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Protein

Gap junction delta-3 protein

Gene

Gjd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

  • gap junction channel activity Source: MGI
  • gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Source: BHF-UCL
  • ion channel activity Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-3 protein
Alternative name(s):
Connexin-30.2
Short name:
Cx30.2
Gap junction alpha-11 protein
Gap junction chi-1 protein
Gene namesi
Name:Gjd3
Synonyms:Gja11, Gjc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2384150 Gjd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 76ExtracellularSequence analysisAdd BLAST31
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 136CytoplasmicSequence analysisAdd BLAST39
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 188ExtracellularSequence analysisAdd BLAST31
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 278CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130091 – 278Gap junction delta-3 proteinAdd BLAST278

Proteomic databases

PaxDbiQ91YD1
PRIDEiQ91YD1

Expressioni

Gene expression databases

BgeeiENSMUSG00000047197 Expressed in 12 organ(s), highest expression level in heart
CleanExiMM_GJC1
MM_GJD3

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

BioGridi237256, 1 interactor
STRINGi10090.ENSMUSP00000055246

Structurei

3D structure databases

ProteinModelPortaliQ91YD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Delta-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGI Eukaryota
ENOG4111HI4 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ91YD1
KOiK07627
OMAiGHLLWKG
OrthoDBiEOG091G0KR7
PhylomeDBiQ91YD1
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91YD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEWAFLGSL LDAVQLQSPL VGRLWLVIML IFRILVLATV GGAVFEDEQE
60 70 80 90 100
EFVCNTLQPG CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVIYSMHQA
110 120 130 140 150
SKEAGGAQLA PPCARGRAEA PCSPCALRAR RARRCYLLSV ALRLLAELAF
160 170 180 190 200
LGGQALLYGF RVDPHYACAG PPCPHTVDCF VSRPTEKTVF VVFYFAVGLL
210 220 230 240 250
SALLSVAELG HLLWKGRQRA KLLPPPPPSP SLPSQRGDPD PFGPPAYAHR
260 270
SPAGDSEGEG GSGHSKASLA TVRQDLAI
Length:278
Mass (Da):30,220
Last modified:December 1, 2001 - v1
Checksum:iA8A3DC827D070DE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 16AVQL → PLQV in AAN65188 (PubMed:12681499).Curated4
Sequence conflicti43A → S in AAN65188 (PubMed:12681499).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414561 Genomic DNA Translation: CAC93843.1
AY166870 Genomic DNA Translation: AAN65188.1
AL591067 Genomic DNA No translation available.
CCDSiCCDS25369.1
RefSeqiNP_848711.2, NM_178596.2
UniGeneiMm.453253

Genome annotation databases

EnsembliENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197
GeneIDi353155
KEGGimmu:353155
UCSCiuc007lib.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414561 Genomic DNA Translation: CAC93843.1
AY166870 Genomic DNA Translation: AAN65188.1
AL591067 Genomic DNA No translation available.
CCDSiCCDS25369.1
RefSeqiNP_848711.2, NM_178596.2
UniGeneiMm.453253

3D structure databases

ProteinModelPortaliQ91YD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237256, 1 interactor
STRINGi10090.ENSMUSP00000055246

Proteomic databases

PaxDbiQ91YD1
PRIDEiQ91YD1

Protocols and materials databases

DNASUi353155
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197
GeneIDi353155
KEGGimmu:353155
UCSCiuc007lib.1 mouse

Organism-specific databases

CTDi125111
MGIiMGI:2384150 Gjd3

Phylogenomic databases

eggNOGiENOG410IEGI Eukaryota
ENOG4111HI4 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ91YD1
KOiK07627
OMAiGHLLWKG
OrthoDBiEOG091G0KR7
PhylomeDBiQ91YD1
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Miscellaneous databases

PROiPR:Q91YD1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047197 Expressed in 12 organ(s), highest expression level in heart
CleanExiMM_GJC1
MM_GJD3

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXD3_MOUSE
AccessioniPrimary (citable) accession number: Q91YD1
Secondary accession number(s): Q80ZH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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