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Protein

Porimin

Gene

Tmem123

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.By similarity

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Porimin
Alternative name(s):
Transmembrane protein 123
Gene namesi
Name:Tmem123
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1919179 Tmem123

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 152ExtracellularSequence analysisAdd BLAST129
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 195CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004505924 – 195PoriminAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei187PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ91Z22
PaxDbiQ91Z22
PeptideAtlasiQ91Z22
PRIDEiQ91Z22

PTM databases

iPTMnetiQ91Z22
PhosphoSitePlusiQ91Z22

Expressioni

Gene expression databases

BgeeiENSMUSG00000050912 Expressed in 289 organ(s), highest expression level in lymph node
CleanExiMM_TMEM123
ExpressionAtlasiQ91Z22 baseline and differential
GenevisibleiQ91Z22 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051966

Structurei

3D structure databases

ProteinModelPortaliQ91Z22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 144Thr-richAdd BLAST98

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1SC Eukaryota
ENOG410ZE8W LUCA
GeneTreeiENSGT00450000040378
HOGENOMiHOG000115612
HOVERGENiHBG059722
InParanoidiQ91Z22
OMAiGCRTYYS
OrthoDBiEOG091G141K
PhylomeDBiQ91Z22
TreeFamiTF350123

Family and domain databases

InterProiView protein in InterPro
IPR007947 CD164_MGC24
PANTHERiPTHR11337 PTHR11337, 1 hit
PfamiView protein in Pfam
PF05283 MGC-24, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91Z22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALCARAALL LGVLQVLALL GAAQDPTDAQ GSASGNHSVL TSNINITENT
60 70 80 90 100
NQTMSVVSNQ TSEMQSTAKP SVLPKTTTLI TVKPATIVKI STPGVLPHVT
110 120 130 140 150
PTASKSTPNA SASPNSTHTS ASMTTPAHSS LLTTVTVSAT THPTKGKGSK
160 170 180 190
FDAGSFVGGI VLTLGVLSIL YIGCKMYYSR RGIRYRSIDE HDAII
Length:195
Mass (Da):20,178
Last modified:December 1, 2001 - v1
Checksum:i64024F8550ABC248
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REH0D6REH0_MOUSE
Porimin
Tmem123
54Annotation score:
D6RI40D6RI40_MOUSE
Porimin
Tmem123
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25D → E in BAE42962 (PubMed:16141072).Curated1
Sequence conflicti25D → E in BAE43065 (PubMed:16141072).Curated1
Sequence conflicti25D → E in BAE43135 (PubMed:16141072).Curated1
Sequence conflicti68A → V in BAE38780 (PubMed:16141072).Curated1
Sequence conflicti106S → T in BAE33427 (PubMed:16141072).Curated1
Sequence conflicti132L → W in BAC25282 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010163 mRNA Translation: BAC25282.1
AK150361 mRNA Translation: BAE29496.1
AK151044 mRNA Translation: BAE30061.1
AK152180 mRNA Translation: BAE31011.1
AK152423 mRNA Translation: BAE31207.1
AK153122 mRNA Translation: BAE31737.1
AK153539 mRNA Translation: BAE32076.1
AK155767 mRNA Translation: BAE33427.1
AK162610 mRNA Translation: BAE36988.1
AK166444 mRNA Translation: BAE38780.1
AK170823 mRNA Translation: BAE42054.1
AK172352 mRNA Translation: BAE42962.1
AK172553 mRNA Translation: BAE43065.1
AK172701 mRNA Translation: BAE43135.1
BC010292 mRNA Translation: AAH10292.1
BC086319 mRNA Translation: AAH86319.1
CCDSiCCDS22810.1
RefSeqiNP_598500.1, NM_133739.2
UniGeneiMm.283293

Genome annotation databases

EnsembliENSMUST00000052865; ENSMUSP00000051966; ENSMUSG00000050912
GeneIDi71929
KEGGimmu:71929
UCSCiuc009ocx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010163 mRNA Translation: BAC25282.1
AK150361 mRNA Translation: BAE29496.1
AK151044 mRNA Translation: BAE30061.1
AK152180 mRNA Translation: BAE31011.1
AK152423 mRNA Translation: BAE31207.1
AK153122 mRNA Translation: BAE31737.1
AK153539 mRNA Translation: BAE32076.1
AK155767 mRNA Translation: BAE33427.1
AK162610 mRNA Translation: BAE36988.1
AK166444 mRNA Translation: BAE38780.1
AK170823 mRNA Translation: BAE42054.1
AK172352 mRNA Translation: BAE42962.1
AK172553 mRNA Translation: BAE43065.1
AK172701 mRNA Translation: BAE43135.1
BC010292 mRNA Translation: AAH10292.1
BC086319 mRNA Translation: AAH86319.1
CCDSiCCDS22810.1
RefSeqiNP_598500.1, NM_133739.2
UniGeneiMm.283293

3D structure databases

ProteinModelPortaliQ91Z22
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051966

PTM databases

iPTMnetiQ91Z22
PhosphoSitePlusiQ91Z22

Proteomic databases

MaxQBiQ91Z22
PaxDbiQ91Z22
PeptideAtlasiQ91Z22
PRIDEiQ91Z22

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052865; ENSMUSP00000051966; ENSMUSG00000050912
GeneIDi71929
KEGGimmu:71929
UCSCiuc009ocx.2 mouse

Organism-specific databases

CTDi114908
MGIiMGI:1919179 Tmem123

Phylogenomic databases

eggNOGiENOG410J1SC Eukaryota
ENOG410ZE8W LUCA
GeneTreeiENSGT00450000040378
HOGENOMiHOG000115612
HOVERGENiHBG059722
InParanoidiQ91Z22
OMAiGCRTYYS
OrthoDBiEOG091G141K
PhylomeDBiQ91Z22
TreeFamiTF350123

Miscellaneous databases

PROiPR:Q91Z22
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050912 Expressed in 289 organ(s), highest expression level in lymph node
CleanExiMM_TMEM123
ExpressionAtlasiQ91Z22 baseline and differential
GenevisibleiQ91Z22 MM

Family and domain databases

InterProiView protein in InterPro
IPR007947 CD164_MGC24
PANTHERiPTHR11337 PTHR11337, 1 hit
PfamiView protein in Pfam
PF05283 MGC-24, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPORIM_MOUSE
AccessioniPrimary (citable) accession number: Q91Z22
Secondary accession number(s): Q3T9F6
, Q3TLL2, Q3U1R6, Q8CEX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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