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Protein

BMP and activin membrane-bound inhibitor homolog

Gene

Bambi

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negatively regulates TGF-beta signaling.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2173788 Downregulation of TGF-beta receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
BMP and activin membrane-bound inhibitor homolog
Alternative name(s):
Kinase-deficient TGFbeta superfamily receptor subunit
Gene namesi
Name:Bambi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi621831 Bambi

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 152ExtracellularSequence analysisAdd BLAST126
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 260CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002078127 – 260BMP and activin membrane-bound inhibitor homologAdd BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91XN4
PRIDEiQ91XN4

Expressioni

Tissue specificityi

Detected in granulosa and thecal cells of adult ovaries and in spermatogonia, spermatocytes, round spermatids, and Sertoli cells of adult testes.1 Publication

Gene expression databases

BgeeiENSRNOG00000016066 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ91XN4 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021801

Structurei

3D structure databases

ProteinModelPortaliQ91XN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAMBI family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU1 Eukaryota
ENOG4110R2C LUCA
GeneTreeiENSGT00390000014168
HOGENOMiHOG000095174
HOVERGENiHBG050659
InParanoidiQ91XN4
KOiK10162
OMAiVTGHENC
OrthoDBiEOG091G0PAE
PhylomeDBiQ91XN4
TreeFamiTF333466

Family and domain databases

InterProiView protein in InterPro
IPR009345 BAMBI
PANTHERiPTHR15505:SF1 PTHR15505:SF1, 1 hit
PfamiView protein in Pfam
PF06211 BAMBI, 1 hit
PIRSFiPIRSF037456 BAMBI, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA
60 70 80 90 100
CFSRLLDPQN TNSPLTHGCL DSLASTADIC RAKQAQNHSG PTMPTLECCH
110 120 130 140 150
EDMCNYRGLH DVLSPPKSEA SGQGNRYQHD SSRNLITKVQ ELTSSKELWF
160 170 180 190 200
RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDQRQQM LSRLHYSFHG
210 220 230 240 250
HHSKKGQVAK LDLECMVPVS GQENCCLTCD KMRQADLSNE KILSLVHWGM
260
YSGHGKLEFV
Length:260
Mass (Da):29,143
Last modified:December 1, 2001 - v1
Checksum:iE33CC1729DE260A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387513 mRNA Translation: AAK67353.1
BC070516 mRNA Translation: AAH70516.1
RefSeqiNP_620782.1, NM_139082.3
UniGeneiRn.25267

Genome annotation databases

EnsembliENSRNOT00000021801; ENSRNOP00000021801; ENSRNOG00000016066
GeneIDi83837
KEGGirno:83837
UCSCiRGD:621831 rat

Similar proteinsi

Entry informationi

Entry nameiBAMBI_RAT
AccessioniPrimary (citable) accession number: Q91XN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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