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Protein

Vang-like protein 2

Gene

Vangl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (PubMed:16495441).3 Publications

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Vang-like protein 2
Alternative name(s):
Loop-tail protein 1
Loop-tail-associated protein
Van Gogh-like protein 2
Gene namesi
Name:Vangl2
Synonyms:Lpp1, Ltap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2135272 Vangl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 108CytoplasmicSequence analysisAdd BLAST108
Transmembranei109 – 129Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini130 – 147ExtracellularSequence analysisAdd BLAST18
Transmembranei148 – 168Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini169 – 178CytoplasmicSequence analysis10
Transmembranei179 – 199Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini200 – 217ExtracellularSequence analysisAdd BLAST18
Transmembranei218 – 238Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini239 – 521CytoplasmicSequence analysisAdd BLAST283

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Vangl2 are a cause of the loop-tail (Lp) mutant phenotype. Heterozygous Lp mice exhibit a characteristic looped tail, while homozygous embryos show a completely open neural tube in the hindbrain and spinal region, a condition similar to the severe craniorachischisis defect in humans. Homozygotes also have complex cardiovascular defects including double-outlet right ventricle, perimembranous ventricular defects, double-sided aortic arch and associated abnormalities in the aortic arch arteries. Homozygotes show cytoplasmic accumulation of Vangl2 instead of the normal membrane localization, and Rhoa expression, which is detected in the mesenchymal cushion cells adjacent to the outflow tract, is lost in homozygotes. Homozygous embryos typically die shortly before or at birth.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861961 – 521Vang-like protein 2Add BLAST521

Proteomic databases

MaxQBiQ91ZD4
PaxDbiQ91ZD4
PRIDEiQ91ZD4

PTM databases

iPTMnetiQ91ZD4
PhosphoSitePlusiQ91ZD4
SwissPalmiQ91ZD4

Expressioni

Tissue specificityi

Primarily expressed in the brain and epididymis. Not detected in the cochlea of Lp mice.4 Publications

Developmental stagei

In the embryo, strongly expressed in the neuroectoderm from the earliest stages of neural induction through the late stages of neural tube closure. Detected in the dorso-ventral axis of the neural tube, but not in the floor plate. Expression is low at day E7; it peaks at E11, and it remains strong at E15 and E17. Also expressed in the cochlear epithelium at days E14.5 and E16.5. Detected at low levels in the outflow tract myocardium from E9.5 with levels increasing by E11.5.3 Publications

Gene expression databases

BgeeiENSMUSG00000026556 Expressed in 245 organ(s), highest expression level in neocortex
CleanExiMM_VANGL2
ExpressionAtlasiQ91ZD4 baseline and differential
GenevisibleiQ91ZD4 MM

Interactioni

Subunit structurei

Homodimer and heterodimer with Vangl1. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Variants Glu-255 and Asn-464 impair interaction with the DVL proteins. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3 (PubMed:15195140). Interacts with PRICKLE3 (By similarity).By similarity4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi220314, 7 interactors
CORUMiQ91ZD4
IntActiQ91ZD4, 11 interactors
MINTiQ91ZD4
STRINGi10090.ENSMUSP00000027837

Structurei

3D structure databases

ProteinModelPortaliQ91ZD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Vang family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3814 Eukaryota
ENOG410XPVT LUCA
GeneTreeiENSGT00390000012496
HOVERGENiHBG058215
InParanoidiQ91ZD4
KOiK04510
TreeFamiTF313467

Family and domain databases

InterProiView protein in InterPro
IPR009539 VANGL
PANTHERiPTHR20886 PTHR20886, 1 hit
PfamiView protein in Pfam
PF06638 Strabismus, 1 hit
PIRSFiPIRSF007991 Strabismus, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q91ZD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTESQYSGY SYKSGHSRSS RKHRDRRDRH RSKSRDGSRG DKSVTIQAPG
60 70 80 90 100
EPLLDNESTR GDERDDNWGE TTTVVTGTSE HSISHDDLTR IAKDMEDSVP
110 120 130 140 150
LDCSRHLGVA AGAILALLSF LTPLAFLLLP PLLWREELEP CGTACEGLFI
160 170 180 190 200
SVAFKLLILL LGSWALFFRR PKASLPRVFV LRALLMVLVF LLVISYWLFY
210 220 230 240 250
GVRILDARER SYQGVVQFAV SLVDALLFVH YLAVVLLELR QLQPQFTLKV
260 270 280 290 300
VRSTDGASRF YNVGHLSIQR VAVWILEKYY HDFPVYNPAL LNLPKSVLAK
310 320 330 340 350
KVSGFKVYSL GEENSTNNST GQSRAVIAAA ARRRDNSHNE YYYEEAEHER
360 370 380 390 400
RVRKRRARLV VAVEEAFTHI KRLQEEEQKN PREVMDPREA AQAIFASMAR
410 420 430 440 450
AMQKYLRTTK QQPYHTMESI LQHLEFCITH DMTPKAFLER YLAAGPTIQY
460 470 480 490 500
HKERWLAKQW TLVSEEPVTN GLKDGIVFLL KRQDFSLVVS TKKVPFFKLS
510 520
EEFVDPKSHK FVMRLQSETS V
Length:521
Mass (Da):59,771
Last modified:June 1, 2002 - v3
Checksum:i94ECEF3EE63DF5BC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YY75D3YY75_MOUSE
Vang-like protein
Vangl2 mCG_4495
561Annotation score:
D3Z4X2D3Z4X2_MOUSE
Vang-like protein 2
Vangl2
130Annotation score:
D3Z374D3Z374_MOUSE
Vang-like protein 2
Vangl2
102Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti255D → E in Lp. 1 Publication1
Natural varianti464S → N in Lp. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035370 mRNA Translation: AAK63188.3
AF365875 mRNA Translation: AAK91927.1
BC052195 mRNA Translation: AAH52195.1
CCDSiCCDS15505.1
RefSeqiNP_277044.1, NM_033509.4
XP_006497114.1, XM_006497051.3
XP_006497115.1, XM_006497052.3
XP_006497116.1, XM_006497053.3
XP_006497117.1, XM_006497054.3
XP_017168497.1, XM_017313008.1
UniGeneiMm.36148
Mm.392110

Genome annotation databases

EnsembliENSMUST00000027837; ENSMUSP00000027837; ENSMUSG00000026556
ENSMUST00000111263; ENSMUSP00000106894; ENSMUSG00000026556
GeneIDi93840
KEGGimmu:93840
UCSCiuc007dpi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035370 mRNA Translation: AAK63188.3
AF365875 mRNA Translation: AAK91927.1
BC052195 mRNA Translation: AAH52195.1
CCDSiCCDS15505.1
RefSeqiNP_277044.1, NM_033509.4
XP_006497114.1, XM_006497051.3
XP_006497115.1, XM_006497052.3
XP_006497116.1, XM_006497053.3
XP_006497117.1, XM_006497054.3
XP_017168497.1, XM_017313008.1
UniGeneiMm.36148
Mm.392110

3D structure databases

ProteinModelPortaliQ91ZD4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220314, 7 interactors
CORUMiQ91ZD4
IntActiQ91ZD4, 11 interactors
MINTiQ91ZD4
STRINGi10090.ENSMUSP00000027837

PTM databases

iPTMnetiQ91ZD4
PhosphoSitePlusiQ91ZD4
SwissPalmiQ91ZD4

Proteomic databases

MaxQBiQ91ZD4
PaxDbiQ91ZD4
PRIDEiQ91ZD4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027837; ENSMUSP00000027837; ENSMUSG00000026556
ENSMUST00000111263; ENSMUSP00000106894; ENSMUSG00000026556
GeneIDi93840
KEGGimmu:93840
UCSCiuc007dpi.1 mouse

Organism-specific databases

CTDi57216
MGIiMGI:2135272 Vangl2

Phylogenomic databases

eggNOGiKOG3814 Eukaryota
ENOG410XPVT LUCA
GeneTreeiENSGT00390000012496
HOVERGENiHBG058215
InParanoidiQ91ZD4
KOiK04510
TreeFamiTF313467

Miscellaneous databases

PROiPR:Q91ZD4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026556 Expressed in 245 organ(s), highest expression level in neocortex
CleanExiMM_VANGL2
ExpressionAtlasiQ91ZD4 baseline and differential
GenevisibleiQ91ZD4 MM

Family and domain databases

InterProiView protein in InterPro
IPR009539 VANGL
PANTHERiPTHR20886 PTHR20886, 1 hit
PfamiView protein in Pfam
PF06638 Strabismus, 1 hit
PIRSFiPIRSF007991 Strabismus, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVANG2_MOUSE
AccessioniPrimary (citable) accession number: Q91ZD4
Secondary accession number(s): Q923Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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