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Protein
Submitted name:

Protocadherin alpha 8

Gene

Pcdha8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin alpha 8Imported
Gene namesi
Name:Pcdha8Imported
Synonyms:Pcdha1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2681879 Pcdha8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei698 – 718HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501509954230 – 946Sequence analysisAdd BLAST917

Expressioni

Gene expression databases

BgeeiENSMUSG00000103800 Expressed in 8 organ(s), highest expression level in Ammon's horn

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 131CAInterPro annotationAdd BLAST112
Domaini155 – 240CAInterPro annotationAdd BLAST86
Domaini264 – 348CAInterPro annotationAdd BLAST85
Domaini372 – 453CAInterPro annotationAdd BLAST82
Domaini477 – 563CAInterPro annotationAdd BLAST87
Domaini594 – 676CAInterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili915 – 935Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00920000148958
HOVERGENiHBG054878
KOiK16493
OMAiGYNPESR
OrthoDBiEOG091G00KR

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits

Sequencei

Sequence statusi: Complete.

Q91Y12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCLGGAVPD DQLLVLSLLL IAVWEVGSGQ LHYSIPEEAK HGTFVGRIAQ
60 70 80 90 100
DLELQLPELV PGLFQLDSKG FGDLLEVNLQ NGILFVNSRI DREELCGRSA
110 120 130 140 150
ECSIHLEVIV DRPLQVFHVE VEVRDINDNP PMFPATQKAL FIPESRLLDS
160 170 180 190 200
RFPLEGASDA DVGSNALLTY RLSTNEHFSL DVPPNHEQVK PLGLVLRKPL
210 220 230 240 250
DREEAAEIRL LLTATDGGKP ELTGTVQLLI TVLDVNDNAP VFDRSLYTVK
260 270 280 290 300
LPENVPNGSL VIKVNASDLD EGVNGDVMYS FSSDVSSDIK SKFHMDTVSG
310 320 330 340 350
EITVIGIIDF EESKAYKIPL EARDKGLPPL IGHCTVLVEV VDANDNAPQL
360 370 380 390 400
NVKTLWLPVK EDAQLGKIIA LISVIDLDSG INGQVTCSLT NHVPFKLVST
410 420 430 440 450
FKNYYSLVLD SALDRETISN YDVIVTARDG GSPSLLATAS VSVEVADVND
460 470 480 490 500
NAPAFAQPEY TVFVKENNPP GAHIFTVSAV DADAQENALV SYSLVERRVG
510 520 530 540 550
ERLLSSYVSV HAESGKVFAL QPLDHEELEL LQFQVSARDA GVPALGSNVT
560 570 580 590 600
LQVFVLDEND NVPMLLGSGT GGSDGVFNQL LSRSVDPGHV VAKVRAVDAD
610 620 630 640 650
SGYNAWLSYE LLSWPGSMRS PFRVGLYTGE ISTTRSLDET DGTRQRLLVL
660 670 680 690 700
VKDHGEPPLT ATVTVLVSLV ESGQAPKTSS RSSVGVTVPE PSLVDVNVYL
710 720 730 740 750
IIAICAVSSL LVLTLLLYTA LRCSATPTGG ACGSGKPMLV CSSAAGTWSY
760 770 780 790 800
SQQRRQRVCS GEGPPKTDLM AFSPGLPPCP GSAEPSVSLD SSEKPRQPNP
810 820 830 840 850
DWRYSASLRA GMHSSVHLEE AGILRAGPGG PDQQWPTVSS ATPEPEAGEV
860 870 880 890 900
SPPVGAGVNS NSWTFKYGPG NPKQSGPGEL PDKFIIPGSP AIISIRQEPA
910 920 930 940
NNQIDKSDFI TFGKKEETKK KKKKKKGNKT QEKKEKGNST TDNSDQ
Length:946
Mass (Da):101,760
Last modified:December 1, 2001 - v1
Checksum:i5E060D4A81E1076F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020972 Genomic DNA No translation available.
AC020973 Genomic DNA No translation available.
BC139424 mRNA Translation: AAI39425.1
BC139426 mRNA Translation: AAI39427.1
AY013766 mRNA Translation: AAK26055.1
RefSeqiNP_957695.1, NM_201243.1
UniGeneiMm.308500

Genome annotation databases

EnsembliENSMUST00000194038; ENSMUSP00000142159; ENSMUSG00000103800
GeneIDi353235
KEGGimmu:353235
UCSCiuc008epd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020972 Genomic DNA No translation available.
AC020973 Genomic DNA No translation available.
BC139424 mRNA Translation: AAI39425.1
BC139426 mRNA Translation: AAI39427.1
AY013766 mRNA Translation: AAK26055.1
RefSeqiNP_957695.1, NM_201243.1
UniGeneiMm.308500

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000194038; ENSMUSP00000142159; ENSMUSG00000103800
GeneIDi353235
KEGGimmu:353235
UCSCiuc008epd.2 mouse

Organism-specific databases

CTDi56140
MGIiMGI:2681879 Pcdha8

Phylogenomic databases

GeneTreeiENSGT00920000148958
HOVERGENiHBG054878
KOiK16493
OMAiGYNPESR
OrthoDBiEOG091G00KR

Miscellaneous databases

ChiTaRSiPcdha1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000103800 Expressed in 8 organ(s), highest expression level in Ammon's horn

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ91Y12_MOUSE
AccessioniPrimary (citable) accession number: Q91Y12
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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