UniProtKB - Q91XT5 (BCDO1_RAT)
Protein
Beta,beta-carotene 15,15'-dioxygenase
Gene
Bco1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.By similarity
Catalytic activityi
- EC:1.13.11.63By similarity
Cofactori
Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity
: retinol metabolism Pathwayi
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 172 | Iron; catalyticBy similarity | 1 | |
Metal bindingi | 237 | Iron; catalyticBy similarity | 1 | |
Metal bindingi | 308 | Iron; catalyticBy similarity | 1 | |
Metal bindingi | 514 | Iron; catalyticBy similarity | 1 |
GO - Molecular functioni
- beta-carotene 15,15'-monooxygenase activity Source: RGD
- carotenoid dioxygenase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- beta-carotene metabolic process Source: RGD
- carotene catabolic process Source: GO_Central
- retinal metabolic process Source: RGD
- retinoid metabolic process Source: UniProtKB
- retinol metabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.99.36, 5301 |
Reactomei | R-RNO-975634, Retinoid metabolism and transport |
UniPathwayi | UPA00912 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta,beta-carotene 15,15'-dioxygenase (EC:1.13.11.63By similarity)Alternative name(s): Beta-carotene dioxygenase 1 Beta-carotene oxygenase 1Imported |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70981, Bco1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143935 | 1 – 566 | Beta,beta-carotene 15,15'-dioxygenaseAdd BLAST | 566 |
Proteomic databases
PaxDbi | Q91XT5 |
PRIDEi | Q91XT5 |
Family & Domainsi
Sequence similaritiesi
Belongs to the carotenoid oxygenase family.Curated
Phylogenomic databases
eggNOGi | KOG1285, Eukaryota |
InParanoidi | Q91XT5 |
PhylomeDBi | Q91XT5 |
Family and domain databases
InterProi | View protein in InterPro IPR004294, Carotenoid_Oase |
PANTHERi | PTHR10543, PTHR10543, 1 hit |
Pfami | View protein in Pfam PF03055, RPE65, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q91XT5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIIFGRNKK EQLEPLRATV TGSIPAWLQG TLLRNGPGMH TVGDSKYNHW
60 70 80 90 100
FDGLALLHSF SIRDGEVFYR SKYLQSDTYN ANIEANRIVV SEFGTMAYPD
110 120 130 140 150
PCKNIFSKAF SYLSHTIPDF TDNCLINIMK CGEDFYATTE TNYIRKIDPQ
160 170 180 190 200
TLETLEKVDY RKYVAVNLAT SHPHYDEAGN VLNMGTSIAD KGGTKYVMFK
210 220 230 240 250
IPATAPGSKK KGKNPLKHSE VFCSIPSRSL LSPSYYHSFG VTENYVVFLE
260 270 280 290 300
QPFKLDILKM ATAYMRGVSW ASCMTFCKED KTYIHIIDQK TRKPVPTKFY
310 320 330 340 350
TDPMVVFHHV NAYEEDGCVL FDVIAYEDNS LYQLFYLANL NKDFEEKSRL
360 370 380 390 400
TSVPTLRRFA VPLHVDKDAE VGSNLVKVSS TTATALKEKD DHVYCQPEVL
410 420 430 440 450
YEGLELPRIN YAHNGKPYRY IFAAEVQWSP VPTKILKYDV LTKSSLKWSE
460 470 480 490 500
ESCWPAEPLF VPTPGAKDED DGVILSAIIS TDPQKLPFLL ILDAKSFTEL
510 520 530 540 550
ARASVDVDMH LDLHGLFIPD AGWNAVKQTP AKTQEDENSD HPTGLTAPGL
560
GHGENDFTAG HGGKSL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V7N1 | G3V7N1_RAT | Beta,beta-carotene 15,15'-dioxygena... | Bco1 Bcmo1, rCG_51466 | 566 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB062912 mRNA Translation: BAB60807.1 |
Genome annotation databases
UCSCi | RGD:70981, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB062912 mRNA Translation: BAB60807.1 |
3D structure databases
SMRi | Q91XT5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016880 |
Proteomic databases
PaxDbi | Q91XT5 |
PRIDEi | Q91XT5 |
Genome annotation databases
UCSCi | RGD:70981, rat |
Organism-specific databases
RGDi | 70981, Bco1 |
Phylogenomic databases
eggNOGi | KOG1285, Eukaryota |
InParanoidi | Q91XT5 |
PhylomeDBi | Q91XT5 |
Enzyme and pathway databases
UniPathwayi | UPA00912 |
BRENDAi | 1.14.99.36, 5301 |
Reactomei | R-RNO-975634, Retinoid metabolism and transport |
Miscellaneous databases
PROi | PR:Q91XT5 |
Family and domain databases
InterProi | View protein in InterPro IPR004294, Carotenoid_Oase |
PANTHERi | PTHR10543, PTHR10543, 1 hit |
Pfami | View protein in Pfam PF03055, RPE65, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BCDO1_RAT | |
Accessioni | Q91XT5Primary (citable) accession number: Q91XT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | October 7, 2020 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families