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UniProtKB - Q91ZI0 (CELR3_MOUSE)

Entry version 158 (05 Jun 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Cadherin EGF LAG seven-pass G-type receptor 3

Gene

Celsr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Celsr3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1858236 Celsr3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 2531ExtracellularSequence analysisAdd BLAST2500
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2532 – 2552Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2553 – 2563CytoplasmicSequence analysisAdd BLAST11
Transmembranei2564 – 2584Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2585 – 2592ExtracellularSequence analysis8
Transmembranei2593 – 2613Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2614 – 2634CytoplasmicSequence analysisAdd BLAST21
Transmembranei2635 – 2655Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2656 – 2673ExtracellularSequence analysisAdd BLAST18
Transmembranei2674 – 2694Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2695 – 2716CytoplasmicSequence analysisAdd BLAST22
Transmembranei2717 – 2737Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2738 – 2744ExtracellularSequence analysis7
Transmembranei2745 – 2765Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2766 – 3301CytoplasmicSequence analysisAdd BLAST536

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291932 – 3301Cadherin EGF LAG seven-pass G-type receptor 3Add BLAST3270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi838N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1318N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1370 ↔ 1381By similarity
Disulfide bondi1375 ↔ 1412By similarity
Disulfide bondi1414 ↔ 1423By similarity
Disulfide bondi1430 ↔ 1441By similarity
Disulfide bondi1435 ↔ 1450By similarity
Disulfide bondi1452 ↔ 1459By similarity
Disulfide bondi1468 ↔ 1479By similarity
Disulfide bondi1473 ↔ 1489By similarity
Disulfide bondi1491 ↔ 1502By similarity
Glycosylationi1638N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1682 ↔ 1708By similarity
Glycosylationi1702N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1715 ↔ 1726By similarity
Disulfide bondi1720 ↔ 1735By similarity
Disulfide bondi1737 ↔ 1746By similarity
Glycosylationi1759N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1904 ↔ 1933By similarity
Disulfide bondi1939 ↔ 1950By similarity
Disulfide bondi1944 ↔ 1959By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1952(3R)-3-hydroxyaspartateSequence analysis1
Disulfide bondi1961 ↔ 1970By similarity
Disulfide bondi1974 ↔ 1985By similarity
Disulfide bondi1979 ↔ 1997By similarity
Disulfide bondi1999 ↔ 2008By similarity
Disulfide bondi2016 ↔ 2029By similarity
Disulfide bondi2031 ↔ 2041By similarity
Glycosylationi2042N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2048 ↔ 2063By similarity
Disulfide bondi2050 ↔ 2066By similarity
Disulfide bondi2068 ↔ 2078By similarity
Disulfide bondi2087 ↔ 2096By similarity
Disulfide bondi2099 ↔ 2111By similarity
Modified residuei2115PhosphotyrosineBy similarity1
Glycosylationi2166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2185N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2497N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei3042PhosphotyrosineBy similarity1
Modified residuei3090PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q91ZI0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q91ZI0

PRoteomics IDEntifications database

More...PRIDEi		Q91ZI0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q91ZI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q91ZI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the CNS and in the eye.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Predominantly expressed in the CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. No expression is detected until somite stages. Between 10 and 12 dpc, expression is strong in the marginal zone (MZ), and lower in the ventricular zone (VZ). At 15 dpc, expression is restricted to the brain and olfactory epithelium. In the brain, it is low in VZ but strong in external fields, particularly those with ongoing migration, such as the telencephalic cortical plate, the olfactory bulb, the cerebellum and the tectum. In the newborn and postnatal stages, expression is high in differentiated neuronal fields.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000023473 Expressed in 84 organ(s), highest expression level in olfactory bulb

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q91ZI0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q91ZI0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q91ZI0, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000024238

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q91ZI0

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini317 – 424Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini425 – 536Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini537 – 642Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini643 – 747Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini748 – 849Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini850 – 952Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini953 – 1058Cadherin 7PROSITE-ProRule annotationAdd BLAST106
Domaini1059 – 1160Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1161 – 1257Cadherin 9PROSITE-ProRule annotationAdd BLAST97
Domaini1366 – 1424EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini1426 – 1460EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST35
Domaini1464 – 1503EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1504 – 1708Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1711 – 1747EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1751 – 1933Laminin G-like 2PROSITE-ProRule annotationAdd BLAST183
Domaini1935 – 1971EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1972 – 2002EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST31
Domaini2003 – 2042EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini2044 – 2079EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini2066 – 2113Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2468 – 2520GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2720 – 2724Poly-Leu5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Curated

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4289 Eukaryota
ENOG410XTGH LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160077

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231346

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q91ZI0

Database of Orthologous Groups

More...OrthoDBi		23882at2759

TreeFam database of animal gene trees

More...TreeFami		TF323983

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 8 hits
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q91ZI0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRPLWWGL PGPSTPVLLL LLLSLFPFSR EELGGGGDQD WDPGVATTTG 
        60         70         80         90        100
PRAQIGSGAV ALCPESPGVW EDGDPGLGVR EPVFMRLRVG RQNARNGRGA 
       110        120        130        140        150
PEQPNAEVVV QALGSREQEA GQGPGYLLCW HPEISSCGRT GPLRRGSLPL 
       160        170        180        190        200
DALSPGDSDL RNSSPHPSEL LAQPDGSRPV AFQRNARRSI RKRVETSRCC 
       210        220        230        240        250
GKLWEPGHKG QGERSATSTV DRGPFRRDCL PGSLGSGLGE DSAPRAVRTA 
       260        270        280        290        300
PTPGSAPRES RTAPGRMRSR GLFRRRFLFE RPGPRPPGFP TGPEAKQILS 
       310        320        330        340        350
TNQARPRRAA NRHPQFPQYN YQTLVPENEA AGTSVLRVVA QDPDPGEAGR 
       360        370        380        390        400
LIYSLAALMN SRSLELFSID PQSGLIRTAA ALDRESMERH YLRVTAQDHG 
       410        420        430        440        450
SPRLSATTMV AVTVADRNDH APVFEQAQYR ETLRENVEEG YPILQLRATD 
       460        470        480        490        500
GDAPPNANLR YRFVGSPAVR TAAAAAFEID PRSGLISTSG RVDREHMESY 
       510        520        530        540        550
ELVVEASDQG QEPGPRSATV RVHITVLDEN DNAPQFSEKR YVAQVREDVR 
       560        570        580        590        600
PHTVVLRVTA TDKDKDANGL VHYNIISGNS RGHFAIDSLT GEIQVMAPLD 
       610        620        630        640        650
FEAEREYALR IRAQDAGRPP LSNNTGLASI QVVDINDHAP IFVSTPFQVS 
       660        670        680        690        700
VLENAPLGHS VIHIQAVDAD HGENSRLEYS LTGVASDTPF VINSATGWVS 
       710        720        730        740        750
VSGPLDRESV EHYFFGVEAR DHGSPPLSAS ASVTVTVLDV NDNRPEFTMK 
       760        770        780        790        800
EYHLRLNEDA AVGTSVVSVT AVDRDANSAI SYQITGGNTR NRFAISTQGG 
       810        820        830        840        850
VGLVTLALPL DYKQERYFKL VLTASDRALH DHCYVHINIT DANTHRPVFQ 
       860        870        880        890        900
SAHYSVSMNE DRPVGSTVVV ISASDDDVGE NARITYLLED NLPQFRIDAD 
       910        920        930        940        950
SGAITLQAPL DYEDQVTYTL AITARDNGIP QKADTTYVEV MVNDVNDNAP 
       960        970        980        990       1000
QFVASHYTGL VSEDAPPFTS VLQISATDRD AHANGRVQYT FQNGEDGDGD 
      1010       1020       1030       1040       1050
FTIEPTSGIV RTVRRLDREA VPVYELTAYA VDRGVPPLRT PVSIQVTVQD 
      1060       1070       1080       1090       1100
VNDNAPVFPA EEFEVRVKEN SIVGSVVAQI TAVDPDDGPN AHIMYQIVEG 
      1110       1120       1130       1140       1150
NIPELFQMDI FSGELTALID LDYEARQEYV IVVQATSAPL VSRATVHVRL 
      1160       1170       1180       1190       1200
VDQNDNSPVL NNFQILFNNY VSNRSDTFPS GIIGRIPAYD PDVSDHLFYS 
      1210       1220       1230       1240       1250
FERGNELQLL VVNRTSGELR LSRKLDNNRP LVASMLVTVT DGLHSVTAQC 
      1260       1270       1280       1290       1300
VLRVVIITEE LLANSLTVRL ENMWQERFLS PLLGHFLEGV AAVLATPTED 
      1310       1320       1330       1340       1350
VFIFNIQNDT DVGGTVLNVS FSALAPRGAG AGAAGPWFSS EELQEQLYVR 
      1360       1370       1380       1390       1400
RAALAARSLL DVLPFDDNVC LREPCENYMK CVSVLRFDSS APFLASTSTL 
      1410       1420       1430       1440       1450
FRPIQPIAGL RCRCPPGFTG DFCETELDLC YSNPCRNGGA CARREGGYTC 
      1460       1470       1480       1490       1500
VCRPRFTDCE LDTEAGRCVP GVCRNGGTCT NAPNGGFRCQ CPAGGAFEGP 
      1510       1520       1530       1540       1550
RCEVAARSFP PSSFVMFRGL RQRFHLTLSL SFATVQPSGL LFYNGRLNEK 
      1560       1570       1580       1590       1600
HDFLALELVA GQVRLTYSTG ESNTVVSPTV PGGLSDGQWH TVHLRYYNKP 
      1610       1620       1630       1640       1650
RTDALGGAQG PSKDKVAVLS VDDCNVAVAL QFGAEIGNYS CAAAGVQTSS 
      1660       1670       1680       1690       1700
KKSLDLTGPL LLGGVPNLPE NFPVSHKDFI GCMRDLHIDG RRMDMAAFVA 
      1710       1720       1730       1740       1750
NNGTMAGCQA KSHFCASGPC KNNGFCSERW GGFSCDCPVG FGGKDCRLTM 
      1760       1770       1780       1790       1800
AHPYHFQGNG TLSWDFGNDM AVSVPWYLGL SFRTRATKGI LMQVQLGPHS 
      1810       1820       1830       1840       1850
VLLCKLDRGL LSVTLNRASG HTVHLLLDQM TVSDGRWHDL RLELQEEPGG 
      1860       1870       1880       1890       1900
RRGHHIFMVS LDFTLFQDTM AMGGELQGLK VKQLHVGGLP PSSKEEGHQG 
      1910       1920       1930       1940       1950
LVGCIQGVWI GFTPFGSSAL LPPSHRVNVE PGCTVTNPCA SGPCPPHADC 
      1960       1970       1980       1990       2000
KDLWQTFSCT CRPGYYGPGC VDACLLNPCQ NQGSCRHLQG APHGYTCDCV 
      2010       2020       2030       2040       2050
SGYFGQHCEH RVDQQCPRGW WGSPTCGPCN CDVHKGFDPN CNKTNGQCHC 
      2060       2070       2080       2090       2100
KEFHYRPRGS DSCLPCDCYP VGSTSRSCAP HSGQCPCRPG ALGRQCNSCD 
      2110       2120       2130       2140       2150
SPFAEVTASG CRVLYDACPK SLRSGVWWPQ TKFGVLATVP CPRGALGAAV 
      2160       2170       2180       2190       2200
RLCDEDQGWL EPDLFNCTSP AFRELSLLLD GLELNKTALD TVEAKKLAQR 
      2210       2220       2230       2240       2250
LREVTGQTDH YFSQDVRVTA RLLAYLLAFE SHQQGFGLTA TQDAHFNENL 
      2260       2270       2280       2290       2300
LWAGSALLAP ETGHLWAALG QRAPGGSPGS AGLVQHLEEY AATLARNMEL 
      2310       2320       2330       2340       2350
TYLNPVGLVT PNIMLSIDRM EHPSSTQGAR RYPRYHSNLF RGQDAWDPHT 
      2360       2370       2380       2390       2400
HVLLPSQASQ PSPSEVLPTS SNAENATASS VVSPPAPLEP ESEPGISIVI 
      2410       2420       2430       2440       2450
LLVYRALGGL LPAQFQAERR GARLPQNPVM NSPVVSVAVF HGRNFLRGVL 
      2460       2470       2480       2490       2500
VSPINLEFRL LQTANRSKAI CVQWDPPGPT DQHGMWTARD CELVHRNGSH 
      2510       2520       2530       2540       2550
ARCRCSRTGT FGVLMDASPR ERLEGDLELL AVFTHVVVAV SVTALVLTAA 
      2560       2570       2580       2590       2600
VLLSLRSLKS NVRGIHANVA AALGVAELLF LLGIHRTHNQ LLCTAVAILL 
      2610       2620       2630       2640       2650
HYFFLSTFAW LLVQGLHLYR MQVEPRNVDR GAMRFYHALG WGVPAVLLGL 
      2660       2670       2680       2690       2700
AVGLDPEGYG NPDFCWISIH EPLIWSFAGP IVLVIVMNGT MFLLAARTSC 
      2710       2720       2730       2740       2750
STGQREAKKT SVLTLRSSFL LLLLVSASWL FGLLAVNHSI LAFHYLHAGL 
      2760       2770       2780       2790       2800
CGLQGLAVLL LFCVLNADAR AAWTPACLGK KAAPEETRPA PGPGSGAYNN 
      2810       2820       2830       2840       2850
TALFEESGLI RITLGASTVS SVSSARSGRA QDQDSQRGRS YLRDNVLVRH 
      2860       2870       2880       2890       2900
GSTAEHTERS LQAHAGPTDL DVAMFHRDAG ADSDSDSDLS LEEERSLSIP 
      2910       2920       2930       2940       2950
SSESEDNGRT RGRFQRPLRR AAQSERLLAH PKDVDGNDLL SYWPALGECE 
      2960       2970       2980       2990       3000
AAPCALQAWG SERRLGLDSN KDAANNNQPE LALTSGDETS LGRAQRQRKG 
      3010       3020       3030       3040       3050
ILKNRLQYPL VPQSRGTPEL SWCRAATLGH RAVPAASYGR IYAGGGTGSL 
      3060       3070       3080       3090       3100
SQPASRYSSR EQLDLLLRRQ LSKERLEEVP VPAPVLHPLS RPGSQERLDT 
      3110       3120       3130       3140       3150
APARLEARDR GSTLPRRQPP RDYPGTMAGR FGSRDALDLG APREWLSTLP 
      3160       3170       3180       3190       3200
PPRRNRDLDP QHPPLPLSPQ RQLSRDPLLP SRPLDSLSRI SNSREGLDQV 
      3210       3220       3230       3240       3250
PSRHPSREAL GPAPQLLRAR EDPASGPSHG PSTEQLDILS SILASFNSSA 
      3260       3270       3280       3290       3300
LSSVQSSSTP SGPHTTATAS ALGPSTPRSA TSHSISELSP DSEVPRSEGH 

S
Length:3,301
Mass (Da):358,478
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29EA6A0D1E5A75AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SUG9A0A1L1SUG9_MOUSE
Cadherin EGF LAG seven-pass G-type ...
Celsr3
3,309Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YX12A0A0A6YX12_MOUSE
Cadherin EGF LAG seven-pass G-type ...
Celsr3
472Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YW76A0A0A6YW76_MOUSE
Cadherin EGF LAG seven-pass G-type ...
Celsr3
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG17057 differs from that shown. Reason: Frameshift at positions 2575 and 2578.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti221D → E in AAL25099 (PubMed:11850187).Curated1
Sequence conflicti537S → G in AAL25099 (PubMed:11850187).Curated1
Sequence conflicti2713L → LR in AAG17057 (PubMed:11677057).Curated1
Sequence conflicti3024R → P in AAG17057 (PubMed:11677057).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF427498 mRNA Translation: AAL25099.1
AC168054 Genomic DNA No translation available.
AF188752 mRNA Translation: AAG17057.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS23539.1

NCBI Reference Sequences

More...RefSeqi		NP_536685.2, NM_080437.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000024238; ENSMUSP00000024238; ENSMUSG00000023473
ENSMUST00000201574; ENSMUSP00000144254; ENSMUSG00000107269

Database of genes from NCBI RefSeq genomes

More...GeneIDi		107934

UCSC genome browser

More...UCSCi		uc009rrb.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF427498 mRNA Translation: AAL25099.1
AC168054 Genomic DNA No translation available.
AF188752 mRNA Translation: AAG17057.1 Frameshift.
CCDSiCCDS23539.1
RefSeqiNP_536685.2, NM_080437.2

3D structure databases

SMRiQ91ZI0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91ZI0, 1 interactor
STRINGi10090.ENSMUSP00000024238

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiQ91ZI0
PhosphoSitePlusiQ91ZI0

Proteomic databases

MaxQBiQ91ZI0
PaxDbiQ91ZI0
PRIDEiQ91ZI0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024238; ENSMUSP00000024238; ENSMUSG00000023473
ENSMUST00000201574; ENSMUSP00000144254; ENSMUSG00000107269
GeneIDi107934
UCSCiuc009rrb.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1951
MGIiMGI:1858236 Celsr3

Phylogenomic databases

eggNOGiKOG4289 Eukaryota
ENOG410XTGH LUCA
GeneTreeiENSGT00940000160077
HOGENOMiHOG000231346
InParanoidiQ91ZI0
OrthoDBi23882at2759
TreeFamiTF323983

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q91ZI0

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000023473 Expressed in 84 organ(s), highest expression level in olfactory bulb
ExpressionAtlasiQ91ZI0 baseline and differential
GenevisibleiQ91ZI0 MM

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 8 hits
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELR3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91ZI0
Secondary accession number(s): E9QLD7, Q9ESD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: July 27, 2011
Last modified: June 5, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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