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Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Gene

Pip4k2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.149 3474
ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-6811555 PI5P Regulates TP53 Acetylation
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8847453 Synthesis of PIPs in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC:2.7.1.149)
Alternative name(s):
Phosphatidylinositol 5-phosphate 4-kinase type II gamma
Short name:
PI(5)P 4-kinase type II gamma
Short name:
PIP4KII-gamma
Gene namesi
Name:Pip4k2c
Synonyms:Pip5k2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2152214 Pip4k2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002857512 – 421Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei26PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91XU3
MaxQBiQ91XU3
PaxDbiQ91XU3
PeptideAtlasiQ91XU3
PRIDEiQ91XU3

PTM databases

iPTMnetiQ91XU3
PhosphoSitePlusiQ91XU3

Expressioni

Developmental stagei

No significant expression was discerned throughout the prenatal brains except for the olfactory mantle zone, which exhibited the expression signals weakly. On P0 and P7, the expression was weakly positive in the gray matter throughout the brain, with higher expression in the olfactory mitral cell layer. In the cerebellum, the expression was evenly positive in external and internal granule cell layers. On P21 and P56, the expression in non-cortical brain parenchyma was negligible. However, the expression was evident in the olfactory mitral cell layer, the piriform cortex, the hippocampal pyramidal CA1-3, and the cerebellar Purkinje cell layer, although much less distinct in the dentate granule cell layer and the cerebellar granule cell layer. In the cerebral cortex, the expression was weaker in layer V than the other layers. No significant expression was seen in the white matter.1 Publication

Gene expression databases

BgeeiENSMUSG00000025417 Expressed in 302 organ(s), highest expression level in ear vesicle
GenevisibleiQ91XU3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228173, 16 interactors
IntActiQ91XU3, 16 interactors
MINTiQ91XU3
STRINGi10090.ENSMUSP00000013970

Structurei

3D structure databases

ProteinModelPortaliQ91XU3
SMRiQ91XU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 420PIPKPROSITE-ProRule annotationAdd BLAST378

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00760000119184
HOGENOMiHOG000007832
HOVERGENiHBG000072
InParanoidiQ91XU3
KOiK00920
OMAiCGLTGPP
OrthoDBiEOG091G0857
PhylomeDBiQ91XU3
TreeFamiTF354315

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSSVPPAT APAAAGGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV
60 70 80 90 100
FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHFFH RENLPSHFKF
110 120 130 140 150
KEYCPQVFRN LRDRFAIDDH DYLVSLTRSP PSETEGSDGR FLISYDRTLV
160 170 180 190 200
IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVENEDSYM
210 220 230 240 250
LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ
260 270 280 290 300
KVYIGEEEKK VFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEG
310 320 330 340 350
PVREEESEWD GDCNLAGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF
360 370 380 390 400
IDVYAIRSAE GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI
410 420
STVHPEQYAK RFLDFIANIF A
Length:421
Mass (Da):47,336
Last modified:December 1, 2001 - v1
Checksum:i368C9CE0C9EA83D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90H → R in BAE28464 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054591 mRNA Translation: BAB62096.1
AK148299 mRNA Translation: BAE28464.1
BC005539 mRNA Translation: AAH05539.1
BC021383 mRNA Translation: AAH21383.1
CCDSiCCDS24232.1
RefSeqiNP_473438.1, NM_054097.3
XP_017169257.1, XM_017313768.1
UniGeneiMm.22682

Genome annotation databases

EnsembliENSMUST00000013970; ENSMUSP00000013970; ENSMUSG00000025417
GeneIDi117150
KEGGimmu:117150
UCSCiuc007hiq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054591 mRNA Translation: BAB62096.1
AK148299 mRNA Translation: BAE28464.1
BC005539 mRNA Translation: AAH05539.1
BC021383 mRNA Translation: AAH21383.1
CCDSiCCDS24232.1
RefSeqiNP_473438.1, NM_054097.3
XP_017169257.1, XM_017313768.1
UniGeneiMm.22682

3D structure databases

ProteinModelPortaliQ91XU3
SMRiQ91XU3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228173, 16 interactors
IntActiQ91XU3, 16 interactors
MINTiQ91XU3
STRINGi10090.ENSMUSP00000013970

PTM databases

iPTMnetiQ91XU3
PhosphoSitePlusiQ91XU3

Proteomic databases

EPDiQ91XU3
MaxQBiQ91XU3
PaxDbiQ91XU3
PeptideAtlasiQ91XU3
PRIDEiQ91XU3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013970; ENSMUSP00000013970; ENSMUSG00000025417
GeneIDi117150
KEGGimmu:117150
UCSCiuc007hiq.2 mouse

Organism-specific databases

CTDi79837
MGIiMGI:2152214 Pip4k2c

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00760000119184
HOGENOMiHOG000007832
HOVERGENiHBG000072
InParanoidiQ91XU3
KOiK00920
OMAiCGLTGPP
OrthoDBiEOG091G0857
PhylomeDBiQ91XU3
TreeFamiTF354315

Enzyme and pathway databases

BRENDAi2.7.1.149 3474
ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-6811555 PI5P Regulates TP53 Acetylation
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8847453 Synthesis of PIPs in the nucleus

Miscellaneous databases

ChiTaRSiPip4k2c mouse
PROiPR:Q91XU3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025417 Expressed in 302 organ(s), highest expression level in ear vesicle
GenevisibleiQ91XU3 MM

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPI42C_MOUSE
AccessioniPrimary (citable) accession number: Q91XU3
Secondary accession number(s): Q3UFU5, Q99K02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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