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Protein

Translation initiation factor IF-2, mitochondrial

Gene

Mtif2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 194GTPBy similarity8
Nucleotide bindingi234 – 237GTPBy similarity4
Nucleotide bindingi288 – 291GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2, mitochondrial
Short name:
IF-2(Mt)
Short name:
IF-2Mt
Short name:
IF2(mt)
Gene namesi
Name:Mtif2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1924034 Mtif2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000001448130 – 727Translation initiation factor IF-2, mitochondrialAdd BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei688Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91YJ5
MaxQBiQ91YJ5
PaxDbiQ91YJ5
PeptideAtlasiQ91YJ5
PRIDEiQ91YJ5

PTM databases

iPTMnetiQ91YJ5
PhosphoSitePlusiQ91YJ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000020459 Expressed in 288 organ(s), highest expression level in spleen
CleanExiMM_MTIF2
ExpressionAtlasiQ91YJ5 baseline and differential
GenevisibleiQ91YJ5 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020749

Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ91YJ5
SMRiQ91YJ5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91YJ5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 346tr-type GAdd BLAST169

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni187 – 194G1By similarity8
Regioni212 – 216G2By similarity5
Regioni234 – 237G3By similarity4
Regioni288 – 291G4By similarity4
Regioni324 – 326G5By similarity3

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1145 Eukaryota
COG0532 LUCA
GeneTreeiENSGT00900000141103
HOGENOMiHOG000076906
HOVERGENiHBG006124
InParanoidiQ91YJ5
KOiK02519
OMAiTSLKHHK
OrthoDBiEOG091G03QC
TreeFamiTF105682

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
HAMAPiMF_00100_B IF_2_B, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR000178 TF_IF2_bacterial-like
IPR015760 TIF_IF2
IPR023115 TIF_IF2_dom3
IPR036925 TIF_IF2_dom3_sf
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR43381 PTHR43381, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF11987 IF-2, 1 hit
SUPFAMiSSF50447 SSF50447, 2 hits
SSF52156 SSF52156, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit
PS01176 IF2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q91YJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNQKLLKLEN LLRFHTICRQ VHSPSQRRLL AWCRHGFAPA SSVWRDLLGA
60 70 80 90 100
RSWQTDMLIG SALHQHRLLV TKKEKRPPRS QLSPVKTKKE VEVWVGMTVE
110 120 130 140 150
DLASAMAKDI DCVYEALLNT AIDVDSLEAN SHLDEVWIKE VIKKAGMKLK
160 170 180 190 200
WSKLKQERIR ENKDAVRRPG TDPALLKPRS PVVTVMGHVD HGKTTLLDKL
210 220 230 240 250
RETQVAAMEV GGITQHIGAF LVSLPSGEKI TFLDTPGHAA FSAMRARGAQ
260 270 280 290 300
VTDIVVLVVA ADDGVMKQTV ESIQHAKDAE VPIILAINKC DKTDADPEKV
310 320 330 340 350
KKELLAYDVV CEEYGGDVQA VHVSALTGDN LMALAEATIA LAEILELKAD
360 370 380 390 400
PTGPVEGTVI ESFTDKGRGP VTTAIIQRGT LRKGSILVAG KSWAKVRLIF
410 420 430 440 450
DENGKILNEA YPSMPVGIIG WRDLPSAGDE ILEVESEPRA REVIEWRKSE
460 470 480 490 500
QKEEKGKDDL KIMEEKRREH QEAHRKAREK YGSLHWKERS YIKFLERKQQ
510 520 530 540 550
RPLKPKEKVE RQSNVLPIII KGDVDGSVEA ILNLLDTYDA SHECELELVH
560 570 580 590 600
FGLGDISEND VTFAETFDGV IYGFNVEAGS AIQQSAAQKG VKIKLHKIIY
610 620 630 640 650
HLIEDLQEEL SSRLPHTLEE YPIGEASILA TFTVTEGKKK IPVAGCRVQK
660 670 680 690 700
GQLERHKKFK LIRNGQVIWK GSLTSLKHHK DDISVIKTGM DCGLSLDEEK
710 720
VEFKPGDQVI CYEENKVPTK TSWDPGF
Length:727
Mass (Da):81,289
Last modified:July 27, 2011 - v2
Checksum:i6BC3FDE9BB363090
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5M6W7Q5M6W7_MOUSE
Translation initiation factor IF-2,...
Mtif2
401Annotation score:
Q5M6W8Q5M6W8_MOUSE
Translation initiation factor IF-2,...
Mtif2
196Annotation score:
F6RR02F6RR02_MOUSE
Translation initiation factor IF-2,...
Mtif2
247Annotation score:
Q5M6W9Q5M6W9_MOUSE
Translation initiation factor IF-2,...
Mtif2
167Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti645G → D in AAH16590 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136344 mRNA Translation: BAE22940.1
AK146961 mRNA Translation: BAE27568.1
BX284634 Genomic DNA No translation available.
BC016590 mRNA Translation: AAH16590.1
CCDSiCCDS24496.1
RefSeqiNP_001269047.1, NM_001282118.1
NP_001269048.1, NM_001282119.1
NP_001269049.1, NM_001282120.1
NP_598528.2, NM_133767.3
XP_006514954.1, XM_006514891.2
XP_006514955.1, XM_006514892.3
UniGeneiMm.285429

Genome annotation databases

EnsembliENSMUST00000020749; ENSMUSP00000020749; ENSMUSG00000020459
ENSMUST00000093239; ENSMUSP00000090926; ENSMUSG00000020459
GeneIDi76784
KEGGimmu:76784
UCSCiuc007ihc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136344 mRNA Translation: BAE22940.1
AK146961 mRNA Translation: BAE27568.1
BX284634 Genomic DNA No translation available.
BC016590 mRNA Translation: AAH16590.1
CCDSiCCDS24496.1
RefSeqiNP_001269047.1, NM_001282118.1
NP_001269048.1, NM_001282119.1
NP_001269049.1, NM_001282120.1
NP_598528.2, NM_133767.3
XP_006514954.1, XM_006514891.2
XP_006514955.1, XM_006514892.3
UniGeneiMm.285429

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRVNMR-A621-727[»]
ProteinModelPortaliQ91YJ5
SMRiQ91YJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020749

PTM databases

iPTMnetiQ91YJ5
PhosphoSitePlusiQ91YJ5

Proteomic databases

EPDiQ91YJ5
MaxQBiQ91YJ5
PaxDbiQ91YJ5
PeptideAtlasiQ91YJ5
PRIDEiQ91YJ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020749; ENSMUSP00000020749; ENSMUSG00000020459
ENSMUST00000093239; ENSMUSP00000090926; ENSMUSG00000020459
GeneIDi76784
KEGGimmu:76784
UCSCiuc007ihc.2 mouse

Organism-specific databases

CTDi4528
MGIiMGI:1924034 Mtif2

Phylogenomic databases

eggNOGiKOG1145 Eukaryota
COG0532 LUCA
GeneTreeiENSGT00900000141103
HOGENOMiHOG000076906
HOVERGENiHBG006124
InParanoidiQ91YJ5
KOiK02519
OMAiTSLKHHK
OrthoDBiEOG091G03QC
TreeFamiTF105682

Miscellaneous databases

EvolutionaryTraceiQ91YJ5
PROiPR:Q91YJ5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020459 Expressed in 288 organ(s), highest expression level in spleen
CleanExiMM_MTIF2
ExpressionAtlasiQ91YJ5 baseline and differential
GenevisibleiQ91YJ5 MM

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
HAMAPiMF_00100_B IF_2_B, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR000178 TF_IF2_bacterial-like
IPR015760 TIF_IF2
IPR023115 TIF_IF2_dom3
IPR036925 TIF_IF2_dom3_sf
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR43381 PTHR43381, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF11987 IF-2, 1 hit
SUPFAMiSSF50447 SSF50447, 2 hits
SSF52156 SSF52156, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit
PS01176 IF2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIF2M_MOUSE
AccessioniPrimary (citable) accession number: Q91YJ5
Secondary accession number(s): Q5M6W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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