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Protein
Submitted name:

Leucine-rich HEV glycoprotein

Gene

Lrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • transforming growth factor beta receptor binding Source: MGI

GO - Biological processi

  • brown fat cell differentiation Source: MGI
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of endothelial cell proliferation Source: MGI
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • response to bacterium Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
Leucine-rich HEV glycoproteinImported
Submitted name:
Leucine-rich alpha-2-glycoproteinImported
Submitted name:
Leucine-rich alpha-2-glycoprotein 1Imported
Gene namesi
Name:Lrg1Imported
Synonyms:LrgImported, lrhgImported
ORF Names:mCG_22979Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1924155 Lrg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_501509949133 – 342Sequence analysisAdd BLAST310

Expressioni

Gene expression databases

BgeeiENSMUSG00000037095 Expressed in 134 organ(s), highest expression level in inguinal mammary gland

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60318N
IntActiQ91XL1, 4 interactors
Q91XL1, 4 interactors
STRINGi10090.ENSMUSP00000038048

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini292 – 342LRRCTInterPro annotationAdd BLAST51

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000234378
HOVERGENiHBG000045
OMAiDTRCAGP
OrthoDBiEOG091G0RZG
TreeFamiTF351919

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

Sequencei

Sequence statusi: Complete.

Q91XL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSWQHQGSL QDLKTCLART LFLLALLGRV SSLKECLILQ SAEGSTVSCH
60 70 80 90 100
GPTEFPSSLP ADTVHLSVEF SNLTQLPAAA LQGCPGLREL HLSSNRLQAL
110 120 130 140 150
SPELLAPVPR LRALDLTRNA LRSLPPGLFS TSANLSTLVL RENQLREVSA
160 170 180 190 200
QWLQGLDALG HLDLAENQLS SLPSGLLASL GALHTLDLGY NLLESLPEGL
210 220 230 240 250
LRGPRRLQRL HLEGNRLQRL EDSLLAPQPF LRVLFLNDNQ LVGVATGSFQ
260 270 280 290 300
GLQHLDMLDL SNNSLSSTPP GLWAFLGRPT RDMQDGFDIS HNPWICDKNL
310 320 330 340
ADLCRWLVAN RNKMFSQNDT RCAGPEAMKG QRLLDVAELG SL
Length:342
Mass (Da):37,431
Last modified:December 1, 2001 - v1
Checksum:iC47D826F57677747
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009719 Genomic DNA No translation available.
BC030733 mRNA Translation: AAH30733.1
BC092077 mRNA Translation: AAH92077.1
AF403429 mRNA Translation: AAK95352.1
AB055885 mRNA Translation: BAB83091.1
CH466559 Genomic DNA Translation: EDL23719.1
RefSeqiNP_084072.1, NM_029796.2
UniGeneiMm.348025

Genome annotation databases

EnsembliENSMUST00000041357; ENSMUSP00000038048; ENSMUSG00000037095
GeneIDi76905
KEGGimmu:76905
UCSCiuc008dbb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009719 Genomic DNA No translation available.
BC030733 mRNA Translation: AAH30733.1
BC092077 mRNA Translation: AAH92077.1
AF403429 mRNA Translation: AAK95352.1
AB055885 mRNA Translation: BAB83091.1
CH466559 Genomic DNA Translation: EDL23719.1
RefSeqiNP_084072.1, NM_029796.2
UniGeneiMm.348025

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60318N
IntActiQ91XL1, 4 interactors
Q91XL1, 4 interactors
STRINGi10090.ENSMUSP00000038048

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041357; ENSMUSP00000038048; ENSMUSG00000037095
GeneIDi76905
KEGGimmu:76905
UCSCiuc008dbb.1 mouse

Organism-specific databases

CTDi116844
MGIiMGI:1924155 Lrg1

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000148957
HOGENOMiHOG000234378
HOVERGENiHBG000045
OMAiDTRCAGP
OrthoDBiEOG091G0RZG
TreeFamiTF351919

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiLrg1 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037095 Expressed in 134 organ(s), highest expression level in inguinal mammary gland

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ91XL1_MOUSE
AccessioniPrimary (citable) accession number: Q91XL1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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