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Protein

Coronin-1A

Gene

Coro1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1A
Alternative name(s):
Coronin-like protein A
Short name:
Clipin-A
Tryptophan aspartate-containing coat protein
Short name:
TACO
Gene namesi
Name:Coro1a
Synonyms:Coro1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620009 Coro1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002708002 – 461Coronin-1AAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine; by PKCBy similarity1
Modified residuei412Phosphoserine; by PKCBy similarity1
Modified residuei418PhosphothreonineCombined sources1
Modified residuei422PhosphoserineBy similarity1

Post-translational modificationi

phosphorylation at Ser-412 by PKC strongly down-regulates the association with actin.By similarity
Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ91ZN1
PRIDEiQ91ZN1

2D gel databases

World-2DPAGEi0004:Q91ZN1

PTM databases

iPTMnetiQ91ZN1
PhosphoSitePlusiQ91ZN1

Expressioni

Gene expression databases

BgeeiENSRNOG00000019430
GenevisibleiQ91ZN1 RN

Interactioni

Subunit structurei

Binds actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250886, 1 interactor
STRINGi10116.ENSRNOP00000026496

Structurei

3D structure databases

ProteinModelPortaliQ91ZN1
SMRiQ91ZN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 63WD 1Add BLAST51
Repeati73 – 110WD 2Add BLAST38
Repeati123 – 160WD 3Add BLAST38
Repeati164 – 204WD 4Add BLAST41
Repeati207 – 251WD 5Add BLAST45
Repeati258 – 296WD 6Add BLAST39
Repeati302 – 349WD 7Add BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili425 – 461Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ91ZN1
KOiK13882
OMAiCYDDIRI
OrthoDBiEOG091G03H5
PhylomeDBiQ91ZN1
TreeFamiTF314280

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR029508 CORO1A
IPR015505 Coronin
IPR015048 DUF1899
IPR015049 Trimer_CC
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF18 PTHR10856:SF18, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF08954 Trimer_CC, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91ZN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFMALI
60 70 80 90 100
CEASGGGAFL VLPLGKTGRV DKNVPLVCGH TAPVLDIAWC PHNDNVIASG
110 120 130 140 150
SEDCTVMVWE IPDGGLVLPL REPVVTLEGH TKRVGIVAWH PTAQNVLLSA
160 170 180 190 200
GCDNVILVWD VGTGAAVLTL GPDVHPDTIY SVDWSRDGAL ICTSCRDKRV
210 220 230 240 250
RVIEPRKGTV VAEKERPHEG TRPVHAVFVS EGKILTTGFS RMSERQVALW
260 270 280 290 300
DTKHLEEPLS LQELDTSSGV LLPFFDPDTN IVYLCGKGDS SIRYFEITSE
310 320 330 340 350
APFLHYLSMF SSKESQRGMG YMPKRGLEVN KCEIARFYKL HERKCEPIAM
360 370 380 390 400
TVPRKSDLFQ EDLYPPTAGP DPALTAEEWL SGRDAGPLLI SLKDGYVPPK
410 420 430 440 450
SRELRVNRGL DSARRRATPE PSSTLSSDTV SRLEEDVRNL NAIVQKLQER
460
LDRLEETVQA K
Length:461
Mass (Da):51,065
Last modified:January 23, 2007 - v3
Checksum:iEE1094B3CF302000
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416730 mRNA Translation: AAL18695.1
AF495469 mRNA Translation: AAM18515.1
BC086971 mRNA Translation: AAH86971.1
RefSeqiNP_569095.1, NM_130411.2
XP_017444198.1, XM_017588709.1
UniGeneiRn.6990

Genome annotation databases

EnsembliENSRNOT00000026496; ENSRNOP00000026496; ENSRNOG00000019430
GeneIDi155151
KEGGirno:155151
UCSCiRGD:620009 rat

Similar proteinsi

Entry informationi

Entry nameiCOR1A_RAT
AccessioniPrimary (citable) accession number: Q91ZN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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