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Protein

Oxysterol-binding protein-related protein 1

Gene

Osbpl1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.By similarity

GO - Molecular functioni

  • cholesterol binding Source: MGI
  • lipid binding Source: GO_Central
  • sterol binding Source: GO_Central
  • sterol transporter activity Source: GO_Central

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-192105 Synthesis of bile acids and bile salts
R-MMU-2132295 MHC class II antigen presentation

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 1
Short name:
ORP-1
Short name:
OSBP-related protein 1
Gene namesi
Name:Osbpl1a
Synonyms:Orp1, Orp1a, Orp1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1927551 Osbpl1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003681 – 950Oxysterol-binding protein-related protein 1Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei499PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91XL9
PaxDbiQ91XL9
PeptideAtlasiQ91XL9
PRIDEiQ91XL9

PTM databases

iPTMnetiQ91XL9
PhosphoSitePlusiQ91XL9

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000044252 Expressed in 290 organ(s), highest expression level in prefrontal cortex
CleanExiMM_OSBPL1A
ExpressionAtlasiQ91XL9 baseline and differential
GenevisibleiQ91XL9 MM

Interactioni

Subunit structurei

Interacts with VAPA (By similarity). Interacts with the GTP-bound form of RAB7A (By similarity). Interacts with OAS1B.By similarity1 Publication

Protein-protein interaction databases

IntActiQ91XL9, 2 interactors
MINTiQ91XL9
STRINGi10090.ENSMUSP00000073957

Structurei

Secondary structure

1950
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ91XL9
SMRiQ91XL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 76ANK 1Add BLAST30
Repeati80 – 109ANK 2Add BLAST30
Repeati175 – 204ANK 3Add BLAST30
Domaini235 – 334PHPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 237Interaction with RAB7ABy similarityAdd BLAST237

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili430 – 463Sequence analysisAdd BLAST34
Coiled coili879 – 913Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the OSBP family.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000048711
HOVERGENiHBG082087
InParanoidiQ91XL9
KOiK20174
OrthoDBiEOG091G07RK
PhylomeDBiQ91XL9
TreeFamiTF320922

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 3 hits
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01237 Oxysterol_BP, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q91XL9-1) [UniParc]FASTAAdd to basket
Also known as: Osbpl1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTEAEQQLL HHARNGNAEE VRKLLAAMAR MEVVADIDCK GRSKSNLGWT
60 70 80 90 100
PLHLACYFGH KQVVEDLLKA GAKVNMLNDM GDTPLHRAAF TGRKELVLLL
110 120 130 140 150
LEYDADSTVV NGSGQTAKEA THDKEIRNML EAVERTQQRK LEELLLGAAR
160 170 180 190 200
EGRTAEVSAL LSRPNPPDVN CSDQLGNTPL HCAAYRAHKQ CVLKLLRSGA
210 220 230 240 250
DPSLKNKNDQ KPLDLAQGAE MKHILVGNKV VHKALKRYEG PLWKSSRFFG
260 270 280 290 300
WKLFWVVLEH GVLSWYRKQP DAVHNSYRQG CKHLTQAVCT VKPTDSCLFS
310 320 330 340 350
IRCFDDTVHC FRVPKNSVQQ SREKWLEAIE EHSAYSTHYC SQDQVTDDEE
360 370 380 390 400
EDVVSAMDLK ESLARAQTCQ QRLDREIYNF LKMIKECDVA KDMLPSFLQK
410 420 430 440 450
ADIVSEASRE TCVALNDCLN LFTKQEGVRN FKLEQEQEKN KILSEALETL
460 470 480 490 500
ATEHHELERS LVEGSPPVSI LSEEEFYDAL SGSESEGSLT CLEAVTAHSF
510 520 530 540 550
EENEVPGSSG KHRMSEGKDC GGGDALSNGI KKHRTSLPSP MFSRNDFSIW
560 570 580 590 600
SILRKCIGME LSKITMPVIF NEPLSFLQRL TEYMEHTYLI HKASSLSDPV
610 620 630 640 650
ERMQCVAAFA VSAVASQWER TGKPFNPLLG ETYELVRDDL GFRLISEQVS
660 670 680 690 700
HHPPISAFHA EGLNNDFIFH GSIYPKLKFW GKSVEAEPKG TITLELLDHN
710 720 730 740 750
EAYTWTNPTC CVHNIIVGKL WIEQYGNVEI INHKTGDKCV LNFKPCGLFG
760 770 780 790 800
KELHKVEGYI QDKSKKKLCA LYGKWTECLY SVDPATFDAY KKNDKKNTEE
810 820 830 840 850
KKNSKQTSSS EESDEMPVPD SESVFIIPGS VLLWRIAPRP PNSAQMYNFT
860 870 880 890 900
SFAMVLNEVD KEMESVIPKT DCRLRPDIRA MENGEIDLAS EEKKRLEEKQ
910 920 930 940 950
RAARKNRSKS EEDWKTRWFH QGPNPYSGAQ DWIYSGSYWD RNYFNLPDIY
Length:950
Mass (Da):107,795
Last modified:March 21, 2006 - v2
Checksum:iAA4F5678999B0EB5
GO
Isoform 2 (identifier: Q91XL9-2) [UniParc]FASTAAdd to basket
Also known as: Osbpl1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-513: Missing.

Show »
Length:437
Mass (Da):50,069
Checksum:i869EDF5199C9C70B
GO
Isoform 3 (identifier: Q91XL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-540: Missing.

Show »
Length:410
Mass (Da):47,344
Checksum:iD37F5D9161BAC7E5
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3V156Q3V156_MOUSE
Oxysterol-binding protein
Osbpl1a
558Annotation score:
D3Z7I9D3Z7I9_MOUSE
Oxysterol-binding protein
Osbpl1a
184Annotation score:
Q8K2D2Q8K2D2_MOUSE
Osbpl1a protein
Osbpl1a mCG_20195
338Annotation score:
D3YZ66D3YZ66_MOUSE
Oxysterol-binding protein-related p...
Osbpl1a
187Annotation score:
D6RDE4D6RDE4_MOUSE
Oxysterol-binding protein-related p...
Osbpl1a
66Annotation score:
D3Z754D3Z754_MOUSE
Oxysterol-binding protein-related p...
Osbpl1a
11Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti572E → D in AAH76637 (PubMed:15489334).Curated1
Sequence conflicti599P → L in BAA33012 (Ref. 3) Curated1
Sequence conflicti685E → K in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti697 – 698LD → FV in AAK71661 (PubMed:12215260).Curated2
Sequence conflicti713H → Q in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti732N → T in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti744K → N in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti759Y → S in AAK71661 (PubMed:12215260).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0177231 – 540Missing in isoform 3. 1 PublicationAdd BLAST540
Alternative sequenceiVSP_0177241 – 513Missing in isoform 2. 3 PublicationsAdd BLAST513

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394063 mRNA Translation: AAK71661.2
AY536214 mRNA Translation: AAT06024.1
AB017026 mRNA Translation: BAA33012.1
AK168366 mRNA Translation: BAE40301.1
BC076637 mRNA Translation: AAH76637.1
CCDSiCCDS29067.1 [Q91XL9-1]
CCDS57114.1 [Q91XL9-2]
RefSeqiNP_001239418.1, NM_001252489.1
NP_001239419.1, NM_001252490.1 [Q91XL9-2]
NP_001239420.1, NM_001252491.1 [Q91XL9-2]
NP_001239421.1, NM_001252492.1 [Q91XL9-2]
NP_001239422.1, NM_001252493.1 [Q91XL9-2]
NP_997413.2, NM_207530.3 [Q91XL9-1]
XP_006526204.1, XM_006526141.3 [Q91XL9-1]
XP_006526205.1, XM_006526142.3 [Q91XL9-1]
XP_006526210.1, XM_006526147.2 [Q91XL9-2]
XP_006526211.1, XM_006526148.2 [Q91XL9-2]
XP_017173451.1, XM_017317962.1 [Q91XL9-2]
XP_017173452.1, XM_017317963.1 [Q91XL9-2]
XP_017173453.1, XM_017317964.1 [Q91XL9-2]
XP_017173454.1, XM_017317965.1 [Q91XL9-2]
UniGeneiMm.259470

Genome annotation databases

EnsembliENSMUST00000074352; ENSMUSP00000073957; ENSMUSG00000044252 [Q91XL9-1]
ENSMUST00000117361; ENSMUSP00000112681; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000118313; ENSMUSP00000113735; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000119043; ENSMUSP00000113357; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000121774; ENSMUSP00000113268; ENSMUSG00000044252 [Q91XL9-3]
ENSMUST00000121808; ENSMUSP00000113841; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000121888; ENSMUSP00000112895; ENSMUSG00000044252 [Q91XL9-2]
GeneIDi64291
KEGGimmu:64291
UCSCiuc008ecp.2 mouse [Q91XL9-2]
uc008ecu.2 mouse [Q91XL9-1]
uc012azm.2 mouse [Q91XL9-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394063 mRNA Translation: AAK71661.2
AY536214 mRNA Translation: AAT06024.1
AB017026 mRNA Translation: BAA33012.1
AK168366 mRNA Translation: BAE40301.1
BC076637 mRNA Translation: AAH76637.1
CCDSiCCDS29067.1 [Q91XL9-1]
CCDS57114.1 [Q91XL9-2]
RefSeqiNP_001239418.1, NM_001252489.1
NP_001239419.1, NM_001252490.1 [Q91XL9-2]
NP_001239420.1, NM_001252491.1 [Q91XL9-2]
NP_001239421.1, NM_001252492.1 [Q91XL9-2]
NP_001239422.1, NM_001252493.1 [Q91XL9-2]
NP_997413.2, NM_207530.3 [Q91XL9-1]
XP_006526204.1, XM_006526141.3 [Q91XL9-1]
XP_006526205.1, XM_006526142.3 [Q91XL9-1]
XP_006526210.1, XM_006526147.2 [Q91XL9-2]
XP_006526211.1, XM_006526148.2 [Q91XL9-2]
XP_017173451.1, XM_017317962.1 [Q91XL9-2]
XP_017173452.1, XM_017317963.1 [Q91XL9-2]
XP_017173453.1, XM_017317964.1 [Q91XL9-2]
XP_017173454.1, XM_017317965.1 [Q91XL9-2]
UniGeneiMm.259470

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z2MX-ray2.14B/D1-136[»]
5Z2NX-ray2.14A/B1-136[»]
ProteinModelPortaliQ91XL9
SMRiQ91XL9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91XL9, 2 interactors
MINTiQ91XL9
STRINGi10090.ENSMUSP00000073957

PTM databases

iPTMnetiQ91XL9
PhosphoSitePlusiQ91XL9

Proteomic databases

EPDiQ91XL9
PaxDbiQ91XL9
PeptideAtlasiQ91XL9
PRIDEiQ91XL9

Protocols and materials databases

DNASUi64291
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074352; ENSMUSP00000073957; ENSMUSG00000044252 [Q91XL9-1]
ENSMUST00000117361; ENSMUSP00000112681; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000118313; ENSMUSP00000113735; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000119043; ENSMUSP00000113357; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000121774; ENSMUSP00000113268; ENSMUSG00000044252 [Q91XL9-3]
ENSMUST00000121808; ENSMUSP00000113841; ENSMUSG00000044252 [Q91XL9-2]
ENSMUST00000121888; ENSMUSP00000112895; ENSMUSG00000044252 [Q91XL9-2]
GeneIDi64291
KEGGimmu:64291
UCSCiuc008ecp.2 mouse [Q91XL9-2]
uc008ecu.2 mouse [Q91XL9-1]
uc012azm.2 mouse [Q91XL9-3]

Organism-specific databases

CTDi114876
MGIiMGI:1927551 Osbpl1a

Phylogenomic databases

eggNOGiKOG1737 Eukaryota
ENOG410XP9E LUCA
GeneTreeiENSGT00760000119155
HOGENOMiHOG000048711
HOVERGENiHBG082087
InParanoidiQ91XL9
KOiK20174
OrthoDBiEOG091G07RK
PhylomeDBiQ91XL9
TreeFamiTF320922

Enzyme and pathway databases

ReactomeiR-MMU-192105 Synthesis of bile acids and bile salts
R-MMU-2132295 MHC class II antigen presentation

Miscellaneous databases

PROiPR:Q91XL9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044252 Expressed in 290 organ(s), highest expression level in prefrontal cortex
CleanExiMM_OSBPL1A
ExpressionAtlasiQ91XL9 baseline and differential
GenevisibleiQ91XL9 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 3 hits
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01237 Oxysterol_BP, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSBL1_MOUSE
AccessioniPrimary (citable) accession number: Q91XL9
Secondary accession number(s): O88318
, Q3TH97, Q673L8, Q6DFU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 21, 2006
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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