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Protein
Submitted name:

Protocadherin alpha 3

Gene

Pcdha3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin alpha 3Imported
Gene namesi
Name:Pcdha3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2447313 Pcdha3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei692 – 715HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501509953327 – 942Sequence analysisAdd BLAST916

Expressioni

Gene expression databases

BgeeiENSMUSG00000102312 Expressed in 6 organ(s), highest expression level in Ammon's horn

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 128CAInterPro annotationAdd BLAST87
Domaini152 – 237CAInterPro annotationAdd BLAST86
Domaini261 – 345CAInterPro annotationAdd BLAST85
Domaini369 – 450CAInterPro annotationAdd BLAST82
Domaini474 – 560CAInterPro annotationAdd BLAST87
Domaini588 – 670CAInterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili911 – 931Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00920000148964
HOVERGENiHBG054878
KOiK16493
OMAiFISESRQ
OrthoDBiEOG091G00KR

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits

Sequencei

Sequence statusi: Complete.

Q91Y16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVFSQREDRH LLLWLLLFAA WEAGSGQLHY SVPEEAKHGT FVGRIAQDLG
60 70 80 90 100
LELAELVPRL FRVASKDRGD LLEVNLQNGI LFVNSRIDRE ELCGRSAECS
110 120 130 140 150
IHLEVIVDRP LQVFHVEVEV RDINDNPPVF PVATKNLFIY ESRPLGSRFS
160 170 180 190 200
LEGASDADIG TNSLLSYSLN SSEYFSLDVK RKDEEIKSLG LVLKKLLNRE
210 220 230 240 250
DIPEHNLLIT AVDGGKPELT GTTQVKITVL DVNDNAPAFE KTFYKVRLPE
260 270 280 290 300
NAPNGTVVVD VDASDLDEGV NKDIVYSFHQ DMSLEILSKF HLDPISGYIT
310 320 330 340 350
VKGNIDFEET KSFEIQIEAA DKGTPPMTDH CTVLVEIVDV NDNVPELVIK
360 370 380 390 400
SLSLPVLENS APSTVIALIS VSDRDSGANG QVTCSLTPQV PFKLVSTFKN
410 420 430 440 450
YYSLVLDSVL DRETISNYNV VVTARDGGSP SLCTTASVSV EVADVNDNAP
460 470 480 490 500
AFAQPEYTVF VKENNPPGAH IFTVSAMDAD AQENALVSYS LVERRVGERL
510 520 530 540 550
LSSYVSVHAE SGKVFALQPL DHEELELLQF QVSARDAGVP ALGSNVTLQV
560 570 580 590 600
FVLDENDNAP TLLGPHAGSA VSELVSRTVG AGHVVTKVRA VDADSGYNAW
610 620 630 640 650
LSYELQSAAG SGRLPFRVGL YTGEISTTRV LDETDAPRQR LLVLVKDHGE
660 670 680 690 700
PVLTATATLL VSLVESGHTP NTPSRTLVDS AGREASLVDI NVYLIIAICA
710 720 730 740 750
VSSLLVLTLL LYLALRCSTA PTEGGPGKPM LVCSSAVGTW SYSQQRRQRV
760 770 780 790 800
CSGEGPPKTD LMAFSPSLTP CPVNQDKEDK LVGDIDFSIK PRQPNPDWRY
810 820 830 840 850
SASLRAGMHS SVHLEEAGIL RAGPGGPDQQ WPTVSSATPE PEAGEVSPPV
860 870 880 890 900
GAGVNSNSWT FKYGPGNPKQ SGPGELPDKF IIPGSPAIIS IRQEPANNQI
910 920 930 940
DKSDFITFGK KEETKKKKKK KKGNKTQEKK EKGNSTTDNS DQ
Length:942
Mass (Da):102,248
Last modified:December 1, 2001 - v1
Checksum:iAAB791DB7FFE593C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020968 Genomic DNA No translation available.
AC020972 Genomic DNA No translation available.
AC020973 Genomic DNA No translation available.
BC141348 mRNA Translation: AAI41349.1
AY013761 mRNA Translation: AAK26050.1
RefSeqiNP_619603.1, NM_138662.1
UniGeneiMm.308500

Genome annotation databases

EnsembliENSMUST00000192503; ENSMUSP00000141989; ENSMUSG00000102312
GeneIDi192163
KEGGimmu:192163
UCSCiuc008eow.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020968 Genomic DNA No translation available.
AC020972 Genomic DNA No translation available.
AC020973 Genomic DNA No translation available.
BC141348 mRNA Translation: AAI41349.1
AY013761 mRNA Translation: AAK26050.1
RefSeqiNP_619603.1, NM_138662.1
UniGeneiMm.308500

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000192503; ENSMUSP00000141989; ENSMUSG00000102312
GeneIDi192163
KEGGimmu:192163
UCSCiuc008eow.2 mouse

Organism-specific databases

CTDi56145
MGIiMGI:2447313 Pcdha3

Phylogenomic databases

GeneTreeiENSGT00920000148964
HOVERGENiHBG054878
KOiK16493
OMAiFISESRQ
OrthoDBiEOG091G00KR

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000102312 Expressed in 6 organ(s), highest expression level in Ammon's horn

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ91Y16_MOUSE
AccessioniPrimary (citable) accession number: Q91Y16
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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