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Protein

Cold shock domain-containing protein C2

Gene

Csdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: InterPro
  • mRNA 3'-UTR binding Source: GO_Central
  • RNA binding Source: MGI
  • transcription factor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock domain-containing protein C2
Alternative name(s):
RNA-binding protein PIPPin
Gene namesi
Name:Csdc2
Synonyms:Pippin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146027 Csdc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003521 – 154Cold shock domain-containing protein C2Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91YQ3
PaxDbiQ91YQ3
PRIDEiQ91YQ3

PTM databases

iPTMnetiQ91YQ3
PhosphoSitePlusiQ91YQ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000042109 Expressed in 280 organ(s), highest expression level in olfactory bulb
CleanExiMM_CSDC2
ExpressionAtlasiQ91YQ3 baseline and differential
GenevisibleiQ91YQ3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222938, 2 interactors
STRINGi10090.ENSMUSP00000044441

Structurei

3D structure databases

ProteinModelPortaliQ91YQ3
SMRiQ91YQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 136CSDAdd BLAST68

Phylogenomic databases

eggNOGiKOG3070 Eukaryota
COG1278 LUCA
GeneTreeiENSGT00390000000022
HOGENOMiHOG000059524
HOVERGENiHBG050947
InParanoidiQ91YQ3
OMAiWPTFPFQ
OrthoDBiEOG091G0TYX
TreeFamiTF324381

Family and domain databases

CDDicd04458 CSP_CDS, 1 hit
InterProiView protein in InterPro
IPR019844 Cold-shock_CS
IPR011129 CSD
IPR002059 CSP_DNA-bd
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF00313 CSD, 1 hit
SMARTiView protein in SMART
SM00357 CSP, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00352 CSD_1, 1 hit
PS51857 CSD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q91YQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSESTLPPV VPPLHSPKSP VWPTFPFHRE GSRIWERGGG IAPRDLPSPL
60 70 80 90 100
PTKRTRTYSA TARASAGPVF KGVCKQFSRS QGHGFITPEN GSEDIFVHVS
110 120 130 140 150
DIEGEYVPVE GDEVTYKICP IPPKNQKFQA VEVVLTQLAP HTPHETWSGQ

VVGS
Length:154
Mass (Da):16,853
Last modified:October 3, 2012 - v2
Checksum:i85D36118B2775930
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTN0D3YTN0_MOUSE
Cold shock domain-containing protei...
Csdc2
38Annotation score:
A0A2R8VK06A0A2R8VK06_MOUSE
Cold shock domain-containing protei...
Csdc2
30Annotation score:
A0A2R8VHB0A0A2R8VHB0_MOUSE
Cold shock domain-containing protei...
Csdc2
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7L → S in AAH16109 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028916 mRNA Translation: BAC26194.1
AK132493 mRNA Translation: BAE21201.1
AC102103 Genomic DNA No translation available.
BC016109 mRNA Translation: AAH16109.1
CCDSiCCDS27677.1
RefSeqiNP_663448.2, NM_145473.3
UniGeneiMm.22524

Genome annotation databases

EnsembliENSMUST00000038757; ENSMUSP00000044441; ENSMUSG00000042109
GeneIDi105859
KEGGimmu:105859
UCSCiuc007wxs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028916 mRNA Translation: BAC26194.1
AK132493 mRNA Translation: BAE21201.1
AC102103 Genomic DNA No translation available.
BC016109 mRNA Translation: AAH16109.1
CCDSiCCDS27677.1
RefSeqiNP_663448.2, NM_145473.3
UniGeneiMm.22524

3D structure databases

ProteinModelPortaliQ91YQ3
SMRiQ91YQ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222938, 2 interactors
STRINGi10090.ENSMUSP00000044441

PTM databases

iPTMnetiQ91YQ3
PhosphoSitePlusiQ91YQ3

Proteomic databases

MaxQBiQ91YQ3
PaxDbiQ91YQ3
PRIDEiQ91YQ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038757; ENSMUSP00000044441; ENSMUSG00000042109
GeneIDi105859
KEGGimmu:105859
UCSCiuc007wxs.2 mouse

Organism-specific databases

CTDi27254
MGIiMGI:2146027 Csdc2

Phylogenomic databases

eggNOGiKOG3070 Eukaryota
COG1278 LUCA
GeneTreeiENSGT00390000000022
HOGENOMiHOG000059524
HOVERGENiHBG050947
InParanoidiQ91YQ3
OMAiWPTFPFQ
OrthoDBiEOG091G0TYX
TreeFamiTF324381

Miscellaneous databases

PROiPR:Q91YQ3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042109 Expressed in 280 organ(s), highest expression level in olfactory bulb
CleanExiMM_CSDC2
ExpressionAtlasiQ91YQ3 baseline and differential
GenevisibleiQ91YQ3 MM

Family and domain databases

CDDicd04458 CSP_CDS, 1 hit
InterProiView protein in InterPro
IPR019844 Cold-shock_CS
IPR011129 CSD
IPR002059 CSP_DNA-bd
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF00313 CSD, 1 hit
SMARTiView protein in SMART
SM00357 CSP, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00352 CSD_1, 1 hit
PS51857 CSD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSDC2_MOUSE
AccessioniPrimary (citable) accession number: Q91YQ3
Secondary accession number(s): Q3V1F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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