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UniProtKB - Q91ZI0 (CELR3_MOUSE)
Protein
Cadherin EGF LAG seven-pass G-type receptor 3
Gene
Celsr3
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor that may have an important role in cell/cell signaling during nervous system formation.
GO - Molecular functioni
- calcium ion binding Source: InterPro
- G protein-coupled receptor activity Source: UniProtKB-KW
GO - Biological processi
- axonal fasciculation Source: MGI
- cell-cell adhesion Source: GO_Central
- cilium assembly Source: MGI
- dopaminergic neuron axon guidance Source: ParkinsonsUK-UCL
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- neuron migration Source: MGI
- planar cell polarity pathway involved in axon guidance Source: ParkinsonsUK-UCL
- regulation of protein localization Source: MGI
- regulation of protein phosphorylation Source: MGI
- serotonergic neuron axon guidance Source: ParkinsonsUK-UCL
Keywordsi
Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin EGF LAG seven-pass G-type receptor 3 |
Gene namesi | Name:Celsr3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1858236, Celsr3 |
VEuPathDBi | HostDB:ENSMUSG00000023473 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 2531 | ExtracellularSequence analysisAdd BLAST | 2500 | |
Transmembranei | 2532 – 2552 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2553 – 2563 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 2564 – 2584 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2585 – 2592 | ExtracellularSequence analysis | 8 | |
Transmembranei | 2593 – 2613 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2614 – 2634 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 2635 – 2655 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2656 – 2673 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 2674 – 2694 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2695 – 2716 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 2717 – 2737 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2738 – 2744 | ExtracellularSequence analysis | 7 | |
Transmembranei | 2745 – 2765 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 2766 – 3301 | CytoplasmicSequence analysisAdd BLAST | 536 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000012919 | 32 – 3301 | Cadherin EGF LAG seven-pass G-type receptor 3Add BLAST | 3270 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 623 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 838 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1173 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1213 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1308 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1318 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1370 ↔ 1381 | By similarity | ||
Disulfide bondi | 1375 ↔ 1412 | By similarity | ||
Disulfide bondi | 1414 ↔ 1423 | By similarity | ||
Disulfide bondi | 1430 ↔ 1441 | By similarity | ||
Disulfide bondi | 1435 ↔ 1450 | By similarity | ||
Disulfide bondi | 1452 ↔ 1459 | By similarity | ||
Disulfide bondi | 1468 ↔ 1479 | By similarity | ||
Disulfide bondi | 1473 ↔ 1489 | By similarity | ||
Disulfide bondi | 1491 ↔ 1502 | By similarity | ||
Glycosylationi | 1638 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1682 ↔ 1708 | By similarity | ||
Glycosylationi | 1702 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1715 ↔ 1726 | By similarity | ||
Disulfide bondi | 1720 ↔ 1735 | By similarity | ||
Disulfide bondi | 1737 ↔ 1746 | By similarity | ||
Glycosylationi | 1759 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1904 ↔ 1933 | By similarity | ||
Disulfide bondi | 1939 ↔ 1950 | By similarity | ||
Disulfide bondi | 1944 ↔ 1959 | By similarity | ||
Modified residuei | 1952 | (3R)-3-hydroxyaspartateSequence analysis | 1 | |
Disulfide bondi | 1961 ↔ 1970 | By similarity | ||
Disulfide bondi | 1974 ↔ 1985 | By similarity | ||
Disulfide bondi | 1979 ↔ 1997 | By similarity | ||
Disulfide bondi | 1999 ↔ 2008 | By similarity | ||
Disulfide bondi | 2016 ↔ 2029 | By similarity | ||
Disulfide bondi | 2031 ↔ 2041 | By similarity | ||
Glycosylationi | 2042 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 2048 ↔ 2063 | By similarity | ||
Disulfide bondi | 2050 ↔ 2066 | By similarity | ||
Disulfide bondi | 2068 ↔ 2078 | By similarity | ||
Disulfide bondi | 2087 ↔ 2096 | By similarity | ||
Disulfide bondi | 2099 ↔ 2111 | By similarity | ||
Modified residuei | 2115 | PhosphotyrosineBy similarity | 1 | |
Glycosylationi | 2166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2185 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2375 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2465 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2497 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 3042 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 3090 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Hydroxylation, PhosphoproteinProteomic databases
MaxQBi | Q91ZI0 |
PaxDbi | Q91ZI0 |
PRIDEi | Q91ZI0 |
ProteomicsDBi | 281580 |
PTM databases
GlyGeni | Q91ZI0, 15 sites |
iPTMneti | Q91ZI0 |
PhosphoSitePlusi | Q91ZI0 |
Expressioni
Tissue specificityi
Expressed in the CNS and in the eye.1 Publication
Developmental stagei
Predominantly expressed in the CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. No expression is detected until somite stages. Between 10 and 12 dpc, expression is strong in the marginal zone (MZ), and lower in the ventricular zone (VZ). At 15 dpc, expression is restricted to the brain and olfactory epithelium. In the brain, it is low in VZ but strong in external fields, particularly those with ongoing migration, such as the telencephalic cortical plate, the olfactory bulb, the cerebellum and the tectum. In the newborn and postnatal stages, expression is high in differentiated neuronal fields.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000023473, Expressed in olfactory bulb and 122 other tissues |
ExpressionAtlasi | Q91ZI0, baseline and differential |
Genevisiblei | Q91ZI0, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 223701, 1 interactor |
IntActi | Q91ZI0, 1 interactor |
STRINGi | 10090.ENSMUSP00000024238 |
Miscellaneous databases
RNActi | Q91ZI0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 317 – 424 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 425 – 536 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 537 – 642 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 643 – 747 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 748 – 849 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 850 – 952 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 953 – 1058 | Cadherin 7PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 1059 – 1160 | Cadherin 8PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 1161 – 1257 | Cadherin 9PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 1366 – 1424 | EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 1426 – 1460 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 1464 – 1503 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 1504 – 1708 | Laminin G-like 1PROSITE-ProRule annotationAdd BLAST | 205 | |
Domaini | 1711 – 1747 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1751 – 1933 | Laminin G-like 2PROSITE-ProRule annotationAdd BLAST | 183 | |
Domaini | 1935 – 1971 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1972 – 2002 | EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 31 | |
Domaini | 2003 – 2042 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 2044 – 2079 | EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 2066 – 2113 | Laminin EGF-likePROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 2468 – 2520 | GPSPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 148 – 189 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 202 – 314 | DisorderedSequence analysisAdd BLAST | 113 | |
Regioni | 2353 – 2388 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 2823 – 2844 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 2879 – 2919 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 2969 – 2992 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 3083 – 3301 | DisorderedSequence analysisAdd BLAST | 219 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2353 – 2382 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 2970 – 2991 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 3101 – 3116 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 3185 – 3199 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 3228 – 3291 | Polar residuesSequence analysisAdd BLAST | 64 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4289, Eukaryota |
GeneTreei | ENSGT00940000160077 |
HOGENOMi | CLU_000158_1_0_1 |
InParanoidi | Q91ZI0 |
OrthoDBi | 23882at2759 |
PhylomeDBi | Q91ZI0 |
TreeFami | TF323983 |
Family and domain databases
CDDi | cd00055, EGF_Lam, 2 hits cd00110, LamG, 2 hits |
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR032471, GAIN_dom_N IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR001791, Laminin_G IPR002049, LE_dom |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00028, Cadherin, 8 hits PF00008, EGF, 2 hits PF16489, GAIN, 1 hit PF00053, Laminin_EGF, 1 hit PF02210, Laminin_G_2, 2 hits |
PRINTSi | PR00205, CADHERIN PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00112, CA, 9 hits SM00181, EGF, 6 hits SM00179, EGF_CA, 5 hits SM00180, EGF_Lam, 1 hit SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00282, LamG, 2 hits |
SUPFAMi | SSF49313, SSF49313, 9 hits SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00232, CADHERIN_1, 7 hits PS50268, CADHERIN_2, 8 hits PS00022, EGF_1, 5 hits PS01186, EGF_2, 4 hits PS50026, EGF_3, 6 hits PS01248, EGF_LAM_1, 1 hit PS50027, EGF_LAM_2, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS50025, LAM_G_DOMAIN, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q91ZI0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARRPLWWGL PGPSTPVLLL LLLSLFPFSR EELGGGGDQD WDPGVATTTG
60 70 80 90 100
PRAQIGSGAV ALCPESPGVW EDGDPGLGVR EPVFMRLRVG RQNARNGRGA
110 120 130 140 150
PEQPNAEVVV QALGSREQEA GQGPGYLLCW HPEISSCGRT GPLRRGSLPL
160 170 180 190 200
DALSPGDSDL RNSSPHPSEL LAQPDGSRPV AFQRNARRSI RKRVETSRCC
210 220 230 240 250
GKLWEPGHKG QGERSATSTV DRGPFRRDCL PGSLGSGLGE DSAPRAVRTA
260 270 280 290 300
PTPGSAPRES RTAPGRMRSR GLFRRRFLFE RPGPRPPGFP TGPEAKQILS
310 320 330 340 350
TNQARPRRAA NRHPQFPQYN YQTLVPENEA AGTSVLRVVA QDPDPGEAGR
360 370 380 390 400
LIYSLAALMN SRSLELFSID PQSGLIRTAA ALDRESMERH YLRVTAQDHG
410 420 430 440 450
SPRLSATTMV AVTVADRNDH APVFEQAQYR ETLRENVEEG YPILQLRATD
460 470 480 490 500
GDAPPNANLR YRFVGSPAVR TAAAAAFEID PRSGLISTSG RVDREHMESY
510 520 530 540 550
ELVVEASDQG QEPGPRSATV RVHITVLDEN DNAPQFSEKR YVAQVREDVR
560 570 580 590 600
PHTVVLRVTA TDKDKDANGL VHYNIISGNS RGHFAIDSLT GEIQVMAPLD
610 620 630 640 650
FEAEREYALR IRAQDAGRPP LSNNTGLASI QVVDINDHAP IFVSTPFQVS
660 670 680 690 700
VLENAPLGHS VIHIQAVDAD HGENSRLEYS LTGVASDTPF VINSATGWVS
710 720 730 740 750
VSGPLDRESV EHYFFGVEAR DHGSPPLSAS ASVTVTVLDV NDNRPEFTMK
760 770 780 790 800
EYHLRLNEDA AVGTSVVSVT AVDRDANSAI SYQITGGNTR NRFAISTQGG
810 820 830 840 850
VGLVTLALPL DYKQERYFKL VLTASDRALH DHCYVHINIT DANTHRPVFQ
860 870 880 890 900
SAHYSVSMNE DRPVGSTVVV ISASDDDVGE NARITYLLED NLPQFRIDAD
910 920 930 940 950
SGAITLQAPL DYEDQVTYTL AITARDNGIP QKADTTYVEV MVNDVNDNAP
960 970 980 990 1000
QFVASHYTGL VSEDAPPFTS VLQISATDRD AHANGRVQYT FQNGEDGDGD
1010 1020 1030 1040 1050
FTIEPTSGIV RTVRRLDREA VPVYELTAYA VDRGVPPLRT PVSIQVTVQD
1060 1070 1080 1090 1100
VNDNAPVFPA EEFEVRVKEN SIVGSVVAQI TAVDPDDGPN AHIMYQIVEG
1110 1120 1130 1140 1150
NIPELFQMDI FSGELTALID LDYEARQEYV IVVQATSAPL VSRATVHVRL
1160 1170 1180 1190 1200
VDQNDNSPVL NNFQILFNNY VSNRSDTFPS GIIGRIPAYD PDVSDHLFYS
1210 1220 1230 1240 1250
FERGNELQLL VVNRTSGELR LSRKLDNNRP LVASMLVTVT DGLHSVTAQC
1260 1270 1280 1290 1300
VLRVVIITEE LLANSLTVRL ENMWQERFLS PLLGHFLEGV AAVLATPTED
1310 1320 1330 1340 1350
VFIFNIQNDT DVGGTVLNVS FSALAPRGAG AGAAGPWFSS EELQEQLYVR
1360 1370 1380 1390 1400
RAALAARSLL DVLPFDDNVC LREPCENYMK CVSVLRFDSS APFLASTSTL
1410 1420 1430 1440 1450
FRPIQPIAGL RCRCPPGFTG DFCETELDLC YSNPCRNGGA CARREGGYTC
1460 1470 1480 1490 1500
VCRPRFTDCE LDTEAGRCVP GVCRNGGTCT NAPNGGFRCQ CPAGGAFEGP
1510 1520 1530 1540 1550
RCEVAARSFP PSSFVMFRGL RQRFHLTLSL SFATVQPSGL LFYNGRLNEK
1560 1570 1580 1590 1600
HDFLALELVA GQVRLTYSTG ESNTVVSPTV PGGLSDGQWH TVHLRYYNKP
1610 1620 1630 1640 1650
RTDALGGAQG PSKDKVAVLS VDDCNVAVAL QFGAEIGNYS CAAAGVQTSS
1660 1670 1680 1690 1700
KKSLDLTGPL LLGGVPNLPE NFPVSHKDFI GCMRDLHIDG RRMDMAAFVA
1710 1720 1730 1740 1750
NNGTMAGCQA KSHFCASGPC KNNGFCSERW GGFSCDCPVG FGGKDCRLTM
1760 1770 1780 1790 1800
AHPYHFQGNG TLSWDFGNDM AVSVPWYLGL SFRTRATKGI LMQVQLGPHS
1810 1820 1830 1840 1850
VLLCKLDRGL LSVTLNRASG HTVHLLLDQM TVSDGRWHDL RLELQEEPGG
1860 1870 1880 1890 1900
RRGHHIFMVS LDFTLFQDTM AMGGELQGLK VKQLHVGGLP PSSKEEGHQG
1910 1920 1930 1940 1950
LVGCIQGVWI GFTPFGSSAL LPPSHRVNVE PGCTVTNPCA SGPCPPHADC
1960 1970 1980 1990 2000
KDLWQTFSCT CRPGYYGPGC VDACLLNPCQ NQGSCRHLQG APHGYTCDCV
2010 2020 2030 2040 2050
SGYFGQHCEH RVDQQCPRGW WGSPTCGPCN CDVHKGFDPN CNKTNGQCHC
2060 2070 2080 2090 2100
KEFHYRPRGS DSCLPCDCYP VGSTSRSCAP HSGQCPCRPG ALGRQCNSCD
2110 2120 2130 2140 2150
SPFAEVTASG CRVLYDACPK SLRSGVWWPQ TKFGVLATVP CPRGALGAAV
2160 2170 2180 2190 2200
RLCDEDQGWL EPDLFNCTSP AFRELSLLLD GLELNKTALD TVEAKKLAQR
2210 2220 2230 2240 2250
LREVTGQTDH YFSQDVRVTA RLLAYLLAFE SHQQGFGLTA TQDAHFNENL
2260 2270 2280 2290 2300
LWAGSALLAP ETGHLWAALG QRAPGGSPGS AGLVQHLEEY AATLARNMEL
2310 2320 2330 2340 2350
TYLNPVGLVT PNIMLSIDRM EHPSSTQGAR RYPRYHSNLF RGQDAWDPHT
2360 2370 2380 2390 2400
HVLLPSQASQ PSPSEVLPTS SNAENATASS VVSPPAPLEP ESEPGISIVI
2410 2420 2430 2440 2450
LLVYRALGGL LPAQFQAERR GARLPQNPVM NSPVVSVAVF HGRNFLRGVL
2460 2470 2480 2490 2500
VSPINLEFRL LQTANRSKAI CVQWDPPGPT DQHGMWTARD CELVHRNGSH
2510 2520 2530 2540 2550
ARCRCSRTGT FGVLMDASPR ERLEGDLELL AVFTHVVVAV SVTALVLTAA
2560 2570 2580 2590 2600
VLLSLRSLKS NVRGIHANVA AALGVAELLF LLGIHRTHNQ LLCTAVAILL
2610 2620 2630 2640 2650
HYFFLSTFAW LLVQGLHLYR MQVEPRNVDR GAMRFYHALG WGVPAVLLGL
2660 2670 2680 2690 2700
AVGLDPEGYG NPDFCWISIH EPLIWSFAGP IVLVIVMNGT MFLLAARTSC
2710 2720 2730 2740 2750
STGQREAKKT SVLTLRSSFL LLLLVSASWL FGLLAVNHSI LAFHYLHAGL
2760 2770 2780 2790 2800
CGLQGLAVLL LFCVLNADAR AAWTPACLGK KAAPEETRPA PGPGSGAYNN
2810 2820 2830 2840 2850
TALFEESGLI RITLGASTVS SVSSARSGRA QDQDSQRGRS YLRDNVLVRH
2860 2870 2880 2890 2900
GSTAEHTERS LQAHAGPTDL DVAMFHRDAG ADSDSDSDLS LEEERSLSIP
2910 2920 2930 2940 2950
SSESEDNGRT RGRFQRPLRR AAQSERLLAH PKDVDGNDLL SYWPALGECE
2960 2970 2980 2990 3000
AAPCALQAWG SERRLGLDSN KDAANNNQPE LALTSGDETS LGRAQRQRKG
3010 3020 3030 3040 3050
ILKNRLQYPL VPQSRGTPEL SWCRAATLGH RAVPAASYGR IYAGGGTGSL
3060 3070 3080 3090 3100
SQPASRYSSR EQLDLLLRRQ LSKERLEEVP VPAPVLHPLS RPGSQERLDT
3110 3120 3130 3140 3150
APARLEARDR GSTLPRRQPP RDYPGTMAGR FGSRDALDLG APREWLSTLP
3160 3170 3180 3190 3200
PPRRNRDLDP QHPPLPLSPQ RQLSRDPLLP SRPLDSLSRI SNSREGLDQV
3210 3220 3230 3240 3250
PSRHPSREAL GPAPQLLRAR EDPASGPSHG PSTEQLDILS SILASFNSSA
3260 3270 3280 3290 3300
LSSVQSSSTP SGPHTTATAS ALGPSTPRSA TSHSISELSP DSEVPRSEGH
S
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SUG9 | A0A1L1SUG9_MOUSE | Cadherin EGF LAG seven-pass G-type ... | Celsr3 | 3,309 | Annotation score: | ||
A0A0A6YX12 | A0A0A6YX12_MOUSE | Cadherin EGF LAG seven-pass G-type ... | Celsr3 | 472 | Annotation score: | ||
A0A0A6YW76 | A0A0A6YW76_MOUSE | Cadherin EGF LAG seven-pass G-type ... | Celsr3 | 240 | Annotation score: |
Sequence cautioni
The sequence AAG17057 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 221 | D → E in AAL25099 (PubMed:11850187).Curated | 1 | |
Sequence conflicti | 537 | S → G in AAL25099 (PubMed:11850187).Curated | 1 | |
Sequence conflicti | 2713 | L → LR in AAG17057 (PubMed:11677057).Curated | 1 | |
Sequence conflicti | 3024 | R → P in AAG17057 (PubMed:11677057).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF427498 mRNA Translation: AAL25099.1 AC168054 Genomic DNA No translation available. AF188752 mRNA Translation: AAG17057.1 Frameshift. |
RefSeqi | NP_536685.2, NM_080437.2 |
Genome annotation databases
Ensembli | ENSMUST00000024238; ENSMUSP00000024238; ENSMUSG00000023473 |
GeneIDi | 107934 |
KEGGi | mmu:107934 |
UCSCi | uc009rrb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF427498 mRNA Translation: AAL25099.1 AC168054 Genomic DNA No translation available. AF188752 mRNA Translation: AAG17057.1 Frameshift. |
RefSeqi | NP_536685.2, NM_080437.2 |
3D structure databases
SMRi | Q91ZI0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 223701, 1 interactor |
IntActi | Q91ZI0, 1 interactor |
STRINGi | 10090.ENSMUSP00000024238 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q91ZI0, 15 sites |
iPTMneti | Q91ZI0 |
PhosphoSitePlusi | Q91ZI0 |
Proteomic databases
MaxQBi | Q91ZI0 |
PaxDbi | Q91ZI0 |
PRIDEi | Q91ZI0 |
ProteomicsDBi | 281580 |
Protocols and materials databases
Antibodypediai | 13269, 315 antibodies from 32 providers |
DNASUi | 107934 |
Genome annotation databases
Ensembli | ENSMUST00000024238; ENSMUSP00000024238; ENSMUSG00000023473 |
GeneIDi | 107934 |
KEGGi | mmu:107934 |
UCSCi | uc009rrb.1, mouse |
Organism-specific databases
CTDi | 1951 |
MGIi | MGI:1858236, Celsr3 |
VEuPathDBi | HostDB:ENSMUSG00000023473 |
Phylogenomic databases
eggNOGi | KOG4289, Eukaryota |
GeneTreei | ENSGT00940000160077 |
HOGENOMi | CLU_000158_1_0_1 |
InParanoidi | Q91ZI0 |
OrthoDBi | 23882at2759 |
PhylomeDBi | Q91ZI0 |
TreeFami | TF323983 |
Miscellaneous databases
BioGRID-ORCSi | 107934, 2 hits in 65 CRISPR screens |
PROi | PR:Q91ZI0 |
RNActi | Q91ZI0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023473, Expressed in olfactory bulb and 122 other tissues |
ExpressionAtlasi | Q91ZI0, baseline and differential |
Genevisiblei | Q91ZI0, MM |
Family and domain databases
CDDi | cd00055, EGF_Lam, 2 hits cd00110, LamG, 2 hits |
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR032471, GAIN_dom_N IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR001791, Laminin_G IPR002049, LE_dom |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00028, Cadherin, 8 hits PF00008, EGF, 2 hits PF16489, GAIN, 1 hit PF00053, Laminin_EGF, 1 hit PF02210, Laminin_G_2, 2 hits |
PRINTSi | PR00205, CADHERIN PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00112, CA, 9 hits SM00181, EGF, 6 hits SM00179, EGF_CA, 5 hits SM00180, EGF_Lam, 1 hit SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00282, LamG, 2 hits |
SUPFAMi | SSF49313, SSF49313, 9 hits SSF49899, SSF49899, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00232, CADHERIN_1, 7 hits PS50268, CADHERIN_2, 8 hits PS00022, EGF_1, 5 hits PS01186, EGF_2, 4 hits PS50026, EGF_3, 6 hits PS01248, EGF_LAM_1, 1 hit PS50027, EGF_LAM_2, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS50025, LAM_G_DOMAIN, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CELR3_MOUSE | |
Accessioni | Q91ZI0Primary (citable) accession number: Q91ZI0 Secondary accession number(s): E9QLD7, Q9ESD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 2, 2002 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families