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Protein

Ly6/PLAUR domain-containing protein 3

Gene

Lypd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Supports cell migration. May be involved in tumor progression (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 3
Alternative name(s):
GPI-anchored metastasis-associated protein C4.4A homolog
Gene namesi
Name:Lypd3
Synonyms:C4.4a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1919684 Lypd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000022675333 – 343Ly6/PLAUR domain-containing protein 3Add BLAST311
PropeptideiPRO_0000226754344 – 363Removed in mature formSequence analysisAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi343GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ91YK8
PeptideAtlasiQ91YK8
PRIDEiQ91YK8

PTM databases

iPTMnetiQ91YK8
PhosphoSitePlusiQ91YK8

Expressioni

Inductioni

Up-regulated in suprabasal keratinocytes of hyperplastic skin induced by phorbol-ester.1 Publication

Gene expression databases

BgeeiENSMUSG00000057454 Expressed in 77 organ(s), highest expression level in esophagus
CleanExiMM_LYPD3
GenevisibleiQ91YK8 MM

Interactioni

Subunit structurei

Binds laminin-1 and laminin-5. Interacts with LGALS3. Interacts with AGR2 and AGR3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079543

Structurei

3D structure databases

ProteinModelPortaliQ91YK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 128UPAR/Ly6 1Add BLAST94
Domaini142 – 224UPAR/Ly6 2Add BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi268 – 271Poly-Thr4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIUT Eukaryota
ENOG41116C6 LUCA
GeneTreeiENSGT00910000144240
HOGENOMiHOG000059631
HOVERGENiHBG053008
InParanoidiQ91YK8
OMAiCSPHKMK
OrthoDBiEOG091G0FQ6
PhylomeDBiQ91YK8
TreeFamiTF337983

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 2 hits
SMARTiView protein in SMART
SM00134 LU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91YK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAARRGDTQ PVMWTTGWLL LLPLLLCEGA QALECYSCVQ KADDGCSPHR
60 70 80 90 100
MKTVKCGPGV DVCTEAVGAV ETIHGQFSVA VRGCGSGIPG KNDRGLDLHG
110 120 130 140 150
LLAFFQLQQC SEDRCNAKLN LTLRGLNPAG NESAYEPNGA ECYSCVGLSR
160 170 180 190 200
EKCQGSMPPV VNCYNASGRV YKGCFDGNVT LTAANVTVSL PVRGCVQDET
210 220 230 240 250
CTRDGVTGPG FTLSGSCCQG PRCNADLRNK TYFSPRIPPL VLLPPPTTAA
260 270 280 290 300
PSTRAQNSSS TTSTAAPTTT TSIIKPTTAQ ASHTSPHEMD LEVIQEEGAS
310 320 330 340 350
LSGGAAGHGG TAGHGGAAGH QDRSNMEKYP GKGGAQIPAK GGSGTLGSWL
360
SAVLLTVVAG AML
Length:363
Mass (Da):37,489
Last modified:December 1, 2001 - v1
Checksum:iD6CE5139A17CC5FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016549 mRNA Translation: AAH16549.1
BC094282 mRNA Translation: AAH94282.1
CCDSiCCDS20958.1
RefSeqiNP_598504.1, NM_133743.1
UniGeneiMm.281093

Genome annotation databases

EnsembliENSMUST00000080718; ENSMUSP00000079543; ENSMUSG00000057454
GeneIDi72434
KEGGimmu:72434
UCSCiuc009fqe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016549 mRNA Translation: AAH16549.1
BC094282 mRNA Translation: AAH94282.1
CCDSiCCDS20958.1
RefSeqiNP_598504.1, NM_133743.1
UniGeneiMm.281093

3D structure databases

ProteinModelPortaliQ91YK8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079543

PTM databases

iPTMnetiQ91YK8
PhosphoSitePlusiQ91YK8

Proteomic databases

PaxDbiQ91YK8
PeptideAtlasiQ91YK8
PRIDEiQ91YK8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080718; ENSMUSP00000079543; ENSMUSG00000057454
GeneIDi72434
KEGGimmu:72434
UCSCiuc009fqe.1 mouse

Organism-specific databases

CTDi27076
MGIiMGI:1919684 Lypd3

Phylogenomic databases

eggNOGiENOG410IIUT Eukaryota
ENOG41116C6 LUCA
GeneTreeiENSGT00910000144240
HOGENOMiHOG000059631
HOVERGENiHBG053008
InParanoidiQ91YK8
OMAiCSPHKMK
OrthoDBiEOG091G0FQ6
PhylomeDBiQ91YK8
TreeFamiTF337983

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

PROiPR:Q91YK8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057454 Expressed in 77 organ(s), highest expression level in esophagus
CleanExiMM_LYPD3
GenevisibleiQ91YK8 MM

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 2 hits
SMARTiView protein in SMART
SM00134 LU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYPD3_MOUSE
AccessioniPrimary (citable) accession number: Q91YK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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