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Protein

Protein THEMIS2

Gene

Themis2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production.1 Publication

GO - Biological processi

  • inflammatory response Source: UniProtKB-KW
  • T cell receptor signaling pathway Source: MGI

Keywordsi

Biological processImmunity, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Protein THEMIS2
Alternative name(s):
Induced by contact to basement membrane 1 protein
Short name:
Protein ICB-1
Thymocyte-expressed molecule involved in selection protein 2
Gene namesi
Name:Themis2
Synonyms:Icb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2446213 Themis2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi552P → A: Drastic decrease in GRB2-binding, but no effect on VAV-binding; when associated with A-555. Partial loss of enhancement of LPS-induced TNF production; when associated with A-555. 1
Mutagenesisi555P → A: Drastic decrease in GRB2-binding, but no effect on VAV-binding; when associated with A-552. Partial loss of enhancement of LPS-induced TNF production; when associated with A-552. 1
Mutagenesisi660Y → F: Loss of phosphorylation. Loss of LYN-binding. Slight decrease in GRB2-binding. No effect on VAV-binding. Partial loss of enhancement of LPS-induced TNF production. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841441 – 663Protein THEMIS2Add BLAST663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei596PhosphothreonineBy similarity1
Modified residuei660Phosphotyrosine1 Publication1

Post-translational modificationi

Phosphorylation at Tyr-660 is induced by LPS.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91YX0
PaxDbiQ91YX0
PeptideAtlasiQ91YX0
PRIDEiQ91YX0

PTM databases

iPTMnetiQ91YX0
PhosphoSitePlusiQ91YX0

Expressioni

Tissue specificityi

Restricted to B-cells, macrophages and dendritic cells. Down-regulated in splenocytes of mice developing arthritis in a collagen-induced model, not in those of mice failing to develop the disease. Transiently down-regulated in splenocytes of mice infected with influenza virus.1 Publication

Developmental stagei

Up-regulated during the differentiation of bone marrow precursors into macrophages.1 Publication

Inductioni

Up-regulated by pro-inflammatory stimuli, such as IFNG (at protein level). Down-regulated by anti-inflammatory stimuli, such as TGFB1 and dexamethasone (at protein level).

Gene expression databases

BgeeiENSMUSG00000037731 Expressed in 140 organ(s), highest expression level in lymph node
CleanExiMM_BC013712
GenevisibleiQ91YX0 MM

Interactioni

Subunit structurei

When phosphorylated, interacts with LYN. Interacts with VAV1 and GRB2.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036945

Structurei

3D structure databases

ProteinModelPortaliQ91YX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 237CABIT 1Add BLAST236
Regioni238 – 515CABIT 2Add BLAST278

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi403 – 419Glu-richAdd BLAST17

Sequence similaritiesi

Belongs to the themis family.Curated

Phylogenomic databases

eggNOGiENOG410IF5X Eukaryota
ENOG4110SKT LUCA
GeneTreeiENSGT00530000063770
HOGENOMiHOG000112995
InParanoidiQ91YX0
OMAiQRLCIYG
OrthoDBiEOG091G02V6
PhylomeDBiQ91YX0
TreeFamiTF333479

Family and domain databases

InterProiView protein in InterPro
IPR025946 CABIT_dom
IPR039671 THEMIS
PANTHERiPTHR15215 PTHR15215, 1 hit
PfamiView protein in Pfam
PF12736 CABIT, 2 hits

Sequencei

Sequence statusi: Complete.

Q91YX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPVPLQDFV SGLDPTSLPR VLRVCSGVYF EGSVYELFGN ECCLSTGDLI
60 70 80 90 100
KVTHVQLQKV VCEYPETGQT LELNPNFTGL FSPLTSLRSY RTLEDLVSAM
110 120 130 140 150
PQNSTRWPIY FKSTQRIVTK ASVVPEDQPL RLEAVEIHHG IRYARCVQVS
160 170 180 190 200
KTKELLHLPL SQKGPFWRCK PSAPQTLHQI LQDPALKDLT LSCPSLPWNS
210 220 230 240 250
VILKPQYMLQ AIMHMRSSIV KIPSTLEVEV EDVTASSQHI HFFKPLRLSE
260 270 280 290 300
VLAGGGPFPL TTEILEVPEG PPVFLSPWVS FLRKGQRLCI YGPASPSWRV
310 320 330 340 350
VASSKSRKVP RYFMLSGAYQ GKLKRRPREF STAYDLLGAL QPGRPLRVVA
360 370 380 390 400
TKDCDGNEEE NPDFSFLAVG DRLEVLRSGQ VCGTKGQDID VLVCQRLSEQ
410 420 430 440 450
SGEEEEDLEE IEDEAEDKEQ ILLPLYLSGS FVEEVNDSRR YNLVDLTAQY
460 470 480 490 500
SLPCEVKVVT KDTRHPTDPL ASFPGLRLEE KLTEPFLVVS LDSQPEMCFE
510 520 530 540 550
IPPRWLDLTV VEAEGQPAQV ARPLSIAPVE ELSEAFYYSL RKLPASESQA
560 570 580 590 600
PPPRPPKSQG INKKQQNIQS CKESSVKPQV VEPQKSCPQP QLKAKTLEAL
610 620 630 640 650
PKNKSNVYSK ISVHKKDRKP NPQTQNSVLS MKPKTSSSLG KHSTMESHLL
660
PDPDMDDHDY EEI
Length:663
Mass (Da):74,378
Last modified:August 30, 2005 - v2
Checksum:iC14C53B493D62A13
GO

Sequence cautioni

The sequence AAH13712 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150471 mRNA Translation: BAE29588.1
AK153536 mRNA Translation: BAE32073.1
AK155536 mRNA Translation: BAE33313.1
AK171009 mRNA Translation: BAE42180.1
AL627130, AL671190 Genomic DNA Translation: CAM24493.1
AL671190, AL627130 Genomic DNA Translation: CAM25193.1
BC013712 mRNA Translation: AAH13712.1 Different initiation.
BC151122 mRNA Translation: AAI51123.1
BC151126 mRNA Translation: AAI51127.1
CCDSiCCDS18735.1
RefSeqiNP_001028480.1, NM_001033308.2
UniGeneiMm.290912

Genome annotation databases

EnsembliENSMUST00000045154; ENSMUSP00000036945; ENSMUSG00000037731
GeneIDi230787
KEGGimmu:230787
UCSCiuc008vbv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150471 mRNA Translation: BAE29588.1
AK153536 mRNA Translation: BAE32073.1
AK155536 mRNA Translation: BAE33313.1
AK171009 mRNA Translation: BAE42180.1
AL627130, AL671190 Genomic DNA Translation: CAM24493.1
AL671190, AL627130 Genomic DNA Translation: CAM25193.1
BC013712 mRNA Translation: AAH13712.1 Different initiation.
BC151122 mRNA Translation: AAI51123.1
BC151126 mRNA Translation: AAI51127.1
CCDSiCCDS18735.1
RefSeqiNP_001028480.1, NM_001033308.2
UniGeneiMm.290912

3D structure databases

ProteinModelPortaliQ91YX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036945

PTM databases

iPTMnetiQ91YX0
PhosphoSitePlusiQ91YX0

Proteomic databases

MaxQBiQ91YX0
PaxDbiQ91YX0
PeptideAtlasiQ91YX0
PRIDEiQ91YX0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045154; ENSMUSP00000036945; ENSMUSG00000037731
GeneIDi230787
KEGGimmu:230787
UCSCiuc008vbv.1 mouse

Organism-specific databases

CTDi9473
MGIiMGI:2446213 Themis2

Phylogenomic databases

eggNOGiENOG410IF5X Eukaryota
ENOG4110SKT LUCA
GeneTreeiENSGT00530000063770
HOGENOMiHOG000112995
InParanoidiQ91YX0
OMAiQRLCIYG
OrthoDBiEOG091G02V6
PhylomeDBiQ91YX0
TreeFamiTF333479

Miscellaneous databases

PROiPR:Q91YX0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037731 Expressed in 140 organ(s), highest expression level in lymph node
CleanExiMM_BC013712
GenevisibleiQ91YX0 MM

Family and domain databases

InterProiView protein in InterPro
IPR025946 CABIT_dom
IPR039671 THEMIS
PANTHERiPTHR15215 PTHR15215, 1 hit
PfamiView protein in Pfam
PF12736 CABIT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTHMS2_MOUSE
AccessioniPrimary (citable) accession number: Q91YX0
Secondary accession number(s): Q3U5K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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