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Protein

Fructose-bisphosphate aldolase B

Gene

Aldob

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi)
  3. ATP-dependent 6-phosphofructokinase (Pfkp), ATP-dependent 6-phosphofructokinase, muscle type (Pfkm), ATP-dependent 6-phosphofructokinase, platelet type (Pfkp), ATP-dependent 6-phosphofructokinase, liver type (Pfkl), ATP-dependent 6-phosphofructokinase (Pfkm)
  4. Fructose-bisphosphate aldolase (Aldob), Fructose-bisphosphate aldolase (Aldoart1), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoart1), Fructose-bisphosphate aldolase (Aldoart2), Fructose-bisphosphate aldolase A (Aldoa), Fructose-bisphosphate aldolase C (Aldoc), Fructose-bisphosphate aldolase B (Aldob), Fructose-bisphosphate aldolase (Aldob), Fructose-bisphosphate aldolase (Aldoa)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56Substrate1
Binding sitei147Substrate1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

  • ATPase binding Source: MGI
  • cytoskeletal protein binding Source: MGI
  • fructose-1-phosphate aldolase activity Source: MGI
  • fructose binding Source: MGI
  • fructose-bisphosphate aldolase activity Source: MGI
  • identical protein binding Source: MGI
  • phosphatidylcholine binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-MMU-70171 Glycolysis
R-MMU-70263 Gluconeogenesis
R-MMU-70350 Fructose catabolism
UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Aldolase 2
Liver-type aldolase
Gene namesi
Name:Aldob
Synonyms:Aldo2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:87995 Aldob

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002169412 – 364Fructose-bisphosphate aldolase BAdd BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei13N6-succinyllysineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei39PhosphothreonineCombined sources1
Modified residuei89PhosphoserineBy similarity1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei121N6-succinyllysineCombined sources1
Modified residuei132PhosphoserineBy similarity1
Modified residuei206PhosphoserineCombined sources1
Modified residuei272PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Modified residuei317N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91Y97
PaxDbiQ91Y97
PeptideAtlasiQ91Y97
PRIDEiQ91Y97

PTM databases

CarbonylDBiQ91Y97
iPTMnetiQ91Y97
PhosphoSitePlusiQ91Y97
SwissPalmiQ91Y97

Expressioni

Gene expression databases

BgeeiENSMUSG00000028307 Expressed in 149 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_ALDOB
ExpressionAtlasiQ91Y97 baseline and differential
GenevisibleiQ91Y97 MM

Interactioni

Subunit structurei

Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91Y97, 5 interactors
MINTiQ91Y97
STRINGi10090.ENSMUSP00000029987

Structurei

3D structure databases

ProteinModelPortaliQ91Y97
SMRiQ91Y97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOGENOMiHOG000220876
HOVERGENiHBG002386
InParanoidiQ91Y97
KOiK01623
OMAiPLCKPWA
OrthoDBiEOG091G0A9T
PhylomeDBiQ91Y97
TreeFamiTF314203

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91Y97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHRFPALTP EQKKELSEIA QRIVANGKGI LAADESVGTM GNRLQRIKVE
60 70 80 90 100
NTEENRRQFR ELLFSVDNSI SQSIGGVILF HETLYQKDSQ GNLFRNVLKE
110 120 130 140 150
KGIVVGIKLD QGGAPLAGTN KETTIQGLDG LSERCAQYKK DGVDFGKWRA
160 170 180 190 200
VLRIADQCPS SLAIQENANA LARYASICQQ NGLVPIVEPE VLPDGDHDLE
210 220 230 240 250
HCQYVSEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHAC TKKYTPEQVA
260 270 280 290 300
MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINRC PLPRPWKLSF
310 320 330 340 350
SYGRALQASA LAAWGGKAAN KKATQEAFMK RAMANCQAAQ GQYVHTGSSG
360
AAATQSLFTA SYTY
Length:364
Mass (Da):39,507
Last modified:January 23, 2007 - v3
Checksum:iE6CD995D0073ED47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81H → Y in AAH34173 (PubMed:15489334).Curated1
Sequence conflicti155 – 156AD → DH in AAL06323 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403567, AF403565, AF403566 Genomic DNA Translation: AAL06323.1
BC016435 mRNA Translation: AAH16435.1
BC022113 mRNA Translation: AAH22113.1
BC024056 mRNA Translation: AAH24056.1
BC024112 mRNA Translation: AAH24112.1
BC026577 mRNA Translation: AAH26577.1
BC030724 mRNA Translation: AAH30724.1
BC030725 mRNA Translation: AAH30725.1
BC034169 mRNA Translation: AAH34169.1
BC034171 mRNA Translation: AAH34171.1
BC034172 mRNA Translation: AAH34172.1
BC034173 mRNA Translation: AAH34173.1
BC036130 mRNA Translation: AAH36130.1
BC036131 mRNA Translation: AAH36131.1
BC036132 mRNA Translation: AAH36132.1
BC036133 mRNA Translation: AAH36133.1
CCDSiCCDS18176.1
RefSeqiNP_659152.1, NM_144903.3
UniGeneiMm.482116

Genome annotation databases

EnsembliENSMUST00000029987; ENSMUSP00000029987; ENSMUSG00000028307
GeneIDi230163
KEGGimmu:230163
UCSCiuc008svw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403567, AF403565, AF403566 Genomic DNA Translation: AAL06323.1
BC016435 mRNA Translation: AAH16435.1
BC022113 mRNA Translation: AAH22113.1
BC024056 mRNA Translation: AAH24056.1
BC024112 mRNA Translation: AAH24112.1
BC026577 mRNA Translation: AAH26577.1
BC030724 mRNA Translation: AAH30724.1
BC030725 mRNA Translation: AAH30725.1
BC034169 mRNA Translation: AAH34169.1
BC034171 mRNA Translation: AAH34171.1
BC034172 mRNA Translation: AAH34172.1
BC034173 mRNA Translation: AAH34173.1
BC036130 mRNA Translation: AAH36130.1
BC036131 mRNA Translation: AAH36131.1
BC036132 mRNA Translation: AAH36132.1
BC036133 mRNA Translation: AAH36133.1
CCDSiCCDS18176.1
RefSeqiNP_659152.1, NM_144903.3
UniGeneiMm.482116

3D structure databases

ProteinModelPortaliQ91Y97
SMRiQ91Y97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91Y97, 5 interactors
MINTiQ91Y97
STRINGi10090.ENSMUSP00000029987

PTM databases

CarbonylDBiQ91Y97
iPTMnetiQ91Y97
PhosphoSitePlusiQ91Y97
SwissPalmiQ91Y97

Proteomic databases

MaxQBiQ91Y97
PaxDbiQ91Y97
PeptideAtlasiQ91Y97
PRIDEiQ91Y97

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029987; ENSMUSP00000029987; ENSMUSG00000028307
GeneIDi230163
KEGGimmu:230163
UCSCiuc008svw.1 mouse

Organism-specific databases

CTDi229
MGIiMGI:87995 Aldob

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOGENOMiHOG000220876
HOVERGENiHBG002386
InParanoidiQ91Y97
KOiK01623
OMAiPLCKPWA
OrthoDBiEOG091G0A9T
PhylomeDBiQ91Y97
TreeFamiTF314203

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

ReactomeiR-MMU-70171 Glycolysis
R-MMU-70263 Gluconeogenesis
R-MMU-70350 Fructose catabolism

Miscellaneous databases

ChiTaRSiAldob mouse
PROiPR:Q91Y97
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028307 Expressed in 149 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_ALDOB
ExpressionAtlasiQ91Y97 baseline and differential
GenevisibleiQ91Y97 MM

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALDOB_MOUSE
AccessioniPrimary (citable) accession number: Q91Y97
Secondary accession number(s): Q8K034, Q91W73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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