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Protein

Bcl-2-modifying factor

Gene

Bmf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in apoptosis.

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-modifying factor
Gene namesi
Name:Bmf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2176433 Bmf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi67D → A: Loss of interaction with DLC2. 1 Publication1
Mutagenesisi68K → A: Loss of interaction with DLC2. 1 Publication1
Mutagenesisi69A → P: Loss of interaction with DLC2. 1 Publication1
Mutagenesisi138L → A: Decrease in the interaction with BCL2 and BCL2L2. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431121 – 185Bcl-2-modifying factorAdd BLAST185

Proteomic databases

PaxDbiQ91ZE9
PRIDEiQ91ZE9

PTM databases

iPTMnetiQ91ZE9
PhosphoSitePlusiQ91ZE9

Expressioni

Tissue specificityi

Widely expressed with an abundant expression in pancreas, liver kidney and hematopoietic tissues.1 Publication

Gene expression databases

CleanExiMM_BMF

Interactioni

Subunit structurei

Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2.2 Publications

Binary interactionsi

Protein-protein interaction databases

DIPiDIP-29806N
ELMiQ91ZE9
IntActiQ91ZE9, 6 interactors
MINTiQ91ZE9
STRINGi10090.ENSMUSP00000087686

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00645
SMRiQ91ZE9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91ZE9

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 75Interaction with DLC21 Publication9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi134 – 148BH3Add BLAST15

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiENOG410IHFT Eukaryota
ENOG410YIXY LUCA
HOVERGENiHBG050697
InParanoidiQ91ZE9
KOiK17460

Family and domain databases

InterProiView protein in InterPro
IPR028192 BMF
PANTHERiPTHR32014 PTHR32014, 1 hit
PfamiView protein in Pfam
PF15185 BMF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q91ZE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPPQCVEEL EDDVFQSEDG EPGTQPGGLL SADLFAQSQL DCPLSRLQLF
60 70 80 90 100
PLTHCCGPGL RPISQEDKAT QTLSPASPSQ GVMLPCGVTE EPQRLFYGNA
110 120 130 140 150
GYRLPLPASF PAGSPLGEQP PEGQFLQHRA EVQIARKLQC IADQFHRLHT
160 170 180
QQHQQNRDRA WWQVFLFLQN LALNRQENRE GVGPW
Length:185
Mass (Da):20,682
Last modified:December 1, 2001 - v1
Checksum:iDAE6EA080F3EA06B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AV75A2AV75_MOUSE
Bcl-2-modifying factor
Bmf
271Annotation score:
A2AV74A2AV74_MOUSE
Bcl-2-modifying factor
Bmf
190Annotation score:

Sequence cautioni

The sequence BAC39243 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029253 mRNA Translation: AAK38747.1
AK084658 mRNA Translation: BAC39243.1 Different initiation.
AK040622 mRNA Translation: BAC30649.1
BC079650 mRNA Translation: AAH79650.1
RefSeqiNP_001318150.1, NM_001331221.1
NP_612186.2, NM_138313.4
XP_006498918.1, XM_006498855.2
UniGeneiMm.210125

Genome annotation databases

GeneIDi171543
KEGGimmu:171543
UCSCiuc008lsb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029253 mRNA Translation: AAK38747.1
AK084658 mRNA Translation: BAC39243.1 Different initiation.
AK040622 mRNA Translation: BAC30649.1
BC079650 mRNA Translation: AAH79650.1
RefSeqiNP_001318150.1, NM_001331221.1
NP_612186.2, NM_138313.4
XP_006498918.1, XM_006498855.2
UniGeneiMm.210125

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VOGX-ray1.90B126-152[»]
DisProtiDP00645
SMRiQ91ZE9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29806N
ELMiQ91ZE9
IntActiQ91ZE9, 6 interactors
MINTiQ91ZE9
STRINGi10090.ENSMUSP00000087686

PTM databases

iPTMnetiQ91ZE9
PhosphoSitePlusiQ91ZE9

Proteomic databases

PaxDbiQ91ZE9
PRIDEiQ91ZE9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171543
KEGGimmu:171543
UCSCiuc008lsb.1 mouse

Organism-specific databases

CTDi90427
MGIiMGI:2176433 Bmf

Phylogenomic databases

eggNOGiENOG410IHFT Eukaryota
ENOG410YIXY LUCA
HOVERGENiHBG050697
InParanoidiQ91ZE9
KOiK17460

Miscellaneous databases

EvolutionaryTraceiQ91ZE9
PROiPR:Q91ZE9
SOURCEiSearch...

Gene expression databases

CleanExiMM_BMF

Family and domain databases

InterProiView protein in InterPro
IPR028192 BMF
PANTHERiPTHR32014 PTHR32014, 1 hit
PfamiView protein in Pfam
PF15185 BMF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBMF_MOUSE
AccessioniPrimary (citable) accession number: Q91ZE9
Secondary accession number(s): Q8BUK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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