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Entry version 136 (22 Apr 2020)
Sequence version 2 (02 Nov 2016)
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Protein

Transient receptor potential cation channel subfamily M member 2

Gene

Trpm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonselective, voltage-independent cation channel that mediates Na+ and Ca2+ influx, leading to increased cytoplasmic Ca2+ levels (PubMed:11804595, PubMed:19454650, PubMed:21753080, PubMed:22493272). Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca2+ binding to trigger channel opening. Extracellular calcium passes through the channel and increases channel activity (By similarity). Also contributes to Ca2+ release from intracellular stores in response to ADP-ribose (PubMed:21753080). Plays a role in numerous processes that involve signaling via intracellular Ca2+ levels (PubMed:21753080). Besides, mediates the release of lysosomal Zn2+ stores in response to reactive oxygen species, leading to increased cytosolic Zn2+ levels (By similarity). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:27533035, PubMed:27562954). Activated by intracellular ADP-ribose, beta-NAD (NAD+) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:19454650, PubMed:21753080, PubMed:22493272). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate. Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (By similarity). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272, PubMed:25817999). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis (PubMed:27533035, PubMed:27562954). Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca2+ levels (PubMed:20921208, PubMed:25817999). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection (PubMed:21709234). Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro) (PubMed:22493272). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca2+ levels (PubMed:21753080). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its function in increasing cytoplasmic Ca2+ and Zn2+ levels (By similarity). Confers susceptibility to cell death following oxidative stress (PubMed:25562606).By similarity8 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi840CalciumBy similarity1
Metal bindingi843CalciumBy similarity1
Metal bindingi866CalciumBy similarity1
Metal bindingi1070CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Sodium channel
Biological processCalcium transport, Ion transport, Sodium transport, Transport
LigandCalcium, Metal-binding, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3295583 TRP channels
R-MMU-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 2
Alternative name(s):
Long transient receptor potential channel 2
Short name:
LTrpC-2
Short name:
LTrpC2
Transient receptor potential channel 7
Short name:
TrpC7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trpm2
Synonyms:Ltrpc2, Trpc7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1351901 Trpm2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 750CytoplasmicCuratedAdd BLAST750
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei751 – 767By similarityAdd BLAST17
Topological domaini768 – 792CytoplasmicCuratedAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei793 – 813HelicalBy similarityAdd BLAST21
Topological domaini814 – 824ExtracellularCuratedAdd BLAST11
Transmembranei825 – 845HelicalBy similarityAdd BLAST21
Topological domaini846 – 864CytoplasmicCuratedAdd BLAST19
Transmembranei865 – 885HelicalBy similarityAdd BLAST21
Topological domaini886 – 893ExtracellularCurated8
Transmembranei894 – 914HelicalBy similarityAdd BLAST21
Topological domaini915 – 926CytoplasmicCuratedAdd BLAST12
Transmembranei927 – 947HelicalBy similarityAdd BLAST21
Topological domaini948 – 967ExtracellularCuratedAdd BLAST20
Intramembranei968 – 982Pore-formingBy similarityAdd BLAST15
Topological domaini983 – 1019ExtracellularCuratedAdd BLAST37
Transmembranei1020 – 1041HelicalBy similarityAdd BLAST22
Topological domaini1042 – 1076CytoplasmicCuratedAdd BLAST35
Intramembranei1077 – 1095By similarityAdd BLAST19
Topological domaini1096 – 1506CytoplasmicCuratedAdd BLAST411

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant mice display no obvious phenotype, but display increased blood glucose levels when fed ad libitum (PubMed:20921208). After oral or intraperitoneal glucose administration, they display increased blood glucose and lower plasma insulin levels; basal fasting glucose and insulin levels are not altered (PubMed:20921208). Ca2+ influx into beta-cells is unchanged under basal conditions or upon stimulation with glucose up to 8.3 mM; Ca2+ influx is decreased upon stimulation with high glucose levels (16.7 mM) (PubMed:20921208). Likewise, insulin secretion is decreased only upon stimulation with 11.2 or 16.7 mM glucose, but not in response to more moderate glucose levels (PubMed:20921208). Mutant mice have a reduced number of neurons that are activated by warm temperature (34 to 43 degrees Celsius) in their dorsal root ganglia and superior cervical ganglia (PubMed:27533035). Mutant mice show altered behavorial responses to environmental temperature; contrary to wild-type they show no preference for a cooler environment when exposed to 38 degrees Celsius (PubMed:27533035). Besides, they spend less time than wild-type in a cooler environment (23 degrees Celsius) (PubMed:27533035). Mutant mice develop higher fever in response to prostaglandin E2 injection into the preoptic area of the hypothalamus, a brain area involved in body temperature control (PubMed:27562954). Mutant mice display a defective innate immune response and are highly susceptible to infection by L.monocytogenes (PubMed:21709234). They are unable to contain the bacterial infection; contrary to wild-type, they die within a few days after infection (PubMed:21709234). The defective immune response is due to impaired secretion of Il12b and IFNG; mice are rescued by treatment with recombinant IFNG (PubMed:21709234).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi214M → A: Abolishes lowering of temperature threshold for activation in response to reactive oxygen species. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153271 – 1506Transient receptor potential cation channel subfamily M member 2Add BLAST1506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi993 ↔ 1005By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q91YD4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q91YD4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q91YD4

PRoteomics IDEntifications database

More...
PRIDEi
Q91YD4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q91YD4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91YD4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in the preoptic area of the hypothalamus, a brain area involved in body temperature control (PubMed:27562954). Detected in beta-cells in pancreas islets (at protein level) (PubMed:16601673, PubMed:20921208). Detected in brain cortex, striatum, hippocampus CA1, CA2 and CA3 layers, and in the Purkinje cell layer in cerebellum (PubMed:15708008). Widely expressed, with highest levels in lung, spleen, eye and brain (PubMed:11804595). Detected in dendritic cells and in polymorphonuclear neutrophils (PubMed:21753080).6 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000009292 Expressed in mesenteric lymph node and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q91YD4 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101040

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q91YD4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1350 – 1501Nudix hydrolasePROSITE-ProRule annotationAdd BLAST152

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1386 – 1407Nudix boxPROSITE-ProRule annotationAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytosolic nudix box binds ADP-ribose and is required for channel activation by ADP-ribose.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3614 Eukaryota
KOG4195 Eukaryota
ENOG410XR5B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156404

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q91YD4

KEGG Orthology (KO)

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KOi
K04977

Identification of Orthologs from Complete Genome Data

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OMAi
WEMYLKE

Database of Orthologous Groups

More...
OrthoDBi
738147at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314204

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
IPR029594 TRPM2
IPR041491 TRPM_SLOG

The PANTHER Classification System

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PANTHERi
PTHR13800:SF2 PTHR13800:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55811 SSF55811, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51462 NUDIX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91YD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLDRRRTG SEQEEGFGVQ SRRATDLGMV PNLRRSNSSL CKSRRFLCSF
60 70 80 90 100
SSEKQENLSS WIPENIKKKE CVYFVESSKL SDAGKVVCAC GYTHEQHLEV
110 120 130 140 150
AIKPHTFQGK EWDPKKHVQE MPTDAFGDIV FTDLSQKVGK YVRVSQDTPS
160 170 180 190 200
SVIYQLMTQH WGLDVPNLLI SVTGGAKNFN MKLRLKSIFR RGLVKVAQTT
210 220 230 240 250
GAWIITGGSH TGVMKQVGEA VRDFSLSSSC KEGEVITIGV ATWGTIHNRE
260 270 280 290 300
GLIHPMGGFP AEYMLDEEGQ GNLTCLDSNH SHFILVDDGT HGQYGVEIPL
310 320 330 340 350
RTKLEKFISE QTKERGGVAI KIPIVCVVLE GGPGTLHTIY NAINNGTPCV
360 370 380 390 400
IVEGSGRVAD VIAQVATLPV SEITISLIQQ KLSIFFQEMF ETFTENQIVE
410 420 430 440 450
WTKKIQDIVR RRQLLTIFRE GKDGQQDVDV AILQALLKAS RSQDHFGHEN
460 470 480 490 500
WDHQLKLAVA WNRVDIARSE IFTDEWQWKP ADLHPMMTAA LISNKPEFVR
510 520 530 540 550
LFLENGVRLK EFVTWDTLLC LYENLEPSCL FHSKLQKVLA EEQRLAYASA
560 570 580 590 600
TPRLHMHHVA QVLRELLGDS TQLLYPRPRY TDRPRLSMTV PHIKLNVQGV
610 620 630 640 650
SLRSLYKRST GHVTFTIDPV RDLLIWAVIQ NHRELAGIIW AQSQDCTAAA
660 670 680 690 700
LACSKILKEL SKEEEDTDSS EEMLALADEF EHRAIGVFTE CYRKDEERAQ
710 720 730 740 750
KLLVRVSEAW GKTTCLQLAL EAKDMKFVSH GGIQAFLTKV WWGQLCVDNG
760 770 780 790 800
LWRIILCMLA FPLLFTGFIS FREKRLQALC RPARVRAFFN APVVIFHMNI
810 820 830 840 850
LSYFAFLCLF AYVLMVDFQP SPSWCEYLIY LWLFSLVCEE TRQLFYDPDG
860 870 880 890 900
CGLMKMASLY FSDFWNKLDV GAILLFIVGL TCRLIPATLY PGRIILSLDF
910 920 930 940 950
IMFCLRLMHI FTISKTLGPK IIIVKRMMKD VFFFLFLLAV WVVSFGVAKQ
960 970 980 990 1000
AILIHNESRV DWIFRGVVYH SYLTIFGQIP TYIDGVNFSM DQCSPNGTDP
1010 1020 1030 1040 1050
YKPKCPESDW TGQAPAFPEW LTVTLLCLYL LFANILLLNL LIAMFNYTFQ
1060 1070 1080 1090 1100
EVQEHTDQIW KFQRHDLIEE YHGRPPAPPP LILLSHLQLL IKRIVLKIPA
1110 1120 1130 1140 1150
KRHKQLKNKL EKNEETALLS WELYLKENYL QNQQYQQKQR PEQKIQDISE
1160 1170 1180 1190 1200
KVDTMVDLLD MDQVKRSGST EQRLASLEEQ VTQVTRALHW IVTTLKDSGF
1210 1220 1230 1240 1250
GSGAGALTLA PQRAFDEPDA ELSIRRKVEE PGDGYHVSAR HLLYPNARIM
1260 1270 1280 1290 1300
RFPVPNEKVP WAAEFLIYDP PFYTAEKDVA LTDPVGDTAE PLSKISYNVV
1310 1320 1330 1340 1350
DGPTDRRSFH GVYVVEYGFP LNPMGRTGLR GRGSLSWFGP NHTLQPVVTR
1360 1370 1380 1390 1400
WKRNQGGAIC RKSVRKMLEV LVMKLPRSEH WALPGGSREP GEMLPRKLKR
1410 1420 1430 1440 1450
VLRQEFWVAF ETLLMQGTEV YKGYVDDPRN TDNAWIETVA VSIHFQDQND
1460 1470 1480 1490 1500
MELKRLEENL HTHDPKELTR DLKLSTEWQV VDRRIPLYAN HKTILQKVAS

LFGAHF
Length:1,506
Mass (Da):172,202
Last modified:November 2, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE340C2F4DED121F4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7Q7D3Z7Q7_MOUSE
Transient receptor potential cation...
Trpm2
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6F5A0A1W2P6F5_MOUSE
Transient receptor potential cation...
Trpm2
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti843Q → QY in CAC69081 (Ref. 1) 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ344343 mRNA Translation: CAC69081.1
AB166747 mRNA Translation: BAD83707.1
AJ878415 mRNA Translation: CAI47592.1
AC153507 Genomic DNA No translation available.
AC158612 Genomic DNA No translation available.
CH466553 Genomic DNA Translation: EDL31768.1
BC141391 mRNA Translation: AAI41392.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS48611.1

NCBI Reference Sequences

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RefSeqi
NP_612174.2, NM_138301.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000105401; ENSMUSP00000101040; ENSMUSG00000009292

Database of genes from NCBI RefSeq genomes

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GeneIDi
28240

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:28240

UCSC genome browser

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UCSCi
uc007fwl.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344343 mRNA Translation: CAC69081.1
AB166747 mRNA Translation: BAD83707.1
AJ878415 mRNA Translation: CAI47592.1
AC153507 Genomic DNA No translation available.
AC158612 Genomic DNA No translation available.
CH466553 Genomic DNA Translation: EDL31768.1
BC141391 mRNA Translation: AAI41392.1
CCDSiCCDS48611.1
RefSeqiNP_612174.2, NM_138301.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101040

PTM databases

iPTMnetiQ91YD4
PhosphoSitePlusiQ91YD4

Proteomic databases

EPDiQ91YD4
MaxQBiQ91YD4
PaxDbiQ91YD4
PRIDEiQ91YD4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10236 285 antibodies

Genome annotation databases

EnsembliENSMUST00000105401; ENSMUSP00000101040; ENSMUSG00000009292
GeneIDi28240
KEGGimmu:28240
UCSCiuc007fwl.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7226
MGIiMGI:1351901 Trpm2

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
KOG4195 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00940000156404
InParanoidiQ91YD4
KOiK04977
OMAiWEMYLKE
OrthoDBi738147at2759
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology

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PROi
PR:Q91YD4
RNActiQ91YD4 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000009292 Expressed in mesenteric lymph node and 114 other tissues
ExpressionAtlasiQ91YD4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
IPR029594 TRPM2
IPR041491 TRPM_SLOG
PANTHERiPTHR13800:SF2 PTHR13800:SF2, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91YD4
Secondary accession number(s): Q5KTC0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 2, 2016
Last modified: April 22, 2020
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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