Gjd3

Functionⁱ

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functionⁱ

gap junction channel activity Source: MGI
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22982984
ion channel activity
Source: MGI
Inferred from direct assayⁱ
- 15879306

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

AV node cell to bundle of His cell communication by electrical coupling
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22982984
gap junction assembly
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 12154091
response to glucose Source: MGI

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190861 Gap junction assembly

Reactomeⁱ

R-MMU-190861 Gap junction assembly

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gap junction delta-3 protein Alternative name(s): Connexin-30.2 Short name: Cx30.2 Gap junction alpha-11 protein Gap junction chi-1 protein
Gene namesⁱ	Name:Gjd3 Synonyms:Gja11, Gjc1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:2384150 Gjd3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 24	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	25 – 45	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	46 – 76	ExtracellularSequence analysisAdd BLAST	31
Transmembraneⁱ	77 – 97	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	98 – 136	CytoplasmicSequence analysisAdd BLAST	39
Transmembraneⁱ	137 – 157	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	158 – 188	ExtracellularSequence analysisAdd BLAST	31
Transmembraneⁱ	189 – 209	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	210 – 278	CytoplasmicSequence analysisAdd BLAST	69

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000313009	1 – 278	Gap junction delta-3 proteinAdd BLAST		278

Proteomic databases

PaxDbⁱ	Q91YD1
PRIDEⁱ	Q91YD1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000047197 Expressed in 12 organ(s), highest expression level in heart
CleanExⁱ	MM_GJC1 MM_GJD3

Interactionⁱ

Subunit structureⁱ

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

BioGridⁱ	237256, 1 interactor
STRINGⁱ	10090.ENSMUSP00000055246

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91YD1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the connexin family. Delta-type subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEGI Eukaryota ENOG4111HI4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	Q91YD1
KEGG Orthology (KO) More...KOⁱ	K07627
OMAⁱ	GHLLWKG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KR7
PhylomeDBⁱ	Q91YD1
TreeFamⁱ	TF329606

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00408 CONNEXINS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q91YD1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGEWAFLGSL LDAVQLQSPL VGRLWLVIML IFRILVLATV GGAVFEDEQE 
        60         70         80         90        100
EFVCNTLQPG CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVIYSMHQA 
       110        120        130        140        150
SKEAGGAQLA PPCARGRAEA PCSPCALRAR RARRCYLLSV ALRLLAELAF 
       160        170        180        190        200
LGGQALLYGF RVDPHYACAG PPCPHTVDCF VSRPTEKTVF VVFYFAVGLL 
       210        220        230        240        250
SALLSVAELG HLLWKGRQRA KLLPPPPPSP SLPSQRGDPD PFGPPAYAHR 
       260        270 
SPAGDSEGEG GSGHSKASLA TVRQDLAI

Length:278

Mass (Da):30,220

Last modified:December 1, 2001 - v1

Checksum:ⁱA8A3DC827D070DE9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	13 – 16	AVQL → PLQV in AAN65188 (PubMed:12681499).Curated		4
Sequence conflictⁱ	43	A → S in AAN65188 (PubMed:12681499).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ414561 Genomic DNA Translation: CAC93843.1 AY166870 Genomic DNA Translation: AAN65188.1 AL591067 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25369.1
NCBI Reference Sequences More...RefSeqⁱ	NP_848711.2, NM_178596.2
UniGeneⁱ	Mm.453253

Genome annotation databases

Ensemblⁱ	ENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197
GeneIDⁱ	353155
KEGGⁱ	mmu:353155
UCSC genome browser More...UCSCⁱ	uc007lib.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91YD1	Gap junction protein		RAT		278	UniRef90_Q91YD1
Gap junction protein		NEOLE		277
Connexin30.2 (Fragment)		CRIGR		101
UPI000A31A520		MUSCR		278
UPI000A31165E		MUSPA		277
+2

Protein	Similar proteins		Species	Score	Length	Source
Q91YD1	Gap junction delta-3 protein		HUMAN		294	UniRef50_Q8N144
Gap junction protein		NOMLE		298
Gap junction protein		PAPAN		295
Gap junction protein		MACNE		294
Gap junction protein		PONAB		294
+74

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ414561 Genomic DNA Translation: CAC93843.1 AY166870 Genomic DNA Translation: AAN65188.1 AL591067 Genomic DNA No translation available.
CCDSⁱ	CCDS25369.1
RefSeqⁱ	NP_848711.2, NM_178596.2
UniGeneⁱ	Mm.453253

3D structure databases

ProteinModelPortalⁱ	Q91YD1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	237256, 1 interactor
STRINGⁱ	10090.ENSMUSP00000055246

Proteomic databases

PaxDbⁱ	Q91YD1
PRIDEⁱ	Q91YD1

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	353155
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197
GeneIDⁱ	353155
KEGGⁱ	mmu:353155
UCSCⁱ	uc007lib.1 mouse

Organism-specific databases

CTDⁱ	125111
MGIⁱ	MGI:2384150 Gjd3

Phylogenomic databases

eggNOGⁱ	ENOG410IEGI Eukaryota ENOG4111HI4 LUCA
GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	Q91YD1
KOⁱ	K07627
OMAⁱ	GHLLWKG
OrthoDBⁱ	EOG091G0KR7
PhylomeDBⁱ	Q91YD1
TreeFamⁱ	TF329606

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190861 Gap junction assembly

Reactomeⁱ

R-MMU-190861 Gap junction assembly

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q91YD1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000047197 Expressed in 12 organ(s), highest expression level in heart
CleanExⁱ	MM_GJC1 MM_GJD3

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00408 CONNEXINS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXD3_MOUSE
Accessionⁱ	Q91YD1Primary (citable) accession number: Q91YD1 Secondary accession number(s): Q80ZH0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q91YD1 (CXD3_MOUSE)

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Gap junction delta-3 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ