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Protein

Tandem C2 domains nuclear protein

Gene

Tc2n

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tandem C2 domains nuclear protein
Alternative name(s):
Membrane targeting tandem C2 domain-containing protein 1
Tandem C2 protein in nucleus
Short name:
Tac2-N
Gene namesi
Name:Tc2n
Synonyms:Mtac2d1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921663 Tc2n

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi446 – 448RRK → QQQ: Abolishes nuclear localization. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724151 – 489Tandem C2 domains nuclear proteinAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineBy similarity1
Modified residuei155PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei213PhosphothreonineBy similarity1
Modified residuei215PhosphothreonineBy similarity1
Modified residuei217PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91XT6
PRIDEiQ91XT6

PTM databases

iPTMnetiQ91XT6
PhosphoSitePlusiQ91XT6

Expressioni

Gene expression databases

BgeeiENSMUSG00000021187 Expressed in 115 organ(s), highest expression level in pineal body
CleanExiMM_TC2N
ExpressionAtlasiQ91XT6 baseline and differential
GenevisibleiQ91XT6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105674

Structurei

3D structure databases

ProteinModelPortaliQ91XT6
SMRiQ91XT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 455C2PROSITE-ProRule annotationAdd BLAST104

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi446 – 448Nuclear localization signal3

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00390000009196
HOGENOMiHOG000133064
HOVERGENiHBG056511
InParanoidiQ91XT6
KOiK17287
OMAiANQWKET
OrthoDBiEOG091G06AP
PhylomeDBiQ91XT6
TreeFamiTF317035

Family and domain databases

CDDicd08684 C2A_Tac2-N, 1 hit
cd08692 C2B_Tac2-N, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037786 C2A_Tac2-N
IPR037788 C2B_Tac2-N
IPR030542 Tac2-N
PANTHERiPTHR10024:SF5 PTHR10024:SF5, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91XT6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEFIKSCC RGCLYGETEK QKFSVDRDFK ASASSSQNTI GIPPLTSVLV
60 70 80 90 100
KPQVGCNEDY LLSKLPCDGK EVQFVVPRFK LSYIQPRTQG IPSHLDELEG
110 120 130 140 150
SARASFGDQK TELCSSFYHG PSYDVYNPCY MYQHFSPDLS RRFLPHCETK
160 170 180 190 200
QLYGSVCDLR TSKLPGSSGL SKSMLDLTTS SQRFIQRHDS FSSVPSSSSS
210 220 230 240 250
RKNSQGSNRS LDTITLSGDE RDLGRLNVKL FYNSSAEQIW ITVLQCRDIS
260 270 280 290 300
WPSSYGDTPT ISIKGILTLS KPVHFKSSAK EGSNAIEFME TFVFAIKLQN
310 320 330 340 350
LQAVRLAFKI QTQTPKKKTI GECSLSLRTL STQEMEYSLE IIAPSKISVC
360 370 380 390 400
QAELELGTCF QAVNSRIQLQ ILEAQYLPSS STPLTLSFFV KVGMFSSGEL
410 420 430 440 450
IYKKKTRLLK ASSGRVKWGE TMIFPLIQTE KEIVFLIKLY SRSSVRRKHF
460 470 480
VGQLWISEDS NNIEAVNQWK ETITNPEKVV IKWHKLNPS
Length:489
Mass (Da):54,988
Last modified:July 27, 2011 - v2
Checksum:iCFBB3E069EB68D5A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXQ6E0CXQ6_MOUSE
Tandem C2 domains nuclear protein
Tc2n
425Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35S → N in BAB62893 (PubMed:11526914).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062282 mRNA Translation: BAB62893.1
AK016683 mRNA Translation: BAB30378.1
AK136558 mRNA Translation: BAE23043.1
CH466549 Genomic DNA Translation: EDL18876.1
BC120793 mRNA Translation: AAI20794.1
CCDSiCCDS36524.1
RefSeqiNP_001076445.1, NM_001082976.2
NP_083200.1, NM_028924.3
XP_006516364.1, XM_006516301.3
XP_006516366.1, XM_006516303.3
XP_011242493.1, XM_011244191.2
XP_011242494.1, XM_011244192.2
XP_017170706.1, XM_017315217.1
UniGeneiMm.275939
Mm.390521

Genome annotation databases

EnsembliENSMUST00000110047; ENSMUSP00000105674; ENSMUSG00000021187
ENSMUST00000160830; ENSMUSP00000124287; ENSMUSG00000021187
ENSMUST00000162735; ENSMUSP00000125288; ENSMUSG00000021187
GeneIDi74413
KEGGimmu:74413
UCSCiuc007otm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062282 mRNA Translation: BAB62893.1
AK016683 mRNA Translation: BAB30378.1
AK136558 mRNA Translation: BAE23043.1
CH466549 Genomic DNA Translation: EDL18876.1
BC120793 mRNA Translation: AAI20794.1
CCDSiCCDS36524.1
RefSeqiNP_001076445.1, NM_001082976.2
NP_083200.1, NM_028924.3
XP_006516364.1, XM_006516301.3
XP_006516366.1, XM_006516303.3
XP_011242493.1, XM_011244191.2
XP_011242494.1, XM_011244192.2
XP_017170706.1, XM_017315217.1
UniGeneiMm.275939
Mm.390521

3D structure databases

ProteinModelPortaliQ91XT6
SMRiQ91XT6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105674

PTM databases

iPTMnetiQ91XT6
PhosphoSitePlusiQ91XT6

Proteomic databases

PaxDbiQ91XT6
PRIDEiQ91XT6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110047; ENSMUSP00000105674; ENSMUSG00000021187
ENSMUST00000160830; ENSMUSP00000124287; ENSMUSG00000021187
ENSMUST00000162735; ENSMUSP00000125288; ENSMUSG00000021187
GeneIDi74413
KEGGimmu:74413
UCSCiuc007otm.2 mouse

Organism-specific databases

CTDi123036
MGIiMGI:1921663 Tc2n

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00390000009196
HOGENOMiHOG000133064
HOVERGENiHBG056511
InParanoidiQ91XT6
KOiK17287
OMAiANQWKET
OrthoDBiEOG091G06AP
PhylomeDBiQ91XT6
TreeFamiTF317035

Miscellaneous databases

PROiPR:Q91XT6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021187 Expressed in 115 organ(s), highest expression level in pineal body
CleanExiMM_TC2N
ExpressionAtlasiQ91XT6 baseline and differential
GenevisibleiQ91XT6 MM

Family and domain databases

CDDicd08684 C2A_Tac2-N, 1 hit
cd08692 C2B_Tac2-N, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037786 C2A_Tac2-N
IPR037788 C2B_Tac2-N
IPR030542 Tac2-N
PANTHERiPTHR10024:SF5 PTHR10024:SF5, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAC2N_MOUSE
AccessioniPrimary (citable) accession number: Q91XT6
Secondary accession number(s): Q3UW74, Q9D4A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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