Tfap2d

Functionⁱ

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.Curated1 Publication

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: MGI
Inferred from direct assayⁱ
- 21858141
RNA polymerase II regulatory region sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 21858141

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

inferior colliculus development
Source: MGI
Inferred from mutant phenotypeⁱ
- 21858141
negative regulation of neuron apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 21858141
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 11522791
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 21858141
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Reactomeⁱ

R-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor AP-2-delta Short name: AP2-delta Alternative name(s): Activating enhancer-binding protein 2-delta
Gene namesⁱ	Name:Tfap2d Synonyms:Tcfap2d
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:2153466 Tfap2d

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000309514	1 – 452	Transcription factor AP-2-deltaAdd BLAST		452

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	239	Phosphoserine; by PKABy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q91ZK0
PaxDbⁱ	Q91ZK0
PeptideAtlas More...PeptideAtlasⁱ	Q91ZK0
PRIDEⁱ	Q91ZK0

PTM databases

PhosphoSitePlusⁱ	Q91ZK0

PhosphoSitePlusⁱ

Q91ZK0

Expressionⁱ

Tissue specificityⁱ

Expressed in both embryonic and newborn brain.1 Publication

Developmental stageⁱ

Expression is first detected at E9.5 in the central nervous system and the developing heart. The signal detected in heart persists through to E10.5. Diffusely expressed in developing brain at E10.5 to E11.5, but by E13.5 expression is mostly confined to the midbrain and forebrain. Also expressed in the spinal cord at E10.5, and in retinal epithelium from E13.5 to E16.5. No signals detected in tissues such as the neural crest, facial mesenchyme, and limbs where other Tfap2 genes are expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000042596 Expressed in 94 organ(s), highest expression level in head
CleanExⁱ	MM_TCFAP2D
Genevisibleⁱ	Q91ZK0 MM

Interactionⁱ

Subunit structureⁱ

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Ash2l	Q91X20	4	EBI-15703453,EBI-1556554

With

Entry

#Exp.

IntAct

Notes

Ash2l

Q91X20

4

EBI-15703453,EBI-1556554

Protein-protein interaction databases

BioGridⁱ	230568, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-46108N
IntActⁱ	Q91ZK0, 3 interactors
STRINGⁱ	10090.ENSMUSP00000037699

Structureⁱ

3D structure databases

SMRⁱ	Q91ZK0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	280 – 410	H-S-H (helix-span-helix), dimerizationSequence analysisAdd BLAST		131

Sequence similaritiesⁱ

Belongs to the AP-2 family.Sequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074577
HOGENOMⁱ	HOG000231737
HOVERGENⁱ	HBG002455
InParanoidⁱ	Q91ZK0
KEGG Orthology (KO) More...KOⁱ	K09178
OMAⁱ	YYQQLHH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PR6
PhylomeDBⁱ	Q91ZK0
TreeFamⁱ	TF313718

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR013854 TF_AP2_C
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01748 AP2TNSCPFCT

Sequenceⁱ

Sequence statusⁱ: Complete.

Q91ZK0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTTFPGLVH DAEIRHDGSN SYRLMQLGCL ESVANSTVAY SSSSPLTYST 
        60         70         80         90        100
TGTEFASPYF STNHQYTPLH HQSFHYEFQH SHPAVTPDAY SLNSLHHSQQ 
       110        120        130        140        150
YYQQIHHGEP TDFINLHNAR ALKSSCLDEQ RRELGCLDAY RRHDLSLMSH 
       160        170        180        190        200
GSQYGMHPDQ RLLPGPSLGL AAAGADDLQG SVEAQCGIVL NGQGGVIRRG 
       210        220        230        240        250
GTCVVNPTDL FCSVPGRLSL LSSTSKYKVT IAEVKRRLSP PECLNASLLG 
       260        270        280        290        300
GILRRAKSKN GGRCLREKLD RLGLNLPAGR RKAANVTLLT SLVEGEALHL 
       310        320        330        340        350
ARDFGYTCET EFPAKAVGEH LARQHMEQKE QTARKKMILA TKQICKEFQD 
       360        370        380        390        400
LLSQDRSPLG SSRPTPILDL DIQRHLTHFS LITHGFGTPA ICAALSTFQT 
       410        420        430        440        450
VLSEMLNYLE KHTTHKNGGA ADSGQGHANS EKAPLRKASE AAVKEGKTEK 

TD

Length:452

Mass (Da):49,548

Last modified:December 1, 2001 - v1

Checksum:ⁱ6722342B15CDF9EB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	37	T → A in AAI52326 (PubMed:15489334).Curated		1
Sequence conflictⁱ	37	T → A in AAI52325 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF421891 mRNA Translation: AAL16940.1 BC152324 mRNA Translation: AAI52325.1 BC152325 mRNA Translation: AAI52326.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14838.1
NCBI Reference Sequences More...RefSeqⁱ	NP_694794.1, NM_153154.3
UniGeneⁱ	Mm.244858

Genome annotation databases

Ensemblⁱ	ENSMUST00000037294; ENSMUSP00000037699; ENSMUSG00000042596
GeneIDⁱ	226896
KEGGⁱ	mmu:226896
UCSC genome browser More...UCSCⁱ	uc007akp.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91ZK0	Transcription factor AP-2 delta		PTEAL		536	UniRef90_Q91ZK0
transcription factor AP-2-delta isoform X1		MESAU		456
Transcription factor AP-2-delta		MYODS		456
Uncharacterized protein		CHICK		455
Transcription factor AP-2 delta (Activating enhancer binding protein 2 delta), transcript variant X1		COLLI		455
+85

Protein	Similar proteins		Species	Score	Length	Source
Q91ZK0	Transcription factor AP-2-delta		HUMAN		452	UniRef50_Q91ZK0
Transcription factor AP-2-delta		DANRE		450
Transcription factor AP-2 delta		PTEAL		536
transcription factor AP-2-delta isoform X1		MESAU		456
Transcription factor AP-2-delta		MYODS		456
+225

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF421891 mRNA Translation: AAL16940.1 BC152324 mRNA Translation: AAI52325.1 BC152325 mRNA Translation: AAI52326.1
CCDSⁱ	CCDS14838.1
RefSeqⁱ	NP_694794.1, NM_153154.3
UniGeneⁱ	Mm.244858

3D structure databases

SMRⁱ	Q91ZK0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	230568, 3 interactors
DIPⁱ	DIP-46108N
IntActⁱ	Q91ZK0, 3 interactors
STRINGⁱ	10090.ENSMUSP00000037699

PTM databases

PhosphoSitePlusⁱ	Q91ZK0

PhosphoSitePlusⁱ

Q91ZK0

Proteomic databases

MaxQBⁱ	Q91ZK0
PaxDbⁱ	Q91ZK0
PeptideAtlasⁱ	Q91ZK0
PRIDEⁱ	Q91ZK0

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	226896
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000037294; ENSMUSP00000037699; ENSMUSG00000042596
GeneIDⁱ	226896
KEGGⁱ	mmu:226896
UCSCⁱ	uc007akp.1 mouse

Organism-specific databases

CTDⁱ	83741
MGIⁱ	MGI:2153466 Tfap2d

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
GeneTreeⁱ	ENSGT00550000074577
HOGENOMⁱ	HOG000231737
HOVERGENⁱ	HBG002455
InParanoidⁱ	Q91ZK0
KOⁱ	K09178
OMAⁱ	YYQQLHH
OrthoDBⁱ	EOG091G0PR6
PhylomeDBⁱ	Q91ZK0
TreeFamⁱ	TF313718

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Reactomeⁱ

R-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91ZK0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000042596 Expressed in 94 organ(s), highest expression level in head
CleanExⁱ	MM_TCFAP2D
Genevisibleⁱ	Q91ZK0 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR013854 TF_AP2_C
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit
Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01748 AP2TNSCPFCT
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AP2D_MOUSE
Accessionⁱ	Q91ZK0Primary (citable) accession number: Q91ZK0 Secondary accession number(s): A7MCU6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91ZK0 (AP2D_MOUSE)

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Transcription factor AP-2-delta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ