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Protein

UDP-glucuronic acid decarboxylase 1

Gene

Uxs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity).By similarity

Catalytic activityi

UDP-D-glucuronate = UDP-D-xylose + CO2.

Cofactori

NAD+By similarity

Pathwayi: UDP-alpha-D-xylose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-xylose from UDP-alpha-D-glucuronate.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucuronic acid decarboxylase 1 (Uxs1)
This subpathway is part of the pathway UDP-alpha-D-xylose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-xylose from UDP-alpha-D-glucuronate, the pathway UDP-alpha-D-xylose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228SubstrateBy similarity1
Active sitei231Proton acceptorBy similarity1
Binding sitei260SubstrateBy similarity1
Binding sitei272NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi119 – 144NADBy similarityAdd BLAST26
Nucleotide bindingi231 – 235NADBy similarity5
Nucleotide bindingi273 – 277SubstrateBy similarity5
Nucleotide bindingi290 – 297SubstrateBy similarity8
Nucleotide bindingi357 – 361SubstrateBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandNAD

Enzyme and pathway databases

UniPathwayi
UPA00796;UER00771

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronic acid decarboxylase 1 (EC:4.1.1.35)
Alternative name(s):
UDP-glucuronate decarboxylase 1
Short name:
UGD
Short name:
UXS-1
Gene namesi
Name:Uxs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915133 Uxs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini41 – 420LumenalSequence analysisAdd BLAST380

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001832701 – 420UDP-glucuronic acid decarboxylase 1Add BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei94PhosphothreonineBy similarity1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ91XL3
MaxQBiQ91XL3
PaxDbiQ91XL3
PeptideAtlasiQ91XL3
PRIDEiQ91XL3

PTM databases

iPTMnetiQ91XL3
PhosphoSitePlusiQ91XL3

Expressioni

Gene expression databases

BgeeiENSMUSG00000057363 Expressed in 273 organ(s), highest expression level in primary oocyte
CleanExiMM_UXS1
ExpressionAtlasiQ91XL3 baseline and differential
GenevisibleiQ91XL3 MM

Interactioni

Subunit structurei

Interacts with AKT1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119939

Structurei

3D structure databases

ProteinModelPortaliQ91XL3
SMRiQ91XL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1429 Eukaryota
COG0451 LUCA
GeneTreeiENSGT00530000063128
HOVERGENiHBG094144
InParanoidiQ91XL3
KOiK08678
OMAiTIGEFAE
OrthoDBiEOG091G0BV7
PhylomeDBiQ91XL3
TreeFamiTF105736

Family and domain databases

InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR021761 UXS1_N
PfamiView protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit
PF11803 UXS1_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q91XL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSKGLLRLV SSVNRRRMKL LLGIALFAYA ASVWGNFVNM RSIQENGELK
60 70 80 90 100
IESKIEEIVE PLREKIRDLE KSFTQKYPPV KFLSEKDRKR ILITGGAGFV
110 120 130 140 150
GSHLTDKLMM DGHEVTVVDN FFTGRKRNVE HWIGHENFEL INHDVVEPLY
160 170 180 190 200
IEVDQIYHLA SPASPPNYMY NPIKTLKTNT IGTLNMLGLA KRVGARLLLA
210 220 230 240 250
STSEVYGDPE VHPQSEDYWG HVNPIGPRAC YDEGKRVAET MCYAYMKQEG
260 270 280 290 300
VEVRVARIFN TFGPRMHMND GRVVSNFILQ ALQGEPLTVY GSGSQTRAFQ
310 320 330 340 350
YVSDLVNGLV ALMNSNVSSP VNLGNPEEHT ILEFAQLIKN LVGSGSEIQF
360 370 380 390 400
LSEAQDDPQK RKPDIKKAKL MLGWEPVVPL EEGLNKAIHY FRKELEYQAN
410 420
NQYIPKPKPA RVKKGRTRHS
Length:420
Mass (Da):47,553
Last modified:December 1, 2001 - v1
Checksum:iDB188E2780309AE4
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z411D3Z411_MOUSE
UDP-glucuronic acid decarboxylase 1
Uxs1
127Annotation score:
D3YUF9D3YUF9_MOUSE
UDP-glucuronic acid decarboxylase 1
Uxs1
254Annotation score:
D6RIQ1D6RIQ1_MOUSE
UDP-glucuronic acid decarboxylase 1
Uxs1
40Annotation score:
G5E8H4G5E8H4_MOUSE
UDP-glucuronate decarboxylase 1, is...
Uxs1 mCG_121442
108Annotation score:
A0A0J9YUC7A0A0J9YUC7_MOUSE
UDP-glucuronic acid decarboxylase 1
Uxs1
110Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257R → G in BAE31165 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399958 mRNA Translation: AAK85410.1
AK075806 mRNA Translation: BAC35974.1
AK152376 mRNA Translation: BAE31165.1
BC037049 mRNA Translation: AAH37049.1
CCDSiCCDS35551.1
RefSeqiNP_080706.1, NM_026430.3
UniGeneiMm.387202

Genome annotation databases

EnsembliENSMUST00000126008; ENSMUSP00000119939; ENSMUSG00000057363
GeneIDi67883
KEGGimmu:67883
UCSCiuc007avq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF399958 mRNA Translation: AAK85410.1
AK075806 mRNA Translation: BAC35974.1
AK152376 mRNA Translation: BAE31165.1
BC037049 mRNA Translation: AAH37049.1
CCDSiCCDS35551.1
RefSeqiNP_080706.1, NM_026430.3
UniGeneiMm.387202

3D structure databases

ProteinModelPortaliQ91XL3
SMRiQ91XL3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119939

PTM databases

iPTMnetiQ91XL3
PhosphoSitePlusiQ91XL3

Proteomic databases

EPDiQ91XL3
MaxQBiQ91XL3
PaxDbiQ91XL3
PeptideAtlasiQ91XL3
PRIDEiQ91XL3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000126008; ENSMUSP00000119939; ENSMUSG00000057363
GeneIDi67883
KEGGimmu:67883
UCSCiuc007avq.1 mouse

Organism-specific databases

CTDi80146
MGIiMGI:1915133 Uxs1

Phylogenomic databases

eggNOGiKOG1429 Eukaryota
COG0451 LUCA
GeneTreeiENSGT00530000063128
HOVERGENiHBG094144
InParanoidiQ91XL3
KOiK08678
OMAiTIGEFAE
OrthoDBiEOG091G0BV7
PhylomeDBiQ91XL3
TreeFamiTF105736

Enzyme and pathway databases

UniPathwayi
UPA00796;UER00771

Miscellaneous databases

PROiPR:Q91XL3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057363 Expressed in 273 organ(s), highest expression level in primary oocyte
CleanExiMM_UXS1
ExpressionAtlasiQ91XL3 baseline and differential
GenevisibleiQ91XL3 MM

Family and domain databases

InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR021761 UXS1_N
PfamiView protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit
PF11803 UXS1_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUXS1_MOUSE
AccessioniPrimary (citable) accession number: Q91XL3
Secondary accession number(s): Q3U854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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