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
histone kinase activity (H3-T11 specific) Source: UniProtKB
protein kinase activity
Source: RGD
Inferred from direct assayⁱ
- 11278490
protein serine/threonine kinase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cellular response to caffeine
Source: RGD
Inferred from expression patternⁱ
- 11278490
cellular response to DNA damage stimulus Source: UniProtKB
cellular response to organic substance
Source: RGD
Inferred from expression patternⁱ
- 11278490
chromatin-mediated maintenance of transcription Source: UniProtKB
DNA damage checkpoint Source: UniProtKB
DNA damage induced protein phosphorylation
Source: RGD
Inferred from mutant phenotypeⁱ
- 11278490
DNA repair Source: UniProtKB-KW
intracellular signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of DNA biosynthetic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 12429946
negative regulation of G2/M transition of mitotic cell cycle
Source: RGD
Inferred from mutant phenotypeⁱ
- 11278490
negative regulation of mitotic nuclear division Source: UniProtKB
peptidyl-threonine phosphorylation Source: UniProtKB
protein phosphorylation
Source: RGD
Inferred from direct assayⁱ
- 11278490
regulation of double-strand break repair via homologous recombination Source: UniProtKB
regulation of histone H3-K9 acetylation Source: UniProtKB
regulation of mitotic centrosome separation Source: UniProtKB
regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Cell cycle, DNA damage, DNA repair
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKⁱ	Q91ZN7

SABIO-RKⁱ

Q91ZN7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase Chk1 (EC:2.7.11.1) Alternative name(s): CHK1 checkpoint homolog Checkpoint kinase-1
Gene namesⁱ	Name:Chek1 Synonyms:Chk1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 8

Organism-specific databases

Rat genome database More...RGDⁱ	620545 Chek1

RGDⁱ

620545 Chek1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085850	1 – 476	Serine/threonine-protein kinase Chk1Add BLAST		476

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	280	Phosphoserine; by PKB/AKT1By similarity	1
Modified residueⁱ	286	PhosphoserineBy similarity	1
Modified residueⁱ	296	PhosphoserineBy similarity	1
Modified residueⁱ	301	PhosphoserineBy similarity	1
Modified residueⁱ	317	Phosphoserine; by ATM and ATRBy similarity	1
Modified residueⁱ	345	Phosphoserine; by ATM and ATRBy similarity	1
Cross-linkⁱ	436	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	463	PhosphoserineBy similarity	1
Modified residueⁱ	467	PhosphoserineBy similarity	1
Modified residueⁱ	468	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by ATR in a RAD17-dependent manner in response to ultraviolet irradiation and inhibition of DNA replication. Phosphorylated by ATM in response to ionizing irradiation. ATM and ATR can both phosphorylate Ser-317 and Ser-345 and this results in enhanced kinase activity. Phosphorylation at Ser-345 induces a change in the conformation of the protein, activates the kinase activity and is a prerequisite for interaction with FBXO6 and subsequent ubiquitination at Lys-436. Phosphorylation at Ser-345 also increases binding to 14-3-3 proteins and promotes nuclear retention. Conversely, dephosphorylation at Ser-345 by PPM1D may contribute to exit from checkpoint mediated cell cycle arrest. Phosphorylation at Ser-280 by AKT1/PKB, may promote mono and/or diubiquitination. Also phosphorylated at undefined residues during mitotic arrest, resulting in decreased activity (By similarity).By similarity

Ubiquitinated. Mono or diubiquitination promotes nuclear exclusion. The activated form (phosphorylated on Ser-345) is polyubiquitinated at Lys-436 by some SCF-type E3 ubiquitin ligase complex containing FBXO6 promoting its degradation. Ubiquitination and degradation are required to terminate the checkpoint and ensure that activated CHEK1 does not accumulate as cells progress through S phase, when replication forks encounter transient impediments during normal DNA replication (By similarity).By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q91ZN7
PRIDEⁱ	Q91ZN7

PTM databases

iPTMnetⁱ	Q91ZN7
PhosphoSitePlusⁱ	Q91ZN7

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is expressed in brain, heart, liver, lung, skeletal muscle, spleen and testis. Isoform 2 is expressed only in liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000031896 Expressed in 9 organ(s), highest expression level in liver
ExpressionAtlasⁱ	Q91ZN7 baseline and differential
Genevisibleⁱ	Q91ZN7 RN

Interactionⁱ

Subunit structureⁱ

Interacts (phosphorylated by ATR) with RAD51. Interacts with and phosphorylates CLSPN, an adapter protein that regulates the ATR-dependent phosphorylation of CHEK1. Interacts with BRCA1. Interacts with and phosphorylates CDC25A, CDC25B and CDC25C. Interacts with FBXO6, which regulates CHEK1. Interacts with PPM1D, which regulates CHEK1 through dephosphorylation. Interacts with TIMELESS; DNA damage-dependent. Interacts with FEM1B; activates CHEK1 in response to stress. Interacts with TLK1. Interacts with XPO1 and YWHAZ. Interacts with CDK5RAP3; antagonizes CHEK1.By similarity

Protein-protein interaction databases

BioGridⁱ	250797, 1 interactor
STRINGⁱ	10116.ENSRNOP00000011226

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91ZN7
SMRⁱ	Q91ZN7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	9 – 265	Protein kinasePROSITE-ProRule annotationAdd BLAST		257

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 265	Interaction with CLSPNBy similarityAdd BLAST		265
Regionⁱ	391 – 476	Autoinhibitory regionBy similarityAdd BLAST		86

Domainⁱ

The autoinhibitory region (AIR) inhibits the activity of the kinase domain.By similarity

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0590 Eukaryota ENOG410XQ0D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015238
HOGENOMⁱ	HOG000216658
HOVERGENⁱ	HBG002590
InParanoidⁱ	Q91ZN7
KEGG Orthology (KO) More...KOⁱ	K02216
PhylomeDBⁱ	Q91ZN7
TreeFamⁱ	TF351441

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14069 STKc_Chk1, 1 hit
InterProⁱ	View protein in InterPro IPR034670 Chk1_catalytic_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative promoter usage. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q91ZN7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVPFVEDWD LVQTLGEGAY GEVQLAVNRI TEEAVAVKIV DMKRAIDCPE 
        60         70         80         90        100
NIKKEICINK MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI 
       110        120        130        140        150
GMPEQDAQRF FHQLMAGVVY LHGIGITHRD IKPENLLLDE RDNLKISDFG 
       160        170        180        190        200
LATVFRHNNR ERLLNKMCGT LPYVAPELLK RKEFHAEPVD VWSCGIVLTA 
       210        220        230        240        250
MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA LLHKILVENP 
       260        270        280        290        300
SARITIPDIK KDRWYNKPLN RGAKRPRATS GGMSESSSGF SKHIHSNLDF 
       310        320        330        340        350
SPINSGSSEE NVKFSSSQPE PRTGLSLWDT GPSNVDKLVQ GISFSQPTCP 
       360        370        380        390        400
DHMLVNSQLL GTPGSSQNPW QRLVKRMTRF FTKLDADKSY QCLKETFEKL 
       410        420        430        440        450
GYQWKKSCMN QVTVSTMDRR NNKLIFKINL VEMDEKILVD FRLSKGDGLE 
       460        470 
FKRHFLKIKG KLSDIVSSQK VWFPVT

Length:476

Mass (Da):54,428

Last modified:December 1, 2001 - v1

Checksum:ⁱ5635614A3E5B4657

Isoform 2 (identifier: Q91ZN7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-282: Missing.

« Hide

        10         20         30         40         50
MSESSSGFSK HIHSNLDFSP INSGSSEENV KFSSSQPEPR TGLSLWDTGP 
        60         70         80         90        100
SNVDKLVQGI SFSQPTCPDH MLVNSQLLGT PGSSQNPWQR LVKRMTRFFT 
       110        120        130        140        150
KLDADKSYQC LKETFEKLGY QWKKSCMNQV TVSTMDRRNN KLIFKINLVE 
       160        170        180        190 
MDEKILVDFR LSKGDGLEFK RHFLKIKGKL SDIVSSQKVW FPVT

Show »

Length:194

Mass (Da):22,102

Checksum:ⁱ1E1B1CA8B0C4D7AC

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4F7C9	B4F7C9_RAT	Serine/threonine-protein kinase Chk... Serine/threonine-protein kinase Chk1 (Stt3a protein)	Stt3a Chek1	705	Annotation score:
A0A0G2JWH5	A0A0G2JWH5_RAT	Serine/threonine-protein kinase Chk... Serine/threonine-protein kinase Chk1	Stt3a Chek1	773	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015770	1 – 282	Missing in isoform 2. 1 PublicationAdd BLAST		282

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF414135 mRNA Translation: AAK98619.1 AF414136 mRNA Translation: AAK98620.1 AF443592 mRNA Translation: AAL37894.1
NCBI Reference Sequences More...RefSeqⁱ	NP_536325.1, NM_080400.1 [Q91ZN7-1] XP_008764264.1, XM_008766042.2 [Q91ZN7-1] XP_008764265.1, XM_008766043.1 [Q91ZN7-1]
UniGeneⁱ	Rn.33267

Genome annotation databases

Ensemblⁱ	ENSRNOT00000011226; ENSRNOP00000011226; ENSRNOG00000031896 [Q91ZN7-1] ENSRNOT00000090161; ENSRNOP00000070708; ENSRNOG00000031896 [Q91ZN7-2]
GeneIDⁱ	140583
KEGGⁱ	rno:140583
UCSC genome browser More...UCSCⁱ	RGD:620545 rat [Q91ZN7-1]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91ZN7	Serine/threonine-protein kinase Chk1	)	HUMAN		476	UniRef90_O14757
Serine/threonine-protein kinase Chk1		MOUSE		476
serine/threonine-protein kinase Chk1 isoform X1		URSMA		499
Uncharacterized protein (Fragment)		AILME		454
Uncharacterized protein		MACFA		488
+99

Protein	Similar proteins		Species	Score	Length	Source
Q91ZN7	Serine/threonine-protein kinase Chk1	)	HUMAN		476	UniRef50_O14757
Serine/threonine-protein kinase Chk1		MOUSE		476
serine/threonine-protein kinase Chk1 isoform X1		URSMA		499
Uncharacterized protein (Fragment)		AILME		454
Uncharacterized protein		MACFA		488
+214

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF414135 mRNA Translation: AAK98619.1 AF414136 mRNA Translation: AAK98620.1 AF443592 mRNA Translation: AAL37894.1
RefSeqⁱ	NP_536325.1, NM_080400.1 [Q91ZN7-1] XP_008764264.1, XM_008766042.2 [Q91ZN7-1] XP_008764265.1, XM_008766043.1 [Q91ZN7-1]
UniGeneⁱ	Rn.33267

3D structure databases

ProteinModelPortalⁱ	Q91ZN7
SMRⁱ	Q91ZN7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	250797, 1 interactor
STRINGⁱ	10116.ENSRNOP00000011226

PTM databases

iPTMnetⁱ	Q91ZN7
PhosphoSitePlusⁱ	Q91ZN7

Proteomic databases

PaxDbⁱ	Q91ZN7
PRIDEⁱ	Q91ZN7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000011226; ENSRNOP00000011226; ENSRNOG00000031896 [Q91ZN7-1] ENSRNOT00000090161; ENSRNOP00000070708; ENSRNOG00000031896 [Q91ZN7-2]
GeneIDⁱ	140583
KEGGⁱ	rno:140583
UCSCⁱ	RGD:620545 rat [Q91ZN7-1]

Organism-specific databases

CTDⁱ	1111
RGDⁱ	620545 Chek1

Phylogenomic databases

eggNOGⁱ	KOG0590 Eukaryota ENOG410XQ0D LUCA
GeneTreeⁱ	ENSGT00390000015238
HOGENOMⁱ	HOG000216658
HOVERGENⁱ	HBG002590
InParanoidⁱ	Q91ZN7
KOⁱ	K02216
PhylomeDBⁱ	Q91ZN7
TreeFamⁱ	TF351441

Enzyme and pathway databases

SABIO-RKⁱ	Q91ZN7

SABIO-RKⁱ

Q91ZN7

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91ZN7

PROⁱ

PR:Q91ZN7

Gene expression databases

Bgeeⁱ	ENSRNOG00000031896 Expressed in 9 organ(s), highest expression level in liver
ExpressionAtlasⁱ	Q91ZN7 baseline and differential
Genevisibleⁱ	Q91ZN7 RN

Family and domain databases

CDDⁱ	cd14069 STKc_Chk1, 1 hit
InterProⁱ	View protein in InterPro IPR034670 Chk1_catalytic_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CHK1_RAT
Accessionⁱ	Q91ZN7Primary (citable) accession number: Q91ZN7 Secondary accession number(s): Q91ZN6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniParc

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UniProtKB - Q91ZN7 (CHK1_RAT)

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Serine/threonine-protein kinase Chk1

Chek1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ