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Protein

Suppressor of cytokine signaling 4

Gene

Socs4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 4
Short name:
SOCS-4
Alternative name(s):
Suppressor of cytokine signaling 7
Short name:
SOCS-7
Gene namesi
Name:Socs4
Synonyms:Socs7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1914546 Socs4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812481 – 436Suppressor of cytokine signaling 4Add BLAST436

Proteomic databases

PaxDbiQ91ZA6
PRIDEiQ91ZA6

PTM databases

iPTMnetiQ91ZA6
PhosphoSitePlusiQ91ZA6

Expressioni

Gene expression databases

BgeeiENSMUSG00000048379 Expressed in 255 organ(s), highest expression level in ear
CleanExiMM_SOCS4
MM_SOCS7
GenevisibleiQ91ZA6 MM

Interactioni

Protein-protein interaction databases

BioGridi212083, 3 interactors
STRINGi10090.ENSMUSP00000066031

Structurei

3D structure databases

ProteinModelPortaliQ91ZA6
SMRiQ91ZA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini283 – 378SH2PROSITE-ProRule annotationAdd BLAST96
Domaini373 – 422SOCS boxPROSITE-ProRule annotationAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
InParanoidiQ91ZA6
KOiK04697
OMAiESCSDAE
OrthoDBiEOG091G0EQ0
TreeFamiTF321368

Family and domain databases

CDDicd10385 SH2_SOCS4, 1 hit
cd03738 SOCS_SOCS4, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028416 SOCS4
IPR022252 SOCS4/SOCS5_dom
IPR035864 SOCS4_SH2
IPR037342 SOCS4_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF2 PTHR44282:SF2, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91ZA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENNSKNVD VRPKTSRSRS ADRKDGYVWS GKKLSWSKKS ESCSESEAIG
60 70 80 90 100
TVENVEIPLR SQERQLSCSS IELDLDHSCG HRFLGRSLKQ KLQDAVGQCF
110 120 130 140 150
PIKNCSGRHS PGLPSKRKIH ISELMLDKCP FPPRSDLAFR WHFIKRHTVP
160 170 180 190 200
MSPNSDEWVS ADLSERKLRD AQLKRRNTED DIPCFSHTNG QPCVITANSA
210 220 230 240 250
SCTGGHITGS MMNLVTNNSI EDSDMDSEDE IITLCTSSRK RNKPRWEMEE
260 270 280 290 300
EILQLEAPPK FHTQIDYVHC LVPDLLQISN NPCYWGVMDK YAAEALLEGK
310 320 330 340 350
PEGTFLLRDS AQEDYLFSVS FRRYSRSLHA RIEQWNHNFS FDAHDPCVFH
360 370 380 390 400
SPDITGLLEH YKDPSACMFF EPLLSTPLIR TFPFSLQHIC RTVICNCTTY
410 420 430
DGIDALPIPS PMKLYLKEYH YKSKVRLLRI DVPEQQ
Length:436
Mass (Da):49,918
Last modified:July 27, 2011 - v2
Checksum:iB64BF54C75F27A21
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BQ19A0A2I3BQ19_MOUSE
Suppressor of cytokine-signaling 4
Socs4
129Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12R → W in AAL03942 (Ref. 1) Curated1
Sequence conflicti12R → W in AAI17815 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046322 mRNA Translation: AAL03942.1
CH466605 Genomic DNA Translation: EDL20739.1
BC117814 mRNA Translation: AAI17815.1
BC117815 mRNA Translation: AAI17816.1
CCDSiCCDS26985.1
RefSeqiNP_543119.2, NM_080843.2
UniGeneiMm.23957
Mm.425886

Genome annotation databases

EnsembliENSMUST00000065562; ENSMUSP00000066031; ENSMUSG00000048379
GeneIDi67296
KEGGimmu:67296
UCSCiuc007thx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY046322 mRNA Translation: AAL03942.1
CH466605 Genomic DNA Translation: EDL20739.1
BC117814 mRNA Translation: AAI17815.1
BC117815 mRNA Translation: AAI17816.1
CCDSiCCDS26985.1
RefSeqiNP_543119.2, NM_080843.2
UniGeneiMm.23957
Mm.425886

3D structure databases

ProteinModelPortaliQ91ZA6
SMRiQ91ZA6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212083, 3 interactors
STRINGi10090.ENSMUSP00000066031

PTM databases

iPTMnetiQ91ZA6
PhosphoSitePlusiQ91ZA6

Proteomic databases

PaxDbiQ91ZA6
PRIDEiQ91ZA6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065562; ENSMUSP00000066031; ENSMUSG00000048379
GeneIDi67296
KEGGimmu:67296
UCSCiuc007thx.1 mouse

Organism-specific databases

CTDi122809
MGIiMGI:1914546 Socs4

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
InParanoidiQ91ZA6
KOiK04697
OMAiESCSDAE
OrthoDBiEOG091G0EQ0
TreeFamiTF321368

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

PROiPR:Q91ZA6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048379 Expressed in 255 organ(s), highest expression level in ear
CleanExiMM_SOCS4
MM_SOCS7
GenevisibleiQ91ZA6 MM

Family and domain databases

CDDicd10385 SH2_SOCS4, 1 hit
cd03738 SOCS_SOCS4, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028416 SOCS4
IPR022252 SOCS4/SOCS5_dom
IPR035864 SOCS4_SH2
IPR037342 SOCS4_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF2 PTHR44282:SF2, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOCS4_MOUSE
AccessioniPrimary (citable) accession number: Q91ZA6
Secondary accession number(s): Q149F7, Q149F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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