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Protein

mRNA-decapping enzyme 1A

Gene

Dcp1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-21 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease
R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA-decapping enzyme 1A (EC:3.-.-.-)
Alternative name(s):
MAD homolog 4-interacting transcription coactivator 1
Smad4-interacting transcriptional co-activator
Transcription factor SMIF
Gene namesi
Name:Dcp1a
Synonyms:Mitc1, Smif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1923151 Dcp1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896331 – 602mRNA-decapping enzyme 1AAdd BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei367PhosphothreonineBy similarity1
Modified residuei372PhosphoserineCombined sources1
Modified residuei395Asymmetric dimethylarginineBy similarity1
Modified residuei420PhosphothreonineCombined sources1
Modified residuei441PhosphoserineBy similarity1
Modified residuei542PhosphoserineCombined sources1
Modified residuei543PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei548PhosphothreonineCombined sources1
Modified residuei551PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ91YD3
MaxQBiQ91YD3
PaxDbiQ91YD3
PeptideAtlasiQ91YD3
PRIDEiQ91YD3

PTM databases

iPTMnetiQ91YD3
PhosphoSitePlusiQ91YD3

Expressioni

Gene expression databases

BgeeiENSMUSG00000021962 Expressed in 278 organ(s), highest expression level in secondary oocyte
CleanExiMM_DCP1A
ExpressionAtlasiQ91YD3 baseline and differential
GenevisibleiQ91YD3 MM

Interactioni

Subunit structurei

Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with DCP1B. Interacts with DCP2. Interacts with DDX17 in an RNA-independent manner. Interacts with PNRC2. Interacts with SMAD4. Interacts with UPF1. Interacts with ZC3HAV1. Interacts with ZFP36L1. Interacts with NBDY.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217832, 1 interactor
IntActiQ91YD3, 5 interactors
STRINGi10090.ENSMUSP00000022535

Structurei

3D structure databases

ProteinModelPortaliQ91YD3
SMRiQ91YD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCP1 family.Curated

Phylogenomic databases

eggNOGiKOG2868 Eukaryota
ENOG410XRY6 LUCA
GeneTreeiENSGT00390000014855
HOGENOMiHOG000090228
HOVERGENiHBG051320
InParanoidiQ91YD3
KOiK12610
OrthoDBiEOG091G0JB7
PhylomeDBiQ91YD3
TreeFamiTF320504

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR010334 Dcp1
IPR031953 mRNA_decap_C
IPR011993 PH-like_dom_sf
PANTHERiPTHR16290 PTHR16290, 1 hit
PfamiView protein in Pfam
PF06058 DCP1, 1 hit
PF16741 mRNA_decap_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91YD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSCSTVRP RRRGSALRSK MELLSRAEQE MSLAALKQHD PYITSIADLT
60 70 80 90 100
GQVALYTFCP KANQWEKTDI EGTLFVYRRS ASPYHGFTIV NRLNMHNLVE
110 120 130 140 150
PVNKDLEFQL HEPFLLYRNA SLSIYSIWFY DKNDCHRIAK LMADVVEEET
160 170 180 190 200
RRSQQAARDK QSPSQANGCS DQRPIDILEM LSRAKDEYER NQMGGSNISS
210 220 230 240 250
PGLQPSTQLS NLGSTETLEE TPSGSQDKSA PSGHKHLTVE ELFGTSLPKE
260 270 280 290 300
QPTAMGLESE DTDKLLGDAS QKEPSSFLPF PFEQSGGAPQ SENLGIHSAA
310 320 330 340 350
HHTVQPEVST PVLITPASIA QSGDKHPPSY TLPLSPVLSP TLPAEAPTTQ
360 370 380 390 400
VPHLPRNSTM IQAVKTTPRQ KSPLLNQPVP ELSHSSLVAS QSPFRAPVSL
410 420 430 440 450
ANPAGTALPS VDLLQKLRLT PQHDQIQAQP LGKGTMAPSF SSAAGQLATP
460 470 480 490 500
ESFIEPSSKT AAARAAVSAS LSNMVLAPTL QSMQQNQDPE VFSQPKVLPS
510 520 530 540 550
AIPIAGSPLV PATTTAVSSV LLSPSVFQQT VPRAADLERK ASSPSPLTVG
560 570 580 590 600
TAESQRKPSI ILSKSQLQDT LIHLIKNDSS FLSTLHAVYL QVLTKNKDNH

NL
Length:602
Mass (Da):65,219
Last modified:December 1, 2001 - v1
Checksum:i55BC9C32BCA86CFD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YCN4A0A286YCN4_MOUSE
mRNA-decapping enzyme 1A
Dcp1a
177Annotation score:
A0A286YDC8A0A286YDC8_MOUSE
mRNA-decapping enzyme 1A
Dcp1a
419Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti481Q → R in strain: C57BL/6J. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344447 mRNA Translation: CAC69875.1
BC066173 mRNA Translation: AAH66173.1
CCDSiCCDS36848.1
RefSeqiNP_598522.3, NM_133761.3
UniGeneiMm.28733

Genome annotation databases

EnsembliENSMUST00000022535; ENSMUSP00000022535; ENSMUSG00000021962
ENSMUST00000225196; ENSMUSP00000152897; ENSMUSG00000021962
GeneIDi75901
KEGGimmu:75901
UCSCiuc007sva.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344447 mRNA Translation: CAC69875.1
BC066173 mRNA Translation: AAH66173.1
CCDSiCCDS36848.1
RefSeqiNP_598522.3, NM_133761.3
UniGeneiMm.28733

3D structure databases

ProteinModelPortaliQ91YD3
SMRiQ91YD3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217832, 1 interactor
IntActiQ91YD3, 5 interactors
STRINGi10090.ENSMUSP00000022535

PTM databases

iPTMnetiQ91YD3
PhosphoSitePlusiQ91YD3

Proteomic databases

EPDiQ91YD3
MaxQBiQ91YD3
PaxDbiQ91YD3
PeptideAtlasiQ91YD3
PRIDEiQ91YD3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022535; ENSMUSP00000022535; ENSMUSG00000021962
ENSMUST00000225196; ENSMUSP00000152897; ENSMUSG00000021962
GeneIDi75901
KEGGimmu:75901
UCSCiuc007sva.1 mouse

Organism-specific databases

CTDi55802
MGIiMGI:1923151 Dcp1a

Phylogenomic databases

eggNOGiKOG2868 Eukaryota
ENOG410XRY6 LUCA
GeneTreeiENSGT00390000014855
HOGENOMiHOG000090228
HOVERGENiHBG051320
InParanoidiQ91YD3
KOiK12610
OrthoDBiEOG091G0JB7
PhylomeDBiQ91YD3
TreeFamiTF320504

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease
R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

PROiPR:Q91YD3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021962 Expressed in 278 organ(s), highest expression level in secondary oocyte
CleanExiMM_DCP1A
ExpressionAtlasiQ91YD3 baseline and differential
GenevisibleiQ91YD3 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR010334 Dcp1
IPR031953 mRNA_decap_C
IPR011993 PH-like_dom_sf
PANTHERiPTHR16290 PTHR16290, 1 hit
PfamiView protein in Pfam
PF06058 DCP1, 1 hit
PF16741 mRNA_decap_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCP1A_MOUSE
AccessioniPrimary (citable) accession number: Q91YD3
Secondary accession number(s): Q6NZE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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