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Protein

Docking protein 5

Gene

Dok5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-8853659 RET signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 5
Alternative name(s):
Downstream of tyrosine kinase 5
Gene namesi
Name:Dok5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1924079 Dok5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872781 – 306Docking protein 5Add BLAST306

Post-translational modificationi

Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.By similarity

Proteomic databases

MaxQBiQ91ZM9
PaxDbiQ91ZM9
PRIDEiQ91ZM9

PTM databases

iPTMnetiQ91ZM9
PhosphoSitePlusiQ91ZM9

Expressioni

Tissue specificityi

Specifically expressed in the brain, with a high specificity for neurons.1 Publication

Developmental stagei

In E12.5 and E13 embryos, it is expressed in the central nervous system, e.g. in the neural tube, the dorsal root and the cranial ganglion.

Gene expression databases

BgeeiENSMUSG00000027560 Expressed in 80 organ(s), highest expression level in visual cortex
CleanExiMM_DOK5
GenevisibleiQ91ZM9 MM

Interactioni

Subunit structurei

Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029075

Structurei

3D structure databases

ProteinModelPortaliQ91ZM9
SMRiQ91ZM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 112PHAdd BLAST105
Domaini132 – 237IRS-type PTBPROSITE-ProRule annotationAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi263 – 273DKFBH motifAdd BLAST11

Domaini

PTB domain mediates receptor interaction.

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00730000110348
HOGENOMiHOG000247025
HOVERGENiHBG002356
InParanoidiQ91ZM9
OMAiHAVGIYF
OrthoDBiEOG091G0M38
PhylomeDBiQ91ZM9
TreeFamiTF324994

Family and domain databases

CDDicd14678 PH_DOK4_DOK5_DOK6, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037816 DOK4/5/6_PH
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q91ZM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNFNDIVK QGYVRIRSRR LGIYQRCWLV FKKASSKGPK RLEKFSDERA
60 70 80 90 100
AYFRCYHKVT ELNNVKNVAR LPKSTKKHAI GIYFNDDTSK TFACESDLEA
110 120 130 140 150
DEWCKVLQME CVGTRINDIS LGEPDLLATG VEREQSERFN VYLMPSPNLD
160 170 180 190 200
VHGECALQIT YEYICLWDVQ NPRVKLISWP LSALRRYGRD TTWFTFEAGR
210 220 230 240 250
MCETGEGLFI FQTRDGEAIY QKVHSAALAI AEQHERLLQS VKNSMLQMKK
260 270 280 290 300
SERAASLSTV VPLPRSAYWQ HITRQHSTGQ LYHLQDVTSP LKLHRTETFP

TYRSEH
Length:306
Mass (Da):35,453
Last modified:December 1, 2001 - v1
Checksum:i7889802FBEAC04A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → M in BAC31799 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418208 mRNA Translation: AAL14627.1
AK012430 mRNA Translation: BAB28233.1
AK044148 mRNA Translation: BAC31799.1
CCDSiCCDS17125.1
RefSeqiNP_001157158.1, NM_001163686.1
NP_084037.3, NM_029761.4
UniGeneiMm.41633

Genome annotation databases

EnsembliENSMUST00000029075; ENSMUSP00000029075; ENSMUSG00000027560
GeneIDi76829
KEGGimmu:76829
UCSCiuc008ocg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418208 mRNA Translation: AAL14627.1
AK012430 mRNA Translation: BAB28233.1
AK044148 mRNA Translation: BAC31799.1
CCDSiCCDS17125.1
RefSeqiNP_001157158.1, NM_001163686.1
NP_084037.3, NM_029761.4
UniGeneiMm.41633

3D structure databases

ProteinModelPortaliQ91ZM9
SMRiQ91ZM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029075

PTM databases

iPTMnetiQ91ZM9
PhosphoSitePlusiQ91ZM9

Proteomic databases

MaxQBiQ91ZM9
PaxDbiQ91ZM9
PRIDEiQ91ZM9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029075; ENSMUSP00000029075; ENSMUSG00000027560
GeneIDi76829
KEGGimmu:76829
UCSCiuc008ocg.2 mouse

Organism-specific databases

CTDi55816
MGIiMGI:1924079 Dok5

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00730000110348
HOGENOMiHOG000247025
HOVERGENiHBG002356
InParanoidiQ91ZM9
OMAiHAVGIYF
OrthoDBiEOG091G0M38
PhylomeDBiQ91ZM9
TreeFamiTF324994

Enzyme and pathway databases

ReactomeiR-MMU-8853659 RET signaling

Miscellaneous databases

ChiTaRSiDok5 mouse
PROiPR:Q91ZM9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027560 Expressed in 80 organ(s), highest expression level in visual cortex
CleanExiMM_DOK5
GenevisibleiQ91ZM9 MM

Family and domain databases

CDDicd14678 PH_DOK4_DOK5_DOK6, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037816 DOK4/5/6_PH
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDOK5_MOUSE
AccessioniPrimary (citable) accession number: Q91ZM9
Secondary accession number(s): Q8BRI3, Q9CSM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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