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Entry version 140 (31 Jul 2019)
Sequence version 2 (21 Mar 2006)
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Protein

Oxysterol-binding protein-related protein 1

Gene

Osbpl1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-192105 Synthesis of bile acids and bile salts
R-MMU-2132295 MHC class II antigen presentation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 1
Short name:
ORP-1
Short name:
OSBP-related protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Osbpl1a
Synonyms:Orp1, Orp1a, Orp1l
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1927551 Osbpl1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001003681 – 950Oxysterol-binding protein-related protein 1Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei499PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q91XL9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q91XL9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q91XL9

PeptideAtlas

More...
PeptideAtlasi
Q91XL9

PRoteomics IDEntifications database

More...
PRIDEi
Q91XL9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q91XL9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91XL9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044252 Expressed in 290 organ(s), highest expression level in prefrontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q91XL9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q91XL9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VAPA (By similarity).

Interacts with the GTP-bound form of RAB7A (By similarity).

Interacts with OAS1B.

By similarity1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q91XL9, 2 interactors

Molecular INTeraction database

More...
MINTi
Q91XL9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000073957

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1950
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q91XL9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati47 – 76ANK 1Add BLAST30
Repeati80 – 109ANK 2Add BLAST30
Repeati175 – 204ANK 3Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini235 – 334PHPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 237Interaction with RAB7ABy similarityAdd BLAST237

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili430 – 463Sequence analysisAdd BLAST34
Coiled coili879 – 913Sequence analysisAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OSBP family.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1737 Eukaryota
ENOG410XP9E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155295

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000048711

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q91XL9

KEGG Orthology (KO)

More...
KOi
K20174

Database of Orthologous Groups

More...
OrthoDBi
863978at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q91XL9

TreeFam database of animal gene trees

More...
TreeFami
TF320922

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10972 PTHR10972, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF01237 Oxysterol_BP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF144000 SSF144000, 1 hit
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q91XL9-1) [UniParc]FASTAAdd to basket
Also known as: Osbpl1b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTEAEQQLL HHARNGNAEE VRKLLAAMAR MEVVADIDCK GRSKSNLGWT
60 70 80 90 100
PLHLACYFGH KQVVEDLLKA GAKVNMLNDM GDTPLHRAAF TGRKELVLLL
110 120 130 140 150
LEYDADSTVV NGSGQTAKEA THDKEIRNML EAVERTQQRK LEELLLGAAR
160 170 180 190 200
EGRTAEVSAL LSRPNPPDVN CSDQLGNTPL HCAAYRAHKQ CVLKLLRSGA
210 220 230 240 250
DPSLKNKNDQ KPLDLAQGAE MKHILVGNKV VHKALKRYEG PLWKSSRFFG
260 270 280 290 300
WKLFWVVLEH GVLSWYRKQP DAVHNSYRQG CKHLTQAVCT VKPTDSCLFS
310 320 330 340 350
IRCFDDTVHC FRVPKNSVQQ SREKWLEAIE EHSAYSTHYC SQDQVTDDEE
360 370 380 390 400
EDVVSAMDLK ESLARAQTCQ QRLDREIYNF LKMIKECDVA KDMLPSFLQK
410 420 430 440 450
ADIVSEASRE TCVALNDCLN LFTKQEGVRN FKLEQEQEKN KILSEALETL
460 470 480 490 500
ATEHHELERS LVEGSPPVSI LSEEEFYDAL SGSESEGSLT CLEAVTAHSF
510 520 530 540 550
EENEVPGSSG KHRMSEGKDC GGGDALSNGI KKHRTSLPSP MFSRNDFSIW
560 570 580 590 600
SILRKCIGME LSKITMPVIF NEPLSFLQRL TEYMEHTYLI HKASSLSDPV
610 620 630 640 650
ERMQCVAAFA VSAVASQWER TGKPFNPLLG ETYELVRDDL GFRLISEQVS
660 670 680 690 700
HHPPISAFHA EGLNNDFIFH GSIYPKLKFW GKSVEAEPKG TITLELLDHN
710 720 730 740 750
EAYTWTNPTC CVHNIIVGKL WIEQYGNVEI INHKTGDKCV LNFKPCGLFG
760 770 780 790 800
KELHKVEGYI QDKSKKKLCA LYGKWTECLY SVDPATFDAY KKNDKKNTEE
810 820 830 840 850
KKNSKQTSSS EESDEMPVPD SESVFIIPGS VLLWRIAPRP PNSAQMYNFT
860 870 880 890 900
SFAMVLNEVD KEMESVIPKT DCRLRPDIRA MENGEIDLAS EEKKRLEEKQ
910 920 930 940 950
RAARKNRSKS EEDWKTRWFH QGPNPYSGAQ DWIYSGSYWD RNYFNLPDIY
Length:950
Mass (Da):107,795
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA4F5678999B0EB5
GO
Isoform 2 (identifier: Q91XL9-2) [UniParc]FASTAAdd to basket
Also known as: Osbpl1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-513: Missing.

Show »
Length:437
Mass (Da):50,069
Checksum:i869EDF5199C9C70B
GO
Isoform 3 (identifier: Q91XL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-540: Missing.

Show »
Length:410
Mass (Da):47,344
Checksum:iD37F5D9161BAC7E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3V156Q3V156_MOUSE
Oxysterol-binding protein
Osbpl1a
558Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4EI24A0A3Q4EI24_MOUSE
Oxysterol-binding protein
Osbpl1a
547Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4EG54A0A3Q4EG54_MOUSE
Oxysterol-binding protein
Osbpl1a
528Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z7I9D3Z7I9_MOUSE
Oxysterol-binding protein
Osbpl1a
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z754D3Z754_MOUSE
Oxysterol-binding protein
Osbpl1a
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4L2S6A0A3Q4L2S6_MOUSE
Oxysterol-binding protein
Osbpl1a
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZ66D3YZ66_MOUSE
Oxysterol-binding protein-related p...
Osbpl1a
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8K2D2Q8K2D2_MOUSE
Osbpl1a protein
Osbpl1a mCG_20195
338Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4EG41A0A3Q4EG41_MOUSE
Oxysterol-binding protein-related p...
Osbpl1a
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDE4D6RDE4_MOUSE
Oxysterol-binding protein-related p...
Osbpl1a
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti572E → D in AAH76637 (PubMed:15489334).Curated1
Sequence conflicti599P → L in BAA33012 (Ref. 3) Curated1
Sequence conflicti685E → K in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti697 – 698LD → FV in AAK71661 (PubMed:12215260).Curated2
Sequence conflicti713H → Q in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti732N → T in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti744K → N in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti759Y → S in AAK71661 (PubMed:12215260).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0177231 – 540Missing in isoform 3. 1 PublicationAdd BLAST540
Alternative sequenceiVSP_0177241 – 513Missing in isoform 2. 3 PublicationsAdd BLAST513

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF394063 mRNA Translation: AAK71661.2
AY536214 mRNA Translation: AAT06024.1
AB017026 mRNA Translation: BAA33012.1
AK168366 mRNA Translation: BAE40301.1
BC076637 mRNA Translation: AAH76637.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS29067.1 [Q91XL9-1]
CCDS57114.1 [Q91XL9-2]

NCBI Reference Sequences

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RefSeqi
NP_001239418.1, NM_001252489.1
NP_001239419.1, NM_001252490.1 [Q91XL9-2]
NP_001239420.1, NM_001252491.1 [Q91XL9-2]
NP_001239421.1, NM_001252492.1 [Q91XL9-2]
NP_001239422.1, NM_001252493.1 [Q91XL9-2]
NP_997413.2, NM_207530.3 [Q91XL9-1]
XP_006526204.1, XM_006526141.3 [Q91XL9-1]
XP_006526205.1, XM_006526142.3 [Q91XL9-1]
XP_006526210.1, XM_006526147.2 [Q91XL9-2]
XP_006526211.1, XM_006526148.2 [Q91XL9-2]
XP_017173451.1, XM_017317962.1 [Q91XL9-2]
XP_017173452.1, XM_017317963.1 [Q91XL9-2]
XP_017173453.1, XM_017317964.1 [Q91XL9-2]
XP_017173454.1, XM_017317965.1 [Q91XL9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000074352; ENSMUSP00000073957; ENSMUSG00000044252 [Q91XL9-1]
ENSMUST00000117361; ENSMUSP00000112681; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000118313; ENSMUSP00000113735; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000119043; ENSMUSP00000113357; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000121774; ENSMUSP00000113268; ENSMUSG00000044252 [Q91XL9-3]
ENSMUST00000121808; ENSMUSP00000113841; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000121888; ENSMUSP00000112895; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000234194; ENSMUSP00000157017; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000234871; ENSMUSP00000157342; ENSMUSG00000044252 [Q91XL9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64291

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:64291

UCSC genome browser

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UCSCi
uc008ecp.2 mouse [Q91XL9-2]
uc008ecu.2 mouse [Q91XL9-1]
uc012azm.2 mouse [Q91XL9-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394063 mRNA Translation: AAK71661.2
AY536214 mRNA Translation: AAT06024.1
AB017026 mRNA Translation: BAA33012.1
AK168366 mRNA Translation: BAE40301.1
BC076637 mRNA Translation: AAH76637.1
CCDSiCCDS29067.1 [Q91XL9-1]
CCDS57114.1 [Q91XL9-2]
RefSeqiNP_001239418.1, NM_001252489.1
NP_001239419.1, NM_001252490.1 [Q91XL9-2]
NP_001239420.1, NM_001252491.1 [Q91XL9-2]
NP_001239421.1, NM_001252492.1 [Q91XL9-2]
NP_001239422.1, NM_001252493.1 [Q91XL9-2]
NP_997413.2, NM_207530.3 [Q91XL9-1]
XP_006526204.1, XM_006526141.3 [Q91XL9-1]
XP_006526205.1, XM_006526142.3 [Q91XL9-1]
XP_006526210.1, XM_006526147.2 [Q91XL9-2]
XP_006526211.1, XM_006526148.2 [Q91XL9-2]
XP_017173451.1, XM_017317962.1 [Q91XL9-2]
XP_017173452.1, XM_017317963.1 [Q91XL9-2]
XP_017173453.1, XM_017317964.1 [Q91XL9-2]
XP_017173454.1, XM_017317965.1 [Q91XL9-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z2MX-ray2.14B/D1-136[»]
5Z2NX-ray2.14A/B1-136[»]
SMRiQ91XL9
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ91XL9, 2 interactors
MINTiQ91XL9
STRINGi10090.ENSMUSP00000073957

PTM databases

iPTMnetiQ91XL9
PhosphoSitePlusiQ91XL9

Proteomic databases

EPDiQ91XL9
jPOSTiQ91XL9
PaxDbiQ91XL9
PeptideAtlasiQ91XL9
PRIDEiQ91XL9

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
64291
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074352; ENSMUSP00000073957; ENSMUSG00000044252 [Q91XL9-1]
ENSMUST00000117361; ENSMUSP00000112681; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000118313; ENSMUSP00000113735; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000119043; ENSMUSP00000113357; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000121774; ENSMUSP00000113268; ENSMUSG00000044252 [Q91XL9-3]
ENSMUST00000121808; ENSMUSP00000113841; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000121888; ENSMUSP00000112895; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000234194; ENSMUSP00000157017; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000234871; ENSMUSP00000157342; ENSMUSG00000044252 [Q91XL9-2]
GeneIDi64291
KEGGimmu:64291
UCSCiuc008ecp.2 mouse [Q91XL9-2]
uc008ecu.2 mouse [Q91XL9-1]
uc012azm.2 mouse [Q91XL9-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114876
MGIiMGI:1927551 Osbpl1a

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00940000155295
HOGENOMiHOG000048711
InParanoidiQ91XL9
KOiK20174
OrthoDBi863978at2759
PhylomeDBiQ91XL9
TreeFamiTF320922

Enzyme and pathway databases

ReactomeiR-MMU-192105 Synthesis of bile acids and bile salts
R-MMU-2132295 MHC class II antigen presentation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q91XL9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000044252 Expressed in 290 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiQ91XL9 baseline and differential
GenevisibleiQ91XL9 MM

Family and domain databases

Gene3Di1.25.40.20, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 2 hits
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01237 Oxysterol_BP, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSBL1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91XL9
Secondary accession number(s): O88318
, Q3TH97, Q673L8, Q6DFU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 21, 2006
Last modified: July 31, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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