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Protein
Submitted name:

Tyrosinase, isoform CRA_b

Gene

Tyr

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosinase, isoform CRA_bImported
Gene namesi
Name:TyrImported
ORF Names:mCG_18425Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98880 Tyr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei474 – 501HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501431244819 – 533Sequence analysisAdd BLAST515

Expressioni

Gene expression databases

BgeeiENSMUSG00000004651 Expressed in 82 organ(s), highest expression level in iris
ExpressionAtlasiQ91XK0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ91XK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 219Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini383 – 394Tyrosinase_Cu-bdInterPro annotationAdd BLAST12

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEZU Eukaryota
ENOG410Y42I LUCA
HOVERGENiHBG003553
KOiK00505
OMAiSFFSSWQ
OrthoDBiEOG091G03YR

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
InterProiView protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF00264 Tyrosinase, 1 hit
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 2 hits
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91XK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLAVLYCLL WSFQISDGHF PRACASSKNL LAKECCPPWM GDGSPCGQLS
60 70 80 90 100
GRGSCQDILL SSAPSGPQFP FKGVDDRESW PSVFYNRTCQ CSGNFMGFNC
110 120 130 140 150
GNCKFGFGGP NCTEKRVLIR RNIFDLSVSE KNKFFSYLTL AKHTISSVYV
160 170 180 190 200
IPTGTYGQMN NGSTPMFNDI NIYDLFVWMH YYVSRDTLLG GSEIWRDIDF
210 220 230 240 250
AHEAPGFLPW HRLFLLLWEQ EIRELTGDEN FTVPYWDWRD AENCDICTDE
260 270 280 290 300
YLGGRHPENP NLLSPASFFS SWQIICSRSE EYNSHQVLCD GTPEGPLLRN
310 320 330 340 350
PGNHDKAKTP RLPSSADVEF CLSLTQYESG SMDRTANFSF RNTLEGFASP
360 370 380 390 400
LTGIADPSQS SMHNALHIFM NGTMSQVQGS ANDPIFLLHH AFVDSIFEQW
410 420 430 440 450
LRRHRPLLEV YPEANAPIGH NRDSYMVPFI PLYRNGDFFI TSKDLGYDYS
460 470 480 490 500
YLQESDPGFY RNYIEPYLEQ ASRIWPWLLG AALVGAVIAA ALSGLSSRLC
510 520 530
LQKKKKKKQP QEERQPLLMD KDDYHSLLYQ SHL
Length:533
Mass (Da):60,606
Last modified:December 1, 2001 - v1
Checksum:iA4C109A97CBD5D6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079678 mRNA Translation: AAH79678.1
AK014619 mRNA Translation: BAB29466.1
LC259496 Genomic DNA Translation: BAX25612.1
LC259497 Genomic DNA Translation: BAX25613.1
CH466543 Genomic DNA Translation: EDL06801.1
PIRiA27711 YRMSCS
RefSeqiNP_035791.1, NM_011661.5
UniGeneiMm.238127

Genome annotation databases

GeneIDi22173
KEGGimmu:22173

Similar proteinsi

Entry informationi

Entry nameiQ91XK0_MOUSE
AccessioniPrimary (citable) accession number: Q91XK0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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