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Entry version 133 (08 May 2019)
Sequence version 2 (18 Mar 2008)
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Protein

SH2B adapter protein 1

Gene

Sh2b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity (By similarity). Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis, according the order: isoform 3 > isoform 4 > isoform 1 > isoform 2.By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transmembrane receptor protein tyrosine kinase adaptor activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1170546 Prolactin receptor signaling
R-MMU-982772 Growth hormone receptor signaling
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH2B adapter protein 1
Alternative name(s):
Pro-rich, PH and SH2 domain-containing signaling mediator
Short name:
PSM
SH2 domain-containing protein 1B
SH2-B PH domain-containing signaling mediator 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sh2b1
Synonyms:Sh2bpsm1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1201407 Sh2b1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003235941 – 756SH2B adapter protein 1Add BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei88PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei270Omega-N-methylarginineCombined sources1
Modified residuei417PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei439Phosphotyrosine; by JAK1, JAK2 and PDGFRBy similarity1
Modified residuei494Phosphotyrosine; by JAK1, JAK2By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues in response to IGF-I and PDGF stimulation.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q91ZM2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q91ZM2

PeptideAtlas

More...
PeptideAtlasi
Q91ZM2

PRoteomics IDEntifications database

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PRIDEi
Q91ZM2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q91ZM2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91ZM2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in liver, brain and heart. Isoform 3 is widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030733 Expressed in 280 organ(s), highest expression level in molar tooth

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q91ZM2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q91ZM2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates. Homopentamer (By similarity). Forms a heteromultimeric complex with SH2B2 (By similarity). Interacts with SH2B2. Isoform 1 interacts via its SH2 domain with JAK2. Isoform 2 interacts via its SH2 domain and its N-terminus with JAK2; the SH2 domain is required for the major interaction with JAK2 phosphorylated on tyrosine residues; the N-terminus provides a low-affinity binding to JAK2 independent of JAK2 phosphorylation. Isoform 3 interacts via its SH2 domain with JAK2. Isoform 1 interacts via its SH2 domain with INSR; the interaction requires receptor activation. Isoform 3 interacts via its SH2 domain with INSR; the interaction requires receptor activation and requires INSR phosphorylation at 'Tyr-1175'. Isoform 1 interacts with IGF1R; the interaction requires receptor activation. Isoform 2 interacts via its SH2 domain with FGFR3; the interaction requires FGFR3 'Tyr-719' and 'Tyr-755'. Isoform 2 interacts with RET; the interaction requires RET kinase activity and RET 'Tyr-982'. Isoform 2 interacts with RAC1. Isoform 2 interacts with PDGFRA and/or PDGFRB; the interaction requires receptor activation. Interacts with ISR1 and ISR2. Isoform 3 is probably part of a complex consisting of INSR, ISR1 and SH2B1. Probably part of a ternary complex consisting of SH2B1, JAK2 and ISR1 or ISR2. May interact with FCER1G (By similarity). Interacts (via SH2 domain) with NTRK1 (phosphorylated) (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Jak2Q621203EBI-7178606,EBI-646604

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
203201, 2 interactors

Protein interaction database and analysis system

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IntActi
Q91ZM2, 4 interactors

Molecular INTeraction database

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MINTi
Q91ZM2

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000032978

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1756
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HDVX-ray2.00A/B519-627[»]
2HDXX-ray2.35A/B/C/D/E/F519-627[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q91ZM2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q91ZM2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini267 – 376PHAdd BLAST110
Domaini527 – 625SH2PROSITE-ProRule annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 555Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation)By similarityAdd BLAST555
Regioni24 – 85Required for self-associationBy similarityAdd BLAST62
Regioni85 – 196Interaction with RAC1By similarityAdd BLAST112
Regioni100 – 243Required for NGF signalingBy similarityAdd BLAST144
Regioni224 – 233Required for nuclear localizationBy similarity10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SH2B adapter family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IMWK Eukaryota
ENOG41102PH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183191

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q91ZM2

KEGG Orthology (KO)

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KOi
K12459

Identification of Orthologs from Complete Genome Data

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OMAi
GDRWTHR

Database of Orthologous Groups

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OrthoDBi
556279at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q91ZM2

TreeFam database of animal gene trees

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TreeFami
TF323184

Family and domain databases

Conserved Domains Database

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CDDi
cd10346 SH2_SH2B_family, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR015012 Phe_ZIP
IPR036290 Phe_ZIP_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR030523 SH2B
IPR030521 SH2B1
IPR035057 SH2B1_SH2

The PANTHER Classification System

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PANTHERi
PTHR10872 PTHR10872, 1 hit
PTHR10872:SF3 PTHR10872:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00169 PH, 1 hit
PF08916 Phe_ZIP, 1 hit
PF00017 SH2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00401 SH2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00252 SH2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF109805 SSF109805, 1 hit
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q91ZM2-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGAPSPEDG VFPSPPALPP PPPPSWQEFC ESHARAAALD LARRFRLYLA
60 70 80 90 100
SHPQYAEPGA EAAFSGRFAE LFLQHFEAEV ARASGSLSPP VLAPLSPGVE
110 120 130 140 150
IPPSHDLSLE SCRVGGPLAV LGPSRSSEDL AGPLPSSVPS STTSSKPKLK
160 170 180 190 200
KRFSLRSVGR SVRGSVRGIL QWRGAVDSPS QAGPLETTSG PPVLGGNSNS
210 220 230 240 250
NSSGGAGTVG RALANDGTSP GERWTHRFER LRLSRGGGTL KDGAGMIQRE
260 270 280 290 300
ELLSFMGAEE AAPDPAGVGR GGGAAGLTSG GGGQPQWQKC RLLLRSEGEG
310 320 330 340 350
GGGSRLEFFV PPKASRPRLS IPCSTITDVR TATALEMPDR ENTFVVKVEG
360 370 380 390 400
PSEYILETSD ALHVKAWVSD IQECLSPGPC PAISPRPMTL PLAPGTSFFT
410 420 430 440 450
KDNTDSLELP CLNHSESLPS QDLLLGPSES NDRLSQGAYG GLSDRPSASF
460 470 480 490 500
SPSSASIAAS HFDSMELLPP ELPPRIPIEE GPPAGTVHPL STPYPPLDTP
510 520 530 540 550
EAATGSFLFQ GESEGGEGDQ PLSGYPWFHG MLSRLKAAQL VLEGGTGSHG
560 570 580 590 600
VFLVRQSETR RGEYVLTFNF QGKAKHLRLS LNEEGQCRVQ HLWFQSIFDM
610 620 630 640 650
LEHFRVHPIP LESGGSSDVV LVSYVPSQRQ QERSTSRDPA QPSEPPPWTD
660 670 680 690 700
PPHPGAEEAS GAPEVAAATA AAAKERQEKE KAGSGGVQEE LVPVAELVPM
710 720 730 740 750
VELEEAIAPG TEAQGGAGSS GDLEVSLMVQ LQQLPLGGNG EEGGHPRAIN

NQYSFV
Length:756
Mass (Da):79,625
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i388BDC44267E6DE8
GO
Isoform 2 (identifier: Q91ZM2-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     632-756: ERSTSRDPAQ...RAINNQYSFV → GREQAGSHAG...ASDCVTEHLP

Show »
Length:670
Mass (Da):70,855
Checksum:iBFBFA44F8E97B710
GO
Isoform 3 (identifier: Q91ZM2-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     632-756: ERSTSRDPAQ...RAINNQYSFV → GEQSRSAGEE...PSCPSERVTV

Show »
Length:682
Mass (Da):72,067
Checksum:iBC7F894A42959027
GO
Isoform 4 (identifier: Q91ZM2-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     632-756: ERSTSRDPAQ...RAINNQYSFV → GEQSRSAGEE...WSPWLNWKRP

Show »
Length:724
Mass (Da):77,594
Checksum:iD23C6FC816B3B0C9
GO
Isoform 5 (identifier: Q91ZM2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-443: GAYGGLS → AVDSEKT
     444-756: Missing.

Show »
Length:443
Mass (Da):46,389
Checksum:i24C3C4516A9DE22C
GO
Isoform 6 (identifier: Q91ZM2-6) [UniParc]FASTAAdd to basket
Also known as: Sh2bpsm1 gamma

The sequence of this isoform differs from the canonical sequence as follows:
     441-460: Missing.
     632-756: ERSTSRDPAQ...RAINNQYSFV → GEQSRSAGEE...PSCPSERVTV

Show »
Length:662
Mass (Da):70,190
Checksum:i17417293AF539C7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQ35A0A0U1RQ35_MOUSE
SH2B adapter protein 1
Sh2b1
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti172W → C in AAD41655 (PubMed:10594240).Curated1
Sequence conflicti399F → L in AAH11422 (PubMed:15489334).Curated1
Sequence conflicti564Y → C in AAD41655 (PubMed:10594240).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032029437 – 443GAYGGLS → AVDSEKT in isoform 5. 1 Publication7
Alternative sequenceiVSP_032030441 – 460Missing in isoform 6. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_032031444 – 756Missing in isoform 5. 1 PublicationAdd BLAST313
Alternative sequenceiVSP_032032632 – 756ERSTS…QYSFV → GREQAGSHAGVCEGDRCYPD ASSTLLPFGASDCVTEHLP in isoform 2. 3 PublicationsAdd BLAST125
Alternative sequenceiVSP_032033632 – 756ERSTS…QYSFV → GEQSRSAGEEVPVHPRSEAG SRLGAMQGCARATDATPMPP PPSCPSERVTV in isoform 3 and isoform 6. 3 PublicationsAdd BLAST125
Alternative sequenceiVSP_032034632 – 756ERSTS…QYSFV → GEQSRSAGEEVPVHPRSENG APPVTQPSPLNPLHGQIPHI LGQKRRRGRQKLRQPQPQQP KRGKRKRKRAVEGSRKSWSP WLSWSPWLNWKRP in isoform 4. 2 PublicationsAdd BLAST125

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF020526 mRNA Translation: AAC33414.1
AF380422 mRNA Translation: AAL07566.1
AF074329 mRNA Translation: AAD41655.1
AF421138 mRNA Translation: AAL16069.1
AF421139 mRNA Translation: AAL16070.1
AK168439 mRNA Translation: BAE40344.1
AK170444 mRNA Translation: BAE41802.1
BC011422 mRNA Translation: AAH11422.1
BC051978 mRNA Translation: AAH51978.1
AF036355 mRNA Translation: AAC39955.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS40126.1 [Q91ZM2-3]
CCDS85410.1 [Q91ZM2-4]
CCDS85411.1 [Q91ZM2-1]
CCDS85412.1 [Q91ZM2-2]

Protein sequence database of the Protein Information Resource

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PIRi
JC5886

NCBI Reference Sequences

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RefSeqi
NP_001074928.1, NM_001081459.2 [Q91ZM2-2]
NP_001276467.1, NM_001289538.1 [Q91ZM2-1]
NP_001276468.1, NM_001289539.1 [Q91ZM2-2]
NP_001276469.1, NM_001289540.1 [Q91ZM2-2]
NP_001276470.1, NM_001289541.1 [Q91ZM2-4]
NP_001276471.1, NM_001289542.1 [Q91ZM2-4]
NP_035493.2, NM_011363.3 [Q91ZM2-3]
XP_006507541.1, XM_006507478.3 [Q91ZM2-1]
XP_006507543.1, XM_006507480.3 [Q91ZM2-1]
XP_006507544.1, XM_006507481.3 [Q91ZM2-1]
XP_006507545.1, XM_006507482.1 [Q91ZM2-1]
XP_006507548.1, XM_006507485.3 [Q91ZM2-3]
XP_006507550.1, XM_006507487.3 [Q91ZM2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000032978; ENSMUSP00000032978; ENSMUSG00000030733 [Q91ZM2-3]
ENSMUST00000205340; ENSMUSP00000145953; ENSMUSG00000030733 [Q91ZM2-2]
ENSMUST00000205440; ENSMUSP00000145554; ENSMUSG00000030733 [Q91ZM2-2]
ENSMUST00000205497; ENSMUSP00000145842; ENSMUSG00000030733 [Q91ZM2-4]
ENSMUST00000205733; ENSMUSP00000145754; ENSMUSG00000030733 [Q91ZM2-1]
ENSMUST00000205889; ENSMUSP00000146282; ENSMUSG00000030733 [Q91ZM2-4]
ENSMUST00000206664; ENSMUSP00000146121; ENSMUSG00000030733 [Q91ZM2-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
20399

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20399

UCSC genome browser

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UCSCi
uc009jrh.2 mouse [Q91ZM2-2]
uc009jrj.2 mouse [Q91ZM2-4]
uc009jrk.2 mouse [Q91ZM2-3]
uc009jrm.2 mouse [Q91ZM2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020526 mRNA Translation: AAC33414.1
AF380422 mRNA Translation: AAL07566.1
AF074329 mRNA Translation: AAD41655.1
AF421138 mRNA Translation: AAL16069.1
AF421139 mRNA Translation: AAL16070.1
AK168439 mRNA Translation: BAE40344.1
AK170444 mRNA Translation: BAE41802.1
BC011422 mRNA Translation: AAH11422.1
BC051978 mRNA Translation: AAH51978.1
AF036355 mRNA Translation: AAC39955.2
CCDSiCCDS40126.1 [Q91ZM2-3]
CCDS85410.1 [Q91ZM2-4]
CCDS85411.1 [Q91ZM2-1]
CCDS85412.1 [Q91ZM2-2]
PIRiJC5886
RefSeqiNP_001074928.1, NM_001081459.2 [Q91ZM2-2]
NP_001276467.1, NM_001289538.1 [Q91ZM2-1]
NP_001276468.1, NM_001289539.1 [Q91ZM2-2]
NP_001276469.1, NM_001289540.1 [Q91ZM2-2]
NP_001276470.1, NM_001289541.1 [Q91ZM2-4]
NP_001276471.1, NM_001289542.1 [Q91ZM2-4]
NP_035493.2, NM_011363.3 [Q91ZM2-3]
XP_006507541.1, XM_006507478.3 [Q91ZM2-1]
XP_006507543.1, XM_006507480.3 [Q91ZM2-1]
XP_006507544.1, XM_006507481.3 [Q91ZM2-1]
XP_006507545.1, XM_006507482.1 [Q91ZM2-1]
XP_006507548.1, XM_006507485.3 [Q91ZM2-3]
XP_006507550.1, XM_006507487.3 [Q91ZM2-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HDVX-ray2.00A/B519-627[»]
2HDXX-ray2.35A/B/C/D/E/F519-627[»]
SMRiQ91ZM2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203201, 2 interactors
IntActiQ91ZM2, 4 interactors
MINTiQ91ZM2
STRINGi10090.ENSMUSP00000032978

PTM databases

iPTMnetiQ91ZM2
PhosphoSitePlusiQ91ZM2

Proteomic databases

jPOSTiQ91ZM2
PaxDbiQ91ZM2
PeptideAtlasiQ91ZM2
PRIDEiQ91ZM2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032978; ENSMUSP00000032978; ENSMUSG00000030733 [Q91ZM2-3]
ENSMUST00000205340; ENSMUSP00000145953; ENSMUSG00000030733 [Q91ZM2-2]
ENSMUST00000205440; ENSMUSP00000145554; ENSMUSG00000030733 [Q91ZM2-2]
ENSMUST00000205497; ENSMUSP00000145842; ENSMUSG00000030733 [Q91ZM2-4]
ENSMUST00000205733; ENSMUSP00000145754; ENSMUSG00000030733 [Q91ZM2-1]
ENSMUST00000205889; ENSMUSP00000146282; ENSMUSG00000030733 [Q91ZM2-4]
ENSMUST00000206664; ENSMUSP00000146121; ENSMUSG00000030733 [Q91ZM2-5]
GeneIDi20399
KEGGimmu:20399
UCSCiuc009jrh.2 mouse [Q91ZM2-2]
uc009jrj.2 mouse [Q91ZM2-4]
uc009jrk.2 mouse [Q91ZM2-3]
uc009jrm.2 mouse [Q91ZM2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25970
MGIiMGI:1201407 Sh2b1

Phylogenomic databases

eggNOGiENOG410IMWK Eukaryota
ENOG41102PH LUCA
GeneTreeiENSGT00950000183191
InParanoidiQ91ZM2
KOiK12459
OMAiGDRWTHR
OrthoDBi556279at2759
PhylomeDBiQ91ZM2
TreeFamiTF323184

Enzyme and pathway databases

ReactomeiR-MMU-1170546 Prolactin receptor signaling
R-MMU-982772 Growth hormone receptor signaling
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sh2b1 mouse
EvolutionaryTraceiQ91ZM2

Protein Ontology

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PROi
PR:Q91ZM2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030733 Expressed in 280 organ(s), highest expression level in molar tooth
ExpressionAtlasiQ91ZM2 baseline and differential
GenevisibleiQ91ZM2 MM

Family and domain databases

CDDicd10346 SH2_SH2B_family, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR015012 Phe_ZIP
IPR036290 Phe_ZIP_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR030523 SH2B
IPR030521 SH2B1
IPR035057 SH2B1_SH2
PANTHERiPTHR10872 PTHR10872, 1 hit
PTHR10872:SF3 PTHR10872:SF3, 1 hit
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF08916 Phe_ZIP, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF109805 SSF109805, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSH2B1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91ZM2
Secondary accession number(s): O54867
, Q05DJ7, Q792R7, Q91ZM3, Q91ZV5, Q9WVM5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 8, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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