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Protein

Thymocyte nuclear protein 1

Gene

Thyn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Thymocyte nuclear protein 1
Alternative name(s):
Thymocyte protein Thy28
Short name:
mThy28
Gene namesi
Name:Thyn1
Synonyms:Thy28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1925112 Thyn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002625651 – 226Thymocyte nuclear protein 1Add BLAST226

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91YJ3
MaxQBiQ91YJ3
PaxDbiQ91YJ3
PeptideAtlasiQ91YJ3
PRIDEiQ91YJ3

PTM databases

iPTMnetiQ91YJ3
PhosphoSitePlusiQ91YJ3

Expressioni

Tissue specificityi

Expressed in the medulla containing mature thymocytes, but not the cortex having immature thymocytes (at protein level). Abundant expression seen in testis, liver, brain and kidney with lower levels of the expression in thymus, spleen, heart and stomach.3 Publications

Inductioni

Down-regulated upon induction of apoptosis.2 Publications

Gene expression databases

BgeeiENSMUSG00000035443 Expressed in 271 organ(s), highest expression level in midbrain
CleanExiMM_THYN1
ExpressionAtlasiQ91YJ3 baseline and differential
GenevisibleiQ91YJ3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037614

Structurei

3D structure databases

ProteinModelPortaliQ91YJ3
SMRiQ91YJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 10Nuclear localization signalBy similarity6

Phylogenomic databases

eggNOGiKOG3383 Eukaryota
COG2947 LUCA
GeneTreeiENSGT00390000013297
HOGENOMiHOG000263533
HOVERGENiHBG054408
InParanoidiQ91YJ3
OMAiAYVDHTQ
OrthoDBiEOG091G0MPN
PhylomeDBiQ91YJ3
TreeFamiTF332126

Family and domain databases

InterProiView protein in InterPro
IPR002740 EVE_domain
IPR015947 PUA-like_sf
PfamiView protein in Pfam
PF01878 EVE, 1 hit
SUPFAMiSSF88697 SSF88697, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91YJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRPRKRQTG TAGPDRKKLS GKRTKTENSE STSVKLENSS LEMTTTFKNG
60 70 80 90 100
GKNLSNYWLM KSEPESRLEK GIDMKFSIED LKAQPKQTAC WDGVRNYQAR
110 120 130 140 150
NFLRAMKLED EAFFYHSNCK QPGIVGLMKI VKEAYPDHTQ FEKSNPHYDP
160 170 180 190 200
SSKEDDPKWS MVDVQFVRMM KRFIPLEELK TYHQAHKATG GPLKSMTLFT
210 220
RQRLSVQPLT QEEFDFILSL EETEPS
Length:226
Mass (Da):26,178
Last modified:December 1, 2001 - v1
Checksum:i57D69619D37CDF89
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BJZ7Q8BJZ7_MOUSE
Thymocyte nuclear protein 1
Thyn1 Thy28
167Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080370 mRNA Translation: BAC21100.1
BC016594 mRNA Translation: AAH16594.1
CCDSiCCDS22937.1
RefSeqiNP_653126.1, NM_144543.2
UniGeneiMm.16925

Genome annotation databases

EnsembliENSMUST00000039161; ENSMUSP00000037614; ENSMUSG00000035443
ENSMUST00000213683; ENSMUSP00000150823; ENSMUSG00000035443
GeneIDi77862
KEGGimmu:77862
UCSCiuc009oqb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080370 mRNA Translation: BAC21100.1
BC016594 mRNA Translation: AAH16594.1
CCDSiCCDS22937.1
RefSeqiNP_653126.1, NM_144543.2
UniGeneiMm.16925

3D structure databases

ProteinModelPortaliQ91YJ3
SMRiQ91YJ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037614

PTM databases

iPTMnetiQ91YJ3
PhosphoSitePlusiQ91YJ3

Proteomic databases

EPDiQ91YJ3
MaxQBiQ91YJ3
PaxDbiQ91YJ3
PeptideAtlasiQ91YJ3
PRIDEiQ91YJ3

Protocols and materials databases

DNASUi77862
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039161; ENSMUSP00000037614; ENSMUSG00000035443
ENSMUST00000213683; ENSMUSP00000150823; ENSMUSG00000035443
GeneIDi77862
KEGGimmu:77862
UCSCiuc009oqb.2 mouse

Organism-specific databases

CTDi29087
MGIiMGI:1925112 Thyn1

Phylogenomic databases

eggNOGiKOG3383 Eukaryota
COG2947 LUCA
GeneTreeiENSGT00390000013297
HOGENOMiHOG000263533
HOVERGENiHBG054408
InParanoidiQ91YJ3
OMAiAYVDHTQ
OrthoDBiEOG091G0MPN
PhylomeDBiQ91YJ3
TreeFamiTF332126

Miscellaneous databases

PROiPR:Q91YJ3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035443 Expressed in 271 organ(s), highest expression level in midbrain
CleanExiMM_THYN1
ExpressionAtlasiQ91YJ3 baseline and differential
GenevisibleiQ91YJ3 MM

Family and domain databases

InterProiView protein in InterPro
IPR002740 EVE_domain
IPR015947 PUA-like_sf
PfamiView protein in Pfam
PF01878 EVE, 1 hit
SUPFAMiSSF88697 SSF88697, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHYN1_MOUSE
AccessioniPrimary (citable) accession number: Q91YJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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