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Protein

Deoxynucleotidyltransferase terminal-interacting protein 1

Gene

Dnttip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi157 – 171A.T hookCuratedAdd BLAST15
DNA bindingi214 – 235H-T-H motifCuratedAdd BLAST22

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxynucleotidyltransferase terminal-interacting protein 1
Alternative name(s):
Terminal deoxynucleotidyltransferase-interacting factor 1
Short name:
TdIF1
Short name:
TdT-interacting factor 1
Gene namesi
Name:Dnttip1
Synonyms:Tdif1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621627 Dnttip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724751 – 327Deoxynucleotidyltransferase terminal-interacting protein 1Add BLAST327

Proteomic databases

PRIDEiQ91Y53

Expressioni

Tissue specificityi

Expressed in thymus, bone marrow and spleen.

Interactioni

Subunit structurei

Monomer and homodimer. A minor proportion may form homotrimers. Interacts with ZNF541. Interacts with the terminal deoxynucleotidyltransferase DNTT. Interacts with TRERF1. Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and ELMSAN1; this complex assembles into a tetramer that contains four copies of each protein chain. Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2.By similarity

Structurei

3D structure databases

SMRiQ91Y53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 146Important for dimerizationBy similarityAdd BLAST92
Regioni195 – 314Important for DNA and nucleosome bindingBy similarityAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi162 – 168Nuclear localization signalSequence analysis7

Domaini

The N-terminal domain mediates dimerization.By similarity
The C-terminal domain mediates interaction with DNA and nucleosomes. It contains a HTH motif that mediates recognition of the consensus sequence.By similarity

Phylogenomic databases

HOGENOMiHOG000059597
HOVERGENiHBG057022
InParanoidiQ91Y53

Family and domain databases

InterProiView protein in InterPro
IPR026064 TdIF1
PANTHERiPTHR23399 PTHR23399, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q91Y53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGATGDTGGP RPGTESRRPG NVGNAGAAGQ PVLTNPWNIM IKPRQVQRRG
60 70 80 90 100
RRSQMTTSFT DPAISMDLLR AVLQPSINEE IQSVFNKYMK FFQKAALNVR
110 120 130 140 150
DNVGEEVDAE QLIQEACRSC VEQAKLLFSD GEKVIPRLAH ELPGIKRGRQ
160 170 180 190 200
AEEESHREAP FPKRGKVGLP GHVLSNDRAA AGMVWKPKSC EPIRREGPKW
210 220 230 240 250
DPARLNESTT FVLGSRANKA LGMGGTRGRI YIKHPHLFKY AADPQDKHWL
260 270 280 290 300
AEQHHMRATG GKMAYLLIEE DIRDLAASDD YRGCLDLKLE ELKSFVLPSW
310 320
MVEKMRKYME TLRTENEHRA AEATPQT
Length:327
Mass (Da):36,692
Last modified:December 1, 2001 - v1
Checksum:i657B09069567841B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q497A7Q497A7_RAT
Deoxynucleotidyltransferase termina...
Dnttip1 rCG_32375
328Annotation score:
A0A0G2JVL2A0A0G2JVL2_RAT
Deoxynucleotidyltransferase termina...
Dnttip1
326Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348701 mRNA Translation: AAK49953.1
UniGeneiRn.82702

Genome annotation databases

UCSCiRGD:621627 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348701 mRNA Translation: AAK49953.1
UniGeneiRn.82702

3D structure databases

SMRiQ91Y53
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ91Y53

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621627 rat

Organism-specific databases

RGDi621627 Dnttip1

Phylogenomic databases

HOGENOMiHOG000059597
HOVERGENiHBG057022
InParanoidiQ91Y53

Miscellaneous databases

PROiPR:Q91Y53

Family and domain databases

InterProiView protein in InterPro
IPR026064 TdIF1
PANTHERiPTHR23399 PTHR23399, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTDIF1_RAT
AccessioniPrimary (citable) accession number: Q91Y53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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