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UniProtKB - Q91XZ0 (Q91XZ0_MOUSE)
Protein
Submitted name:
Protocadherin gamma A1
Gene
Pcdhga1
Organism
Mus musculus (Mouse)
Status
Functioni
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
ARBA annotationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 37 | Calcium 1Combined sources | 1 | |
Metal bindingi | 37 | Calcium 2Combined sources | 1 | |
Metal bindingi | 38 | Calcium 1Combined sources | 1 | |
Metal bindingi | 91 | Calcium 1Combined sources | 1 | |
Metal bindingi | 93 | Calcium 1Combined sources | 1 | |
Metal bindingi | 93 | Calcium 2Combined sources | 1 | |
Metal bindingi | 125 | Calcium 2Combined sources | 1 | |
Metal bindingi | 126 | Calcium 2; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 127 | Calcium 3Combined sources | 1 | |
Metal bindingi | 127 | Calcium 4Combined sources | 1 | |
Metal bindingi | 128 | Calcium 1Combined sources | 1 | |
Metal bindingi | 128 | Calcium 2Combined sources | 1 | |
Metal bindingi | 129 | Calcium 3; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 129 | Calcium 4; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 129 | Calcium 5; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 144 | Calcium 6Combined sources | 1 | |
Metal bindingi | 144 | Calcium 7Combined sources | 1 | |
Metal bindingi | 144 | Calcium 8Combined sources | 1 | |
Metal bindingi | 159 | Calcium 3Combined sources | 1 | |
Metal bindingi | 159 | Calcium 5Combined sources | 1 | |
Metal bindingi | 161 | Calcium 2Combined sources | 1 | |
Metal bindingi | 161 | Calcium 4Combined sources | 1 | |
Metal bindingi | 161 | Calcium 5Combined sources | 1 | |
Metal bindingi | 165 | Calcium 3; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 165 | Calcium 4; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 165 | Calcium 5; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 201 | Calcium 6Combined sources | 1 | |
Metal bindingi | 203 | Calcium 6Combined sources | 1 | |
Metal bindingi | 203 | Calcium 7Combined sources | 1 | |
Metal bindingi | 203 | Calcium 8Combined sources | 1 | |
Metal bindingi | 216 | Calcium 3Combined sources | 1 | |
Metal bindingi | 216 | Calcium 4Combined sources | 1 | |
Metal bindingi | 216 | Calcium 5Combined sources | 1 | |
Metal bindingi | 234 | Calcium 7Combined sources | 1 | |
Metal bindingi | 234 | Calcium 8Combined sources | 1 | |
Metal bindingi | 235 | Calcium 7; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 235 | Calcium 8; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 236 | Calcium 10Combined sources | 1 | |
Metal bindingi | 236 | Calcium 9Combined sources | 1 | |
Metal bindingi | 237 | Calcium 6Combined sources | 1 | |
Metal bindingi | 237 | Calcium 7Combined sources | 1 | |
Metal bindingi | 238 | Calcium 10; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 238 | Calcium 9; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 253 | Calcium 11Combined sources | 1 | |
Metal bindingi | 253 | Calcium 12Combined sources | 1 | |
Metal bindingi | 268 | Calcium 9Combined sources | 1 | |
Metal bindingi | 270 | Calcium 10Combined sources | 1 | |
Metal bindingi | 270 | Calcium 7Combined sources | 1 | |
Metal bindingi | 270 | Calcium 9Combined sources | 1 | |
Metal bindingi | 274 | Calcium 10; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 274 | Calcium 9; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 308 | Calcium 11Combined sources | 1 | |
Metal bindingi | 310 | Calcium 11Combined sources | 1 | |
Metal bindingi | 310 | Calcium 12Combined sources | 1 | |
Metal bindingi | 323 | Calcium 10Combined sources | 1 | |
Metal bindingi | 323 | Calcium 9Combined sources | 1 | |
Metal bindingi | 339 | Calcium 12Combined sources | 1 | |
Metal bindingi | 340 | Calcium 12; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 341 | Calcium 13Combined sources | 1 | |
Metal bindingi | 341 | Calcium 14Combined sources | 1 | |
Metal bindingi | 342 | Calcium 11Combined sources | 1 | |
Metal bindingi | 342 | Calcium 12Combined sources | 1 | |
Metal bindingi | 343 | Calcium 13; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 343 | Calcium 14; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 343 | Calcium 15; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 373 | Calcium 13Combined sources | 1 | |
Metal bindingi | 373 | Calcium 14Combined sources | 1 | |
Metal bindingi | 373 | Calcium 15Combined sources | 1 | |
Metal bindingi | 375 | Calcium 12Combined sources | 1 | |
Metal bindingi | 375 | Calcium 13Combined sources | 1 | |
Metal bindingi | 375 | Calcium 15Combined sources | 1 | |
Metal bindingi | 379 | Calcium 13; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 379 | Calcium 14; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 379 | Calcium 15; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 426 | Calcium 14Combined sources | 1 | |
Metal bindingi | 426 | Calcium 15Combined sources | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB-UniRule
GO - Biological processi
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keywordsi
Biological process | Cell adhesionARBA annotation |
Ligand | CalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingCombined sources |
Names & Taxonomyi
Protein namesi | Submitted name: Protocadherin gamma A1ImportedSubmitted name: Protocadherin gamma subfamily A, 1Imported |
Gene namesi | Name:Pcdhga1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1935212, Pcdhga1 |
VEuPathDBi | HostDB:ENSMUSG00000103144 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 691 – 714 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_5015099502 | 29 – 931 | Sequence analysisAdd BLAST | 903 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 96 ↔ 102 | Combined sources | ||
Glycosylationi | 223 | O-linked (Man...) serineCombined sources | 1 | |
Glycosylationi | 225 | O-linked (Man...) serineCombined sources | 1 | |
Glycosylationi | 265 | N-linked (GlcNAc...) asparagineCombined sources | 1 | |
Glycosylationi | 419 | N-linked (GlcNAc...) asparagineCombined sources | 1 |
Proteomic databases
ProteomicsDBi | 338588 |
PTM databases
GlyConnecti | 2657, 1 N-Linked glycan (1 site) |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000103144, Expressed in brain and 67 other tissues |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 133 | CadherinInterPro annotationAdd BLAST | 105 | |
Domaini | 134 – 242 | CadherinInterPro annotationAdd BLAST | 109 | |
Domaini | 243 – 347 | CadherinInterPro annotationAdd BLAST | 105 | |
Domaini | 355 – 452 | CadherinInterPro annotationAdd BLAST | 98 | |
Domaini | 453 – 562 | CadherinInterPro annotationAdd BLAST | 110 | |
Domaini | 579 – 683 | CadherinInterPro annotationAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 808 – 840 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 901 – 931 | DisorderedSequence analysisAdd BLAST | 31 |
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000164018 |
HOGENOMi | CLU_006480_3_0_1 |
OMAi | LMARTKV |
OrthoDBi | 223098at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR032455, Cadherin_C IPR031904, Cadherin_CBD IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030736, PCDHGA1 |
PANTHERi | PTHR24028:SF108, PTHR24028:SF108, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF08266, Cadherin_2, 1 hit PF16492, Cadherin_C_2, 1 hit PF15974, Cadherin_tail, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q91XZ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIPEKLTGW SLLVLVCLSL ELLLEAGAGN IRYSVPEETD KGSFVGSIAK
60 70 80 90 100
DLGLETRELM ERGIRIVSRG RSQLFSLNPR SGSLVTAGRI DREELCAQST
110 120 130 140 150
PCVVSFNILM EDEMKLLPIE VEIIDINDNT PQFQLEELEL KMSEITTPGT
160 170 180 190 200
RIPLPLGQDL DVGINSLQSY QLSANPHFSL DVQQGPEGPQ QPEMVLQRPL
210 220 230 240 250
DREKDAVHYL VLTASDGGSP IHSGTLQIHV QVVDVNDNPP AFTKAEYHVS
260 270 280 290 300
VPENVPLGTR LLKVNATDPD EGANGRVTYS FHKVDHSVVR KFQLDAYTGE
310 320 330 340 350
LSNKEPLDFE EYKVYPMEIQ AQDGAGLMAR AKVLVTVLDV NDNAPEVGIT
360 370 380 390 400
SVTNTVPENF PPGTTIALIS VHDQDADNNG HITCSIPGNL PFKLEKLVDN
410 420 430 440 450
YYRLVTERTL DREQSSRHNI TITATDQGTP PLSTQAHISL LVTDINDNPP
460 470 480 490 500
VFEQDSYSVY IPENNPRGAS IFSVKAQDAD HNENALVTYA LVEDTIQGVP
510 520 530 540 550
LSSYFSINSD TGVVYALQSF DYEQFRDLQL RVMAHDSGNP QLSSNVSLSL
560 570 580 590 600
FMIDQNDNAP EILYPVLPTD GSTGVELAPR SAEPGYLVTK VVAVDKDSGQ
610 620 630 640 650
NSWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLERDALKQ SLVVAVQDHG
660 670 680 690 700
QPPLSTTVTF TIAVADSIPD LLADLGSMGT PADPQDSDLT LYLVVAVAVV
710 720 730 740 750
SCIFLAFVIV LLVLKLRHWY SSRLLQTEAN GLTGLPASNF VGVDGVHAFL
760 770 780 790 800
QTYSREISLT ADSRKSHLIF PQPNYADTLI SHESCEKQEF LSAPQSLLED
810 820 830 840 850
KEEIFSQQAP PNTDWRFSQA QRPGTSGSQN GDETGTWPNN QFDTEMLQAM
860 870 880 890 900
ILASASEAAD GSSTLGGGAG TMGLSARYGP QFTLQHVPDY RQNVYIPGSN
910 920 930
ATLTNAAGKR DGKAPAGGNG NKKKSGKKEK K
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YW27 | A0A0A6YW27_MOUSE | Protocadherin gamma subfamily A, 1 | Pcdhga1 | 810 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY013792 mRNA Translation: AAK26081.1 |
RefSeqi | NP_291062.1, NM_033584.1 |
Genome annotation databases
Ensembli | ENSMUST00000194190; ENSMUSP00000142062; ENSMUSG00000103144 |
GeneIDi | 93709 |
KEGGi | mmu:93709 |
UCSCi | uc008eql.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY013792 mRNA Translation: AAK26081.1 |
RefSeqi | NP_291062.1, NM_033584.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4ZI9 | X-ray | 1.70 | A/B | 29-339 | [»] | |
5SZL | X-ray | 4.20 | A/B/C/D | 29-447 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
PTM databases
GlyConnecti | 2657, 1 N-Linked glycan (1 site) |
Proteomic databases
ProteomicsDBi | 338588 |
Protocols and materials databases
Antibodypediai | 27257, 164 antibodies from 22 providers |
DNASUi | 93709 |
Genome annotation databases
Ensembli | ENSMUST00000194190; ENSMUSP00000142062; ENSMUSG00000103144 |
GeneIDi | 93709 |
KEGGi | mmu:93709 |
UCSCi | uc008eql.1, mouse |
Organism-specific databases
CTDi | 56114 |
MGIi | MGI:1935212, Pcdhga1 |
VEuPathDBi | HostDB:ENSMUSG00000103144 |
Phylogenomic databases
GeneTreei | ENSGT00940000164018 |
HOGENOMi | CLU_006480_3_0_1 |
OMAi | LMARTKV |
OrthoDBi | 223098at2759 |
Miscellaneous databases
BioGRID-ORCSi | 93709, 0 hits in 44 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000103144, Expressed in brain and 67 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR032455, Cadherin_C IPR031904, Cadherin_CBD IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030736, PCDHGA1 |
PANTHERi | PTHR24028:SF108, PTHR24028:SF108, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF08266, Cadherin_2, 1 hit PF16492, Cadherin_C_2, 1 hit PF15974, Cadherin_tail, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q91XZ0_MOUSE | |
Accessioni | Q91XZ0Primary (citable) accession number: Q91XZ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 1, 2001 |
Last sequence update: | December 1, 2001 | |
Last modified: | January 19, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |