Socs4

Functionⁱ

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity).By similarity

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processⁱ

intracellular signal transduction Source: InterPro
negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
protein ubiquitination Source: UniProtKB-UniPathway
regulation of growth Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Signal transduction inhibitor
Biological process	Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayⁱ	UPA00143

UniPathwayⁱ

UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Suppressor of cytokine signaling 4 Short name: SOCS-4 Alternative name(s): Suppressor of cytokine signaling 7 Short name: SOCS-7
Gene namesⁱ	Name:Socs4 Synonyms:Socs7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:1914546 Socs4

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000181248	1 – 436	Suppressor of cytokine signaling 4Add BLAST		436

Proteomic databases

PaxDbⁱ	Q91ZA6
PRIDEⁱ	Q91ZA6

PTM databases

iPTMnetⁱ	Q91ZA6
PhosphoSitePlusⁱ	Q91ZA6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000048379 Expressed in 255 organ(s), highest expression level in ear
CleanExⁱ	MM_SOCS4 MM_SOCS7
Genevisibleⁱ	Q91ZA6 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	212083, 3 interactors
STRINGⁱ	10090.ENSMUSP00000066031

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91ZA6
SMRⁱ	Q91ZA6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	283 – 378	SH2PROSITE-ProRule annotationAdd BLAST		96
Domainⁱ	373 – 422	SOCS boxPROSITE-ProRule annotationAdd BLAST		50

Domainⁱ

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Keywords - Domainⁱ

SH2 domain

Phylogenomic databases

eggNOGⁱ	KOG4566 Eukaryota ENOG4111V4J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119136
HOGENOMⁱ	HOG000027791
HOVERGENⁱ	HBG054138
InParanoidⁱ	Q91ZA6
KEGG Orthology (KO) More...KOⁱ	K04697
OMAⁱ	ESCSDAE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EQ0
TreeFamⁱ	TF321368

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10385 SH2_SOCS4, 1 hit cd03738 SOCS_SOCS4, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR028416 SOCS4 IPR022252 SOCS4/SOCS5_dom IPR035864 SOCS4_SH2 IPR037342 SOCS4_SOCS IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf
PANTHERⁱ	PTHR44282:SF2 PTHR44282:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF12610 SOCS, 1 hit PF07525 SOCS_box, 1 hit
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit
SUPFAMⁱ	SSF158235 SSF158235, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit PS50225 SOCS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q91ZA6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAENNSKNVD VRPKTSRSRS ADRKDGYVWS GKKLSWSKKS ESCSESEAIG 
        60         70         80         90        100
TVENVEIPLR SQERQLSCSS IELDLDHSCG HRFLGRSLKQ KLQDAVGQCF 
       110        120        130        140        150
PIKNCSGRHS PGLPSKRKIH ISELMLDKCP FPPRSDLAFR WHFIKRHTVP 
       160        170        180        190        200
MSPNSDEWVS ADLSERKLRD AQLKRRNTED DIPCFSHTNG QPCVITANSA 
       210        220        230        240        250
SCTGGHITGS MMNLVTNNSI EDSDMDSEDE IITLCTSSRK RNKPRWEMEE 
       260        270        280        290        300
EILQLEAPPK FHTQIDYVHC LVPDLLQISN NPCYWGVMDK YAAEALLEGK 
       310        320        330        340        350
PEGTFLLRDS AQEDYLFSVS FRRYSRSLHA RIEQWNHNFS FDAHDPCVFH 
       360        370        380        390        400
SPDITGLLEH YKDPSACMFF EPLLSTPLIR TFPFSLQHIC RTVICNCTTY 
       410        420        430 
DGIDALPIPS PMKLYLKEYH YKSKVRLLRI DVPEQQ

Length:436

Mass (Da):49,918

Last modified:July 27, 2011 - v2

Checksum:ⁱB64BF54C75F27A21

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A2I3BQ19	A0A2I3BQ19_MOUSE		Suppressor of cytokine-signaling 4 Suppressor of cytokine-signaling 4	Socs4	129	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	12	R → W in AAL03942 (Ref. 1) Curated		1
Sequence conflictⁱ	12	R → W in AAI17815 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY046322 mRNA Translation: AAL03942.1 CH466605 Genomic DNA Translation: EDL20739.1 BC117814 mRNA Translation: AAI17815.1 BC117815 mRNA Translation: AAI17816.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS26985.1
NCBI Reference Sequences More...RefSeqⁱ	NP_543119.2, NM_080843.2
UniGeneⁱ	Mm.23957 Mm.425886

Genome annotation databases

Ensemblⁱ	ENSMUST00000065562; ENSMUSP00000066031; ENSMUSG00000048379
GeneIDⁱ	67296
KEGGⁱ	mmu:67296
UCSC genome browser More...UCSCⁱ	uc007thx.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q91ZA6	Suppressor of cytokine signaling 4		RAT		436	UniRef90_Q91ZA6
Suppressor of cytokine signaling 4		CRIGR		435
UPI00042AD711		PERMB		436
UPI000A30BF9E		MUSPA		436
UPI000A3162FE		MUSCR		436
+2

Protein	Similar proteins		Species	Score	Length	Source
Q91ZA6	Suppressor of cytokine signaling 4	)	HUMAN		440	UniRef50_Q8WXH5
Suppressor of cytokine signaling 4		PONAB		440
Suppressor of cytokine signaling 4		BOVIN		440
Uncharacterized protein		MYOLU		441
Suppressor of cytokine signaling 4		MYOBR		441
+219

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY046322 mRNA Translation: AAL03942.1 CH466605 Genomic DNA Translation: EDL20739.1 BC117814 mRNA Translation: AAI17815.1 BC117815 mRNA Translation: AAI17816.1
CCDSⁱ	CCDS26985.1
RefSeqⁱ	NP_543119.2, NM_080843.2
UniGeneⁱ	Mm.23957 Mm.425886

3D structure databases

ProteinModelPortalⁱ	Q91ZA6
SMRⁱ	Q91ZA6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	212083, 3 interactors
STRINGⁱ	10090.ENSMUSP00000066031

PTM databases

iPTMnetⁱ	Q91ZA6
PhosphoSitePlusⁱ	Q91ZA6

Proteomic databases

PaxDbⁱ	Q91ZA6
PRIDEⁱ	Q91ZA6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000065562; ENSMUSP00000066031; ENSMUSG00000048379
GeneIDⁱ	67296
KEGGⁱ	mmu:67296
UCSCⁱ	uc007thx.1 mouse

Organism-specific databases

CTDⁱ	122809
MGIⁱ	MGI:1914546 Socs4

Phylogenomic databases

eggNOGⁱ	KOG4566 Eukaryota ENOG4111V4J LUCA
GeneTreeⁱ	ENSGT00760000119136
HOGENOMⁱ	HOG000027791
HOVERGENⁱ	HBG054138
InParanoidⁱ	Q91ZA6
KOⁱ	K04697
OMAⁱ	ESCSDAE
OrthoDBⁱ	EOG091G0EQ0
TreeFamⁱ	TF321368

Enzyme and pathway databases

UniPathwayⁱ	UPA00143

UniPathwayⁱ

UPA00143

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91ZA6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000048379 Expressed in 255 organ(s), highest expression level in ear
CleanExⁱ	MM_SOCS4 MM_SOCS7
Genevisibleⁱ	Q91ZA6 MM

Family and domain databases

CDDⁱ	cd10385 SH2_SOCS4, 1 hit cd03738 SOCS_SOCS4, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980 SH2 IPR036860 SH2_dom_sf IPR028416 SOCS4 IPR022252 SOCS4/SOCS5_dom IPR035864 SOCS4_SH2 IPR037342 SOCS4_SOCS IPR001496 SOCS_box IPR036036 SOCS_box-like_dom_sf
PANTHERⁱ	PTHR44282:SF2 PTHR44282:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF12610 SOCS, 1 hit PF07525 SOCS_box, 1 hit
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00253 SOCS, 1 hit SM00969 SOCS_box, 1 hit
SUPFAMⁱ	SSF158235 SSF158235, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit PS50225 SOCS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOCS4_MOUSE
Accessionⁱ	Q91ZA6Primary (citable) accession number: Q91ZA6 Secondary accession number(s): Q149F7, Q149F8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91ZA6 (SOCS4_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Suppressor of cytokine signaling 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ