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Protein

Ras-related protein Rab-7L1

Gene

Rab29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates also neuronal process morphology in the intact central nervous system (CNS) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi33 – 39GTPBy similarity7
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4
Nucleotide bindingi156 – 157GTPBy similarity2

GO - Molecular functioni

  • dynein complex binding Source: MGI
  • GDP binding Source: MGI
  • GTPase activity Source: GO_Central
  • GTP binding Source: MGI
  • kinesin binding Source: MGI
  • Rab GTPase binding Source: MGI

GO - Biological processi

Keywordsi

Biological processDifferentiation, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-7L1
Alternative name(s):
Rab-7-like protein 1
Gene namesi
Name:Rab29
Synonyms:Rab7l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2385107 Rab29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211281 – 204Ras-related protein Rab-7L1Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi203S-geranylgeranyl cysteineBy similarity1
Lipidationi204S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiQ91YQ1
PaxDbiQ91YQ1
PRIDEiQ91YQ1

PTM databases

iPTMnetiQ91YQ1
PhosphoSitePlusiQ91YQ1

Expressioni

Gene expression databases

CleanExiMM_RAB7L1

Interactioni

Subunit structurei

Interacts with LRRK2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91YQ1, 2 interactors
STRINGi10090.ENSMUSP00000027693

Structurei

3D structure databases

ProteinModelPortaliQ91YQ1
SMRiQ91YQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG4423 Eukaryota
ENOG410YITC LUCA
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ91YQ1
PhylomeDBiQ91YQ1

Family and domain databases

CDDicd04107 Rab32_Rab38, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030697 Rab29/Rab38/Rab32
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91YQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSRDHLFKV LVVGDAAVGK TSLVQRYSQD SFSKHYKSTV GVDFALKVLQ
60 70 80 90 100
WSDSEMVRLQ LWDIAGQERF TSMTRLYYRD ASACVIMFDV TNATTFSNSQ
110 120 130 140 150
RWKQDLDSKL TLPSGEPVPC LLLANKSDLS PWAVSRDQID RFSKENGFTG
160 170 180 190 200
WTETSVKENK NINEAMRVLV EKMMNNSRED VMSLSTQGNY INLQAKPSSG

WTCC
Length:204
Mass (Da):23,089
Last modified:December 1, 2001 - v1
Checksum:i1D05E98967E120F3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QLQ7E9QLQ7_MOUSE
Ras-related protein Rab-7L1
Rab29 Rab7l1
204Annotation score:
M0QW55M0QW55_MOUSE
RAB7, member RAS oncogene family-li...
Rab29 Rab7l1, mCG_2620
46Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016133 mRNA Translation: AAH16133.1
BC029056 mRNA Translation: AAH29056.1
CCDSiCCDS15276.1
UniGeneiMm.34027

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016133 mRNA Translation: AAH16133.1
BC029056 mRNA Translation: AAH29056.1
CCDSiCCDS15276.1
UniGeneiMm.34027

3D structure databases

ProteinModelPortaliQ91YQ1
SMRiQ91YQ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91YQ1, 2 interactors
STRINGi10090.ENSMUSP00000027693

PTM databases

iPTMnetiQ91YQ1
PhosphoSitePlusiQ91YQ1

Proteomic databases

MaxQBiQ91YQ1
PaxDbiQ91YQ1
PRIDEiQ91YQ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2385107 Rab29

Phylogenomic databases

eggNOGiKOG4423 Eukaryota
ENOG410YITC LUCA
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ91YQ1
PhylomeDBiQ91YQ1

Miscellaneous databases

ChiTaRSiRab29 mouse
PROiPR:Q91YQ1
SOURCEiSearch...

Gene expression databases

CleanExiMM_RAB7L1

Family and domain databases

CDDicd04107 Rab32_Rab38, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030697 Rab29/Rab38/Rab32
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB7L_MOUSE
AccessioniPrimary (citable) accession number: Q91YQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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