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Entry version 161 (16 Oct 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Cadherin EGF LAG seven-pass G-type receptor 3

Gene

Celsr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Celsr3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1858236 Celsr3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 2531ExtracellularSequence analysisAdd BLAST2500
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2532 – 2552Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2553 – 2563CytoplasmicSequence analysisAdd BLAST11
Transmembranei2564 – 2584Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2585 – 2592ExtracellularSequence analysis8
Transmembranei2593 – 2613Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2614 – 2634CytoplasmicSequence analysisAdd BLAST21
Transmembranei2635 – 2655Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2656 – 2673ExtracellularSequence analysisAdd BLAST18
Transmembranei2674 – 2694Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2695 – 2716CytoplasmicSequence analysisAdd BLAST22
Transmembranei2717 – 2737Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2738 – 2744ExtracellularSequence analysis7
Transmembranei2745 – 2765Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2766 – 3301CytoplasmicSequence analysisAdd BLAST536

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001291932 – 3301Cadherin EGF LAG seven-pass G-type receptor 3Add BLAST3270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi623N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi838N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1318N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1370 ↔ 1381By similarity
Disulfide bondi1375 ↔ 1412By similarity
Disulfide bondi1414 ↔ 1423By similarity
Disulfide bondi1430 ↔ 1441By similarity
Disulfide bondi1435 ↔ 1450By similarity
Disulfide bondi1452 ↔ 1459By similarity
Disulfide bondi1468 ↔ 1479By similarity
Disulfide bondi1473 ↔ 1489By similarity
Disulfide bondi1491 ↔ 1502By similarity
Glycosylationi1638N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1682 ↔ 1708By similarity
Glycosylationi1702N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1715 ↔ 1726By similarity
Disulfide bondi1720 ↔ 1735By similarity
Disulfide bondi1737 ↔ 1746By similarity
Glycosylationi1759N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1904 ↔ 1933By similarity
Disulfide bondi1939 ↔ 1950By similarity
Disulfide bondi1944 ↔ 1959By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1952(3R)-3-hydroxyaspartateSequence analysis1
Disulfide bondi1961 ↔ 1970By similarity
Disulfide bondi1974 ↔ 1985By similarity
Disulfide bondi1979 ↔ 1997By similarity
Disulfide bondi1999 ↔ 2008By similarity
Disulfide bondi2016 ↔ 2029By similarity
Disulfide bondi2031 ↔ 2041By similarity
Glycosylationi2042N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2048 ↔ 2063By similarity
Disulfide bondi2050 ↔ 2066By similarity
Disulfide bondi2068 ↔ 2078By similarity
Disulfide bondi2087 ↔ 2096By similarity
Disulfide bondi2099 ↔ 2111By similarity
Modified residuei2115PhosphotyrosineBy similarity1
Glycosylationi2166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2185N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2497N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei3042PhosphotyrosineBy similarity1
Modified residuei3090PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q91ZI0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q91ZI0

PRoteomics IDEntifications database

More...
PRIDEi
Q91ZI0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q91ZI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91ZI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the CNS and in the eye.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Predominantly expressed in the CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. No expression is detected until somite stages. Between 10 and 12 dpc, expression is strong in the marginal zone (MZ), and lower in the ventricular zone (VZ). At 15 dpc, expression is restricted to the brain and olfactory epithelium. In the brain, it is low in VZ but strong in external fields, particularly those with ongoing migration, such as the telencephalic cortical plate, the olfactory bulb, the cerebellum and the tectum. In the newborn and postnatal stages, expression is high in differentiated neuronal fields.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023473 Expressed in 84 organ(s), highest expression level in olfactory bulb

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q91ZI0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q91ZI0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q91ZI0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000024238

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q91ZI0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini317 – 424Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini425 – 536Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini537 – 642Cadherin 3PROSITE-ProRule annotationAdd BLAST106
Domaini643 – 747Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini748 – 849Cadherin 5PROSITE-ProRule annotationAdd BLAST102
Domaini850 – 952Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini953 – 1058Cadherin 7PROSITE-ProRule annotationAdd BLAST106
Domaini1059 – 1160Cadherin 8PROSITE-ProRule annotationAdd BLAST102
Domaini1161 – 1257Cadherin 9PROSITE-ProRule annotationAdd BLAST97
Domaini1366 – 1424EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST59
Domaini1426 – 1460EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST35
Domaini1464 – 1503EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1504 – 1708Laminin G-like 1PROSITE-ProRule annotationAdd BLAST205
Domaini1711 – 1747EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1751 – 1933Laminin G-like 2PROSITE-ProRule annotationAdd BLAST183
Domaini1935 – 1971EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1972 – 2002EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST31
Domaini2003 – 2042EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini2044 – 2079EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini2066 – 2113Laminin EGF-likePROSITE-ProRule annotationAdd BLAST48
Domaini2468 – 2520GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2720 – 2724Poly-Leu5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4289 Eukaryota
ENOG410XTGH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160077

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231346

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q91ZI0

KEGG Orthology (KO)

More...
KOi
K04602

Database of Orthologous Groups

More...
OrthoDBi
23882at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323983

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 8 hits
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q91ZI0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRPLWWGL PGPSTPVLLL LLLSLFPFSR EELGGGGDQD WDPGVATTTG
60 70 80 90 100
PRAQIGSGAV ALCPESPGVW EDGDPGLGVR EPVFMRLRVG RQNARNGRGA
110 120 130 140 150
PEQPNAEVVV QALGSREQEA GQGPGYLLCW HPEISSCGRT GPLRRGSLPL
160 170 180 190 200
DALSPGDSDL RNSSPHPSEL LAQPDGSRPV AFQRNARRSI RKRVETSRCC
210 220 230 240 250
GKLWEPGHKG QGERSATSTV DRGPFRRDCL PGSLGSGLGE DSAPRAVRTA
260 270 280 290 300
PTPGSAPRES RTAPGRMRSR GLFRRRFLFE RPGPRPPGFP TGPEAKQILS
310 320 330 340 350
TNQARPRRAA NRHPQFPQYN YQTLVPENEA AGTSVLRVVA QDPDPGEAGR
360 370 380 390 400
LIYSLAALMN SRSLELFSID PQSGLIRTAA ALDRESMERH YLRVTAQDHG
410 420 430 440 450
SPRLSATTMV AVTVADRNDH APVFEQAQYR ETLRENVEEG YPILQLRATD
460 470 480 490 500
GDAPPNANLR YRFVGSPAVR TAAAAAFEID PRSGLISTSG RVDREHMESY
510 520 530 540 550
ELVVEASDQG QEPGPRSATV RVHITVLDEN DNAPQFSEKR YVAQVREDVR
560 570 580 590 600
PHTVVLRVTA TDKDKDANGL VHYNIISGNS RGHFAIDSLT GEIQVMAPLD
610 620 630 640 650
FEAEREYALR IRAQDAGRPP LSNNTGLASI QVVDINDHAP IFVSTPFQVS
660 670 680 690 700
VLENAPLGHS VIHIQAVDAD HGENSRLEYS LTGVASDTPF VINSATGWVS
710 720 730 740 750
VSGPLDRESV EHYFFGVEAR DHGSPPLSAS ASVTVTVLDV NDNRPEFTMK
760 770 780 790 800
EYHLRLNEDA AVGTSVVSVT AVDRDANSAI SYQITGGNTR NRFAISTQGG
810 820 830 840 850
VGLVTLALPL DYKQERYFKL VLTASDRALH DHCYVHINIT DANTHRPVFQ
860 870 880 890 900
SAHYSVSMNE DRPVGSTVVV ISASDDDVGE NARITYLLED NLPQFRIDAD
910 920 930 940 950
SGAITLQAPL DYEDQVTYTL AITARDNGIP QKADTTYVEV MVNDVNDNAP
960 970 980 990 1000
QFVASHYTGL VSEDAPPFTS VLQISATDRD AHANGRVQYT FQNGEDGDGD
1010 1020 1030 1040 1050
FTIEPTSGIV RTVRRLDREA VPVYELTAYA VDRGVPPLRT PVSIQVTVQD
1060 1070 1080 1090 1100
VNDNAPVFPA EEFEVRVKEN SIVGSVVAQI TAVDPDDGPN AHIMYQIVEG
1110 1120 1130 1140 1150
NIPELFQMDI FSGELTALID LDYEARQEYV IVVQATSAPL VSRATVHVRL
1160 1170 1180 1190 1200
VDQNDNSPVL NNFQILFNNY VSNRSDTFPS GIIGRIPAYD PDVSDHLFYS
1210 1220 1230 1240 1250
FERGNELQLL VVNRTSGELR LSRKLDNNRP LVASMLVTVT DGLHSVTAQC
1260 1270 1280 1290 1300
VLRVVIITEE LLANSLTVRL ENMWQERFLS PLLGHFLEGV AAVLATPTED
1310 1320 1330 1340 1350
VFIFNIQNDT DVGGTVLNVS FSALAPRGAG AGAAGPWFSS EELQEQLYVR
1360 1370 1380 1390 1400
RAALAARSLL DVLPFDDNVC LREPCENYMK CVSVLRFDSS APFLASTSTL
1410 1420 1430 1440 1450
FRPIQPIAGL RCRCPPGFTG DFCETELDLC YSNPCRNGGA CARREGGYTC
1460 1470 1480 1490 1500
VCRPRFTDCE LDTEAGRCVP GVCRNGGTCT NAPNGGFRCQ CPAGGAFEGP
1510 1520 1530 1540 1550
RCEVAARSFP PSSFVMFRGL RQRFHLTLSL SFATVQPSGL LFYNGRLNEK
1560 1570 1580 1590 1600
HDFLALELVA GQVRLTYSTG ESNTVVSPTV PGGLSDGQWH TVHLRYYNKP
1610 1620 1630 1640 1650
RTDALGGAQG PSKDKVAVLS VDDCNVAVAL QFGAEIGNYS CAAAGVQTSS
1660 1670 1680 1690 1700
KKSLDLTGPL LLGGVPNLPE NFPVSHKDFI GCMRDLHIDG RRMDMAAFVA
1710 1720 1730 1740 1750
NNGTMAGCQA KSHFCASGPC KNNGFCSERW GGFSCDCPVG FGGKDCRLTM
1760 1770 1780 1790 1800
AHPYHFQGNG TLSWDFGNDM AVSVPWYLGL SFRTRATKGI LMQVQLGPHS
1810 1820 1830 1840 1850
VLLCKLDRGL LSVTLNRASG HTVHLLLDQM TVSDGRWHDL RLELQEEPGG
1860 1870 1880 1890 1900
RRGHHIFMVS LDFTLFQDTM AMGGELQGLK VKQLHVGGLP PSSKEEGHQG
1910 1920 1930 1940 1950
LVGCIQGVWI GFTPFGSSAL LPPSHRVNVE PGCTVTNPCA SGPCPPHADC
1960 1970 1980 1990 2000
KDLWQTFSCT CRPGYYGPGC VDACLLNPCQ NQGSCRHLQG APHGYTCDCV
2010 2020 2030 2040 2050
SGYFGQHCEH RVDQQCPRGW WGSPTCGPCN CDVHKGFDPN CNKTNGQCHC
2060 2070 2080 2090 2100
KEFHYRPRGS DSCLPCDCYP VGSTSRSCAP HSGQCPCRPG ALGRQCNSCD
2110 2120 2130 2140 2150
SPFAEVTASG CRVLYDACPK SLRSGVWWPQ TKFGVLATVP CPRGALGAAV
2160 2170 2180 2190 2200
RLCDEDQGWL EPDLFNCTSP AFRELSLLLD GLELNKTALD TVEAKKLAQR
2210 2220 2230 2240 2250
LREVTGQTDH YFSQDVRVTA RLLAYLLAFE SHQQGFGLTA TQDAHFNENL
2260 2270 2280 2290 2300
LWAGSALLAP ETGHLWAALG QRAPGGSPGS AGLVQHLEEY AATLARNMEL
2310 2320 2330 2340 2350
TYLNPVGLVT PNIMLSIDRM EHPSSTQGAR RYPRYHSNLF RGQDAWDPHT
2360 2370 2380 2390 2400
HVLLPSQASQ PSPSEVLPTS SNAENATASS VVSPPAPLEP ESEPGISIVI
2410 2420 2430 2440 2450
LLVYRALGGL LPAQFQAERR GARLPQNPVM NSPVVSVAVF HGRNFLRGVL
2460 2470 2480 2490 2500
VSPINLEFRL LQTANRSKAI CVQWDPPGPT DQHGMWTARD CELVHRNGSH
2510 2520 2530 2540 2550
ARCRCSRTGT FGVLMDASPR ERLEGDLELL AVFTHVVVAV SVTALVLTAA
2560 2570 2580 2590 2600
VLLSLRSLKS NVRGIHANVA AALGVAELLF LLGIHRTHNQ LLCTAVAILL
2610 2620 2630 2640 2650
HYFFLSTFAW LLVQGLHLYR MQVEPRNVDR GAMRFYHALG WGVPAVLLGL
2660 2670 2680 2690 2700
AVGLDPEGYG NPDFCWISIH EPLIWSFAGP IVLVIVMNGT MFLLAARTSC
2710 2720 2730 2740 2750
STGQREAKKT SVLTLRSSFL LLLLVSASWL FGLLAVNHSI LAFHYLHAGL
2760 2770 2780 2790 2800
CGLQGLAVLL LFCVLNADAR AAWTPACLGK KAAPEETRPA PGPGSGAYNN
2810 2820 2830 2840 2850
TALFEESGLI RITLGASTVS SVSSARSGRA QDQDSQRGRS YLRDNVLVRH
2860 2870 2880 2890 2900
GSTAEHTERS LQAHAGPTDL DVAMFHRDAG ADSDSDSDLS LEEERSLSIP
2910 2920 2930 2940 2950
SSESEDNGRT RGRFQRPLRR AAQSERLLAH PKDVDGNDLL SYWPALGECE
2960 2970 2980 2990 3000
AAPCALQAWG SERRLGLDSN KDAANNNQPE LALTSGDETS LGRAQRQRKG
3010 3020 3030 3040 3050
ILKNRLQYPL VPQSRGTPEL SWCRAATLGH RAVPAASYGR IYAGGGTGSL
3060 3070 3080 3090 3100
SQPASRYSSR EQLDLLLRRQ LSKERLEEVP VPAPVLHPLS RPGSQERLDT
3110 3120 3130 3140 3150
APARLEARDR GSTLPRRQPP RDYPGTMAGR FGSRDALDLG APREWLSTLP
3160 3170 3180 3190 3200
PPRRNRDLDP QHPPLPLSPQ RQLSRDPLLP SRPLDSLSRI SNSREGLDQV
3210 3220 3230 3240 3250
PSRHPSREAL GPAPQLLRAR EDPASGPSHG PSTEQLDILS SILASFNSSA
3260 3270 3280 3290 3300
LSSVQSSSTP SGPHTTATAS ALGPSTPRSA TSHSISELSP DSEVPRSEGH

S
Length:3,301
Mass (Da):358,478
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29EA6A0D1E5A75AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SUG9A0A1L1SUG9_MOUSE
Cadherin EGF LAG seven-pass G-type ...
Celsr3
3,309Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YX12A0A0A6YX12_MOUSE
Cadherin EGF LAG seven-pass G-type ...
Celsr3
472Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YW76A0A0A6YW76_MOUSE
Cadherin EGF LAG seven-pass G-type ...
Celsr3
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG17057 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti221D → E in AAL25099 (PubMed:11850187).Curated1
Sequence conflicti537S → G in AAL25099 (PubMed:11850187).Curated1
Sequence conflicti2713L → LR in AAG17057 (PubMed:11677057).Curated1
Sequence conflicti3024R → P in AAG17057 (PubMed:11677057).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF427498 mRNA Translation: AAL25099.1
AC168054 Genomic DNA No translation available.
AF188752 mRNA Translation: AAG17057.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS23539.1

NCBI Reference Sequences

More...
RefSeqi
NP_536685.2, NM_080437.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000024238; ENSMUSP00000024238; ENSMUSG00000023473
ENSMUST00000201574; ENSMUSP00000144254; ENSMUSG00000107269

Database of genes from NCBI RefSeq genomes

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GeneIDi
107934

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:107934

UCSC genome browser

More...
UCSCi
uc009rrb.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF427498 mRNA Translation: AAL25099.1
AC168054 Genomic DNA No translation available.
AF188752 mRNA Translation: AAG17057.1 Frameshift.
CCDSiCCDS23539.1
RefSeqiNP_536685.2, NM_080437.2

3D structure databases

SMRiQ91ZI0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ91ZI0, 1 interactor
STRINGi10090.ENSMUSP00000024238

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ91ZI0
PhosphoSitePlusiQ91ZI0

Proteomic databases

MaxQBiQ91ZI0
PaxDbiQ91ZI0
PRIDEiQ91ZI0

Genome annotation databases

EnsembliENSMUST00000024238; ENSMUSP00000024238; ENSMUSG00000023473
ENSMUST00000201574; ENSMUSP00000144254; ENSMUSG00000107269
GeneIDi107934
KEGGimmu:107934
UCSCiuc009rrb.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1951
MGIiMGI:1858236 Celsr3

Phylogenomic databases

eggNOGiKOG4289 Eukaryota
ENOG410XTGH LUCA
GeneTreeiENSGT00940000160077
HOGENOMiHOG000231346
InParanoidiQ91ZI0
KOiK04602
OrthoDBi23882at2759
TreeFamiTF323983

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q91ZI0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000023473 Expressed in 84 organ(s), highest expression level in olfactory bulb
ExpressionAtlasiQ91ZI0 baseline and differential
GenevisibleiQ91ZI0 MM

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00232 CADHERIN_1, 7 hits
PS50268 CADHERIN_2, 8 hits
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELR3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91ZI0
Secondary accession number(s): E9QLD7, Q9ESD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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