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Protein
Submitted name:

Protocadherin alpha 5

Gene

Pcdha5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin alpha 5Imported
Gene namesi
Name:Pcdha5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1298371 Pcdha5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei695 – 715HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501509950730 – 934Sequence analysisAdd BLAST905

Expressioni

Gene expression databases

BgeeiENSMUSG00000103092 Expressed in 14 organ(s), highest expression level in Ammon's horn

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 131CAInterPro annotationAdd BLAST111
Domaini155 – 240CAInterPro annotationAdd BLAST86
Domaini264 – 348CAInterPro annotationAdd BLAST85
Domaini372 – 453CAInterPro annotationAdd BLAST82
Domaini477 – 563CAInterPro annotationAdd BLAST87
Domaini591 – 673CAInterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili903 – 923Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140770
HOVERGENiHBG054878
KOiK16493
OMAiLDYEDCK
OrthoDBiEOG091G00KR

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits

Sequencei

Sequence statusi: Complete.

Q91Y15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVYFQRGSPG FRRLLISFVL LAAWEAGSGQ LHYSIPEEAK HGTFVGRIAQ
60 70 80 90 100
DLGLELTELV PRLFRVASKD RGDLLEVNLQ NGILFVNSRI DREELCGRSA
110 120 130 140 150
ECSIHLEVIV DRPLQVFHVE VEVKDINDNP PKFSRPEQRL FILESRMPDS
160 170 180 190 200
RFPVEGASDL DIGANAALSY KINPNEYFDL DVKRNEEETS VLQLVLKKPL
210 220 230 240 250
DREETQEHRL LLIAIDGGKP ELTGTVQLLI DVLDANDNAP EFDKSIYNVR
260 270 280 290 300
LLENTPNGTL VIKLNASDAD EGINKEILYF FSNLVLDDVK SKFTIDSSSG
310 320 330 340 350
EIKVKGELDY EDCKVYEINI DAVDRSAFPL AGHCKIIVKL VDVNDNVPEM
360 370 380 390 400
AITSIFLPIK EDAPLATVIA LISVSDRDSG ANGQVTCSLT PHIPFKLVST
410 420 430 440 450
FKNYYSLVLD RALDRETIAN YDVVVTARDG GSPSLWATAS VSVEVADVND
460 470 480 490 500
NVPAFAQPEY TVFVKENNPP GAHIFTVSAM DADAQENALV SYSLVERRVG
510 520 530 540 550
ERLLSSYVSV HAESGKVFAL QPLDHEELEL LQFQVSARDA GVPALGSNVT
560 570 580 590 600
LQVFVLDEND NAPTLLGPQG SGGTIELLSR SVSSGHVVAK VRAVDADSGY
610 620 630 640 650
NAWLSYELQP ATGAVRSPFR VGLYTGEIST TRVLDEADMP RQRLLVLVKD
660 670 680 690 700
HGEPPLTATA TFLVSLVENS QTPKVSSRVL VGTSGSDSTL IDVNVYLIIA
710 720 730 740 750
ICAVSSLLVL TLLLYTAIRC SATPTDGACA PGKPVLVCSS AVGTWSYSQQ
760 770 780 790 800
RRQRVCSGEG PPKTDLMAFS PSLPQGPSST ENPRQPNPDW RYSASLRAGM
810 820 830 840 850
HSSVHLEEAG ILRAGPGGPD QQWPTVSSAT PEPEAGEVSP PVGAGVNSNS
860 870 880 890 900
WTFKYGPGNP KQSGPGELPD KFIIPGSPAI ISIRQEPANN QIDKSDFITF
910 920 930
GKKEETKKKK KKKKGNKTQE KKEKGNSTTD NSDQ
Length:934
Mass (Da):101,694
Last modified:December 1, 2001 - v1
Checksum:i20A03803CE807428
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020968 Genomic DNA No translation available.
AC020972 Genomic DNA No translation available.
AC020973 Genomic DNA No translation available.
AY013763 mRNA Translation: AAK26052.1
RefSeqiNP_034089.1, NM_009959.1
UniGeneiMm.308500

Genome annotation databases

EnsembliENSMUST00000192168; ENSMUSP00000142293; ENSMUSG00000103092
GeneIDi12941
KEGGimmu:12941
UCSCiuc008eoz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020968 Genomic DNA No translation available.
AC020972 Genomic DNA No translation available.
AC020973 Genomic DNA No translation available.
AY013763 mRNA Translation: AAK26052.1
RefSeqiNP_034089.1, NM_009959.1
UniGeneiMm.308500

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi12941
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000192168; ENSMUSP00000142293; ENSMUSG00000103092
GeneIDi12941
KEGGimmu:12941
UCSCiuc008eoz.2 mouse

Organism-specific databases

CTDi56143
MGIiMGI:1298371 Pcdha5

Phylogenomic databases

GeneTreeiENSGT00900000140770
HOVERGENiHBG054878
KOiK16493
OMAiLDYEDCK
OrthoDBiEOG091G00KR

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000103092 Expressed in 14 organ(s), highest expression level in Ammon's horn

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ91Y15_MOUSE
AccessioniPrimary (citable) accession number: Q91Y15
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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