UniProtKB - Q91YD3 (DCP1A_MOUSE)

BLAST

>sp|Q91YD3|DCP1A_MOUSE mRNA-decapping enzyme 1A OS=Mus musculus OX=10090 GN=Dcp1a PE=1 SV=1
MALSCSTVRPRRRGSALRSKMELLSRAEQEMSLAALKQHDPYITSIADLTGQVALYTFCP
KANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNA
SLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDQRPIDILEM
LSRAKDEYERNQMGGSNISSPGLQPSTQLSNLGSTETLEETPSGSQDKSAPSGHKHLTVE
ELFGTSLPKEQPTAMGLESEDTDKLLGDASQKEPSSFLPFPFEQSGGAPQSENLGIHSAA
HHTVQPEVSTPVLITPASIAQSGDKHPPSYTLPLSPVLSPTLPAEAPTTQVPHLPRNSTM
IQAVKTTPRQKSPLLNQPVPELSHSSLVASQSPFRAPVSLANPAGTALPSVDLLQKLRLT
PQHDQIQAQPLGKGTMAPSFSSAAGQLATPESFIEPSSKTAAARAAVSASLSNMVLAPTL
QSMQQNQDPEVFSQPKVLPSAIPIAGSPLVPATTTAVSSVLLSPSVFQQTVPRAADLERK
ASSPSPLTVGTAESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHAVYLQVLTKNKDNH
NL

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History
Entry version 124 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
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Protein

mRNA-decapping enzyme 1A

Gene

Dcp1a

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-21 is the initiator.Curated

GO - Molecular functionⁱ

enzyme activator activity Source: InterPro
hydrolase activity Source: UniProtKB-KW
identical protein binding Source: MGI
kinesin binding Source: MGI
mRNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: MGI
Inferred from sequence alignmentⁱ
- 11836524

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

deadenylation-dependent decapping of nuclear-transcribed mRNA
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
deadenylation-independent decapping of nuclear-transcribed mRNA
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from sequence alignmentⁱ
- 11836524
protein localization to cytoplasmic stress granule Source: MGI
transforming growth factor beta receptor signaling pathway
Source: MGI
Inferred from sequence alignmentⁱ
- 11836524

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Nonsense-mediated mRNA decay

Enzyme and pathway databases

Reactomeⁱ	R-MMU-430039 mRNA decay by 5' to 3' exoribonuclease R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-MMU-430039 mRNA decay by 5' to 3' exoribonuclease
R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: mRNA-decapping enzyme 1A (EC:3.-.-.-) Alternative name(s): MAD homolog 4-interacting transcription coactivator 1 Smad4-interacting transcriptional co-activator Transcription factor SMIF
Gene namesⁱ	Name:Dcp1a Synonyms:Mitc1, Smif
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:1923151 Dcp1a

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000189633	1 – 602	mRNA-decapping enzyme 1AAdd BLAST		602

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	82	PhosphoserineCombined sources	1
Modified residueⁱ	162	PhosphoserineCombined sources	1
Modified residueⁱ	199	PhosphoserineCombined sources	1
Modified residueⁱ	200	PhosphoserineCombined sources	1
Modified residueⁱ	335	PhosphoserineCombined sources	1
Modified residueⁱ	339	PhosphoserineCombined sources	1
Modified residueⁱ	367	PhosphothreonineBy similarity	1
Modified residueⁱ	372	PhosphoserineCombined sources	1
Modified residueⁱ	395	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	420	PhosphothreonineCombined sources	1
Modified residueⁱ	441	PhosphoserineBy similarity	1
Modified residueⁱ	542	PhosphoserineCombined sources	1
Modified residueⁱ	543	PhosphoserineCombined sources	1
Modified residueⁱ	545	PhosphoserineCombined sources	1
Modified residueⁱ	548	PhosphothreonineCombined sources	1
Modified residueⁱ	551	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q91YD3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q91YD3
PaxDbⁱ	Q91YD3
PeptideAtlas More...PeptideAtlasⁱ	Q91YD3
PRIDEⁱ	Q91YD3

PTM databases

iPTMnetⁱ	Q91YD3
PhosphoSitePlusⁱ	Q91YD3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000021962 Expressed in 278 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_DCP1A
ExpressionAtlasⁱ	Q91YD3 baseline and differential
Genevisibleⁱ	Q91YD3 MM

Interactionⁱ

Subunit structureⁱ

Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with DCP1B. Interacts with DCP2. Interacts with DDX17 in an RNA-independent manner. Interacts with PNRC2. Interacts with SMAD4. Interacts with UPF1. Interacts with ZC3HAV1. Interacts with ZFP36L1. Interacts with NBDY.By similarity

GO - Molecular functionⁱ

identical protein binding Source: MGI
kinesin binding Source: MGI
transcription factor binding
Source: MGI
Inferred from sequence alignmentⁱ
- 11836524

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	217832, 1 interactor
IntActⁱ	Q91YD3, 5 interactors
STRINGⁱ	10090.ENSMUSP00000022535

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91YD3
SMRⁱ	Q91YD3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the DCP1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2868 Eukaryota ENOG410XRY6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014855
HOGENOMⁱ	HOG000090228
HOVERGENⁱ	HBG051320
InParanoidⁱ	Q91YD3
KEGG Orthology (KO) More...KOⁱ	K12610
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JB7
PhylomeDBⁱ	Q91YD3
TreeFamⁱ	TF320504

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR010334 Dcp1 IPR031953 mRNA_decap_C IPR011993 PH-like_dom_sf
PANTHERⁱ	PTHR16290 PTHR16290, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06058 DCP1, 1 hit PF16741 mRNA_decap_C, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q91YD3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MALSCSTVRP RRRGSALRSK MELLSRAEQE MSLAALKQHD PYITSIADLT 
        60         70         80         90        100
GQVALYTFCP KANQWEKTDI EGTLFVYRRS ASPYHGFTIV NRLNMHNLVE 
       110        120        130        140        150
PVNKDLEFQL HEPFLLYRNA SLSIYSIWFY DKNDCHRIAK LMADVVEEET 
       160        170        180        190        200
RRSQQAARDK QSPSQANGCS DQRPIDILEM LSRAKDEYER NQMGGSNISS 
       210        220        230        240        250
PGLQPSTQLS NLGSTETLEE TPSGSQDKSA PSGHKHLTVE ELFGTSLPKE 
       260        270        280        290        300
QPTAMGLESE DTDKLLGDAS QKEPSSFLPF PFEQSGGAPQ SENLGIHSAA 
       310        320        330        340        350
HHTVQPEVST PVLITPASIA QSGDKHPPSY TLPLSPVLSP TLPAEAPTTQ 
       360        370        380        390        400
VPHLPRNSTM IQAVKTTPRQ KSPLLNQPVP ELSHSSLVAS QSPFRAPVSL 
       410        420        430        440        450
ANPAGTALPS VDLLQKLRLT PQHDQIQAQP LGKGTMAPSF SSAAGQLATP 
       460        470        480        490        500
ESFIEPSSKT AAARAAVSAS LSNMVLAPTL QSMQQNQDPE VFSQPKVLPS 
       510        520        530        540        550
AIPIAGSPLV PATTTAVSSV LLSPSVFQQT VPRAADLERK ASSPSPLTVG 
       560        570        580        590        600
TAESQRKPSI ILSKSQLQDT LIHLIKNDSS FLSTLHAVYL QVLTKNKDNH 

NL

Length:602

Mass (Da):65,219

Last modified:December 1, 2001 - v1

Checksum:ⁱ55BC9C32BCA86CFD

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A286YCN4	A0A286YCN4_MOUSE	mRNA-decapping enzyme 1A mRNA-decapping enzyme 1A	Dcp1a	177	Annotation score:
A0A286YDC8	A0A286YDC8_MOUSE	mRNA-decapping enzyme 1A mRNA-decapping enzyme 1A	Dcp1a	419	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	481	Q → R in strain: C57BL/6J. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ344447 mRNA Translation: CAC69875.1 BC066173 mRNA Translation: AAH66173.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36848.1
NCBI Reference Sequences More...RefSeqⁱ	NP_598522.3, NM_133761.3
UniGeneⁱ	Mm.28733

Genome annotation databases

Ensemblⁱ	ENSMUST00000022535; ENSMUSP00000022535; ENSMUSG00000021962 ENSMUST00000225196; ENSMUSP00000152897; ENSMUSG00000021962
GeneIDⁱ	75901
KEGGⁱ	mmu:75901
UCSC genome browser More...UCSCⁱ	uc007sva.1 mouse

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91YD3	Uncharacterized protein (Fragment)		MOUSE		412	UniRef100_Q91YD3

Protein	Similar proteins		Species	Score	Length	Source
Q91YD3	Uncharacterized protein (Fragment)		MOUSE		412	UniRef90_Q91YD3
Decapping mRNA 1A		RAT		601
mRNA-decapping enzyme 1A		CRIGR		582
UPI00038C4BAC		MICOH		602
UPI000A3166F2		MUSCR		602
+5

Protein	Similar proteins		Species	Score	Length	Source
Q91YD3	mRNA-decapping enzyme 1A	)	HUMAN		582	UniRef50_Q9NPI6
mRNA-decapping enzyme 1A		PIG		580
Uncharacterized protein		MUSPF		600
mRNA-decapping enzyme 1A isoform X1		LEPWE		600
mRNA-decapping enzyme 1A isoform X1		URSMA		599
+195

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ344447 mRNA Translation: CAC69875.1 BC066173 mRNA Translation: AAH66173.1
CCDSⁱ	CCDS36848.1
RefSeqⁱ	NP_598522.3, NM_133761.3
UniGeneⁱ	Mm.28733

3D structure databases

ProteinModelPortalⁱ	Q91YD3
SMRⁱ	Q91YD3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	217832, 1 interactor
IntActⁱ	Q91YD3, 5 interactors
STRINGⁱ	10090.ENSMUSP00000022535

PTM databases

iPTMnetⁱ	Q91YD3
PhosphoSitePlusⁱ	Q91YD3

Proteomic databases

EPDⁱ	Q91YD3
MaxQBⁱ	Q91YD3
PaxDbⁱ	Q91YD3
PeptideAtlasⁱ	Q91YD3
PRIDEⁱ	Q91YD3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000022535; ENSMUSP00000022535; ENSMUSG00000021962 ENSMUST00000225196; ENSMUSP00000152897; ENSMUSG00000021962
GeneIDⁱ	75901
KEGGⁱ	mmu:75901
UCSCⁱ	uc007sva.1 mouse

Organism-specific databases

CTDⁱ	55802
MGIⁱ	MGI:1923151 Dcp1a

Phylogenomic databases

eggNOGⁱ	KOG2868 Eukaryota ENOG410XRY6 LUCA
GeneTreeⁱ	ENSGT00390000014855
HOGENOMⁱ	HOG000090228
HOVERGENⁱ	HBG051320
InParanoidⁱ	Q91YD3
KOⁱ	K12610
OrthoDBⁱ	EOG091G0JB7
PhylomeDBⁱ	Q91YD3
TreeFamⁱ	TF320504

Enzyme and pathway databases

Reactomeⁱ	R-MMU-430039 mRNA decay by 5' to 3' exoribonuclease R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91YD3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021962 Expressed in 278 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_DCP1A
ExpressionAtlasⁱ	Q91YD3 baseline and differential
Genevisibleⁱ	Q91YD3 MM

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR010334 Dcp1 IPR031953 mRNA_decap_C IPR011993 PH-like_dom_sf
PANTHERⁱ	PTHR16290 PTHR16290, 1 hit
Pfamⁱ	View protein in Pfam PF06058 DCP1, 1 hit PF16741 mRNA_decap_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DCP1A_MOUSE
Accessionⁱ	Q91YD3Primary (citable) accession number: Q91YD3 Secondary accession number(s): Q6NZE3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91YD3 (DCP1A_MOUSE)

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mRNA-decapping enzyme 1A

Dcp1a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ