UniProtKB - Q91YD1 (CXD3_MOUSE)
Protein
Gap junction delta-3 protein
Gene
Gjd3
Organism
Mus musculus (Mouse)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity
GO - Molecular functioni
- gap junction channel activity Source: MGI
- gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Source: BHF-UCL
- ion channel activity Source: MGI
GO - Biological processi
- AV node cell to bundle of His cell communication by electrical coupling Source: BHF-UCL
- cell-cell signaling Source: GO_Central
- gap junction assembly Source: UniProtKB
- response to glucose Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-190861, Gap junction assembly |
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction delta-3 proteinAlternative name(s): Connexin-30.2 Short name: Cx30.2 Gap junction alpha-11 protein Gap junction chi-1 protein |
Gene namesi | Name:Gjd3 Synonyms:Gja11, Gjc1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384150, Gjd3 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- gap junction By similarity
Plasma Membrane
- connexin complex Source: MGI
Other locations
- cell surface Source: UniProtKB
- gap junction Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 24 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 25 – 45 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 46 – 76 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 98 – 136 | CytoplasmicSequence analysisAdd BLAST | 39 | |
Transmembranei | 137 – 157 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 158 – 188 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 189 – 209 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 278 | CytoplasmicSequence analysisAdd BLAST | 69 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000313009 | 1 – 278 | Gap junction delta-3 proteinAdd BLAST | 278 |
Proteomic databases
PaxDbi | Q91YD1 |
PRIDEi | Q91YD1 |
PTM databases
iPTMneti | Q91YD1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000047197, Expressed in heart and 35 other tissues |
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
By similarityProtein-protein interaction databases
BioGRIDi | 237256, 1 interactor |
STRINGi | 10090.ENSMUSP00000055246 |
Miscellaneous databases
RNActi | Q91YD1, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R6H2, Eukaryota |
GeneTreei | ENSGT01010000222399 |
HOGENOMi | CLU_037388_4_2_1 |
InParanoidi | Q91YD1 |
OMAi | RRARRCY |
OrthoDBi | 1263142at2759 |
PhylomeDBi | Q91YD1 |
TreeFami | TF329606 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q91YD1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEWAFLGSL LDAVQLQSPL VGRLWLVIML IFRILVLATV GGAVFEDEQE
60 70 80 90 100
EFVCNTLQPG CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVIYSMHQA
110 120 130 140 150
SKEAGGAQLA PPCARGRAEA PCSPCALRAR RARRCYLLSV ALRLLAELAF
160 170 180 190 200
LGGQALLYGF RVDPHYACAG PPCPHTVDCF VSRPTEKTVF VVFYFAVGLL
210 220 230 240 250
SALLSVAELG HLLWKGRQRA KLLPPPPPSP SLPSQRGDPD PFGPPAYAHR
260 270
SPAGDSEGEG GSGHSKASLA TVRQDLAI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 – 16 | AVQL → PLQV in AAN65188 (PubMed:12681499).Curated | 4 | |
Sequence conflicti | 43 | A → S in AAN65188 (PubMed:12681499).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ414561 Genomic DNA Translation: CAC93843.1 AY166870 Genomic DNA Translation: AAN65188.1 AL591067 Genomic DNA No translation available. |
CCDSi | CCDS25369.1 |
RefSeqi | NP_848711.2, NM_178596.2 |
Genome annotation databases
Ensembli | ENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197 |
GeneIDi | 353155 |
KEGGi | mmu:353155 |
UCSCi | uc007lib.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ414561 Genomic DNA Translation: CAC93843.1 AY166870 Genomic DNA Translation: AAN65188.1 AL591067 Genomic DNA No translation available. |
CCDSi | CCDS25369.1 |
RefSeqi | NP_848711.2, NM_178596.2 |
3D structure databases
SMRi | Q91YD1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 237256, 1 interactor |
STRINGi | 10090.ENSMUSP00000055246 |
PTM databases
iPTMneti | Q91YD1 |
Proteomic databases
PaxDbi | Q91YD1 |
PRIDEi | Q91YD1 |
Protocols and materials databases
Antibodypediai | 51141, 33 antibodies |
DNASUi | 353155 |
Genome annotation databases
Ensembli | ENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197 |
GeneIDi | 353155 |
KEGGi | mmu:353155 |
UCSCi | uc007lib.1, mouse |
Organism-specific databases
CTDi | 125111 |
MGIi | MGI:2384150, Gjd3 |
Phylogenomic databases
eggNOGi | ENOG502R6H2, Eukaryota |
GeneTreei | ENSGT01010000222399 |
HOGENOMi | CLU_037388_4_2_1 |
InParanoidi | Q91YD1 |
OMAi | RRARRCY |
OrthoDBi | 1263142at2759 |
PhylomeDBi | Q91YD1 |
TreeFami | TF329606 |
Enzyme and pathway databases
Reactomei | R-MMU-190861, Gap junction assembly |
Miscellaneous databases
BioGRID-ORCSi | 353155, 2 hits in 17 CRISPR screens |
ChiTaRSi | Gjd3, mouse |
PROi | PR:Q91YD1 |
RNActi | Q91YD1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000047197, Expressed in heart and 35 other tissues |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXD3_MOUSE | |
Accessioni | Q91YD1Primary (citable) accession number: Q91YD1 Secondary accession number(s): Q80ZH0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families