Themis2

Functionⁱ

May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production.1 Publication

GO - Biological processⁱ

inflammatory response Source: UniProtKB-KW
T cell receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 22732588

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Immunity, Inflammatory response

Biological process

Immunity, Inflammatory response

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein THEMIS2 Alternative name(s): Induced by contact to basement membrane 1 protein Short name: Protein ICB-1 Thymocyte-expressed molecule involved in selection protein 2
Gene namesⁱ	Name:Themis2 Synonyms:Icb1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:2446213 Themis2

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	552	P → A: Drastic decrease in GRB2-binding, but no effect on VAV-binding; when associated with A-555. Partial loss of enhancement of LPS-induced TNF production; when associated with A-555.	1
Mutagenesisⁱ	555	P → A: Drastic decrease in GRB2-binding, but no effect on VAV-binding; when associated with A-552. Partial loss of enhancement of LPS-induced TNF production; when associated with A-552.	1
Mutagenesisⁱ	660	Y → F: Loss of phosphorylation. Loss of LYN-binding. Slight decrease in GRB2-binding. No effect on VAV-binding. Partial loss of enhancement of LPS-induced TNF production. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084144	1 – 663	Protein THEMIS2Add BLAST		663

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	596	PhosphothreonineBy similarity		1
Modified residueⁱ	660	Phosphotyrosine1 Publication		1

Post-translational modificationⁱ

Phosphorylation at Tyr-660 is induced by LPS.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q91YX0
PaxDbⁱ	Q91YX0
PeptideAtlas More...PeptideAtlasⁱ	Q91YX0
PRIDEⁱ	Q91YX0

PTM databases

iPTMnetⁱ	Q91YX0
PhosphoSitePlusⁱ	Q91YX0

Expressionⁱ

Tissue specificityⁱ

Restricted to B-cells, macrophages and dendritic cells. Down-regulated in splenocytes of mice developing arthritis in a collagen-induced model, not in those of mice failing to develop the disease. Transiently down-regulated in splenocytes of mice infected with influenza virus.1 Publication

Developmental stageⁱ

Up-regulated during the differentiation of bone marrow precursors into macrophages.1 Publication

Inductionⁱ

Up-regulated by pro-inflammatory stimuli, such as IFNG (at protein level). Down-regulated by anti-inflammatory stimuli, such as TGFB1 and dexamethasone (at protein level).

Gene expression databases

Bgeeⁱ	ENSMUSG00000037731 Expressed in 140 organ(s), highest expression level in lymph node
CleanExⁱ	MM_BC013712
Genevisibleⁱ	Q91YX0 MM

Interactionⁱ

Subunit structureⁱ

When phosphorylated, interacts with LYN. Interacts with VAV1 and GRB2.1 Publication

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000036945

STRINGⁱ

10090.ENSMUSP00000036945

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91YX0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 237	CABIT 1Add BLAST		236
Regionⁱ	238 – 515	CABIT 2Add BLAST		278

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	403 – 419	Glu-richAdd BLAST		17

Sequence similaritiesⁱ

Belongs to the themis family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IF5X Eukaryota ENOG4110SKT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063770
HOGENOMⁱ	HOG000112995
InParanoidⁱ	Q91YX0
OMAⁱ	QRLCIYG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02V6
PhylomeDBⁱ	Q91YX0
TreeFamⁱ	TF333479

Family and domain databases

InterProⁱ	View protein in InterPro IPR025946 CABIT_dom IPR039671 THEMIS
PANTHERⁱ	PTHR15215 PTHR15215, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12736 CABIT, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q91YX0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEPVPLQDFV SGLDPTSLPR VLRVCSGVYF EGSVYELFGN ECCLSTGDLI 
        60         70         80         90        100
KVTHVQLQKV VCEYPETGQT LELNPNFTGL FSPLTSLRSY RTLEDLVSAM 
       110        120        130        140        150
PQNSTRWPIY FKSTQRIVTK ASVVPEDQPL RLEAVEIHHG IRYARCVQVS 
       160        170        180        190        200
KTKELLHLPL SQKGPFWRCK PSAPQTLHQI LQDPALKDLT LSCPSLPWNS 
       210        220        230        240        250
VILKPQYMLQ AIMHMRSSIV KIPSTLEVEV EDVTASSQHI HFFKPLRLSE 
       260        270        280        290        300
VLAGGGPFPL TTEILEVPEG PPVFLSPWVS FLRKGQRLCI YGPASPSWRV 
       310        320        330        340        350
VASSKSRKVP RYFMLSGAYQ GKLKRRPREF STAYDLLGAL QPGRPLRVVA 
       360        370        380        390        400
TKDCDGNEEE NPDFSFLAVG DRLEVLRSGQ VCGTKGQDID VLVCQRLSEQ 
       410        420        430        440        450
SGEEEEDLEE IEDEAEDKEQ ILLPLYLSGS FVEEVNDSRR YNLVDLTAQY 
       460        470        480        490        500
SLPCEVKVVT KDTRHPTDPL ASFPGLRLEE KLTEPFLVVS LDSQPEMCFE 
       510        520        530        540        550
IPPRWLDLTV VEAEGQPAQV ARPLSIAPVE ELSEAFYYSL RKLPASESQA 
       560        570        580        590        600
PPPRPPKSQG INKKQQNIQS CKESSVKPQV VEPQKSCPQP QLKAKTLEAL 
       610        620        630        640        650
PKNKSNVYSK ISVHKKDRKP NPQTQNSVLS MKPKTSSSLG KHSTMESHLL 
       660 
PDPDMDDHDY EEI

Length:663

Mass (Da):74,378

Last modified:August 30, 2005 - v2

Checksum:ⁱC14C53B493D62A13

GO

Sequence cautionⁱ

The sequence AAH13712 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK150471 mRNA Translation: BAE29588.1 AK153536 mRNA Translation: BAE32073.1 AK155536 mRNA Translation: BAE33313.1 AK171009 mRNA Translation: BAE42180.1 AL627130, AL671190 Genomic DNA Translation: CAM24493.1 AL671190, AL627130 Genomic DNA Translation: CAM25193.1 BC013712 mRNA Translation: AAH13712.1 Different initiation. BC151122 mRNA Translation: AAI51123.1 BC151126 mRNA Translation: AAI51127.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18735.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001028480.1, NM_001033308.2
UniGeneⁱ	Mm.290912

Genome annotation databases

Ensemblⁱ	ENSMUST00000045154; ENSMUSP00000036945; ENSMUSG00000037731
GeneIDⁱ	230787
KEGGⁱ	mmu:230787
UCSC genome browser More...UCSCⁱ	uc008vbv.1 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91YX0	Thymocyte selection associated family member 2		BOVIN		667	UniRef50_Q91YX0
Protein THEMIS2 (Fragment)		wild yak		668
protein THEMIS2 isoform X2		MESAU		638
Uncharacterized protein		AOTNA		580
Protein THEMIS2		CRIGR		672
+55

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK150471 mRNA Translation: BAE29588.1 AK153536 mRNA Translation: BAE32073.1 AK155536 mRNA Translation: BAE33313.1 AK171009 mRNA Translation: BAE42180.1 AL627130, AL671190 Genomic DNA Translation: CAM24493.1 AL671190, AL627130 Genomic DNA Translation: CAM25193.1 BC013712 mRNA Translation: AAH13712.1 Different initiation. BC151122 mRNA Translation: AAI51123.1 BC151126 mRNA Translation: AAI51127.1
CCDSⁱ	CCDS18735.1
RefSeqⁱ	NP_001028480.1, NM_001033308.2
UniGeneⁱ	Mm.290912

3D structure databases

ProteinModelPortalⁱ	Q91YX0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000036945

STRINGⁱ

10090.ENSMUSP00000036945

PTM databases

iPTMnetⁱ	Q91YX0
PhosphoSitePlusⁱ	Q91YX0

Proteomic databases

MaxQBⁱ	Q91YX0
PaxDbⁱ	Q91YX0
PeptideAtlasⁱ	Q91YX0
PRIDEⁱ	Q91YX0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000045154; ENSMUSP00000036945; ENSMUSG00000037731
GeneIDⁱ	230787
KEGGⁱ	mmu:230787
UCSCⁱ	uc008vbv.1 mouse

Organism-specific databases

CTDⁱ	9473
MGIⁱ	MGI:2446213 Themis2

Phylogenomic databases

eggNOGⁱ	ENOG410IF5X Eukaryota ENOG4110SKT LUCA
GeneTreeⁱ	ENSGT00530000063770
HOGENOMⁱ	HOG000112995
InParanoidⁱ	Q91YX0
OMAⁱ	QRLCIYG
OrthoDBⁱ	EOG091G02V6
PhylomeDBⁱ	Q91YX0
TreeFamⁱ	TF333479

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91YX0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037731 Expressed in 140 organ(s), highest expression level in lymph node
CleanExⁱ	MM_BC013712
Genevisibleⁱ	Q91YX0 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR025946 CABIT_dom IPR039671 THEMIS
PANTHERⁱ	PTHR15215 PTHR15215, 1 hit
Pfamⁱ	View protein in Pfam PF12736 CABIT, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THMS2_MOUSE
Accessionⁱ	Q91YX0Primary (citable) accession number: Q91YX0 Secondary accession number(s): Q3U5K5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	August 30, 2005
	Last modified:	November 7, 2018
	This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91YX0 (THMS2_MOUSE)

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Protein THEMIS2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ