UniProtKB - Q91Z61 (DIRA1_MOUSE)
Protein
GTP-binding protein Di-Ras1
Gene
Diras1
Organism
Mus musculus (Mouse)
Status
Functioni
Displays low GTPase activity and exists predominantly in the GTP-bound form.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 151 | GTP; via amide nitrogenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 17 – 22 | GTPBy similarity | 6 | |
Nucleotide bindingi | 33 – 39 | GTPBy similarity | 7 | |
Nucleotide bindingi | 61 – 65 | GTPBy similarity | 5 | |
Nucleotide bindingi | 121 – 125 | GTPBy similarity | 5 | |
Nucleotide bindingi | 151 – 152 | GTPBy similarity | 2 |
GO - Molecular functioni
- GDP binding Source: GO_Central
- GTPase activity Source: MGI
- GTP binding Source: MGI
GO - Biological processi
- signal transduction Source: InterPro
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: GTP-binding protein Di-Ras1Alternative name(s): Distinct subgroup of the Ras family member 1 Small GTP-binding tumor suppressor 1 |
Gene namesi | Name:Diras1 Synonyms:Gbts1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2183442, Diras1 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Plasma Membrane
- plasma membrane Source: MGI
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191649 | 1 – 195 | GTP-binding protein Di-Ras1Add BLAST | 195 | |
PropeptideiPRO_0000370776 | 196 – 198 | Removed in mature formSequence analysis | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 195 | Cysteine methyl esterSequence analysis | 1 | |
Lipidationi | 195 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Methylation, PrenylationProteomic databases
MaxQBi | Q91Z61 |
PaxDbi | Q91Z61 |
PeptideAtlasi | Q91Z61 |
PRIDEi | Q91Z61 |
PTM databases
iPTMneti | Q91Z61 |
PhosphoSitePlusi | Q91Z61 |
SwissPalmi | Q91Z61 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000043670, Expressed in primary visual cortex and 175 other tissues |
Genevisiblei | Q91Z61, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000055605 |
Miscellaneous databases
RNActi | Q91Z61, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 36 – 44 | Effector regionSequence analysis | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000159915 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | Q91Z61 |
OMAi | RIKGKCI |
OrthoDBi | 1218505at2759 |
PhylomeDBi | Q91Z61 |
TreeFami | TF313014 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q91Z61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEQSNDYRV VVFGAGGVGK SSLVLRFVKG TFRDTYIPTI EDTYRQVISC
60 70 80 90 100
DKSVCTLQIT DTTGSHQFPA MQRLSISKGH AFILVFSVTS KQSLDELSPI
110 120 130 140 150
YKLIVQIKGS VEDIPIMLVG NKCDETQREV HTREAQAVAQ EWKCAFMETS
160 170 180 190
AKMNYNVKEL FQELLTLETR RSVSLSVDGK RSSKQKRADR IKGKCALM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z0Z5 | D3Z0Z5_MOUSE | GTP-binding protein Di-Ras1 | Diras1 | 108 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY059640 mRNA Translation: AAL17967.1 BC057556 mRNA Translation: AAH57556.1 |
CCDSi | CCDS24040.1 |
RefSeqi | NP_660252.1, NM_145217.2 XP_006513501.1, XM_006513438.3 |
Genome annotation databases
Ensembli | ENSMUST00000055125; ENSMUSP00000055605; ENSMUSG00000043670 |
GeneIDi | 208666 |
KEGGi | mmu:208666 |
UCSCi | uc007gfo.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY059640 mRNA Translation: AAL17967.1 BC057556 mRNA Translation: AAH57556.1 |
CCDSi | CCDS24040.1 |
RefSeqi | NP_660252.1, NM_145217.2 XP_006513501.1, XM_006513438.3 |
3D structure databases
SMRi | Q91Z61 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000055605 |
PTM databases
iPTMneti | Q91Z61 |
PhosphoSitePlusi | Q91Z61 |
SwissPalmi | Q91Z61 |
Proteomic databases
MaxQBi | Q91Z61 |
PaxDbi | Q91Z61 |
PeptideAtlasi | Q91Z61 |
PRIDEi | Q91Z61 |
Protocols and materials databases
Antibodypediai | 23037, 222 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000055125; ENSMUSP00000055605; ENSMUSG00000043670 |
GeneIDi | 208666 |
KEGGi | mmu:208666 |
UCSCi | uc007gfo.1, mouse |
Organism-specific databases
CTDi | 148252 |
MGIi | MGI:2183442, Diras1 |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000159915 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | Q91Z61 |
OMAi | RIKGKCI |
OrthoDBi | 1218505at2759 |
PhylomeDBi | Q91Z61 |
TreeFami | TF313014 |
Miscellaneous databases
BioGRID-ORCSi | 208666, 0 hits in 17 CRISPR screens |
PROi | PR:Q91Z61 |
RNActi | Q91Z61, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000043670, Expressed in primary visual cortex and 175 other tissues |
Genevisiblei | Q91Z61, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DIRA1_MOUSE | |
Accessioni | Q91Z61Primary (citable) accession number: Q91Z61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families