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Protein

Tetratricopeptide repeat protein 1

Gene

Ttc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 1
Short name:
TPR repeat protein 1
Gene namesi
Name:Ttc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914077 Ttc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063771 – 292Tetratricopeptide repeat protein 1Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91Z38
MaxQBiQ91Z38
PaxDbiQ91Z38
PeptideAtlasiQ91Z38
PRIDEiQ91Z38

PTM databases

iPTMnetiQ91Z38
PhosphoSitePlusiQ91Z38

Expressioni

Gene expression databases

BgeeiENSMUSG00000041278 Expressed in 287 organ(s), highest expression level in secondary oocyte
CleanExiMM_TTC1
ExpressionAtlasiQ91Z38 baseline and differential
GenevisibleiQ91Z38 MM

Interactioni

Subunit structurei

Interacts with the GAP domain of NF1. Interacts (via TPR repeats) with HSP90AA1 and HSPA8.By similarity

Protein-protein interaction databases

BioGridi211746, 1 interactor
STRINGi10090.ENSMUSP00000040779

Structurei

3D structure databases

ProteinModelPortaliQ91Z38
SMRiQ91Z38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati116 – 149TPR 1Add BLAST34
Repeati155 – 188TPR 2Add BLAST34
Repeati189 – 222TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4234 Eukaryota
ENOG4111IF0 LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000231571
HOVERGENiHBG001208
InParanoidiQ91Z38
OMAiYSINFNQ
OrthoDBiEOG091G0OWV
PhylomeDBiQ91Z38
TreeFamiTF317515

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91Z38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEKSEDCKV PEDLFNGLKV ADPQEGESAS PMVSDPKGQH CQSKLPKAAE
60 70 80 90 100
AHPQDDHVEE ECFHDCSASF EEEQPGAHVA GSKASDDSSS ELDEEYLIEL
110 120 130 140 150
EKNMPEEEKQ KRREESAKLK EEGNERFKRG DYMEAESSYS QALQMCPACF
160 170 180 190 200
QKDRSVLFSN RAAARMKQDK KETAITDCSK AIQLNPTYIR AILRRAELYE
210 220 230 240 250
KTDKLDEALE DYKSVLEKDP SVHQAREACM RLPKQIEERN ERLKEEMLGK
260 270 280 290
LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR
Length:292
Mass (Da):33,263
Last modified:December 1, 2001 - v1
Checksum:iC88711F320DD1106
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AJK8A2AJK8_MOUSE
Tetratricopeptide repeat protein 1
Ttc1
250Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077715 mRNA Translation: BAC36975.1
AK166431 mRNA Translation: BAE38772.1
BC010236 mRNA Translation: AAH10236.1
CCDSiCCDS24561.1
RefSeqiNP_598556.1, NM_133795.1
UniGeneiMm.271974

Genome annotation databases

EnsembliENSMUST00000048578; ENSMUSP00000040779; ENSMUSG00000041278
GeneIDi66827
KEGGimmu:66827
UCSCiuc007imx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077715 mRNA Translation: BAC36975.1
AK166431 mRNA Translation: BAE38772.1
BC010236 mRNA Translation: AAH10236.1
CCDSiCCDS24561.1
RefSeqiNP_598556.1, NM_133795.1
UniGeneiMm.271974

3D structure databases

ProteinModelPortaliQ91Z38
SMRiQ91Z38
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211746, 1 interactor
STRINGi10090.ENSMUSP00000040779

PTM databases

iPTMnetiQ91Z38
PhosphoSitePlusiQ91Z38

Proteomic databases

EPDiQ91Z38
MaxQBiQ91Z38
PaxDbiQ91Z38
PeptideAtlasiQ91Z38
PRIDEiQ91Z38

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048578; ENSMUSP00000040779; ENSMUSG00000041278
GeneIDi66827
KEGGimmu:66827
UCSCiuc007imx.1 mouse

Organism-specific databases

CTDi7265
MGIiMGI:1914077 Ttc1

Phylogenomic databases

eggNOGiKOG4234 Eukaryota
ENOG4111IF0 LUCA
GeneTreeiENSGT00900000140844
HOGENOMiHOG000231571
HOVERGENiHBG001208
InParanoidiQ91Z38
OMAiYSINFNQ
OrthoDBiEOG091G0OWV
PhylomeDBiQ91Z38
TreeFamiTF317515

Miscellaneous databases

PROiPR:Q91Z38
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041278 Expressed in 287 organ(s), highest expression level in secondary oocyte
CleanExiMM_TTC1
ExpressionAtlasiQ91Z38 baseline and differential
GenevisibleiQ91Z38 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTC1_MOUSE
AccessioniPrimary (citable) accession number: Q91Z38
Secondary accession number(s): Q3TLM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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