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UniProtKB - Q91ZJ5 (UGPA_MOUSE)
Protein
UTP--glucose-1-phosphate uridylyltransferase
Gene
Ugp2
Organism
Mus musculus (Mouse)
Status
Functioni
UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.
By similarityCatalytic activityi
: glycogen biosynthesis Pathwayi
This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.By similarityView all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 127 | MagnesiumBy similarity | 1 | |
Binding sitei | 127 | UTPBy similarity | 1 | |
Binding sitei | 190 | UTPBy similarity | 1 | |
Binding sitei | 222 | UTP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 223 | SubstrateBy similarity | 1 | |
Metal bindingi | 253 | MagnesiumBy similarity | 1 | |
Binding sitei | 253 | UTPBy similarity | 1 | |
Active sitei | 396 | By similarity | 1 | |
Binding sitei | 396 | UTPBy similarity | 1 |
GO - Molecular functioni
- glucose binding Source: MGI
- identical protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- pyrimidine ribonucleotide binding Source: MGI
- UTP:glucose-1-phosphate uridylyltransferase activity Source: MGI
GO - Biological processi
- brain development Source: MGI
- glucose 1-phosphate metabolic process Source: MGI
- glycogen biosynthetic process Source: MGI
- glycogen metabolic process Source: GO_Central
- UDP-glucose metabolic process Source: MGI
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-173599, Formation of the active cofactor, UDP-glucuronate R-MMU-3322077, Glycogen synthesis |
UniPathwayi | UPA00164 |
Names & Taxonomyi
Protein namesi | Recommended name: UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9By similarity)Alternative name(s): UDP-glucose pyrophosphorylase Short name: UDPGP Short name: UGPase |
Gene namesi | Name:Ugp2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2183447, Ugp2 |
VEuPathDBi | HostDB:ENSMUSG00000001891 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185753 | 1 – 508 | UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST | 508 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Modified residuei | 426 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 434 | PhosphoserineBy similarity | 1 | |
Modified residuei | 438 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 448 | PhosphoserineCombined sources | 1 | |
Modified residuei | 461 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q91ZJ5 |
jPOSTi | Q91ZJ5 |
MaxQBi | Q91ZJ5 |
PaxDbi | Q91ZJ5 |
PeptideAtlasi | Q91ZJ5 |
PRIDEi | Q91ZJ5 |
ProteomicsDBi | 299640 [Q91ZJ5-1] 299641 [Q91ZJ5-2] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00279474 |
PTM databases
iPTMneti | Q91ZJ5 |
PhosphoSitePlusi | Q91ZJ5 |
SwissPalmi | Q91ZJ5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000001891, Expressed in gastrocnemius and 315 other tissues |
ExpressionAtlasi | Q91ZJ5, baseline and differential |
Genevisiblei | Q91ZJ5, MM |
Interactioni
Subunit structurei
Homooctamer.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 229760, 10 interactors |
IntActi | Q91ZJ5, 1 interactor |
STRINGi | 10090.ENSMUSP00000099939 |
Miscellaneous databases
RNActi | Q91ZJ5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 113 – 116 | UTP bindingBy similarity | 4 | |
Regioni | 115 – 116 | Substrate bindingBy similarity | 2 | |
Regioni | 251 – 253 | Substrate bindingBy similarity | 3 | |
Regioni | 457 – 508 | OligomerizationBy similarityAdd BLAST | 52 | |
Regioni | 502 – 503 | Critical for end-to-end subunit interactionBy similarity | 2 |
Sequence similaritiesi
Belongs to the UDPGP type 1 family.Curated
Phylogenomic databases
eggNOGi | KOG2638, Eukaryota |
GeneTreei | ENSGT00940000153464 |
HOGENOMi | CLU_023632_3_0_1 |
InParanoidi | Q91ZJ5 |
OMAi | TNNLWAK |
OrthoDBi | 503037at2759 |
PhylomeDBi | Q91ZJ5 |
TreeFami | TF300567 |
Family and domain databases
CDDi | cd00897, UGPase_euk, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR029044, Nucleotide-diphossugar_trans IPR002618, UDPGP_fam IPR016267, UDPGP_trans |
PANTHERi | PTHR43511, PTHR43511, 1 hit |
Pfami | View protein in Pfam PF01704, UDPGP, 1 hit |
PIRSFi | PIRSF000806, UDPGP, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q91ZJ5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRFVQDLSK AMSQDGASQF QEVILQELEL SVKKELEKIL TTAASHEFEH
60 70 80 90 100
TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN
110 120 130 140 150
ISSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN
160 170 180 190 200
KTYNTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES
210 220 230 240 250
LLPIAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI EEGKEYIFVS
260 270 280 290 300
NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG
310 320 330 340 350
KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLGAVK RLQEQNAIDM
360 370 380 390 400
EIIVNPKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD
410 420 430 440 450
LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP
460 470 480 490 500
DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS
GNLRILDH
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012835 | 1 – 11 | Missing in isoform 2. 1 PublicationAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF424698 mRNA Translation: AAL24807.1 AK033445 mRNA Translation: BAC28291.1 AL772195 Genomic DNA No translation available. AL833772 Genomic DNA No translation available. BC023810 mRNA Translation: AAH23810.1 BC025585 mRNA Translation: AAH25585.1 BC061208 mRNA Translation: AAH61208.1 |
CCDSi | CCDS24464.1 [Q91ZJ5-1] CCDS70148.1 [Q91ZJ5-2] |
RefSeqi | NP_001277563.1, NM_001290634.1 [Q91ZJ5-2] NP_647458.1, NM_139297.6 [Q91ZJ5-1] |
Genome annotation databases
Ensembli | ENSMUST00000060895; ENSMUSP00000056324; ENSMUSG00000001891 [Q91ZJ5-2] ENSMUST00000102875; ENSMUSP00000099939; ENSMUSG00000001891 [Q91ZJ5-1] |
GeneIDi | 216558 |
KEGGi | mmu:216558 |
UCSCi | uc007idr.4, mouse [Q91ZJ5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF424698 mRNA Translation: AAL24807.1 AK033445 mRNA Translation: BAC28291.1 AL772195 Genomic DNA No translation available. AL833772 Genomic DNA No translation available. BC023810 mRNA Translation: AAH23810.1 BC025585 mRNA Translation: AAH25585.1 BC061208 mRNA Translation: AAH61208.1 |
CCDSi | CCDS24464.1 [Q91ZJ5-1] CCDS70148.1 [Q91ZJ5-2] |
RefSeqi | NP_001277563.1, NM_001290634.1 [Q91ZJ5-2] NP_647458.1, NM_139297.6 [Q91ZJ5-1] |
3D structure databases
AlphaFoldDBi | Q91ZJ5 |
SMRi | Q91ZJ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229760, 10 interactors |
IntActi | Q91ZJ5, 1 interactor |
STRINGi | 10090.ENSMUSP00000099939 |
PTM databases
iPTMneti | Q91ZJ5 |
PhosphoSitePlusi | Q91ZJ5 |
SwissPalmi | Q91ZJ5 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00279474 |
Proteomic databases
EPDi | Q91ZJ5 |
jPOSTi | Q91ZJ5 |
MaxQBi | Q91ZJ5 |
PaxDbi | Q91ZJ5 |
PeptideAtlasi | Q91ZJ5 |
PRIDEi | Q91ZJ5 |
ProteomicsDBi | 299640 [Q91ZJ5-1] 299641 [Q91ZJ5-2] |
Protocols and materials databases
Antibodypediai | 30782, 213 antibodies from 24 providers |
DNASUi | 216558 |
Genome annotation databases
Ensembli | ENSMUST00000060895; ENSMUSP00000056324; ENSMUSG00000001891 [Q91ZJ5-2] ENSMUST00000102875; ENSMUSP00000099939; ENSMUSG00000001891 [Q91ZJ5-1] |
GeneIDi | 216558 |
KEGGi | mmu:216558 |
UCSCi | uc007idr.4, mouse [Q91ZJ5-1] |
Organism-specific databases
CTDi | 7360 |
MGIi | MGI:2183447, Ugp2 |
VEuPathDBi | HostDB:ENSMUSG00000001891 |
Phylogenomic databases
eggNOGi | KOG2638, Eukaryota |
GeneTreei | ENSGT00940000153464 |
HOGENOMi | CLU_023632_3_0_1 |
InParanoidi | Q91ZJ5 |
OMAi | TNNLWAK |
OrthoDBi | 503037at2759 |
PhylomeDBi | Q91ZJ5 |
TreeFami | TF300567 |
Enzyme and pathway databases
UniPathwayi | UPA00164 |
Reactomei | R-MMU-173599, Formation of the active cofactor, UDP-glucuronate R-MMU-3322077, Glycogen synthesis |
Miscellaneous databases
BioGRID-ORCSi | 216558, 20 hits in 77 CRISPR screens |
ChiTaRSi | Ugp2, mouse |
PROi | PR:Q91ZJ5 |
RNActi | Q91ZJ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001891, Expressed in gastrocnemius and 315 other tissues |
ExpressionAtlasi | Q91ZJ5, baseline and differential |
Genevisiblei | Q91ZJ5, MM |
Family and domain databases
CDDi | cd00897, UGPase_euk, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR029044, Nucleotide-diphossugar_trans IPR002618, UDPGP_fam IPR016267, UDPGP_trans |
PANTHERi | PTHR43511, PTHR43511, 1 hit |
Pfami | View protein in Pfam PF01704, UDPGP, 1 hit |
PIRSFi | PIRSF000806, UDPGP, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UGPA_MOUSE | |
Accessioni | Q91ZJ5Primary (citable) accession number: Q91ZJ5 Secondary accession number(s): Q8R3D2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 152 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families