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Protein

BAG family molecular chaperone regulator 2

Gene

Bag2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 2
Short name:
BAG-2
Alternative name(s):
Bcl-2-associated athanogene 2
Gene namesi
Name:Bag2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1891254 Bag2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000888672 – 210BAG family molecular chaperone regulator 2Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei20PhosphoserineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91YN9
MaxQBiQ91YN9
PaxDbiQ91YN9
PeptideAtlasiQ91YN9
PRIDEiQ91YN9
TopDownProteomicsiQ91YN9

PTM databases

iPTMnetiQ91YN9
PhosphoSitePlusiQ91YN9

Expressioni

Gene expression databases

BgeeiENSMUSG00000042215 Expressed in 247 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_BAG2
ExpressionAtlasiQ91YN9 baseline and differential
GenevisibleiQ91YN9 MM

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. May interact with NWD1. Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229449, 70 interactors
IntActiQ91YN9, 74 interactors
MINTiQ91YN9
STRINGi10090.ENSMUSP00000042009

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ91YN9
SMRiQ91YN9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91YN9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 189BAGPROSITE-ProRule annotationAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 60Sequence analysisAdd BLAST41

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3633 Eukaryota
ENOG410XRW0 LUCA
GeneTreeiENSGT00390000017590
HOGENOMiHOG000073529
HOVERGENiHBG004808
InParanoidiQ91YN9
KOiK09556
OMAiQLEMRVE
OrthoDBiEOG091G0G1G
PhylomeDBiQ91YN9
TreeFamiTF102012

Family and domain databases

InterProiView protein in InterPro
IPR037689 BAG2
IPR003103 BAG_domain
PANTHERiPTHR12334 PTHR12334, 1 hit
SMARTiView protein in SMART
SM00264 BAG, 1 hit
PROSITEiView protein in PROSITE
PS51035 BAG, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q91YN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQAKISAKA HEGRFCRSSS MADRSSRLLE SLDQLELRVE ALRDAATAVE
60 70 80 90 100
QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET
110 120 130 140 150
IRNPQQEESL KHATRIIDEV VSKFLDDLGN AKSHLMSLYS ACSSEVPPGP
160 170 180 190 200
VDQKFQSIVI GCALEDQKKI KRRLETLLRN IDNSDKAIKL LEHAKGAGSK
210
SLQNTDGKFN
Length:210
Mass (Da):23,474
Last modified:December 1, 2001 - v1
Checksum:i96D693F88A1D35D3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WNX9A0A087WNX9_MOUSE
BAG family molecular chaperone regu...
Bag2
57Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083600 mRNA Translation: BAC38967.1
AK144720 mRNA Translation: BAE26031.1
BC016230 mRNA Translation: AAH16230.1
BC028944 mRNA Translation: AAH28944.1
CCDSiCCDS14864.1
RefSeqiNP_663367.1, NM_145392.2
UniGeneiMm.247037

Genome annotation databases

EnsembliENSMUST00000044691; ENSMUSP00000042009; ENSMUSG00000042215
GeneIDi213539
KEGGimmu:213539
UCSCiuc007any.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBAG2_MOUSE
AccessioniPrimary (citable) accession number: Q91YN9
Secondary accession number(s): Q3UMR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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