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Protein

Atlastin-3

Gene

Atl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 74GTPBy similarity8
Nucleotide bindingi114 – 116GTPBy similarity3
Nucleotide bindingi213 – 214GTPBy similarity2
Nucleotide bindingi272 – 275GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Atlastin-3 (EC:3.6.5.-)
Gene namesi
Name:Atl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1924270 Atl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 445CytoplasmicBy similarityAdd BLAST445
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467LumenalSequence analysis1
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Topological domaini489 – 541CytoplasmicBy similarityAdd BLAST53

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871101 – 541Atlastin-3Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei391N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91YH5
PaxDbiQ91YH5
PeptideAtlasiQ91YH5
PRIDEiQ91YH5

PTM databases

iPTMnetiQ91YH5
PhosphoSitePlusiQ91YH5
SwissPalmiQ91YH5

Expressioni

Gene expression databases

BgeeiENSMUSG00000024759 Expressed in 255 organ(s), highest expression level in testis
ExpressionAtlasiQ91YH5 baseline and differential
GenevisibleiQ91YH5 MM

Interactioni

Subunit structurei

Interacts with ZFYVE27.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91YH5, 1 interactor
MINTiQ91YH5
STRINGi10090.ENSMUSP00000025668

Structurei

3D structure databases

ProteinModelPortaliQ91YH5
SMRiQ91YH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 305GB1/RHD3-type GAdd BLAST249

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2037 Eukaryota
ENOG410XR6Z LUCA
GeneTreeiENSGT00390000008959
HOGENOMiHOG000234332
HOVERGENiHBG062891
InParanoidiQ91YH5
KOiK17339
OMAiWAFIRYS
OrthoDBiEOG091G053P
PhylomeDBiQ91YH5
TreeFamiTF105251

Family and domain databases

InterProiView protein in InterPro
IPR030386 G_GB1_RHD3_dom
IPR003191 Guanylate-bd/ATL_C
IPR036543 Guanylate-bd_C_sf
IPR015894 Guanylate-bd_N
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02263 GBP, 1 hit
PF02841 GBP_C, 1 hit
SUPFAMiSSF48340 SSF48340, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51715 G_GB1_RHD3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q91YH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSPQRTAAV ASRGAGDAME NGKPGPVQVV LVHKEQHSFE LEERALASVL
60 70 80 90 100
LQDHIRDLDV VVVSVAGAFR KGKSFILDFM LRYLYSQKEG GHSDWLGDPE
110 120 130 140 150
EPLTGFSWRG GSDPETTGIQ IWSEVFTVKK PCGKKVAVVL MDTQGAFDSQ
160 170 180 190 200
STVKDCATIF ALSTMTSSVQ IYNLSQNIQE DDLQQLQLFT EYGRLAMDEI
210 220 230 240 250
FQKPFQTLMF LIRDWSFPYE YNYGLQGGMA FLDKRLHVKE HQHEEIQNVR
260 270 280 290 300
NHIHSCFSDV TCFLLPHPGL QVATSPNFDG KLKDIASEFK EQLQALIPYV
310 320 330 340 350
LNPSKLMEKE INGSKVTCRG LLEYFKAYIK IYQGEDLPHP KSMLQATAEA
360 370 380 390 400
NNLAAAASAK DIYYNNMEEI CGGEKPYLSP DILEEKHLEF KQLALDHFKK
410 420 430 440 450
IKKMGGKDFS FRYQQELEEE IKELYENFCK HNGSKNVFST FRTPAVLFTG
460 470 480 490 500
IAALYIASGF TGFIGLEVVA QLFNCMVGLL LIALLTWGYI RYSGQYRELG
510 520 530 540
GAIDSGAAYV LEQASSHIGN STQAAVRDAV VGRPPADKKS Q
Length:541
Mass (Da):60,575
Last modified:December 1, 2001 - v1
Checksum:i8D183335EAF88542
GO
Isoform 2 (identifier: Q91YH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Show »
Length:377
Mass (Da):42,738
Checksum:i14ABC3C3F819B836
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PYT3E9PYT3_MOUSE
Atlastin-3
Atl3
536Annotation score:

Sequence cautioni

The sequence AAH02149 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271Q → K in BAC27066 (PubMed:16141072).Curated1
Sequence conflicti397H → N in BAE28094 (PubMed:16141072).Curated1
Sequence conflicti489Y → C in BAC26148 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253141 – 164Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028842 mRNA Translation: BAC26148.1
AK030660 mRNA Translation: BAC27066.1
AK077752 mRNA Translation: BAC36992.1
AK147720 mRNA Translation: BAE28094.1
AK169476 mRNA Translation: BAE41194.1
BC002149 mRNA Translation: AAH02149.1 Different initiation.
BC017138 mRNA Translation: AAH17138.1
CCDSiCCDS29527.1 [Q91YH5-1]
RefSeqiNP_001156977.1, NM_001163505.1
NP_666203.3, NM_146091.4 [Q91YH5-1]
UniGeneiMm.264016

Genome annotation databases

EnsembliENSMUST00000025668; ENSMUSP00000025668; ENSMUSG00000024759 [Q91YH5-1]
GeneIDi109168
KEGGimmu:109168
UCSCiuc008glg.2 mouse [Q91YH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028842 mRNA Translation: BAC26148.1
AK030660 mRNA Translation: BAC27066.1
AK077752 mRNA Translation: BAC36992.1
AK147720 mRNA Translation: BAE28094.1
AK169476 mRNA Translation: BAE41194.1
BC002149 mRNA Translation: AAH02149.1 Different initiation.
BC017138 mRNA Translation: AAH17138.1
CCDSiCCDS29527.1 [Q91YH5-1]
RefSeqiNP_001156977.1, NM_001163505.1
NP_666203.3, NM_146091.4 [Q91YH5-1]
UniGeneiMm.264016

3D structure databases

ProteinModelPortaliQ91YH5
SMRiQ91YH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91YH5, 1 interactor
MINTiQ91YH5
STRINGi10090.ENSMUSP00000025668

PTM databases

iPTMnetiQ91YH5
PhosphoSitePlusiQ91YH5
SwissPalmiQ91YH5

Proteomic databases

EPDiQ91YH5
PaxDbiQ91YH5
PeptideAtlasiQ91YH5
PRIDEiQ91YH5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025668; ENSMUSP00000025668; ENSMUSG00000024759 [Q91YH5-1]
GeneIDi109168
KEGGimmu:109168
UCSCiuc008glg.2 mouse [Q91YH5-1]

Organism-specific databases

CTDi25923
MGIiMGI:1924270 Atl3

Phylogenomic databases

eggNOGiKOG2037 Eukaryota
ENOG410XR6Z LUCA
GeneTreeiENSGT00390000008959
HOGENOMiHOG000234332
HOVERGENiHBG062891
InParanoidiQ91YH5
KOiK17339
OMAiWAFIRYS
OrthoDBiEOG091G053P
PhylomeDBiQ91YH5
TreeFamiTF105251

Miscellaneous databases

PROiPR:Q91YH5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024759 Expressed in 255 organ(s), highest expression level in testis
ExpressionAtlasiQ91YH5 baseline and differential
GenevisibleiQ91YH5 MM

Family and domain databases

InterProiView protein in InterPro
IPR030386 G_GB1_RHD3_dom
IPR003191 Guanylate-bd/ATL_C
IPR036543 Guanylate-bd_C_sf
IPR015894 Guanylate-bd_N
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02263 GBP, 1 hit
PF02841 GBP_C, 1 hit
SUPFAMiSSF48340 SSF48340, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51715 G_GB1_RHD3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATLA3_MOUSE
AccessioniPrimary (citable) accession number: Q91YH5
Secondary accession number(s): Q3UGW3
, Q8C0L7, Q8C174, Q99LZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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