UniProtKB - Q91ZA6 (SOCS4_MOUSE)
Protein
Suppressor of cytokine signaling 4
Gene
Socs4
Organism
Mus musculus (Mouse)
Status
Functioni
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).By similarity
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- 1-phosphatidylinositol-3-kinase regulator activity Source: GO_Central
GO - Biological processi
- intracellular signal transduction Source: InterPro
- negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
- phosphatidylinositol phosphorylation Source: GO_Central
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein ubiquitination Source: UniProtKB-UniPathway
- regulation of growth Source: UniProtKB-KW
Keywordsi
Molecular function | Signal transduction inhibitor |
Biological process | Growth regulation, Ubl conjugation pathway |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Suppressor of cytokine signaling 4Short name: SOCS-4 Alternative name(s): Suppressor of cytokine signaling 7 Short name: SOCS-7 |
Gene namesi | Name:Socs4 Synonyms:Socs7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914546, Socs4 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Other locations
- phosphatidylinositol 3-kinase complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181248 | 1 – 436 | Suppressor of cytokine signaling 4Add BLAST | 436 |
Proteomic databases
PaxDbi | Q91ZA6 |
PRIDEi | Q91ZA6 |
PTM databases
iPTMneti | Q91ZA6 |
PhosphoSitePlusi | Q91ZA6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000048379, Expressed in liver and 272 other tissues |
ExpressionAtlasi | Q91ZA6, baseline and differential |
Genevisiblei | Q91ZA6, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 212083, 3 interactors |
STRINGi | 10090.ENSMUSP00000066031 |
Miscellaneous databases
RNActi | Q91ZA6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 283 – 378 | SH2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 373 – 422 | SOCS boxPROSITE-ProRule annotationAdd BLAST | 50 |
Domaini
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity
Keywords - Domaini
SH2 domainPhylogenomic databases
eggNOGi | KOG4566, Eukaryota |
GeneTreei | ENSGT00940000161456 |
HOGENOMi | CLU_035609_0_0_1 |
InParanoidi | Q91ZA6 |
OMAi | AFRWHLI |
OrthoDBi | 722019at2759 |
TreeFami | TF321368 |
Family and domain databases
CDDi | cd10385, SH2_SOCS4, 1 hit cd03738, SOCS_SOCS4, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR028416, SOCS4 IPR022252, SOCS4/SOCS5_dom IPR035864, SOCS4_SH2 IPR037342, SOCS4_SOCS IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF21, PTHR10155:SF21, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12610, SOCS, 1 hit PF07525, SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q91ZA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAENNSKNVD VRPKTSRSRS ADRKDGYVWS GKKLSWSKKS ESCSESEAIG
60 70 80 90 100
TVENVEIPLR SQERQLSCSS IELDLDHSCG HRFLGRSLKQ KLQDAVGQCF
110 120 130 140 150
PIKNCSGRHS PGLPSKRKIH ISELMLDKCP FPPRSDLAFR WHFIKRHTVP
160 170 180 190 200
MSPNSDEWVS ADLSERKLRD AQLKRRNTED DIPCFSHTNG QPCVITANSA
210 220 230 240 250
SCTGGHITGS MMNLVTNNSI EDSDMDSEDE IITLCTSSRK RNKPRWEMEE
260 270 280 290 300
EILQLEAPPK FHTQIDYVHC LVPDLLQISN NPCYWGVMDK YAAEALLEGK
310 320 330 340 350
PEGTFLLRDS AQEDYLFSVS FRRYSRSLHA RIEQWNHNFS FDAHDPCVFH
360 370 380 390 400
SPDITGLLEH YKDPSACMFF EPLLSTPLIR TFPFSLQHIC RTVICNCTTY
410 420 430
DGIDALPIPS PMKLYLKEYH YKSKVRLLRI DVPEQQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3BQ19 | A0A2I3BQ19_MOUSE | Suppressor of cytokine-signaling 4 | Socs4 | 129 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | R → W in AAL03942 (Ref. 1) Curated | 1 | |
Sequence conflicti | 12 | R → W in AAI17815 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY046322 mRNA Translation: AAL03942.1 CH466605 Genomic DNA Translation: EDL20739.1 BC117814 mRNA Translation: AAI17815.1 BC117815 mRNA Translation: AAI17816.1 |
CCDSi | CCDS26985.1 |
RefSeqi | NP_543119.2, NM_080843.2 |
Genome annotation databases
Ensembli | ENSMUST00000065562; ENSMUSP00000066031; ENSMUSG00000048379 |
GeneIDi | 67296 |
KEGGi | mmu:67296 |
UCSCi | uc007thx.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY046322 mRNA Translation: AAL03942.1 CH466605 Genomic DNA Translation: EDL20739.1 BC117814 mRNA Translation: AAI17815.1 BC117815 mRNA Translation: AAI17816.1 |
CCDSi | CCDS26985.1 |
RefSeqi | NP_543119.2, NM_080843.2 |
3D structure databases
SMRi | Q91ZA6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212083, 3 interactors |
STRINGi | 10090.ENSMUSP00000066031 |
PTM databases
iPTMneti | Q91ZA6 |
PhosphoSitePlusi | Q91ZA6 |
Proteomic databases
PaxDbi | Q91ZA6 |
PRIDEi | Q91ZA6 |
Protocols and materials databases
Antibodypediai | 4604, 282 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000065562; ENSMUSP00000066031; ENSMUSG00000048379 |
GeneIDi | 67296 |
KEGGi | mmu:67296 |
UCSCi | uc007thx.1, mouse |
Organism-specific databases
CTDi | 122809 |
MGIi | MGI:1914546, Socs4 |
Phylogenomic databases
eggNOGi | KOG4566, Eukaryota |
GeneTreei | ENSGT00940000161456 |
HOGENOMi | CLU_035609_0_0_1 |
InParanoidi | Q91ZA6 |
OMAi | AFRWHLI |
OrthoDBi | 722019at2759 |
TreeFami | TF321368 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Miscellaneous databases
BioGRID-ORCSi | 67296, 3 hits in 17 CRISPR screens |
ChiTaRSi | Socs4, mouse |
PROi | PR:Q91ZA6 |
RNActi | Q91ZA6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048379, Expressed in liver and 272 other tissues |
ExpressionAtlasi | Q91ZA6, baseline and differential |
Genevisiblei | Q91ZA6, MM |
Family and domain databases
CDDi | cd10385, SH2_SOCS4, 1 hit cd03738, SOCS_SOCS4, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR028416, SOCS4 IPR022252, SOCS4/SOCS5_dom IPR035864, SOCS4_SH2 IPR037342, SOCS4_SOCS IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF21, PTHR10155:SF21, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF12610, SOCS, 1 hit PF07525, SOCS_box, 1 hit |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOCS4_MOUSE | |
Accessioni | Q91ZA6Primary (citable) accession number: Q91ZA6 Secondary accession number(s): Q149F7, Q149F8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways