The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q91ZK0 (AP2D_MOUSE)
Protein
Transcription factor AP-2-delta
Gene
Tfap2d
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.
Curated1 PublicationGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
GO - Biological processi
- anatomical structure development Source: GO_Central
- inferior colliculus development Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of cell population proliferation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-MMU-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor AP-2-deltaShort name: AP2-delta Alternative name(s): Activating enhancer-binding protein 2-delta |
Gene namesi | Name:Tfap2d Synonyms:Tcfap2d |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2153466, Tfap2d |
VEuPathDBi | HostDB:ENSMUSG00000042596 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309514 | 1 – 452 | Transcription factor AP-2-deltaAdd BLAST | 452 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 239 | Phosphoserine; by PKABy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q91ZK0 |
PaxDbi | Q91ZK0 |
PeptideAtlasi | Q91ZK0 |
PRIDEi | Q91ZK0 |
ProteomicsDBi | 281785 |
PTM databases
PhosphoSitePlusi | Q91ZK0 |
Expressioni
Tissue specificityi
Expressed in both embryonic and newborn brain.1 Publication
Developmental stagei
Expression is first detected at 9.5 dpc in the central nervous system and the developing heart. The signal detected in heart persists through to 10.5 dpc. Diffusely expressed in developing brain at 10.5 dpc to 11.5 dpc, but by 13.5 dpc expression is mostly confined to the midbrain and forebrain. Also expressed in the spinal cord at 10.5 dpc, and in retinal epithelium from 13.5 dpc to 16.5 dpc. No signals detected in tissues such as the neural crest, facial mesenchyme, and limbs where other Tfap2 genes are expressed.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000042596, Expressed in head and 107 other tissues |
Genevisiblei | Q91ZK0, MM |
Interactioni
Subunit structurei
Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members.
1 PublicationBinary interactionsi
Q91ZK0
With | #Exp. | IntAct |
---|---|---|
Ash2l [Q91X20] | 4 | EBI-15703453,EBI-1556554 |
Protein-protein interaction databases
BioGRIDi | 230568, 14 interactors |
DIPi | DIP-46108N |
IntActi | Q91ZK0, 3 interactors |
STRINGi | 10090.ENSMUSP00000037699 |
Miscellaneous databases
RNActi | Q91ZK0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 280 – 410 | H-S-H (helix-span-helix), dimerizationSequence analysisAdd BLAST | 131 | |
Regioni | 416 – 452 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 433 – 452 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the AP-2 family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_5_0_1 |
InParanoidi | Q91ZK0 |
OMAi | GHTNSEK |
OrthoDBi | 641707at2759 |
PhylomeDBi | Q91ZK0 |
TreeFami | TF313718 |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01748, AP2TNSCPFCT |
i Sequence
Sequence statusi: Complete.
Q91ZK0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTTFPGLVH DAEIRHDGSN SYRLMQLGCL ESVANSTVAY SSSSPLTYST
60 70 80 90 100
TGTEFASPYF STNHQYTPLH HQSFHYEFQH SHPAVTPDAY SLNSLHHSQQ
110 120 130 140 150
YYQQIHHGEP TDFINLHNAR ALKSSCLDEQ RRELGCLDAY RRHDLSLMSH
160 170 180 190 200
GSQYGMHPDQ RLLPGPSLGL AAAGADDLQG SVEAQCGIVL NGQGGVIRRG
210 220 230 240 250
GTCVVNPTDL FCSVPGRLSL LSSTSKYKVT IAEVKRRLSP PECLNASLLG
260 270 280 290 300
GILRRAKSKN GGRCLREKLD RLGLNLPAGR RKAANVTLLT SLVEGEALHL
310 320 330 340 350
ARDFGYTCET EFPAKAVGEH LARQHMEQKE QTARKKMILA TKQICKEFQD
360 370 380 390 400
LLSQDRSPLG SSRPTPILDL DIQRHLTHFS LITHGFGTPA ICAALSTFQT
410 420 430 440 450
VLSEMLNYLE KHTTHKNGGA ADSGQGHANS EKAPLRKASE AAVKEGKTEK
TD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | T → A in AAI52326 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 37 | T → A in AAI52325 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF421891 mRNA Translation: AAL16940.1 BC152324 mRNA Translation: AAI52325.1 BC152325 mRNA Translation: AAI52326.1 |
CCDSi | CCDS14838.1 |
RefSeqi | NP_694794.1, NM_153154.3 |
Genome annotation databases
Ensembli | ENSMUST00000037294; ENSMUSP00000037699; ENSMUSG00000042596 |
GeneIDi | 226896 |
KEGGi | mmu:226896 |
UCSCi | uc007akp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF421891 mRNA Translation: AAL16940.1 BC152324 mRNA Translation: AAI52325.1 BC152325 mRNA Translation: AAI52326.1 |
CCDSi | CCDS14838.1 |
RefSeqi | NP_694794.1, NM_153154.3 |
3D structure databases
AlphaFoldDBi | Q91ZK0 |
SMRi | Q91ZK0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 230568, 14 interactors |
DIPi | DIP-46108N |
IntActi | Q91ZK0, 3 interactors |
STRINGi | 10090.ENSMUSP00000037699 |
PTM databases
PhosphoSitePlusi | Q91ZK0 |
Proteomic databases
MaxQBi | Q91ZK0 |
PaxDbi | Q91ZK0 |
PeptideAtlasi | Q91ZK0 |
PRIDEi | Q91ZK0 |
ProteomicsDBi | 281785 |
Protocols and materials databases
Antibodypediai | 30864, 141 antibodies from 25 providers |
DNASUi | 226896 |
Genome annotation databases
Ensembli | ENSMUST00000037294; ENSMUSP00000037699; ENSMUSG00000042596 |
GeneIDi | 226896 |
KEGGi | mmu:226896 |
UCSCi | uc007akp.1, mouse |
Organism-specific databases
CTDi | 83741 |
MGIi | MGI:2153466, Tfap2d |
VEuPathDBi | HostDB:ENSMUSG00000042596 |
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_5_0_1 |
InParanoidi | Q91ZK0 |
OMAi | GHTNSEK |
OrthoDBi | 641707at2759 |
PhylomeDBi | Q91ZK0 |
TreeFami | TF313718 |
Enzyme and pathway databases
Reactomei | R-MMU-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-MMU-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
Miscellaneous databases
BioGRID-ORCSi | 226896, 2 hits in 71 CRISPR screens |
PROi | PR:Q91ZK0 |
RNActi | Q91ZK0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042596, Expressed in head and 107 other tissues |
Genevisiblei | Q91ZK0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01748, AP2TNSCPFCT |
MobiDBi | Search... |
Entry informationi
Entry namei | AP2D_MOUSE | |
Accessioni | Q91ZK0Primary (citable) accession number: Q91ZK0 Secondary accession number(s): A7MCU6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families